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[PMID]:28450249
[Au] Autor:Kurt A; Toker OS; Tornuk F
[Ad] Endereço:Department of Food Engineering, Engineering Faculty, Ondokuz Mayis University, 55139, Samsun, Turkey; Department of Food Engineering, Engineering and Architecture Faculty, Bitlis Eren University, 13000 Bitlis, Turkey. Electronic address: abdullahkurt48@gmail.com.
[Ti] Título:Effect of xanthan and locust bean gum synergistic interaction on characteristics of biodegradable edible film.
[So] Source:Int J Biol Macromol;102:1035-1044, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was aimed to use different combinations of xanthan (XG) and locust bean gum (LBG) in the biodegradable edible film preparation by benefitting from their synergistic interactions for the first time. Concentrations of LBG, XG and glycerol of the optimized film sample were found to be 89.6%, 10.4% and 20%, respectively. At the optimum point the WVP, TS, E% and EM values of film were found 0.22gmmh m kPa, 86.97MPa, 33.34% and 177.25MPa, respectively. The optimized film was characterized for its physical, thermal and structural behavior. The scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR) analyses exhibited miscibility and presence of interaction between polymers. In conclusion, XG and LBG interaction was used successfully to get biodegradable films and coatings with improved characteristics.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Galactanos/química
Mananas/química
Gomas Vegetais/química
Polissacarídeos Bacterianos/química
Embalagem de Produtos
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/metabolismo
Composição de Medicamentos
Glicerol/química
Fenômenos Mecânicos
Permeabilidade
Reologia
Vapor
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); 0 (Polysaccharides, Bacterial); 0 (Steam); PDC6A3C0OX (Glycerol); TTV12P4NEE (xanthan gum); V4716MY704 (locust bean gum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28873574
[Au] Autor:Owens C; Griffin K; Khouryieh H; Williams K
[Ad] Endereço:Department of Chemistry, Western Kentucky University, Bowling Green, KY, USA.
[Ti] Título:Creaming and oxidative stability of fish oil-in-water emulsions stabilized by whey protein-xanthan-locust bean complexes: Impact of pH.
[So] Source:Food Chem;239:314-322, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The impact of pH on the physicochemical properties of 10% menhaden oil-in-water (O/W) emulsions containing 2% whey protein isolate (WPI) and 0.1% xanthan (XG)-locust bean gum (LBG) mixtures was investigated. The O/W emulsions containing 0.1% XG-LBG mixtures were compared to emulsions with 0.1% XG and 0.1% LBG. The results indicated that stability is dependent on pH and biopolymer type. At both pH 3 and 5, emulsions containing either XG or XG-LBG mixtures had large particle sizes, viscosity, droplet aggregation, and creaming index, resulting in poor physical stability which can be related to the adsorbed protein-polysaccharide interactions. At pH7, the XG-LBG emulsions showed the greatest resistance to phase separation and resulted in stable emulsions. Lipid oxidation measurements also indicated that XG-LBG mixtures can be used to form stable emulsions at pH 3 and pH 7. These results have significant implications for the development of novel structures containing lipid phases susceptible to lipid oxidation.
[Mh] Termos MeSH primário: Óleos de Peixe/química
[Mh] Termos MeSH secundário: Animais
Emulsões
Galactanos
Gafanhotos
Concentração de Íons de Hidrogênio
Mananas
Gomas Vegetais
Polissacarídeos Bacterianos
Água
Proteínas do Soro do Leite
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Fish Oils); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); 0 (Polysaccharides, Bacterial); 0 (Whey Proteins); 059QF0KO0R (Water); TTV12P4NEE (xanthan gum); V4716MY704 (locust bean gum)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28910310
[Au] Autor:Leiva A; Contreras-Duarte S; Amigo L; Sepúlveda E; Boric M; Quiñones V; Busso D; Rigotti A
[Ad] Endereço:Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
[Ti] Título:Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice.
[So] Source:PLoS One;12(9):e0184280, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:For proper cholesterol metabolism, normal expression and function of scavenger receptor class B type I (SR-BI), a high-density lipoprotein (HDL) receptor, is required. Among the factors that regulate overall cholesterol homeostasis and HDL metabolism, the nuclear farnesoid X receptor plays an important role. Guggulsterone, a bioactive compound present in the natural product gugulipid, is an antagonist of this receptor. This natural product is widely used globally as a natural lipid-lowering agent, although its anti-atherogenic cardiovascular benefit in animal models or humans is unknown. The aim of this study was to determine the effects of gugulipid on cholesterol homeostasis and development of mild and severe atherosclerosis in male mice. For this purpose, we evaluated the impact of gugulipid treatment on liver histology, plasma lipoprotein cholesterol, endothelial function, and development of atherosclerosis and/or ischemic heart disease in wild-type mice; apolipoprotein E knockout mice, a model of atherosclerosis without ischemic complications; and SR-B1 knockout and atherogenic-diet-fed apolipoprotein E hypomorphic (SR-BI KO/ApoER61h/h) mice, a model of lethal ischemic heart disease due to severe atherosclerosis. Gugulipid administration was associated with histological abnormalities in liver, increased alanine aminotransferase levels, lower hepatic SR-BI content, hypercholesterolemia due to increased HDL cholesterol levels, endothelial dysfunction, enhanced atherosclerosis, and accelerated death in animals with severe ischemic heart disease. In conclusion, our data show important adverse effects of gugulipid intake on HDL metabolism and atherosclerosis in male mice, suggesting potential and unknown deleterious effects on cardiovascular health in humans. In addition, these findings reemphasize the need for rigorous preclinical and clinical studies to provide guidance on the consumption of natural products and regulation of their use in the general population.
[Mh] Termos MeSH primário: Aterosclerose/metabolismo
Endotélio Vascular/metabolismo
Hipercolesterolemia/metabolismo
Isquemia Miocárdica/metabolismo
Extratos Vegetais/toxicidade
Gomas Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Aterosclerose/induzido quimicamente
Aterosclerose/genética
Aterosclerose/patologia
Endotélio Vascular/patologia
Hipercolesterolemia/induzido quimicamente
Hipercolesterolemia/genética
Hipercolesterolemia/patologia
Proteínas Relacionadas a Receptor de LDL/deficiência
Masculino
Camundongos
Camundongos Knockout
Isquemia Miocárdica/induzido quimicamente
Isquemia Miocárdica/genética
Isquemia Miocárdica/patologia
Receptores Depuradores Classe B/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (LDL-Receptor Related Proteins); 0 (Plant Extracts); 0 (Plant Gums); 0 (Scarb1 protein, mouse); 0 (Scavenger Receptors, Class B); 0 (guggulu extract)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184280


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[PMID]:28608892
[Au] Autor:Torcello-Gómez A; Foster TJ
[Ad] Endereço:School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK. M.A.TorcelloGomez@leeds.ac.uk.
[Ti] Título:Instant polysaccharide-based emulsions: impact of microstructure on lipolysis.
[So] Source:Food Funct;8(6):2231-2242, 2017 Jun 21.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The development of emulsion-based products through optimisation of ingredients, reduction in energy-input during manufacture, while fulfilling healthy attributes, are major objectives within the food industry. Instant emulsions can meet these features, but comprehensive studies are necessary to investigate the effect of the initial formulation on the final microstructure and, in turn, on the in vitro lipolysis, comprising the double aim of this work. The instant emulsion is formed within 1.5-3 min after pouring the aqueous phase into the oil phase which contains a mixture of emulsifier (Tween 20), swelling particles (Sephadex) and thickeners (hydroxypropylmethylcellulose, HPMC, and guar gum, GG) under mild shearing (180 rpm). The creation of oil-in-water emulsions is monitored in situ by viscosity analysis, the final microstructure visualised by microscopy and the release of free fatty acids under simulated intestinal conditions quantified by titration. Increasing the concentration and molecular weight (M ) of GG leads to smaller emulsion droplets due to increased bulk viscosity upon shearing. This droplet size reduction is magnified when increasing the M of HPMC or swelling capacity of viscosifying particles. In addition, in the absence of the emulsifier Tween 20, the sole use of high-Mw HPMC is effective in emulsification due to combined increased bulk viscosity and interfacial activity. Hence, optimisation of the ingredient choice and usage level is possible when designing microstructures. Finally, emulsions with larger droplet size (>20 µm) display a slower rate and lower extent of lipolysis, while finer emulsions (droplet size ≤20 µm) exhibit maximum rate and extent profiles. This correlates with the extent of emulsion destabilisation observed under intestinal conditions.
[Mh] Termos MeSH primário: Emulsões/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Emulsificantes/química
Galactanos/química
Lipólise
Mananas/química
Peso Molecular
Tamanho da Partícula
Gomas Vegetais/química
Polissorbatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Emulsions); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); 0 (Polysaccharides); 0 (Polysorbates); E89I1637KE (guar gum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00536a


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[PMID]:28574393
[Au] Autor:Chichoyan N
[Ad] Endereço:Yerevan state medical university after M. Heratsi, Department of Pharmacognosy, Armenia.
[Ti] Título:[RATIONAL USE APRICOT GUM (GUMMI ARMENIACAE) IN REPUBLIC OF ARMENIA].
[So] Source:Georgian Med News;(265):109-114, 2017 Apr.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:rus
[Ab] Resumo:Till nowadays the sources of gums of Armenian flora are remaining unutilized because of absence of resoursological and phytochemical research as well as standards corresponding. Amongst the camed-bearing trees of the flora of Armenia (apricot, peach, plum, almond) and the other families representatives (eleagnus, tragakant) the apricot trees (Armeniaca vulgaris Lam.) became an object of our great interests, considering its being as the most important cultivating fruit-bearing trees in Armenia and the fact, that they cover significant areas in the Ararat valley, Kotayk, Aragatsotn and the footings of the Vayk region. The goal of our investigation was the pharmacognostic (resoursological, commodity and analytical, phythochemical) complex evaluation encountering and the apricot tree camed's (gummi armeniacae) biological activity evaluation, as well as the natural resourses rational concepts elaboration. On the base of the investigation results got a concept of rational use of the apricot gums was developed, which assumes the local sources enlargement, as well as its wide application in medicine and in different aspects of industry.
[Mh] Termos MeSH primário: Gomas Vegetais
Prunus
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Armênia
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Gomas Vegetais/química
Gomas Vegetais/normas
Polissacarídeos/química
Polissacarídeos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Phytochemicals); 0 (Plant Gums); 0 (Polysaccharides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


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[PMID]:28535789
[Au] Autor:Islam NU; Amin R; Shahid M; Amin M; Zaib S; Iqbal J
[Ad] Endereço:Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, 25000, Pakistan. islanaz@yahoo.com.
[Ti] Título:A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.
[So] Source:BMC Complement Altern Med;17(1):276, 2017 May 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Phytotherapeutics exhibit diverse pharmacological effects that are based on the combined action of a mixture of phytoconstituents. In this study, Prunus domestica gum-loaded, stabilized gold and silver nanoparticles (Au/Ag-NPs) were evaluated for their prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory, and analgesic properties. METHODS: Au/Ag-NPs were biosynthesized and characterized with UV-Vis, FTIR, SEM, EDX, and XRD techniques. The effect of gum and metal ion concentration, reaction temperature, and time on the synthetic stability of nanoparticles was studied along with their post-synthetic stability against varying pH and salt concentrations, long-term storage and extremes of temperature. Nanoparticles were tested for anticancer (HeLa cervical cancer cells), antibacterial (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), urease inhibition (jack-bean urease), anti-inflammatory (carrageenan-induced paw edema), and antinociceptive (abdominal constriction response) activities. RESULTS: The nanoparticles were mostly spherical with an average particle size between 7 and 30 nm (Au-NPs) and 5-30 nm (Ag-NPs). Au/Ag-NPs maintained their colloidal stability and nanoscale characteristics against variations in physicochemical factors. Au/Ag-NPs have potent anticancer potential (IC = 2.14 ± 0.15 µg/mL and 3.45 ± 0.23 µg/mL). Au/Ag-NPs selectively suppressed the growth of S. aureus (10.5 ± 0.6 mm, 19.7 ± 0.4 mm), E. coli (10 ± 0.4 mm, 14.4 ± 0.7 mm), and P. aeruginosa (8.2 ± 0.3 mm, 13.1 ± 0.2 mm), as well as showed preferential inhibition against jack-bean urease (19.2 ± 0.86%, 21.5 ± 1.17%). At doses of 40 and 80 mg/kg, Au-NPs significantly ameliorated the increase in paw edema during the 1st h (P < 0.05, P < 0.01) and 2-5 h (P < 0.001) of carrageenan-induced inflammation compared to the 200 and 400 mg/kg doses of P. domestica gum (P < 0.05, P < 0.001). At similar doses, Au-NPs also significantly abolished (P < 0.01) the tonic visceral, chemically-induced nociception, which was comparable to that of P. domestica gum (200 mg/kg; P < 0.05, 400 mg/kg; P < 0.01).
[Mh] Termos MeSH primário: Analgésicos/química
Antibacterianos/química
Anti-Inflamatórios/química
Inibidores Enzimáticos/química
Extratos Vegetais/administração & dosagem
Gomas Vegetais/administração & dosagem
Prunus domestica/química
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Analgésicos/síntese química
Animais
Antibacterianos/administração & dosagem
Antibacterianos/síntese química
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/síntese química
Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral
Edema/tratamento farmacológico
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/síntese química
Feminino
Ouro/administração & dosagem
Ouro/química
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Nanopartículas/administração & dosagem
Nanopartículas/química
Extratos Vegetais/química
Gomas Vegetais/química
Prata/administração & dosagem
Prata/química
Urease/antagonistas & inibidores
Urease/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (Plant Gums); 3M4G523W1G (Silver); 7440-57-5 (Gold); EC 3.5.1.5 (Urease)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1791-3


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[PMID]:28534922
[Au] Autor:Macho-González A; Garcimartín A; López-Oliva ME; Bertocco G; Naes F; Bastida S; Sánchez-Muniz FJ; Benedí J
[Ad] Endereço:Departamento de Nutrición y Bromatología I. Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n., 28040-Madrid, Spain.
[Ti] Título:Fiber purified extracts of carob fruit decrease carbohydrate absorption.
[So] Source:Food Funct;8(6):2258-2265, 2017 Jun 21.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The postprandial state plays a central role in the development and setting of chronic diseases. Condensed tannins (CT) are polyphenols with a known ability to modify carbohydrate digestion and absorption. The high concentration of CT in the pulp of carob fruit suggests a potential antidiabetic effect. The aim of this work was to analyze the in vitro and in vivo effects of carob fruit extract (CFE) on the digestion and absorption of carbohydrates. α-Glucosidase activity and glucose diffusion were tested in vitro using 0.5, 1, 2 and 5 mg mL CFE concentrations. Two in vivo absorption studies, acute and subchronic, were carried out in four groups of 6 two-month-old male Wistar rats (control and CFE 25, 50 and 150 mg per kg b.w.), administering 1 mL of olive oil and 0.5 g per kg b.w. of glucose solution by oral gavage. CFE significantly inhibited α-glucosidase activity, through a competitive mechanism, from 1 mg mL , and also reduced glucose diffusion in a dose-dependent manner. In the acute study, CFE (50 and 150 mg per kg b.w.) significantly reduced the area under the curve (AUC) of blood glucose. Subchronic CFE administration induced further AUC decreases; and CFE at 150 mg per kg b.w. reduced sodium-glucose-linked transporter-1 (SGLT1) levels in the duodenum. This study demonstrates the hypoglycemic properties of CFE, highlighting its potential role as a suitable nutritional strategy in diabetic patients.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico
Galactanos/química
Glucose/metabolismo
Inibidores de Glicosídeo Hidrolases/administração & dosagem
Hipoglicemiantes/administração & dosagem
Mananas/química
Extratos Vegetais/administração & dosagem
Gomas Vegetais/química
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Tipo 2/enzimologia
Diabetes Mellitus Tipo 2/metabolismo
Duodeno/metabolismo
Frutas/química
Glucose/química
Seres Humanos
Cinética
Masculino
Ratos
Ratos Wistar
Transportador 1 de Glucose-Sódio/metabolismo
alfa-Glucosidases/química
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Galactans); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Mannans); 0 (Plant Extracts); 0 (Plant Gums); 0 (Slc5a1 protein, rat); 0 (Sodium-Glucose Transporter 1); EC 3.2.1.20 (alpha-Glucosidases); IY9XDZ35W2 (Glucose); V4716MY704 (locust bean gum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00166e


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[PMID]:28407893
[Au] Autor:Liang S; Liao W; Ma X; Li X; Wang Y
[Ad] Endereço:Guangdong Saskatchewan Oilseed Joint Laboratory, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center for Oils and Fats Biorefinery, Guangzhou 510632, China.
[Ti] Título:H O oxidative preparation, characterization and antiradical activity of a novel oligosaccharide derived from flaxseed gum.
[So] Source:Food Chem;230:135-144, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this present study, a novel flaxseed gum oligosaccharide (FGOS) was prepared by H O oxidative degradation method followed by physicochemical properties characterization and antiradical activity evaluation. Results indicated that the degradation rate of flaxseed gum is 37.81% under the optimum conditions (i.e., reaction temperature of 120°C, H O concentration of 0.2M and reaction time of 2.0h) and FGOS as a reddish brown semisolid was obtained. Physicochemical properties identification showed that FGOS has a molecular weight of 1047Da and is a typical oligosaccharide which contains uronic acid. Characterizations showed FGOS is acid glycopyranose that consists of rhamnose, fucose, xylose, mannose, arabinose, glucose and galactose with mole percentages of 8.26%, 7.54%, 12.85%, 7.93%, 29.31%, 14.28% and 19.82% respectively. FGOS exhibited good free radical scavenging ability (OH 82.58%, DPPH 52.74% and ABTS 91.29% at most, respectively), suggesting its potent antiradical activity.
[Mh] Termos MeSH primário: Linho/química
Depuradores de Radicais Livres/química
Oligossacarídeos/química
Gomas Vegetais/química
[Mh] Termos MeSH secundário: Peróxido de Hidrogênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Oligosaccharides); 0 (Plant Gums); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28372153
[Au] Autor:Li X; Ge S; Yang J; Chang R; Liang C; Xiong L; Zhao M; Li M; Sun Q
[Ad] Endereço:College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, China.
[Ti] Título:Synthesis and study the properties of StNPs/gum nanoparticles for salvianolic acid B-oral delivery system.
[So] Source:Food Chem;229:111-119, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To fabricate stable sized and shaped controlled release delivery systems for salvianolic acid B (Sal B), different food gums were individually added to short-chain glucan solution to prepare starch nanoparticles (StNPs)/gum nanocomposites by self-assembly, and Sal B was embedded in situ. The results showed that size of StNPs was reduced to ca. 45nm with the addition of chitosan and rosin, which decreased by over 50% than that of StNPs without the gum. The StNPs/guar gum nanocomposites had the largest size (109.2nm) among samples of StNPs with gums. The StNPs with chitosan and gum arabic exhibited an obvious core-shell structure. The loading capacities of Sal B in StNPs, StNPs/chitosan, and StNPs/gum arabic nanocomposites were 5.2, 8.26 and 8.08%, respectively. The in vitro release of Sal B from StNPs/gum nanocomposites were sustained and prolonged for over 12h, indicating that StNPs/gum nanocomposites are good candidates to control Sal B release.
[Mh] Termos MeSH primário: Benzofuranos/química
Nanopartículas/química
Amido/química
[Mh] Termos MeSH secundário: Gomas Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Plant Gums); 9005-25-8 (Starch); C1GQ844199 (salvianolic acid B)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28273797
[Au] Autor:Carvalho L; Brait D; Vaz M; Lollo P; Morato P; Oesterreich S; Raposo J; Freitas K
[Ad] Endereço:School of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79825-070, Brazil. luciana_nbc@hotmail.com.
[Ti] Título:Partially Hydrolyzed Guar Gum Increases  Ferroportin Expression in the Colon of Anemic  Growing Rats.
[So] Source:Nutrients;9(3), 2017 Mar 03.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Studies have reported a positive effect of prebiotics on the bioavailability of iron. This study evaluated the effect of partially hydrolyzed guar gum (PHGG) on iron absorption mechanisms in anemic rats. Male Wistar rats were fed 75g American Institute of Nutrition Rodent Diets for growth, pregnancy and lactation (AIN93-G) without iron for three weeks in order to induce iron deficiency anemia. Then they were fed a control diet (n = 12; without fiber) or a diet with 7.5% of PHGG (n = 12), both without iron. Food intake, body growth and the feed efficiency coefficient (FEC) were measured. The animals were euthanized after two weeks of treatment. The weight of the organs, the pH of the cecal content, and the hepatic iron and ferroportin expression in the cecum, duodenum, and liver were assessed. The intake of PHGG reduced food intake without affecting body growth, and there was a difference between the groups regarding the FEC (p = 0.026), with the highest value found in the PHGG group. The weight of the cecal content increased (p ≤ 0.001) and the pH of the cecal content was significantly lower in the PHGG group. The intake of PHGG significantly increased ferroportin expression in the cecum; however, the difference was not significant in the duodenum and the liver. PHGG seems to have a positive influence on iron absorption through transporter expression, and structural and physiological changes in the colon of anemic growing animals.
[Mh] Termos MeSH primário: Anemia Ferropriva/dietoterapia
Proteínas de Transporte de Cátions/biossíntese
Ceco/metabolismo
Modelos Animais de Doenças
Galactanos/uso terapêutico
Mucosa Intestinal/metabolismo
Mananas/uso terapêutico
Gomas Vegetais/uso terapêutico
Prebióticos
[Mh] Termos MeSH secundário: Anemia Ferropriva/sangue
Anemia Ferropriva/metabolismo
Anemia Ferropriva/patologia
Animais
Biomarcadores/sangue
Proteínas de Transporte de Cátions/metabolismo
Ceco/patologia
Colo/metabolismo
Colo/patologia
Ingestão de Energia
Galactanos/efeitos adversos
Galactanos/metabolismo
Hidrólise
Absorção Intestinal
Mucosa Intestinal/patologia
Ferro/metabolismo
Ferro na Dieta/metabolismo
Fígado/metabolismo
Fígado/patologia
Masculino
Mananas/efeitos adversos
Mananas/metabolismo
Tamanho do Órgão
Especificidade de Órgãos
Gomas Vegetais/efeitos adversos
Gomas Vegetais/metabolismo
Prebióticos/efeitos adversos
Ratos Wistar
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cation Transport Proteins); 0 (Galactans); 0 (Iron, Dietary); 0 (Mannans); 0 (Plant Gums); 0 (Prebiotics); 0 (metal transporting protein 1); E1UOL152H7 (Iron); E89I1637KE (guar gum)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE



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