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  1 / 23431 MEDLINE  
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[PMID]:29385201
[Au] Autor:Zhou Z; Liu F; Zhang X; Zhou X; Zhong Z; Su H; Li J; Li H; Feng F; Lan J; Zhang Z; Fu H; Hu Y; Cao S; Chen W; Deng J; Yu J; Zhang W; Peng G
[Ad] Endereço:The Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
[Ti] Título:Cellulose-dependent expression and antibacterial characteristics of surfactin from Bacillus subtilis HH2 isolated from the giant panda.
[So] Source:PLoS One;13(1):e0191991, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Surfactin secreted by Bacillus subtilis can confer strong, diverse antipathogenic effects, thereby benefitting the host. Carbon source is an important factor for surfactin production. However, the mechanism that bacteria utilize cellulose, the most abundant substance in the intestines of herbivores, to produce surfactin remains unclear. Here, we used B. subtilis HH2, isolated from the feces of a giant panda, as a model to determine changes in surfactin expression in the presence of different concentrations of cellulose by quantitative polymerase chain reaction and high-performance liquid chromatography. We further investigated the antimicrobial effects of surfactin against three common intestinal pathogens (Escherichia coli, Staphylococcus aureus, and Salmonella enterica) and its resistance to high temperature (60-121°C), pH (1-12), trypsin (100-300 µg/mL, pH 8), and pepsin (100-300 µg/mL, pH 2). The results showed that the surfactin expressed lowest in bacteria cultured in the presence of 1% glucose medium as the carbon source, whereas increased in an appropriate cellulose concentration (0.67% glucose and 0.33% cellulose). The surfactin could inhibit E. coli and Staphylococcus aureus, but did not affect efficiently for Salmonella enterica. The antibacterial ability of surfactin did not differ according to temperature (60-100°C), pH (2-11), trypsin (100-300 µg/mL), and pepsin (100-300 µg/mL; P > 0.05), but decreased significantly at extreme environments (121°C, pH 1 or 12; P < 0.05) compared with that in the control group (37°C, pH = 7, without any protease). In conclusion, our findings indicated that B. subtilis HH2 could increase surfactin expression in an appropriate cellulose environment and thus provide benefits to improve the intestinal health of herbivores.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Bacillus subtilis/metabolismo
Celulose/metabolismo
Lipopeptídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Meios de Cultura
Lipopeptídeos/farmacologia
Ursidae
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Culture Media); 0 (Lipopeptides); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191991


  2 / 23431 MEDLINE  
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[PMID]:28456645
[Au] Autor:Wang W; Bai Q; Liang T; Bai H; Liu X
[Ad] Endereço:Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China. Electronic address: ww12230098@sina.com.
[Ti] Título:Preparation of amino-functionalized regenerated cellulose membranes with high catalytic activity.
[So] Source:Int J Biol Macromol;102:944-951, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The modification of regenerated cellulose (RC) membranes was carried out by using silane coupling agents presenting primary and secondary amino-groups. The grafting of the amino groups onto the modified cellulose molecule was confirmed by X-ray photoelectron spectroscopies and C nuclear magnetic resonance spectroscopic analyses. The crystallinity of the cellulose membranes (CM) decreased after chemical modification as indicated by the X-ray diffraction results. Moreover, a denser structure was observed at the surface and cross section of the modified membranes by SEM images. The contact angle measurements showed that the silane coupling treatment enhanced the hydrophobicity of the obtained materials. Then the catalytic properties of two types of modified membranes were studied in a batch process by evaluating their catalytic performance in a Knoevenagel condensation. The results indicated that the cellulose membrane grafted with many secondary amines exhibited a better catalytic activity compared to the one grafted only by primary amines. In addition, the compact structure of the modified membranes permitted their application in a pervaporation catalytic membrane reactor. Therefore, functional CM that prepared in this paper represented a promising material in the field of industrial catalysis.
[Mh] Termos MeSH primário: Celulose/química
Membranas Artificiais
[Mh] Termos MeSH secundário: Catálise
Silanos/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membranes, Artificial); 0 (Silanes); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  3 / 23431 MEDLINE  
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[PMID]:29478637
[Au] Autor:Gurtowski LA; Griggs CS; Gude VG; Shukla MK
[Ad] Endereço:Environmental Laboratory, Engineer Research and Development Center, Vicksburg, MS 39180, USA.
[Ti] Título:An integrated theoretical and experimental investigation of insensitive munition compounds adsorption on cellulose, cellulose triacetate, chitin and chitosan surfaces.
[So] Source:J Environ Sci (China);64:174-180, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This manuscript reports results of combined computational chemistry and batch adsorption investigation of insensitive munition compounds, 2,4-dinitroanisole (DNAN), triaminotrinitrobenzene (TATB), 1,1-diamino-2,2-dinitroethene (FOX-7) and nitroguanidine (NQ), and traditional munition compound 2,4,6-trinitrotoluene (TNT) on the surfaces of cellulose, cellulose triacetate, chitin and chitosan biopolymers. Cellulose, cellulose triacetate, chitin and chitosan were modeled as trimeric form of the linear chain of C chair conformation of ß-d-glucopyranos, its triacetate form, ß-N-acetylglucosamine and D-glucosamine, respectively, in the 1âž”4 linkage. Geometries were optimized at the M062X functional level of the density functional theory (DFT) using the 6-31G(d,p) basis set in the gas phase and in the bulk water solution using the conductor-like polarizable continuum model (CPCM) approach. The nature of potential energy surfaces of the optimized geometries were ascertained through the harmonic vibrational frequency analysis. The basis set superposition error (BSSE) corrected interaction energies were obtained using the 6-311G(d,p) basis set at the same theoretical level. The computed BSSE in the gas phase was used to correct interaction energy in the bulk water solution. Computed and experimental results regarding the ability of considered surfaces in adsorbing the insensitive munitions compounds are discussed.
[Mh] Termos MeSH primário: Substâncias Explosivas/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Anisóis/química
Celulose/análogos & derivados
Celulose/química
Quitina/química
Quitosana/química
Guanidinas/química
Nitrocompostos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,1-diamino-2,2-dinitroethene); 0 (Anisoles); 0 (Explosive Agents); 0 (Guanidines); 0 (Nitro Compounds); 1398-61-4 (Chitin); 1L0OD70295 (2,4-dinitroanisole); 9004-34-6 (Cellulose); 9012-09-3 (cellulose triacetate); 9012-76-4 (Chitosan); NAY6KWL67F (nitroguanidine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


  4 / 23431 MEDLINE  
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[PMID]:29249536
[Au] Autor:Serroukh S; Huber P; Lallam A
[Ad] Endereço:Centre Technique du Papier, Domaine universitaire - CS, 90251 - 38044 Grenoble, France; Université de Haute Alsace, 18 Rue des Frères Lumière, 68093 Mulhouse, France. Electronic address: serroukhsonia@hotmail.com.
[Ti] Título:Adsorption behavior of optical brightening agent on microfibrillated cellulose studied through inverse liquid chromatography: The need to correct for axial dispersion effect.
[So] Source:J Chromatogr A;1533:17-29, 2018 Jan 19.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inverse liquid chromatography is a technique for studying solid/liquid interaction and most specifically for the determination of solute adsorption isotherm. For the first time, the adsorption behaviour of microfibrillated cellulose was assessed using inverse liquid chromatography. We showed that microfibrillated cellulose could adsorb 17 mg/g of tetrasulfonated optical brightening agent in typical papermaking conditions. The adsorbed amount of hexasulfonated optical brightening agent was lower (7 mg/g). The packing of the column with microfibrillated cellulose caused important axial dispersion (D = 5e-7 m²/s). Simulation of transport phenomena in the column showed that neglecting axial dispersion in the analysis of the chromatogram caused significant error (8%) in the determination of maximum adsorbed amount. We showed that conventional chromatogram analysis technique such as elution by characteristic point could not be used to fit our data. Using a bi-Langmuir isotherm model improved the fitting, but did not take into account axial dispersion, thus provided adsorption parameters which may have no physical significance. Using an inverse method with a single Langmuir isotherm, and fitting the transport equation to the chromatogram was shown to provide a satisfactory fitting to the chromatogram data. In general, the inverse method could be recommended to analyse inverse liquid chromatography data for column packing with significant axial dispersion (D > 1e-7 m²/s).
[Mh] Termos MeSH primário: Celulose/química
Técnicas de Química Analítica/instrumentação
Técnicas de Química Analítica/métodos
Cromatografia Líquida
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Adsorção
Resíduos Industriais
Modelos Químicos
Papel
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Industrial Waste); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  5 / 23431 MEDLINE  
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[PMID]:29289927
[Au] Autor:Rajeswari A; Jackcina Stobel Christy E; Pius A
[Ad] Endereço:Department of Chemistry, The Gandhigram Rural Institute - Deemed University, Gandhigram, Dindigul 624 302, Tamil Nadu, India.
[Ti] Título:New insight of hybrid membrane to degrade Congo red and Reactive yellow under sunlight.
[So] Source:J Photochem Photobiol B;179:7-17, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A study was carried out to investigate the degradation of organic contaminants (Congo red and Reactive yellow - 105) using cellulose acetate - polystyrene (CA-PS) membrane with and without ZnO impregnation. Scanning electron microscope (SEM), electron dispersive analysis of X-rays (EDAX), Fourier transform infrared spectrometer (FTIR), atomic force microscope (AFM) and thermogravimeric analysis (TG-DTA) analysis were carried out to characterize bare and ZnO impregnated CA-PS membranes. Membrane efficiency was also tested for pure water flux and antifouling performance. The modified membrane showed almost 85% water flux recovery. Blending of ZnO nanoparticles to CA-PS matrix could decrease membrane fouling and increase permeation quality of the membrane with above 90% of photocatalytic degradation efficiency for dyes. The rate of degradation of dyes was observed using UV-Vis spectrometer. Reusability of CA-PS-ZnO membrane was studied and no significant change was noted in the degradation efficiency until fourth cycle. Langmuir-Hinshelwood kinetic model well describes the photo degradation capacity and the degradation of dyes CR and RY - 105 exhibited pseudo-first order kinetics. The regression coefficient (R) of CR and RY - 105 found to be 0.99. The novelty of the prepared CA-PS-ZnO membrane is that it has better efficiency and high thermal stability than our previously reported material. Therefore, ZnO impregnated CA-PS membrane had proved to be an innovative alternative for the degradation of CR and RY - 105 dyes.
[Mh] Termos MeSH primário: Corantes/química
Vermelho Congo/química
Nanocompostos/química
Fotólise/efeitos da radiação
Luz Solar
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Catálise
Celulose/análogos & derivados
Celulose/química
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Poliestirenos/química
Espectrofotometria
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Polystyrenes); 3J2P07GVB6 (acetylcellulose); 3U05FHG59S (Congo Red); 9004-34-6 (Cellulose); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  6 / 23431 MEDLINE  
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[PMID]:28470531
[Au] Autor:Vielreicher M; Friedrich O
[Ad] Endereço:Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Institute of Medical Biotechnology, Paul-Gordan-Street 3, Erlangen, 91052, Germany. martin.vielreicher@mbt.uni-erlangen.de.
[Ti] Título:Assessment of Population and ECM Production Using Multiphoton Microscopy as an Indicator of Cell Viability.
[So] Source:Methods Mol Biol;1601:243-255, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiphoton microscopy allows continuous depth-resolved, nondestructive imaging of scaffold-seeded cells during cell or tissue culture. Spectrally separated images in high resolution can be provided while cells are conserved in their native state. Here we describe the seeding of mesenchymal stem cells to bacterial nanocellulose hydropolymer scaffolds followed by 2-channel imaging of cellular autofluorescence (AF) and collagen-I formation using second harmonic generation (SHG) signals. With this approach the simultaneous observation of the progression of cell morphology and production of extracellular matrix as hallmarks of viability and cell fitness is possible.
[Mh] Termos MeSH primário: Sobrevivência Celular
Matriz Extracelular/metabolismo
Células Mesenquimais Estromais/química
Microscopia de Fluorescência por Excitação Multifotônica
[Mh] Termos MeSH secundário: Animais
Medula Óssea/química
Células Cultivadas
Celulose/química
Colágeno Tipo I/biossíntese
Matriz Extracelular/ultraestrutura
Células Mesenquimais Estromais/citologia
Imagem Óptica
Ratos
Tecidos Suporte/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6960-9_19


  7 / 23431 MEDLINE  
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[PMID]:29251504
[Au] Autor:Khan A; Wen Y; Huq T; Ni Y
[Ad] Endereço:Limerick Pulp and Paper Centre, Department of Chemical Engineering, University of New Brunswick , Fredericton, New Brunswick E3B 5A3, Canada.
[Ti] Título:Cellulosic Nanomaterials in Food and Nutraceutical Applications: A Review.
[So] Source:J Agric Food Chem;66(1):8-19, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellulosic nanomaterials (CNMs) are organic, green nanomaterials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made these nanomaterials an intriguing prospect for various applications including the food and nutraceutical industry. From the immobilization of various bioactive agents and enzymes, emulsion stabilization, direct food additives, to the development of intelligent packaging systems or pathogen or pH detectors, the potential food related applications for CNMs are endless. Over the past decade, there have been several reviews published covering different aspects of cellulosic nanomaterials, such as processing-structure-property relationship, physical and chemical properties, rheology, extraction, nanocomposites, etc. In this critical review, we have discussed and provided a summary of the recent developments in the utilization of cellulosic nanomaterials in applications related to food and nutraceuticals.
[Mh] Termos MeSH primário: Celulose
Suplementos Nutricionais
Indústria Alimentícia/métodos
Nanoestruturas/química
[Mh] Termos MeSH secundário: Animais
Células Imobilizadas
Emulsificantes/química
Enzimas Imobilizadas
Aditivos Alimentares/química
Embalagem de Alimentos
Seres Humanos
Mamíferos
Nanoestruturas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Enzymes, Immobilized); 0 (Food Additives); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04204


  8 / 23431 MEDLINE  
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[PMID]:29303269
[Au] Autor:Liu S; Li X; Chen L; Li L; Li B; Zhu J
[Ad] Endereço:Ministry of Education Engineering Research Center of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Sciences and Engineering, South China University of Technology , Guangzhou 510640, China.
[Ti] Título:Tunable d-Limonene Permeability in Starch-Based Nanocomposite Films Reinforced by Cellulose Nanocrystals.
[So] Source:J Agric Food Chem;66(4):979-987, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to control d-limonene permeability, cellulose nanocrystals (CNC) were used to regulate starch-based film multiscale structures. The effect of sphere-like cellulose nanocrystal (CS) and rod-like cellulose nanocrystal (CR) on starch molecular interaction, short-range molecular conformation, crystalline structure, and micro-ordered aggregated region structure were systematically discussed. CNC aspect ratio and content were proved to be independent variables to control d-limonene permeability via film-structure regulation. New hydrogen bonding formation and increased hydroxypropyl starch (HPS) relative crystallinity could be the reason for the lower d-limonene permeability compared with tortuous path model approximation. More hydrogen bonding formation, higher HPS relative crystallinity and larger size of micro-ordered aggregated region in CS0.5 and CR2 could explain the lower d-limonene permeability than CS2 and CR0.5, respectively. This study provided new insight for the control of the flavor release from starch-based films, which favored its application in biodegradable food packaging and flavor encapsulation.
[Mh] Termos MeSH primário: Celulose/química
Nanocompostos/química
Nanopartículas/química
Amido/química
[Mh] Termos MeSH secundário: Cicloexenos
Embalagem de Alimentos/instrumentação
Ligações de Hidrogênio
Conformação Molecular
Permeabilidade
Terpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Terpenes); 9004-34-6 (Cellulose); 9005-25-8 (Starch); 9MC3I34447 (limonene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05457


  9 / 23431 MEDLINE  
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[PMID]:29283261
[Au] Autor:Xu J; Liu S; Chen G; Chen T; Song T; Wu J; Shi C; He M; Tian J
[Ad] Endereço:State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering and ‡School of Medicine, South China University of Technology , Guangzhou 510640, P. R. China.
[Ti] Título:Engineering Biocompatible Hydrogels from Bicomponent Natural Nanofibers for Anticancer Drug Delivery.
[So] Source:J Agric Food Chem;66(4):935-942, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural hydrogels have attracted extensive research interest and shown great potential for many biomedical applications. In this study, a series of biocompatible hydrogels was reported based on the self-assembly of positively charged partially deacetylated α-chitin nanofibers (α-DECHN) and negatively charged 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) for anticancer drug delivery. The formation mechanisms of the α-DECHN/TOCNF hydrogels with different mixing proportions were studied, and their morphological, mechanical, and swelling properties were comprehensively investigated. Additionally, the drug delivery performance of the hydrogels was compared via sustained release test of an anticancer drug (5-fluorouracil). The results showed that the hydrogel with higher physical cross-linking degree exhibited a higher drug loading efficiency and drug release percentage.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Materiais Biocompatíveis
Quitina/química
Óxidos N-Cíclicos/química
Sistemas de Liberação de Medicamentos
Nanofibras/química
[Mh] Termos MeSH secundário: Celulose/química
Reagentes para Ligações Cruzadas
Preparações de Ação Retardada
Fluoruracila/administração & dosagem
Hidrogéis
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biocompatible Materials); 0 (Cross-Linking Reagents); 0 (Cyclic N-Oxides); 0 (Delayed-Action Preparations); 0 (Hydrogels); 1398-61-4 (Chitin); 9004-34-6 (Cellulose); U3P01618RT (Fluorouracil); VQN7359ICQ (TEMPO)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04210


  10 / 23431 MEDLINE  
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[PMID]:29224351
[Au] Autor:Luan Q; Zhou W; Zhang H; Bao Y; Zheng M; Shi J; Tang H; Huang F
[Ad] Endereço:Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences , Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Wuhan 43006
[Ti] Título:Cellulose-Based Composite Macrogels from Cellulose Fiber and Cellulose Nanofiber as Intestine Delivery Vehicles for Probiotics.
[So] Source:J Agric Food Chem;66(1):339-345, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellulose-based composite macrogels made by cellulose fiber/cellulose nanofiber (CCNM) were used as an intestine delivery vehicle for probiotics. Cellulose nanofiber (CNF) was prepared by a 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation system, and the carboxyl groups in CNF acted as pore size and pH responsibility regulators in CCNMs to regulate the probiotics loading and controlled release property. The macrogel presented a porosity of 92.68% with a CNF content of 90%, and the corresponding released viable Lactobacillus plantarum (L. plantarum) was up to 2.68 × 10 cfu/mL. The porous structure and high porosity benefited L. plantarum cells to infiltrate into the core of macrogels. In addition, the macrogels made with high contents of CNF showed sustainable release of L. plantarum cells and delivered enough viable cells to the desired region of intestine tracts. The porous cellulose macrogels prepared by a green and environmental friendly method show potential in the application of fabricating targeted delivery vehicles of bioactive agents.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos
Intestinos/efeitos dos fármacos
Lactobacillus plantarum/química
Probióticos/química
[Mh] Termos MeSH secundário: Celulose/química
Excipientes/química
Géis/química
Seres Humanos
Intestinos/microbiologia
Lactobacillus plantarum/fisiologia
Nanofibras/química
Probióticos/farmacologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Gels); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04754



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