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[PMID]:29195214
[Au] Autor:Murugesan B; Sonamuthu J; Pandiyan N; Pandi B; Samayanan S; Mahalingam S
[Ad] Endereço:Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
[Ti] Título:Photoluminescent reduced graphene oxide quantum dots from latex of Calotropis gigantea for metal sensing, radical scavenging, cytotoxicity, and bioimaging in Artemia salina: A greener route.
[So] Source:J Photochem Photobiol B;178:371-379, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this work, we report the fabrication of green fluorescent reduced graphene oxide quantum dots (rGOQDs) from the latex of Calotropis gigantea by simple one-step microwave assisted greener route. The latex of Calotropis gigantea calcined at 300°C and its ethanolic extract is used for the synthesis of QDs, The rGOQDs showed particle size ranging from 2 to 8nm and it exhibited green fluorescent in longer UV region at 360-520nm. The rGOQDs graphitic nature was confirmed by RAMAN and XRD analysis. The FTIR, XPS demonstrate that presence of functional groups such as CO, COC, -OH, hence it's addressing them as rGOQDs. It is used to design the greener and economically adopted fluorescent probe for the detection of Pb ions. It provides simple and appropriate for the selective and sensitive detection of Pb ions in water purification process. It also trapped the free radicals and neutralized that and act as an excellent radical scavenger in DPPH radical scavenging assessment. These rGOQDs showed excellent biocompatibility on brine shrimp nauplii (Artemia salina) up to 160µg/mL for 24h incubation. Furthermore, rGOQDS were demonstrated as fluorescent bioimaging probe selectively in the inner digestion part of Artemia salina. In summary, stable, economically viable, highly biocompatible, greener method based rGOQDs were prepared for heavy metal ion detecting, radical scavenging, bioimaging applications which can play a vital role in the future nanotechnology-based biomedical field.
[Mh] Termos MeSH primário: Artemia/metabolismo
Calotropis/química
Depuradores de Radicais Livres/química
Grafite/química
Pontos Quânticos/química
[Mh] Termos MeSH secundário: Animais
Artemia/química
Artemia/efeitos dos fármacos
Materiais Biocompatíveis/química
Materiais Biocompatíveis/toxicidade
Calotropis/metabolismo
Técnicas Eletroquímicas
Corantes Fluorescentes/química
Íons/química
Látex/química
Chumbo/análise
Microscopia Eletrônica de Transmissão
Microscopia de Fluorescência
Micro-Ondas
Óxidos/química
Tamanho da Partícula
Pontos Quânticos/toxicidade
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Fluorescent Dyes); 0 (Free Radical Scavengers); 0 (Ions); 0 (Latex); 0 (Oxides); 2P299V784P (Lead); 7782-42-5 (Graphite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28468331
[Au] Autor:Tong Z; Wang D; Sun Y; Yang Q; Meng X; Wang L; Feng W; Li L; Wurtele ES; Wang X
[Ad] Endereço:Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. tongzheng@itbb.org.cn.
[Ti] Título:Comparative Proteomics of Rubber Latex Revealed Multiple Protein Species of REF/SRPP Family Respond Diversely to Ethylene Stimulation among Different Rubber Tree Clones.
[So] Source:Int J Mol Sci;18(5), 2017 May 02.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Rubber elongation factor (REF) and small rubber particle protein (SRPP) are two key factors for natural rubber biosynthesis. To further understand the roles of these proteins in rubber formation, six different genes for latex abundant REF or SRPP proteins, including REF and SRPP , were characterized from Reyan (RY) 7-33-97. Sequence analysis showed that REFs have a variable and long N-terminal, whereas SRPPs have a variable and long C-terminal beyond the REF domain, and REF has a ß subunit of ATPase in its N-terminal. Through two-dimensional electrophoresis (2-DE), each REF/SRPP protein was separated into multiple protein spots on 2-DE gels, indicating they have multiple protein species. The abundance of REF/SRPP proteins was compared between ethylene and control treatments or among rubber tree clones with different levels of latex productivity by analyzing 2-DE gels. The total abundance of each REF/SRPP protein decreased or changed a little upon ethylene stimulation, whereas the abundance of multiple protein species of the same REF/SRPP changed diversely. Among the three rubber tree clones, the abundance of the protein species also differed significantly. Especially, two protein species of REF or REF were ethylene-responsive only in the high latex productivity clone RY 8-79 instead of in RY 7-33-97 and PR 107. Some individual protein species were positively related to ethylene stimulation and latex productivity. These results suggested that the specific protein species could be more important than others for rubber production and post-translational modifications might play important roles in rubber biosynthesis.
[Mh] Termos MeSH primário: Etilenos/farmacologia
Hevea/efeitos dos fármacos
Látex/biossíntese
Proteínas de Plantas/metabolismo
Proteoma/metabolismo
[Mh] Termos MeSH secundário: Hevea/metabolismo
Proteínas de Plantas/genética
Proteoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 0 (Latex); 0 (Plant Proteins); 0 (Proteome); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:29172497
[Au] Autor:An D; Yang L; Liu B; Wang TJ; Kan C
[Ad] Endereço:Department of Chemical Engineering, Tsinghua University , Beijing 100084, China.
[Ti] Título:Diffusion Performance of Fertilizer Nutrient through Polymer Latex Film.
[So] Source:J Agric Food Chem;65(50):10868-10874, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Matching the nutrient release rate of coated fertilizer with the nutrient uptake rate of the crop is the best way to increase the utilization efficiency of nutrients and reduce environmental pollution from the fertilizer. The diffusion property and mechanism of nutrients through the film are the theoretical basis for the product pattern design of coated fertilizers. For the coated fertilizer with a single-component nutrient, an extended solution-diffusion model was used to describe the difference of nutrient release rate, and the release rate is proportional to the permeation coefficient and the solubility of the nutrient. For the double- and triple-component fertilizer of N-K, N-P, and N-P-K, because of the interaction among nutrient molecules and ions, the release rates of different nutrients were significantly affected by the components in the composite fertilizer. Coating the single-component fertilizer (i.e., nitrogen fertilizer, phosphate fertilizer, and potash fertilizer) first and subsequently bulk blending is expected to be a promising way to adjust flexibly the nutrient release rate to meet the nutrient uptake rate of the crop.
[Mh] Termos MeSH primário: Produtos Agrícolas/metabolismo
Fertilizantes/análise
Látex/química
Nitrogênio/química
Fosfatos/química
Potássio/química
[Mh] Termos MeSH secundário: Difusão
Cinética
Nitrogênio/metabolismo
Fosfatos/metabolismo
Polímeros/química
Potássio/metabolismo
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Latex); 0 (Phosphates); 0 (Polymers); N762921K75 (Nitrogen); RWP5GA015D (Potassium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04225


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[PMID]:28817932
[Au] Autor:Müller M; Hogg M; Ulms K; Vetter W
[Ad] Endereço:Department of Food Chemistry (170b), Institute of Food Chemistry, University of Hohenheim , Garbenstraße 28, D-70593 Stuttgart, Germany.
[Ti] Título:Concentrations, Stability, and Isolation of the Furan Fatty Acid 9-(3-Methyl-5-pentylfuran-2-yl)-nonanoic Acid from Disposable Latex Gloves.
[So] Source:J Agric Food Chem;65(36):7919-7925, 2017 Sep 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Because of their antioxidant properties, furan fatty acids (furan-FAs) are valuable minor compounds with a widespread occurrence in all living matter. Unfortunately, pure standards are not readily available, because they usually contribute only 1% to the lipid fraction. A known exception of this is the milky fluid of Hevea brasiliensis, commonly known as latex, in which the furan-FA 9-(3-methyl-5-pentylfuran-2-yl)-nonanoic acid (9M5) contributes about 90% to the triacylglycerides. In this study, we investigated the content of 9M5 in 30 different disposable latex gloves, which ranged from 0.7 to 8.2 mg/g of glove. The light degradability of 9M5 in latex gloves was investigated, and different amounts of 9M5 in disposable latex gloves were attributed to varying exposure time to light. Additionally, over 100 mg of the methyl or ethyl ester of 9M5 (purity of >98%) could be extracted from disposable latex gloves, employing cold extraction and silver ion chromatography. With this method, standards for the quantitation of furan-FAs are obtained easily and rapidly in all laboratories.
[Mh] Termos MeSH primário: Ácidos Graxos/química
Furanos/química
Hevea/química
Látex/química
[Mh] Termos MeSH secundário: Luvas Protetoras
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Furans); 0 (Latex); 97SEH7577T (pelargonic acid); UC0XV6A8N9 (furan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02444


  5 / 4731 MEDLINE  
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[PMID]:28753630
[Au] Autor:Augusto RC; Tetreau G; Chan P; Walet-Balieu ML; Mello-Silva CC; Santos CP; Grunau C
[Ad] Endereço:Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Brasil.
[Ti] Título:Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites.
[So] Source:PLoS Negl Trop Dis;11(7):e0005789, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cercariae stage is one of the key points in which the parasite is vulnerable to different soluble compounds that can significantly alter the parasite's life cycle. Molluscicides are recommended by the World Health Organization for the control of schistosomiasis transmission and Euphorbia milii latex is effective against snails intermediate hosts. METHODOLOGY/PRINCIPAL FINDINGS: We used parasitological tools and electron microscopy to verify the effects of cercariae exposure to natural molluscicide (Euphorbia milii latex) on morphology, physiology and fitness of adult parasite worms. In order to generate insights into key metabolic pathways that lead to the observed phenotypes we used comparative transcriptomics and proteomics. CONCLUSIONS/SIGNIFICANCE: We describe here that the effect of latex on the adult is not due to direct toxicity but it triggers an early change in developmental trajectory and perturbs cell memory, mobility, energy metabolism and other key pathways. We conclude that latex has not only an effect on the vector but applies also long lasting schistosomastatic action. We believe that these results are of interest not only to parasitologists since it shows that natural compounds, presumably without side effects, can have an impact that occurred unexpectedly on developmental processes. Such collateral damage is in this case positive, since it impacts the true target of the treatment campaign. This type of treatment could also provide a rational for the control of other pests. Our results will contribute to enforce the use of E. milii latex in Brazil and other endemic countries as cheap alternative or complement to mass drug treatment with Praziquantel, the only available drug to cure the patients (without preventing re-infection).
[Mh] Termos MeSH primário: Cercárias/crescimento & desenvolvimento
Látex/administração & dosagem
Moluscocidas/administração & dosagem
Schistosoma mansoni/efeitos dos fármacos
Schistosoma mansoni/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Biomphalaria/parasitologia
Brasil
Cercárias/efeitos dos fármacos
Feminino
Modelos Lineares
Fígado/patologia
Masculino
Camundongos
Microscopia Eletrônica
Carga Parasitária
Extratos Vegetais/administração & dosagem
Esquistossomose mansoni/parasitologia
Esquistossomose mansoni/prevenção & controle
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex); 0 (Molluscacides); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005789


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[PMID]:28711667
[Au] Autor:Nanthini J; Ong SY; Sudesh K
[Ad] Endereço:School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
[Ti] Título:Identification of three homologous latex-clearing protein (lcp) genes from the genome of Streptomyces sp. strain CFMR 7.
[So] Source:Gene;628:146-155, 2017 Sep 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Rubber materials have greatly contributed to human civilization. However, being a polymeric material does not decompose easily, it has caused huge environmental problems. On the other hand, only few bacteria are known to degrade rubber, with studies pertaining them being intensively focusing on the mechanism involved in microbial rubber degradation. The Streptomyces sp. strain CFMR 7, which was previously confirmed to possess rubber-degrading ability, was subjected to whole genome sequencing using the single molecule sequencing technology of the PacBio® RS II system. The genome was further analyzed and compared with previously reported rubber-degrading bacteria in order to identify the potential genes involved in rubber degradation. This led to the interesting discovery of three homologues of latex-clearing protein (Lcp) on the chromosome of this strain, which are probably responsible for rubber degrading activities. Genes encoding oxidoreductase α-subunit (oxiA) and oxidoreductase ß-subunit (oxiB) were also found downstream of two lcp genes which are located adjacent to each other. In silico analysis reveals genes that have been identified to be involved in the microbial degradation of rubber in the Streptomyces sp. strain CFMR 7. This is the first whole genome sequence of a clear-zone-forming natural rubber- degrading Streptomyces sp., which harbours three Lcp homologous genes with the presence of oxiA and oxiB genes compared to the previously reported Gordonia polyisoprenivorans strain VH2 (with two Lcp homologous genes) and Nocardia nova SH22a (with only one Lcp gene).
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Streptomyces/genética
[Mh] Termos MeSH secundário: Genoma Bacteriano
Látex
Oxirredutases/genética
Borracha/metabolismo
Streptomyces/metabolismo
Streptomyces/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Latex); 9006-04-6 (Rubber); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28709944
[Au] Autor:Bezerra CF; Mota ÉF; Silva ACM; Tomé AR; Silva MZR; de Brito D; Porfírio CTMN; Oliveira AC; Lima-Filho JV; Ramos MV
[Ad] Endereço:Instituto Federal de Educação, Ciência e Tecnologia do Estado do Rio Grande do Norte, Pau dos Ferros, Rio Grande do Norte, Brazil. Electronic address: bfmila@yahoo.com.br.
[Ti] Título:Latex proteins from Calotropis procera: Toxicity and immunological tolerance revisited.
[So] Source:Chem Biol Interact;274:138-149, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Many thousands of plants are disseminated worldwide in traditional and folk medicines based on the belief that their leaves, roots, seeds, bark or secretions, when adequately handled, can treat, alleviate or ameliorate numerous disease symptoms. Calotropis procera (Apocynaceae) is a popular medicinal plant and the claims of this shrub's phytomedicinal properties have been scientifically validated. In this study, further prospects towards the in vivo toxicity and oral immunological tolerance of phytomodulatory proteins isolated from the latex of C. procera are reported. Acute toxicity was determined in mice by oral and intraperitoneal administration of latex proteins (LP) and was followed behavioral, hematological and histological analyses. Oral immunological tolerance to LP was assessed by intraperitoneal immunization in mice that had received LP orally before. Animals given 5000 mg/kg orally exhibited only discrete behavioral alterations and augmentation of monocytes. Death was not notified 14 days after exposure. However, all animals receiving LP 150 mg/kg by i.p. died in 1 h. Death (20%) was documented when LP (75 mg/kg) was given in the peritoneum and signs of harmful effects were observed in the survivors (80%). Oral immunological tolerance was observed in animals previously given LP orally, when they were further immunized/challenged with peritoneal exposure to different doses of LP. This was confirmed by the lowering of IgE and IgG in the serum, IL-4 and IFN-γ in spleen homogenates and the absence of anaphylaxis signs. It is therefore concluded that LP exhibited quite discrete adverse effects when orally administrated at higher concentrations and this route of administration did not stimulate adverse immunological reactions. Instead it was observed immunological tolerance. The present study contributes very important information concerning the safe use of C. procera as a phytotherapeutic agent.
[Mh] Termos MeSH primário: Calotropis/metabolismo
Tolerância Imunológica/efeitos dos fármacos
Látex/toxicidade
Proteínas de Plantas/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Anafilaxia/etiologia
Animais
Feminino
Hipersensibilidade Tardia/etiologia
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Infusões Parenterais
Interferon gama
Interleucina-4/metabolismo
Rim/efeitos dos fármacos
Rim/patologia
Látex/imunologia
Látex/metabolismo
Camundongos
Proteínas de Plantas/imunologia
Plantas Medicinais/metabolismo
Baço/efeitos dos fármacos
Baço/metabolismo
Baço/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Latex); 0 (Plant Proteins); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28477790
[Au] Autor:Wudy AE; Negro C; Adami A; Larese Filon F
[Ad] Endereço:Unit of Occupational Medicine, University of Trieste, Trieste, Italy. Electronic address: annawudy@tiscali.it.
[Ti] Título:Atopic status and latex sensitization in a cohort of 1,628 students of health care faculties.
[So] Source:Ann Allergy Asthma Immunol;118(5):603-607, 2017 May.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atopic diseases have increased since the second half of the previous century. Atopic workers are at higher risk to be sensitized to latex, and the first years of exposure are supposed to be especially risky. OBJECTIVE: To assess atopic status and rate of latex sensitization in health care students starting their exposure to latex gloves. METHODS: We analyzed medical surveillance data from 1,628 health care students from 2010 to 2016. Students completed a questionnaire focused on their previous and current latex exposure and personal and family histories of allergic diseases; underwent skin prick testing with common allergens and latex extract (and/or total and latex-specific immunoglobulin E in serum); and underwent a medical examination. RESULTS: Skin prick test results for common inhalant allergens showed that 807 of 1,628 students (49.6%) had atopy. Atopy by skin prick testing was associated with male sex (odds ratio 1.49, 95% confidence interval 1.18-1.86), a personal history of oculorhinitis or asthma (odds ratio 10.22, 95% confidence interval 7.4-14.13), and atopic eczema (odds ratio 1.87, 95% confidence interval 1.05-3.36) at multivariate regression analysis. Eleven students (0.7% of total population) were found to be sensitized to latex and all had atopy. CONCLUSION: Despite the high prevalence of atopy in health care students of Trieste, the latex sensitization rate is very low and comparable to general population. This is reasonably due to the low exposure to latex gloves at the time of the evaluation and to low latex release from the gloves currently used in our hospital.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Instalações de Saúde
Hipersensibilidade Imediata/tratamento farmacológico
Hipersensibilidade Imediata/imunologia
Hipersensibilidade ao Látex/epidemiologia
Hipersensibilidade ao Látex/imunologia
Látex/efeitos adversos
Estudantes
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos Transversais
Feminino
Pessoal de Saúde
Seres Humanos
Hipersensibilidade Imediata/diagnóstico
Hipersensibilidade ao Látex/diagnóstico
Masculino
Doenças Profissionais
Exposição Ocupacional
Razão de Chances
Fenótipo
Vigilância em Saúde Pública
Fatores de Risco
Testes Cutâneos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Latex)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


  9 / 4731 MEDLINE  
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[PMID]:28431015
[Au] Autor:Makita Y; Ng KK; Veera Singham G; Kawashima M; Hirakawa H; Sato S; Othman AS; Matsui M
[Ad] Endereço:Synthetic Genomics Research Group, Biomass Engineering Research Division, RIKEN Center for Sustainable Resource Science (CSRS), Yokohama, Kanagawa 230-0045, Japan.
[Ti] Título:Large-scale collection of full-length cDNA and transcriptome analysis in Hevea brasiliensis.
[So] Source:DNA Res;24(2):159-167, 2017 Apr 01.
[Is] ISSN:1756-1663
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural rubber has unique physical properties that cannot be replaced by products from other latex-producing plants or petrochemically produced synthetic rubbers. Rubber from Hevea brasiliensis is the main commercial source for this natural rubber that has a cis-polyisoprene configuration. For sustainable production of enough rubber to meet demand elucidation of the molecular mechanisms involved in the production of latex is vital. To this end, we firstly constructed rubber full-length cDNA libraries of RRIM 600 cultivar and sequenced around 20,000 clones by the Sanger method and over 15,000 contigs by Illumina sequencer. With these data, we updated around 5,500 gene structures and newly annotated around 9,500 transcription start sites. Second, to elucidate the rubber biosynthetic pathways and their transcriptional regulation, we carried out tissue- and cultivar-specific RNA-Seq analysis. By using our recently published genome sequence, we confirmed the expression patterns of the rubber biosynthetic genes. Our data suggest that the cytoplasmic mevalonate (MVA) pathway is the main route for isoprenoid biosynthesis in latex production. In addition to the well-studied polymerization factors, we suggest that rubber elongation factor 8 (REF8) is a candidate factor in cis-polyisoprene biosynthesis. We have also identified 39 transcription factors that may be key regulators in latex production. Expression profile analysis using two additional cultivars, RRIM 901 and PB 350, via an RNA-Seq approach revealed possible expression differences between a high latex-yielding cultivar and a disease-resistant cultivar.
[Mh] Termos MeSH primário: Vias Biossintéticas/genética
Hevea/genética
Látex/biossíntese
Borracha/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Hevea/metabolismo
Proteínas de Plantas/genética
RNA Mensageiro
RNA de Plantas
Análise de Sequência de RNA
Fatores de Transcrição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex); 0 (Plant Proteins); 0 (RNA, Messenger); 0 (RNA, Plant); 0 (Transcription Factors); 9006-04-6 (Rubber)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1093/dnares/dsw056


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[PMID]:28420254
[Au] Autor:Counts J; Weisbrod A; Yin S
[Ad] Endereço:1 Procter & Gamble, Cincinnati, OH, USA.
[Ti] Título:Common Diaper Ingredient Questions: Modern Disposable Diaper Materials Are Safe and Extensively Tested.
[So] Source:Clin Pediatr (Phila);56(5_suppl):23S-27S, 2017 May.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Today's disposable diapers are high-performance and well-tested products, designed to keep skin dry and healthy. They are primarily made of biologically inert polymers, commonly used in fabrics and other materials that are in contact with skin, and in foods and cosmetics. Still, product safety and ingredients in everyday products can be a source of anxiety for new parents. This article provides the facts behind some commonly asked questions from consumers about diaper ingredients and safety, including myths and facts related to chlorine, latex, dyes, and chemical additives.
[Mh] Termos MeSH primário: Fraldas Infantis/normas
[Mh] Termos MeSH secundário: Pré-Escolar
Cloro/análise
Corantes/análise
Equipamentos Descartáveis
Seres Humanos
Lactente
Látex/análise
Polímeros
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Latex); 0 (Polymers); 4R7X1O2820 (Chlorine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1177/0009922817706998



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