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Pesquisa : D05.750.078.739.625 [Categoria DeCS]
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  1 / 101 MEDLINE  
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[PMID]:28284934
[Au] Autor:Singh B; Singh B
[Ad] Endereço:Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
[Ti] Título:Influence of graphene-oxide nanosheets impregnation on properties of sterculia gum-polyacrylamide hydrogel formed by radiation induced polymerization.
[So] Source:Int J Biol Macromol;99:699-712, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Present work is an attempt, to explore the potential of graphene oxide nanoplates impregnation, on the mechanical and drug delivery properties of sterculia gum-polyacrylamide composite hydrogel formed by radiation induced polymerization. These polymers were characterized by SEM, cryo-SEM, AFM, FTIR's, C NMR and swelling studies. Release profile of an anticancer drug 'gemcitabine' was studied to determine the drug release mechanism and best fit kinetic model. Furthermore, some important biomedical properties of the polymers such as blood compatibility, mucoadhesion, antioxidant properties and gel strength were also studied. Impregnation of GO into sterculia gum-poly(AAm) hydrogels decreased the swelling of hydrogels but improved the mechanical, drug loading and drug release properties of the hydrogels. Release of gemcitabine from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile was best fitted in first order kinetic model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Grafite/química
Hidrogéis/química
Goma de Karaya/química
Óxidos/química
Polimerização
Radiação
[Mh] Termos MeSH secundário: Adesividade
Antioxidantes/química
Antioxidantes/farmacologia
Antioxidantes/toxicidade
Materiais Biocompatíveis/química
Materiais Biocompatíveis/farmacologia
Materiais Biocompatíveis/toxicidade
Portadores de Fármacos/química
Portadores de Fármacos/farmacologia
Portadores de Fármacos/toxicidade
Liberação Controlada de Fármacos
Fluoroquinolonas/química
Mucosa Intestinal/química
Cinética
Modelos Moleculares
Conformação Molecular
Nanoestruturas/química
Naftiridinas/química
Sterculia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Antioxidants); 0 (Biocompatible Materials); 0 (Drug Carriers); 0 (Fluoroquinolones); 0 (Hydrogels); 0 (Naphthyridines); 0 (Oxides); 7782-42-5 (Graphite); 9000-36-6 (Karaya Gum); 9003-05-8 (polyacrylamide); OKR68Y0E4T (gemifloxacin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  2 / 101 MEDLINE  
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[PMID]:28144851
[Au] Autor:Ganguly A; Ian CK; Sheshala R; Sahu PS; Al-Waeli H; Meka VS
[Ad] Endereço:School of Dentistry, International Medical University, Kuala Lumpur, 57000, Malaysia.
[Ti] Título:Application of diverse natural polymers in the design of oral gels for the treatment of periodontal diseases.
[So] Source:J Mater Sci Mater Med;28(3):39, 2017 Mar.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to prepare periodontal gels using natural polymers such as badam gum, karaya gum and chitosan. These gels were tested for their physical and biochemical properties and assessed for their antibacterial activity against Aggregatibacter actinomycetemcomitans and Streptococcus mutans, two pathogens associated with periodontal disease. Badam gum, karaya gum and chitosan were used to prepare gels of varying concentrations. Moxifloxacin hydrochloride, a known antimicrobial drug was choosen in the present study and it was added to the above gels. The gels were then run through a battery of tests in order to determine their physical properties such as pH and viscosity. Diffusion studies were carried out on the gels containing the drug. Antimicrobial testing of the gels against various bacteria was then carried out to determine the effectiveness of the gels against these pathogens. The results showed that natural polymers can be used to produce gels. These gels do not have inherent antimicrobial properties against A. actinomycetemcomitans and S. mutans. However, they can be used as a transport vehicle to carry and release antimicrobial drugs.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Géis/administração & dosagem
Doenças Periodontais/tratamento farmacológico
Polímeros/administração & dosagem
Streptococcus mutans/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Anti-Infecciosos/química
Produtos Biológicos/uso terapêutico
Quitosana/química
Difusão
Fluoroquinolonas/química
Seres Humanos
Concentração de Íons de Hidrogênio
Goma de Karaya/química
Teste de Materiais
Polímeros/química
Propriedades de Superfície
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Biological Products); 0 (Fluoroquinolones); 0 (Gels); 0 (Polymers); 9000-36-6 (Karaya Gum); 9012-76-4 (Chitosan); U188XYD42P (moxifloxacin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5852-4


  3 / 101 MEDLINE  
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[PMID]:27212218
[Au] Autor:Padil VV; Senan C; Waclawek S; Cerník M
[Ad] Endereço:Centre for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, Liberec 1 461 17, Czech Republic. Electronic address: vinod.padil@tul.cz.
[Ti] Título:Electrospun fibers based on Arabic, karaya and kondagogu gums.
[So] Source:Int J Biol Macromol;91:299-309, 2016 Oct.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nanofibers of natural tree polysaccharides based on three gums namely Arabic (GA), karaya (GK) and kondagogu (KG) have been prepared for the first time using electrospinning. Electrospinning solutions were prepared by mixing gum solutions of GA, GK & KG with eco-friendly polymers such as polyvinyl alcohol (PVA) or polyethylene oxide (PEO). The present study focuses on the effect of electrospinning blended solutions of GA, GK or KG with PVA or PEO, additives which influence system parameters and process parameters. This has important effects on the electrospinning process and the resulting fibers whose morphology and physicochemical properties were evaluated. The mass ratios of 70:30 to 90:10 for PVA: GA, PVA: GK and PVA: KG were observed to establish an optimum blend solution ratio in order to fabricate uniform beadless nanofibers with an average diameter of 240±50, 220±40 and 210±30nm, respectively. Various structural and physicochemical properties of the electrospun fibers were investigated. Furthermore, the comparisons of various functionalities of the untreated and plasma treated electrospun fibers were assessed. The methane plasma treated nanofibers were shown to be of extremely specific surface area, improved water contact angle, high surface porosity and roughness and superior hydrophobic properties compared to untreated fibers.
[Mh] Termos MeSH primário: Goma Arábica/química
Goma de Karaya/química
Nanofibras/química
[Mh] Termos MeSH secundário: Nanofibras/ultraestrutura
Gases em Plasma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasma Gases); 9000-01-5 (Gum Arabic); 9000-36-6 (Karaya Gum)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


  4 / 101 MEDLINE  
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[PMID]:27041650
[Au] Autor:Magalhães GA; Moura Neto E; Sombra VG; Richter AR; Abreu CM; Feitosa JP; Paula HC; Goycoolea FM; de Paula RC
[Ad] Endereço:Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil, CP 6021, CEP 60455-760.
[Ti] Título:Chitosan/Sterculia striata polysaccharides nanocomplex as a potential chloroquine drug release device.
[So] Source:Int J Biol Macromol;88:244-53, 2016 Jul.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nanoparticles are produced by means of polyelectrolyte complexation (PEC) of oppositely charged polycationic chitosan (CH) with polyanionic polysaccharide extracted from Sterculia striata exudates (rhamnogalacturonoglycan (RG)-type polysaccharide). The nanoparticles formed with low-molar-mass CH are larger than those formed with high-molar-mass CH. This behavior is in contrast with that previously observed for other systems and may be attributed to different mechanisms related to the association of CH with RG of higher persistence length chain than that of CH. Nanoparticles harnessed with a charge ratio (n(+)/n(-)) of <1 are smaller than particles with an excess of polycations. Particles with hydrodynamic sizes smaller than 100nm are achieved using a polyelectrolyte concentration of 10(-4)gmL(-1) and charge ratio (n(+)/n(-)) of <1. The CH/RG nanoparticles are associated with chloroquine (CQ) with an efficiency of 28% and release it for up to ∼60% within ∼10h, whereas in the latter, only ∼40% of the CQ was released after 24h. The main factor that influenced drug release rate is the nanoparticle charge ratio.
[Mh] Termos MeSH primário: Quitosana/química
Cloroquina/química
Preparações de Ação Retardada
Goma de Karaya/química
Nanopartículas/química
Sterculia/química
[Mh] Termos MeSH secundário: Composição de Medicamentos
Liberação Controlada de Fármacos
Concentração de Íons de Hidrogênio
Goma de Karaya/isolamento & purificação
Peso Molecular
Nanopartículas/ultraestrutura
Tamanho da Partícula
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 886U3H6UFF (Chloroquine); 9000-36-6 (Karaya Gum); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


  5 / 101 MEDLINE  
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[PMID]:26093321
[Au] Autor:Pooja D; Panyaram S; Kulhari H; Reddy B; Rachamalla SS; Sistla R
[Ad] Endereço:Medicinal Chemistry & Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India; Faculty of Pharmacy, College of Technology, Osmania University, Hyderabad, India.
[Ti] Título:Natural polysaccharide functionalized gold nanoparticles as biocompatible drug delivery carrier.
[So] Source:Int J Biol Macromol;80:48-56, 2015 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biocompatibility is one of the major concerns with inorganic nanoparticles for their applications as drug delivery system. Natural compounds such as sugars, hydrocolloids and plant extracts have shown potential for the green synthesis of biocompatible gold nanoparticles. In this study, we report the synthesis of gum karaya (GK) stabilized gold nanoparticles (GKNP) and the application of prepared nanoparticles in the delivery of anticancer drugs. GKNP were characterized using different analytical techniques. GKNP exhibited high biocompatibility during cell survival study against CHO normal ovary cells and A549 human non-small cell lung cancer cells and during hemolytic toxicity studies. Gemcitabine hydrochloride (GEM), an anticancer drug, was loaded on the surface of nanoparticles with 19.2% drug loading efficiency. GEM loaded nanoparticles (GEM-GNP) showed better inhibition of growth of cancer cells in anti-proliferation and clonogenic assays than native GEM. This effect was correlated with higher reactive oxygen species generation by GEM-GNP in A549 cells than native GEM. In summary, GK has significant potential in the synthesis of biocompatible gold nanoparticles that could be used as prospective drug delivery carrier for anticancer drugs.
[Mh] Termos MeSH primário: Antineoplásicos/química
Desoxicitidina/análogos & derivados
Portadores de Fármacos/química
Ouro/química
Goma de Karaya/química
Nanopartículas Metálicas/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Células CHO
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Cricetinae
Cricetulus
Desoxicitidina/química
Desoxicitidina/farmacologia
Portadores de Fármacos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Estabilidade de Medicamentos
Seres Humanos
Goma de Karaya/farmacologia
Teste de Materiais
Tamanho da Partícula
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drug Carriers); 0 (Reactive Oxygen Species); 0W860991D6 (Deoxycytidine); 7440-57-5 (Gold); 9000-36-6 (Karaya Gum); B76N6SBZ8R (gemcitabine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150831
[Lr] Data última revisão:
150831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150621
[St] Status:MEDLINE


  6 / 101 MEDLINE  
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[PMID]:26076615
[Au] Autor:Bahulkar SS; Munot NM; Surwase SS
[Ad] Endereço:Department of Pharmaceutics, Sinhgad Technical Education Society's Smt. Kashibai Navale College of Pharmacy, Kondhwa(Bk), Pune, 411038, India. Electronic address: swati.bahulkar@gmail.com.
[Ti] Título:Synthesis, characterization of thiolated karaya gum and evaluation of effect of pH on its mucoadhesive and sustained release properties.
[So] Source:Carbohydr Polym;130:183-90, 2015 Oct 05.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Present study aims at synthesis and characterization of thiolated gum karaya by reacting karaya gum with 80% thioglycolic acid resulting in esterification and immobilization of thiol groups on polymeric backbone. Immobilized thiol groups were found to be 5.026 mM/g determined by Ellman's method. It was characterized by FTIR, DSC and XRD. Directly compressible tablets prepared using thiolated gum displayed more disintegration time, swelling and mucoadhesion with increase in pH of medium simulating gastric and intestinal environment than plain gum. Controlled drug release for more than 24h by Fickian diffusion following Korsemeyer-Peppas model was observed with Metoprolol Succinate as a model drug as compared to plain gum which released more than 90% of the drug within 2h. Synthesized thiomer showed no cytotoxicity determined using HepG2 cell line. According to these results, thiolated gum karaya seems to be promising excipient for the development of mucoadhesive drug delivery systems.
[Mh] Termos MeSH primário: Excipientes/química
Goma de Karaya/química
Comprimidos/química
[Mh] Termos MeSH secundário: Animais
Varredura Diferencial de Calorimetria
Preparações de Ação Retardada/química
Sistemas de Liberação de Medicamentos
Células Hep G2/efeitos dos fármacos
Seres Humanos
Concentração de Íons de Hidrogênio
Mucosa Intestinal
Goma de Karaya/síntese química
Goma de Karaya/farmacologia
Espectroscopia de Infravermelho com Transformada de Fourier
Compostos de Sulfidrila/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Excipients); 0 (Sulfhydryl Compounds); 0 (Tablets); 9000-36-6 (Karaya Gum)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150616
[Lr] Data última revisão:
150616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150617
[St] Status:MEDLINE


  7 / 101 MEDLINE  
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[PMID]:25797306
[Au] Autor:Padil VV; Senan C; Cerník M
[Ad] Endereço:†Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec 1, Czech Republic.
[Ti] Título:Dodecenylsuccinic anhydride derivatives of gum karaya (Sterculia urens): preparation, characterization, and their antibacterial properties.
[So] Source:J Agric Food Chem;63(14):3757-65, 2015 Apr 15.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Esterifications of the tree-based gum, gum karaya (GK), using dodecenylsuccinic anhydride (DDSA) were carried out in aqueous solutions. GK was deacetylated using alkali treatment to obtain deacetylated gum karaya (DGK). The DGK and its DDSA derivative were characterized using gel permeation chromatography/multiangle laser light scattering (GPC/MALLS), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), proton nuclear magnetic resonance spectroscopy ((1)H NMR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) analysis, and rheological studies. The degree of substitution was found to be 10.25% for DGK using (1)H NMR spectroscopy. The critical aggregation concentration of DDSA-DGK was determined using dye solubilization and surface tension methods. The antibacterial activity of the DDSA-DGK derivative was then investigated against Gram-negative Escherichia coli and Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus. The DDSA-DGK derivative has the potential for use as a stabilizing agent in food and nonfood applications. It can also be developed as an antibacterial agent.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Goma de Karaya/química
Goma de Karaya/farmacologia
Sterculia/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Bactérias/efeitos dos fármacos
Goma de Karaya/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Anidridos Succínicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Succinic Anhydrides); 6RF4O17Z8J (succinic anhydride); 9000-36-6 (Karaya Gum)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150416
[Lr] Data última revisão:
150416
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150324
[St] Status:MEDLINE
[do] DOI:10.1021/jf505783e


  8 / 101 MEDLINE  
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[PMID]:25636139
[Au] Autor:Padil VV; Cerník M
[Ad] Endereço:Department of Nanomaterials in Natural Sciences, Centre for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, Liberec 1, Czech Republic, 461 17.
[Ti] Título:Poly (vinyl alcohol)/gum karaya electrospun plasma treated membrane for the removal of nanoparticles (Au, Ag, Pt, CuO and Fe3O4) from aqueous solutions.
[So] Source:J Hazard Mater;287:102-10, 2015 Apr 28.
[Is] ISSN:1873-3336
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the present work, nanofibre membranes composed of polyvinyl alcohol (PVA) and a natural gum karaya (GK) hydrocolloid were prepared using electrospinning. The electrospun membranes of PVA/GK were cross-linked with heat treatment and later methane plasma was used to obtain a hydrophobic membrane. The morphology, characterization and adsorption ability of P-NFM was assessed using scanning electron microscopy, UV-vis spectroscopy, ATR-FTIR techniques, water contact angle and ICP-MS analytical methods. The membrane was employed for the extraction of nanoparticles (Ag, Au, Pt, CuO and Fe3O4) from water. The nanoparticle extraction kinetic and adsorption isotherm perform the pseudo-second-order model and Langmuir isotherm model, respectively. The adsorption capacities of the membrane for the removal of NPs from water diverge in the order Pt>Au>Ag>CuO>Fe3O4. The high adsorption efficiency for the removal of NPs from water was compared with an untreated membrane. Physisorption, functional group interactions, complexation reactions between metal/metal oxide nanoparticles with various functional groups present in NFM and modified surface properties such as the balance of hydrophilicity/hydrophobicity, surface free energy, and the high surface area of the plasma treated membrane were possible mechanisms of NPs adsorption onto NFM. The regeneration and reusability were tested in five consecutive adsorption/desorption cycles.
[Mh] Termos MeSH primário: Goma de Karaya/química
Nanopartículas Metálicas
Nanofibras/química
Álcool de Polivinil/química
Poluentes da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
Cinética
Membranas Artificiais
Microscopia Eletrônica de Varredura
Nanofibras/ultraestrutura
Espectroscopia de Infravermelho com Transformada de Fourier
Termodinâmica
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Membranes, Artificial); 0 (Water Pollutants); 9000-36-6 (Karaya Gum); 9002-89-5 (Polyvinyl Alcohol)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150403
[Lr] Data última revisão:
150403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150131
[St] Status:MEDLINE


  9 / 101 MEDLINE  
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[PMID]:25495646
[Au] Autor:Harshitha K; Kulkarni PK; Vaghela R; Kumar Varma VN; Deshpande DR; Hani U
[Ti] Título:Probiotic and prebiotic-probiotic PEC microparticles for sustaining and enhancing intestinal probiotic growth.
[So] Source:Curr Drug Deliv;12(3):299-307, 2015.
[Is] ISSN:1875-5704
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to develop and evaluate Polyelectrolyte complex (PEC) microparticles composing Lactobacillus Acidophilus (probiotic) and Fructo oligosaccharide-Lactobacillus Acidophilus (prebiotic-probiotic), for sustaining and enhancing intestinal growth of probiotic bacteria. Gum Karaya-Chitosan(GK-CH) was used to fabricate PEC microparticles by extrusion method. The prepared microparticles were characterized for FT-IR, DSC and particle size and evaluated for percentage yield, swelling, surface morphology, entrapment rate and further studied for influence of prebiotic over probiotic growth. The fabricated PEC microparticles composed of Probiotic and Prebiotic- Probiotic have exhibited sustainability of probiotic bacteria for 12 hrs in GIT conditions and presence of prebiotic in the preparation enhanced the probiotic cell growth. Hence, it can be concluded that PEC between GK-CH was found to be successful in sustaining cell release and presence of prebiotic was found to enhance the probiotic cell growth.
[Mh] Termos MeSH primário: Lactobacillus acidophilus
Oligossacarídeos
Prebióticos/administração & dosagem
Probióticos/administração & dosagem
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Quitosana/química
Intestinos/microbiologia
Goma de Karaya/química
Tamanho da Partícula
Espectroscopia de Infravermelho com Transformada de Fourier
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Prebiotics); 0 (fructooligosaccharide); 9000-36-6 (Karaya Gum); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150609
[Lr] Data última revisão:
150609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE


  10 / 101 MEDLINE  
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[PMID]:24471787
[Au] Autor:Patil S; Talele GS
[Ad] Endereço:Alkem Research Centre , Mumbai, Maharashtra , India and.
[Ti] Título:Gastroretentive mucoadhesive tablet of lafutidine for controlled release and enhanced bioavailability.
[So] Source:Drug Deliv;22(3):312-9, 2015 May.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lafutidine a newly developed histamine H2-receptor antagonist having biological half-life of 1.92 ± 0.94 h due to its selective absorption from upper part of gastrointestinal tract the development of mucoadhesive sustained release drug delivery system is recommended in order to enhance the bioavailability. A mucoadhesive tablets was developed using the natural polymer, sodium alginate, xanthan gum and karaya gum. Mucoadhesion is a complex phenomenon which involves wetting, adsorption and interpenetration of polymer chains. The prepared tablets of various formulations were evaluated for a total mucoadhesion time, buoyancy lag time and percentage drug released. The formulation with xanthan gum showed better results. Thus, it may be useful for prolonged drug release in stomach to improve the bioavailability and reduced dosing frequency. Non-fickians release transport was confirmed as the drug release mechanism from the optimized formulation by Korsmeyer-Peppas. The optimized formulation (B3) showed a mucoadhesive strength >35 g. In vivo study was performed using rabbits by X-ray imaging technique. Radiological evidences suggest that, a formulated tablet was well adhered for >10 h in rabbit's stomach. Optimized lafutidine mucoadhesive tablets showed no significant change in physical appearance, drug content, mucoadhesive properties and in vitro dissolution pattern after storage at 40 °C temperature 75 ± 5% relative humidity for 3 months.
[Mh] Termos MeSH primário: Acetamidas/química
Mucosa Gástrica/metabolismo
Antagonistas dos Receptores Histamínicos H2/química
Piperidinas/química
Piridinas/química
Adesivos Teciduais/química
[Mh] Termos MeSH secundário: Acetamidas/administração & dosagem
Acetamidas/farmacocinética
Adesividade
Alginatos/química
Animais
Disponibilidade Biológica
Preparações de Ação Retardada
Composição de Medicamentos
Liberação Controlada de Fármacos
Mucosa Gástrica/efeitos dos fármacos
Ácido Glucurônico/química
Ácidos Hexurônicos/química
Antagonistas dos Receptores Histamínicos H2/administração & dosagem
Antagonistas dos Receptores Histamínicos H2/farmacocinética
Técnicas In Vitro
Goma de Karaya/química
Piperidinas/administração & dosagem
Piperidinas/farmacocinética
Polissacarídeos Bacterianos/química
Piridinas/administração & dosagem
Piridinas/farmacocinética
Coelhos
Espectroscopia de Infravermelho com Transformada de Fourier
Suínos
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Alginates); 0 (Delayed-Action Preparations); 0 (Hexuronic Acids); 0 (Histamine H2 Antagonists); 0 (Piperidines); 0 (Polysaccharides, Bacterial); 0 (Pyridines); 0 (Tablets); 0 (Tissue Adhesives); 49S4O7ADLC (lafutidine); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9000-36-6 (Karaya Gum); TTV12P4NEE (xanthan gum)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150601
[Lr] Data última revisão:
150601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140130
[St] Status:MEDLINE
[do] DOI:10.3109/10717544.2013.877099



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