Base de dados : MEDLINE
Pesquisa : D05.750.078.562.855.750 [Categoria DeCS]
Referências encontradas : 5969 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 597 ir para página                         

  1 / 5969 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29363966
[Au] Autor:Van den Abbeele P; Taminiau B; Pinheiro I; Duysburgh C; Jacobs H; Pijls L; Marzorati M
[Ad] Endereço:ProDigest bvba , Technologiepark 3, 9052 Ghent, Belgium.
[Ti] Título:Arabinoxylo-Oligosaccharides and Inulin Impact Inter-Individual Variation on Microbial Metabolism and Composition, Which Immunomodulates Human Cells.
[So] Source:J Agric Food Chem;66(5):1121-1130, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fecal batch fermentations coupled to cocultures of epithelial cells and macrophages were used to compare how arabinoxylo-oligosaccharides (AXOS) and inulin modulate gut microbial activity and composition of three different human donors and subsequently the epithelial permeability and immune response. Both inulin and AXOS decreased the pH during incubation (-1.5 pH units), leading to increased productions of acetate, propionate, and butyrate. Differences in terms of metabolites production could be linked to specific microbial alterations at genus level upon inulin/AXOS supplementation (i.e., Bifidobacterium, Bacteroides, Prevotella and unclassified Erysipelotrichaceae), as shown by 16S-targeted Illumina sequencing. Both products stimulated gut barrier and immune function with increases in TEER, NF-KB, IL-10, and IL-6. Ingredients with different structures selectively modulate the microbiota of a specific donor leading to differential changes at metabolic level. The extent of this effect is donor specific and is linked to a final specific modulation of the host's immune system.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/efeitos dos fármacos
Imunomodulação/efeitos dos fármacos
Inulina/farmacologia
Oligossacarídeos/farmacologia
Xilanos/farmacologia
[Mh] Termos MeSH secundário: Acetatos/metabolismo
Butiratos/metabolismo
Células CACO-2
Fezes/microbiologia
Fermentação
Microbioma Gastrointestinal/imunologia
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Concentração de Íons de Hidrogênio
Propionatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Butyrates); 0 (Oligosaccharides); 0 (Propionates); 0 (Xylans); 9005-80-5 (Inulin); 9040-27-1 (arabinoxylan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04611


  2 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29378102
[Au] Autor:Pilipenko VI; Teplyuk DA; Shakhovskaya AK; Isakov VA; Vorobyova VM; Vorobyova IS; Glazkova IV; Kochetkova AA; Mikheeva GA; Yudina AV
[Ti] Título:[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study].
[So] Source:Vopr Pitan;84(6):83-91, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Irritable bowel syndrome (IBS) is highly prevalent functional gastrointestinal disorder associated with decrease in quality of life and a high social cost. Diet is one of several therapeutic options in IBS treatment; therefore the development and clinical evaluation of innovative functional food for IBS patients is useful. Dry jelly concentrate containing 3 g inulin, 10 mg curcumin and 1.8 mg of pyridoxine was developed and clinically evaluated. Fifty patients fulfilling the Rome III criteria for IBS-C were randomly assigned into two groups: one received standard diet plus two jelly drinks a day for 2 weeks and control group received standard diet. Response to therapy was recorded on a daily basis using Likert scale of abdominal pain, bloating and feeling of incomplete bowel emptying, frequency of bowel movement, Bristol stool scale, and quality of life assessed by IBSQoL questionnaire before and after the treatment. Intake of functional food product (jelly) containing inulin and curcumin is associated with a significant positive effect on the stool parameters (from 0.6±0.24 to 1.15±0.65 t/d in stool frequency, p=0.001, from 2.62±1.23 to 3.99±1.27, index Bristol scale, p=0.001), a reduce of the severity of abdominal pain (from 1.69±0.71 to 1.36±0.44 Likert scale points, p=0.001), bloating (from 2.03±0.89 to 1.55±0.81 points of Likert scale, p=0.02) and a sense of incomplete bowel emptying (from 2.25±0.98 to 1.68±0.92 points of Likert scale, p=0.001), as well as an increase in quality of life (from 64.5±13.5 to 81.2±9.1%, Ñ€=0.05). Patients in control group have improvement in abdominal pain (from 2.16±0.58 to 1.8±0.61 Likert scale points, p=0.05) and bloating (from 2.42±0.83 to 2.16±0.71 Likert scale points, p=0.05) only. During the treatment period no significant adverse events were found. These results indicate that jelly concentrate containing inulin, curcumin and pyridoxine improves abdominal pain score, Bristol scale index and quality of life in patients with IBS-C.
[Mh] Termos MeSH primário: Bebidas
Constipação Intestinal
Fibras na Dieta/administração & dosagem
Síndrome do Intestino Irritável
Vitaminas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Constipação Intestinal/dietoterapia
Constipação Intestinal/fisiopatologia
Curcumina/administração & dosagem
Feminino
Seres Humanos
Inulina/administração & dosagem
Síndrome do Intestino Irritável/dietoterapia
Síndrome do Intestino Irritável/fisiopatologia
Masculino
Meia-Idade
Piridoxina/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Fiber); 0 (Vitamins); 9005-80-5 (Inulin); IT942ZTH98 (Curcumin); KV2JZ1BI6Z (Pyridoxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  3 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28776993
[Au] Autor:Yu S; Zhang Y; Zhu Y; Zhang T; Jiang B; Mu W
[Ad] Endereço:State Key Laboratory of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu 214122, China.
[Ti] Título:Improving the Catalytic Behavior of DFA I-Forming Inulin Fructotransferase from Streptomyces davawensis with Site-Directed Mutagenesis.
[So] Source:J Agric Food Chem;65(34):7579-7587, 2017 Aug 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previously, a α-d-fructofuranose-ß-d-fructofuranose 1,2':2,1'-dianhydride (DFA I)-forming inulin fructotransferase (IFTase), namely, SdIFTase, was identified. The enzyme does not show high performances. In this work, to improve catalytic behavior including activity and thermostability, the enzyme was modified using site-directed mutagenesis on the basis of structure. The mutated residues were divided into three groups. Those in group I are located at central tunnel including G236, A257, G281, T313, and A314S. The group II contains residues at the inner edge of substrate binding pocket including I80, while group III at the outer edge includes G121 and T122. The thermostability was reflected by the melting temperature (T ) determined by Nano DSC. Finally, the T values of G236S/G281S/A257S/T313S/A314S in group I and G121A/T122L in group III were enhanced by 3.2 and 4.5 °C, and the relative activities were enhanced to 140.5% and 148.7%, respectively. The method in this work may be applicable to other DFA I-forming IFTases.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
Dissacarídeos/metabolismo
Hexosiltransferases/química
Hexosiltransferases/metabolismo
Inulina/metabolismo
Streptomyces/enzimologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Catálise
Clonagem Molecular
Estabilidade Enzimática
Hexosiltransferases/genética
Mutagênese Sítio-Dirigida
Streptomyces/química
Streptomyces/genética
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Disaccharides); 9005-80-5 (Inulin); EC 2.4.1.- (Hexosyltransferases); EC 2.4.1.9 (inulosucrase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02897


  4 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28758637
[Au] Autor:Menon V; Ayala VI; Rangaswamy SP; Kalisz I; Whitney S; Galmin L; Ashraf A; LaBranche C; Montefiori D; Petrovsky N; Kalyanaraman VS; Pal R
[Ad] Endereço:1​Advanced BioScience Laboratories, Inc., Rockville, MD, USA.
[Ti] Título:DNA prime/protein boost vaccination elicits robust humoral response in rhesus macaques using oligomeric simian immunodeficiency virus envelope and Advax delta inulin adjuvant.
[So] Source:J Gen Virol;98(8):2143-2155, 2017 Aug.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The partial success of the RV144 trial underscores the importance of envelope-specific antibody responses for an effective HIV-1 vaccine. Oligomeric HIV-1 envelope proteins delivered with a potent adjuvant are expected to elicit strong antibody responses with broad neutralization specificity. To test this hypothesis, two SIV envelope proteins were formulated with delta inulin-based adjuvant (Advax) and used to immunize nonhuman primates. Oligomeric gp140-gp145 from SIVmac251 and SIVsmE660 was purified to homogeneity. Oligomers showed high-affinity interaction with CD4 and were highly immunogenic in rabbits, inducing Tier 2 SIV-neutralizing antibodies. The immunogenicity of an oligomeric Env DNA prime and protein boost together with Advax was evaluated in Chinese rhesus macaques. DNA administration elicited antibodies to both envelopes, and titres were markedly enhanced following homologous protein boosts via intranasal and intramuscular routes. Strong antibody responses were detected against the V1 and V2 domains of gp120. During peak immune responses, a low to moderate level of neutralizing activity was detected against Tier 1A/1B SIV isolates, with a moderate level noted against a Tier 2 isolate. Increased serum antibody affinity to SIVmac251 gp140 and generation of Env-specific memory B cells were observed in the immunized macaques. Animals were subjected to low-dose intravaginal challenge with SIVmac251 one week after the last protein boost. One out of three immunized animals was protected from infection. Although performed with a small number of macaques, this study demonstrates the utility of oligomeric envelopes formulated with Advax in eliciting broad antibody responses with the potential to provide protection against SIV transmission.
[Mh] Termos MeSH primário: Anticorpos Antivirais/imunologia
DNA Viral/imunologia
Proteína gp120 do Envelope de HIV/imunologia
Infecções por HIV/imunologia
Vacinas contra a SAIDS/imunologia
Vírus da Imunodeficiência Símia/imunologia
[Mh] Termos MeSH secundário: Vacinas contra a AIDS
Adjuvantes Imunológicos/administração & dosagem
Animais
Anticorpos Neutralizantes/imunologia
DNA Viral/administração & dosagem
DNA Viral/genética
Anticorpos Anti-HIV/imunologia
Proteína gp120 do Envelope de HIV/administração & dosagem
Proteína gp120 do Envelope de HIV/genética
Infecções por HIV/prevenção & controle
Infecções por HIV/virologia
HIV-1/genética
HIV-1/imunologia
Seres Humanos
Imunidade Humoral
Imunização Secundária
Inulina/administração & dosagem
Macaca mulatta
Coelhos
Vacinas contra a SAIDS/administração & dosagem
Vacinas contra a SAIDS/genética
Vírus da Imunodeficiência Símia/genética
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIDS Vaccines); 0 (Adjuvants, Immunologic); 0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (DNA, Viral); 0 (HIV Antibodies); 0 (HIV Envelope Protein gp120); 0 (SAIDS Vaccines); 9005-80-5 (Inulin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000863


  5 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28596023
[Au] Autor:Nicolucci AC; Hume MP; Martínez I; Mayengbam S; Walter J; Reimer RA
[Ad] Endereço:Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
[Ti] Título:Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity.
[So] Source:Gastroenterology;153(3):711-722, 2017 Sep.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity. METHODS: We performed a single-center, double-blind, placebo-controlled trial of 2 separate cohorts (March 2014 and August 2014) at the University of Calgary in Canada. Participants included children, 7-12 years old, with overweight or obesity (>85th percentile of body mass index) but otherwise healthy. Participants were randomly assigned to groups given either oligofructose-enriched inulin (OI; 8 g/day; n=22) or maltodextrin placebo (isocaloric dose, controls; n=20) once daily for 16 weeks. Fat mass and lean mass were measured using dual-energy-x-ray absorptiometry. Height, weight, and waist circumference were measured at baseline and every 4 weeks thereafter. Blood samples were collected at baseline and 16 weeks, and analyzed for lipids, cytokines, lipopolysaccharide, and insulin. Fecal samples were collected at baseline and 16 weeks; bile acids were profiled using high-performance liquid chromatography and the composition of the microbiota was analyzed by 16S rRNA sequencing and quantitative polymerase chain reaction. The primary outcome was change in percent body fat from baseline to 16 weeks. RESULTS: After 16 weeks, children who consumed OI had significant decreases in body weight z-score (decrease of 3.1%), percent body fat (decrease of 2.4%), and percent trunk fat (decrease of 3.8%) compared with children given placebo (increase of 0.5%, increase of 0.05%, and decrease of 0.3%, respectively). Children who consumed OI also had a significant reduction in level of interleukin 6 from baseline (decrease of 15%) compared with the placebo group (increase of 25%). There was a significant decrease in serum triglycerides (decrease of 19%) in the OI group. Quantitative polymerase chain reaction showed a significant increase in Bifidobacterium spp. in the OI group compared with controls. 16S rRNA sequencing revealed significant increases in species of the genus Bifidobacterium and decreases in Bacteroides vulgatus within the group who consumed OI. In fecal samples, levels of primary bile acids increased in the placebo group but not in the OI group over the 16-week study period. CONCLUSIONS: In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weight z-score, percent body fat, percent trunk fat, and serum level of interleukin 6 in children with overweight or obesity (Clinicaltrials.gov no: NCT02125955).
[Mh] Termos MeSH primário: Adiposidade/efeitos dos fármacos
Microbioma Gastrointestinal/efeitos dos fármacos
Inulina/farmacologia
Oligossacarídeos/farmacologia
Sobrepeso/tratamento farmacológico
Obesidade Pediátrica/tratamento farmacológico
Prebióticos
[Mh] Termos MeSH secundário: Bacteroides/isolamento & purificação
Bifidobacterium/isolamento & purificação
Ácidos e Sais Biliares/análise
Estatura/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Criança
Fezes/química
Fezes/microbiologia
Feminino
Seres Humanos
Interleucina-6/sangue
Inulina/efeitos adversos
Masculino
Oligossacarídeos/efeitos adversos
Sobrepeso/sangue
Obesidade Pediátrica/sangue
Prebióticos/efeitos adversos
Triglicerídeos/sangue
Circunferência da Cintura/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Interleukin-6); 0 (Oligosaccharides); 0 (Prebiotics); 0 (Triglycerides); 0 (oligofructose); 9005-80-5 (Inulin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  6 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28583137
[Au] Autor:Jafarpour D; Shekarforoush SS; Ghaisari HR; Nazifi S; Sajedianfard J; Eskandari MH
[Ad] Endereço:Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
[Ti] Título:Protective effects of synbiotic diets of Bacillus coagulans, Lactobacillus plantarum and inulin against acute cadmium toxicity in rats.
[So] Source:BMC Complement Altern Med;17(1):291, 2017 Jun 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cadmium is a heavy metal that causes oxidative stress and has toxic effects in humans. The aim of this study was to investigate the influence of two probiotics along with a prebiotic in preventing the toxic effects of cadmium in rats. METHODS: Twenty-four male Wistar rats were randomly divided into four groups namely control, cadmium only, cadmium along with Lactobacillus plantarum (1 × 109 CFU/day) and inulin (5% of feedstuff) and cadmium along with Bacillus coagulans (1 × 109 spore/day) and inulin (5% of feedstuff). Cadmium treated groups received 200 µg/rat/day CdCl2 administered by gavage. During the 42-day experimental period, they were weighed weekly. For evaluation of changes in oxidative stress, the levels of some biochemicals and enzymes of serum including SOD, GPX, MDA, AST, ALT, total bilirubin, BUN and creatinine, and also SOD level of livers were measured at day 21 and 42 of treatment. The cadmium content of kidney and liver was determined by using atomic absorption mass spectrophotometry. Data were analyzed using analysis of variance (ANOVA) followed by Duncan's post hoc test. RESULTS: Treatment of cadmium induced rats with synbiotic diets significantly improved the liver enzymes and biochemical parameters that decreased AST, ALT, total bilirubin, BUN and metal accumulation in the liver and kidney and increased body weight, serum and liver SOD values in comparison with the cadmium-treated group. No significant differences were observed with MDA and GP values between all groups (p > 0.05). CONCLUSIONS: This study showed that synbiotic diets containing probiotics (L. plantarum and B. coagulans) in combination with the prebiotic (inulin) can reduce the level of cadmium in the liver and kidney, preventing their damage and recover antioxidant enzymes in acute cadmium poisoning in rat.
[Mh] Termos MeSH primário: Bacillus coagulans/fisiologia
Intoxicação por Cádmio/prevenção & controle
Cádmio/toxicidade
Inulina/administração & dosagem
Lactobacillus plantarum/fisiologia
Substâncias Protetoras/administração & dosagem
Simbióticos/administração & dosagem
[Mh] Termos MeSH secundário: Doença Aguda/terapia
Animais
Intoxicação por Cádmio/microbiologia
Seres Humanos
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protective Agents); 00BH33GNGH (Cadmium); 9005-80-5 (Inulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1803-3


  7 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28424190
[Au] Autor:Weitkunat K; Schumann S; Nickel D; Hornemann S; Petzke KJ; Schulze MB; Pfeiffer AF; Klaus S
[Ad] Endereço:Departments of Physiology of Energy Metabolism, karolin.weitkunat@dife.de.
[Ti] Título:Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate.
[So] Source:Am J Clin Nutr;105(6):1544-1551, 2017 Jun.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The risk of type 2 diabetes is inversely correlated with plasma concentrations of odd-chain fatty acids [OCFAs; pentadecanoic acid (15:0) and heptadecanoic acid (17:0)], which are considered as biomarkers for dairy fat intake in humans. However, rodent studies suggest that OCFAs are synthesized endogenously from gut-derived propionate. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity. We hypothesized that OCFAs are produced in humans from dietary fibers by a novel endogenous pathway. In a randomized, double-blind crossover study, 16 healthy individuals were supplemented with cellulose (30 g/d), inulin (30 g/d), or propionate (6 g/d) for 7 d. In addition, human hepatoma cells were incubated with different propionate concentrations. OCFAs were determined in plasma phospholipids and hepatoma cells by gas chromatography. Cellulose did not affect plasma OCFA levels, whereas inulin and propionate increased pentadecanoic acid by ∼17% ( < 0.05) and 13% ( = 0.05), respectively. The effect on heptadecanoic acid was even more pronounced, because it was elevated in almost all participants by inulin (11%; < 0.01) and propionate (13%; < 0.001). Furthermore, cell culture experiments showed a positive association between propionate and OCFA levels ( = 0.99, < 0.0001), whereas palmitate (16:0) was negatively correlated ( = 0.83, = 0.004). Our data show that gut-derived propionate is used for the hepatic synthesis of OCFAs in humans. The association of OCFAs with a decreased risk of type 2 diabetes may therefore also relate to dietary fiber intake and not only dairy fat. This trial was registered at www.germanctr.de as DRKS00010121.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/sangue
Fibras na Dieta/farmacologia
Ácidos Graxos/sangue
Fígado/efeitos dos fármacos
Propionatos/metabolismo
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Linhagem Celular Tumoral
Celulose/farmacologia
Estudos Cross-Over
Diabetes Mellitus Tipo 2/prevenção & controle
Fibras na Dieta/metabolismo
Fibras na Dieta/uso terapêutico
Método Duplo-Cego
Ácidos Graxos/biossíntese
Feminino
Seres Humanos
Inulina/farmacologia
Inulina/uso terapêutico
Fígado/metabolismo
Masculino
Meia-Idade
Fosfolipídeos/sangue
Propionatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dietary Fiber); 0 (Fatty Acids); 0 (Phospholipids); 0 (Propionates); 9004-34-6 (Cellulose); 9005-80-5 (Inulin); CCW02D961F (pentadecanoic acid); JHU490RVYR (propionic acid); V987Y9OZ8L (margaric acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.152702


  8 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28372184
[Au] Autor:Luo D; Li Y; Xu B; Ren G; Li P; Li X; Han S; Liu J
[Ad] Endereço:College of Food and Bioengineering, Henan University of Science & Technology, 471023 Luoyang, Henan Province, China; Henan Engineering Research Center of Food Material, 471023 Luoyang, Henan Province, China. Electronic address: luodenglin@163.com.
[Ti] Título:Effects of inulin with different degree of polymerization on gelatinization and retrogradation of wheat starch.
[So] Source:Food Chem;229:35-43, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of three types of inulin, including FS (DP≤10), FI (DP of 2-60) and FXL (DP≥23), on the gelatinization and retrogradation characteristics of wheat starch were investigated. As the concentration of inulin added into starch increased, the gelatinization temperature increased whereas the breakdown value decreased, and the value of setback first decreased and then increased slightly. The three types of inulin with lower concentrations (<15%) all showed obvious suppression effects on the short-term retrogradation of wheat starch. After 7days of storage, the three types of inulin showed a significant suppression of starch retrogradation in the addition range of 5-7.5%. They can all inhibit amylose retrogradation, but accelerate amylopectin retrogradation. Inulin with lower DP has stronger effects on the starch retrogradation. Generally, the three types of inulin can all retard the retrogradation performance of wheat starch to some extent in the long-term storage.
[Mh] Termos MeSH primário: Gelatina/química
Inulina/química
Amido/química
Triticum/química
[Mh] Termos MeSH secundário: Polimerização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9000-70-8 (Gelatin); 9005-25-8 (Starch); 9005-80-5 (Inulin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  9 / 5969 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28368356
[Au] Autor:Nurdin SU; Le Leu RK; Young GP; Stangoulis JC; Christophersen CT; Abbott CA
[Ad] Endereço:School of Biological Sciences, Flinders University, Adelaide, SA 5042, Australia. samsu.udayana@fp.unila.ac.id.
[Ti] Título:Analysis of the Anti-Cancer Effects of Cincau Extract (Premna oblongifolia Merr) and Other Types of Non-Digestible Fibre Using Faecal Fermentation Supernatants and Caco-2 Cells as a Model of the Human Colon.
[So] Source:Nutrients;9(4), 2017 04 03.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Green cincau ( Merr) is an Indonesian food plant with a high dietary fibre content. Research has shown that dietary fibre mixtures may be more beneficial for colorectal cancer prevention than a single dietary fibre type. The aim of this study was to investigate the effects of green cincau extract on short chain fatty acid (SCFA) production in anaerobic batch cultures inoculated with human faecal slurries and to compare these to results obtained using different dietary fibre types (pectin, inulin, and cellulose), singly and in combination. Furthermore, fermentation supernatants (FSs) were evaluated in Caco-2 cells for their effect on cell viability, differentiation, and apoptosis. Cincau increased total SCFA concentration by increasing acetate and propionate, but not butyrate concentration. FSs from all dietary fibre sources, including cincau, reduced Caco-2 cell viability. However, the effects of all FSs on cell viability, cell differentiation, and apoptosis were not simply explainable by their butyrate content. In conclusion, products of fermentation of cincau extracts induced cell death, but further work is required to understand the mechanism of action. This study demonstrates for the first time that this Indonesian traditional source of dietary fibre may be protective against colorectal cancer.
[Mh] Termos MeSH primário: Anticarcinógenos/metabolismo
Apoptose
Neoplasias do Colo/prevenção & controle
Fibras na Dieta/metabolismo
Microbioma Gastrointestinal
Extratos Vegetais/metabolismo
Prebióticos
[Mh] Termos MeSH secundário: Anticarcinógenos/isolamento & purificação
Células CACO-2
Diferenciação Celular
Sobrevivência Celular
Celulose/metabolismo
Neoplasias do Colo/metabolismo
Neoplasias do Colo/microbiologia
Neoplasias do Colo/patologia
Ácidos Graxos Voláteis/metabolismo
Fezes/microbiologia
Fermentação
Bactérias Aeróbias Gram-Negativas/crescimento & desenvolvimento
Bactérias Aeróbias Gram-Negativas/isolamento & purificação
Bactérias Aeróbias Gram-Negativas/metabolismo
Bactérias Gram-Positivas/crescimento & desenvolvimento
Bactérias Gram-Positivas/isolamento & purificação
Bactérias Gram-Positivas/metabolismo
Seres Humanos
Indonésia
Inulina/metabolismo
Lamiaceae/química
Pectinas/metabolismo
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Prebióticos/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Dietary Fiber); 0 (Fatty Acids, Volatile); 0 (Pectins); 0 (Plant Extracts); 0 (Prebiotics); 89NA02M4RX (pectin); 9004-34-6 (Cellulose); 9005-80-5 (Inulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


  10 / 5969 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28363806
[Au] Autor:Sweazea KL; Braun EJ; Sparr R
[Ad] Endereço:School of Nutrition and Health Promotion, Arizona State University, 550 North 3rd Street, Phoenix, AZ 85004, USA; School of Life Sciences, Arizona State University, 427 E Tyler Mall, Tempe, AZ 85287, USA. Electronic address: Karen.Sweazea@asu.edu.
[Ti] Título:Novel role of insulin in the regulation of glucose excretion by mourning doves (Zenaida macroura).
[So] Source:Zoology (Jena);122:58-62, 2017 Jun.
[Is] ISSN:1873-2720
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In mammals, insulin primarily lowers plasma glucose (P ) by increasing its uptake into tissues. Studies have also shown that insulin lowers P in mammals by modulating glomerular filtration rate (GFR). Birds have naturally high P and, although insulin administration significantly decreases glucose concentrations, birds are resistant to insulin-mediated glucose uptake into tissues. Since prior work has not examined the effects of insulin on GFR in birds, the purpose of the present study was to assess whether insulin can augment renal glucose excretion and thereby lower P . Therefore, the hypothesis of the present study was that insulin lowers P in birds by augmenting GFR, as estimated by inulin clearance (C ). Adult mourning doves (Zenaida macroura) were used as experimental animals. Doves were anesthetized and the brachial vein was cannulated for administration of [ C]-inulin and insulin and the brachial artery was cannulated for blood collections. Ureteral urine was collected via a catheter inserted into the cloaca. Ten minutes following administration of exogenous insulin (400µg/kg body mass, i.v.) plasma glucose was significantly decreased (p=0.0003). Twenty minutes following insulin administration, increases in GFR (p=0.016) were observed along with decreases in urine glucose concentrations (p=0.008), glucose excretion (p=0.028), and the fractional excretion of glucose (p=0.003). Urine flow rate (p=0.051) also tended to increase after administration of insulin. These data demonstrate a significant role for insulin in modulating GFR in mourning doves, which may in part explain the lower P measured following insulin administration.
[Mh] Termos MeSH primário: Glicemia
Columbiformes/metabolismo
Glucose/metabolismo
Insulina/farmacologia
[Mh] Termos MeSH secundário: Animais
Glicemia/efeitos dos fármacos
Taxa de Filtração Glomerular/efeitos dos fármacos
Taxa de Filtração Glomerular/fisiologia
Insulina/administração & dosagem
Inulina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 9005-80-5 (Inulin); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE



página 1 de 597 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde