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  1 / 3802 MEDLINE  
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[PMID]:29402248
[Au] Autor:Al-Afifi NA; Alabsi AM; Bakri MM; Ramanathan A
[Ad] Endereço:Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats.
[So] Source:BMC Complement Altern Med;18(1):50, 2018 Feb 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. METHODS: In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications. In acute oral toxicity test, DC resin methanol extract administered to female Sprague Dawley rats by oral gavage at a single dose of 300 and 2000 mg/kg body weight. Rats observed for toxic signs for 14 days. In sub-acute oral toxicity test, DC resin methanol extract administered to the rats by oral gavage at 500, 1000, and 1500 mg/kg body weight daily up to 28 days to male and female Spradgue Dawley rats. The control and high dose in satellite groups were also maintained and handled as the previous groups to determine the late onset toxicity of DC resin methanol extract. At the end of each test, hematological and biochemical analysis of the collected blood were performed as well as gross and microscopic pathology. RESULTS: In acute oral toxicity, no treatment-related death or toxic signs were observed. It revealed that the DC resin methanol extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. The sub-acute test observations indicated that there are no treatment-related changes up to the high dose level compared to the control. Food consumption, body weight, organ weight, hematological parameters, biochemical parameters and histopathological examination (liver, kidney, heart, spleen and lung) revealed no abnormalities. Water intake was significantly higher in the DC resin methanol extract treated groups compared to the control. CONCLUSION: This study demonstrates tolerability of DC resin methanol extract administered daily for 28 days up to 1500 mg/kg dose.
[Mh] Termos MeSH primário: Dracaena/química
Resinas Vegetais/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal/efeitos dos fármacos
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Feminino
Coração/efeitos dos fármacos
Rim/efeitos dos fármacos
Masculino
Metanol
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Resinas Vegetais/administração & dosagem
Testes de Toxicidade Aguda
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resins, Plant); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2110-3


  2 / 3802 MEDLINE  
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[PMID]:28764002
[Au] Autor:Leyton A; Vergara-Salinas JR; Pérez-Correa JR; Lienqueo ME
[Ad] Endereço:Center for Biotechnology and Bioengineering (CeBiB), University of Chile, Department of Chemical Engineering and Biotechnology, Beauchef 851, Santiago, Chile; Center for Biotechnology and Bioengineering (CeBiB), Universidad de La Frontera, Temuco, Chile.
[Ti] Título:Purification of phlorotannins from Macrocystis pyrifera using macroporous resins.
[So] Source:Food Chem;237:312-319, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phlorotannins are secondary metabolites produced by brown seaweed, which are known for their nutraceutical and pharmacological properties. The aim of this work was to determine the type of macroporous resin and the conditions of operation that improve the purification of phlorotannins extracted from brown seaweed, Macrocystis pyrifera. For the purification of phlorotannins, six resins (HP-20, SP-850, XAD-7, XAD-16N, XAD-4 and XAD-2) were assessed. The kinetic adsorption allowed determination of an average adsorption time for the resins of 9h. The highest level of purification of phlorotannins was obtained with XAD-16N, 42%, with an adsorption capacity of 183±18mgPGE/g resin, and a desorption ratio of 38.2±7.7%. According to the adsorption isotherm the best temperature of operation was 25°C, and the model that best described the adsorption properties was the Freundlich model. The purification of phlorotannins might expand their use as a bioactive substance in the food, nutraceutical and pharmaceutical industries.
[Mh] Termos MeSH primário: Macrocystis/química
[Mh] Termos MeSH secundário: Resinas Acrílicas
Adsorção
Poliestirenos
Resinas Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Polystyrenes); 0 (Resins, Plant); 0 (SP-850); 37380-43-1 (amberlite XAD 7)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  3 / 3802 MEDLINE  
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[PMID]:28666012
[Au] Autor:Song F; Wang P; Chen S; Wang Z; Fan G
[Ad] Endereço:College of Forestry, Jiangxi Agricultural University, Nanchang, P.R. China.
[Ti] Título:Ordered lamellar supermicroporous titania templating by rosin-derived quaternary ammonium salt.
[So] Source:PLoS One;12(6):e0180178, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:By using dehydroabietyltrimethyl ammonium bromine (DTAB), a novel rosin-derived quaternary ammonium salt, as template and peroxotitanium acid as precursor, ordered lamellar supermicroporous titania has been synthesized via a hydrothermal process. The template agent:titanium source molar ratio in the synthesis system and the hydrothermal temperature have great impact on the microstructure characteristics of the samples. The increase of DTAB:TiO2 molar ratio from 0.04:1 to 0.10:1 is favorable to the increase of regularity of pore structures, but has no significant effects on the crystalline structures. The increase of the hydrothermal temperature from 343 to 393 K can induce an increase in crystallinity of the samples. However, the exorbitant hydrothermal temperature will reduce the regularity of pore structures. When the mole ratio of DTAB:TiO2 is 0.10:1 and the hydrothermal temperature is 373 K, the as-synthesized sample possesses pore structure with the highest level of long-range order, as well as pore wall with semicrystallized anatase phase. The pore size and the pore wall thickness are about 2.0 nm and 1.0 nm, respectively.
[Mh] Termos MeSH primário: Compostos de Amônio Quaternário/química
Resinas Vegetais/química
Titânio/química
[Mh] Termos MeSH secundário: Microscopia Eletrônica de Transmissão
Porosidade
Temperatura Ambiente
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Quaternary Ammonium Compounds); 0 (Resins, Plant); 15FIX9V2JP (titanium dioxide); 88S87KL877 (rosin); D1JT611TNE (Titanium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180178


  4 / 3802 MEDLINE  
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[PMID]:28648631
[Au] Autor:Wang H; Jiang HM; Li FX; Chen HQ; Liu WC; Ren SZ; Mei WL; Dai HF
[Ad] Endereço:Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
[Ti] Título:Flavonoids from artificially induced dragon's blood of Dracaena cambodiana.
[So] Source:Fitoterapia;121:1-5, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dragon's blood is a rare traditional medicine used in many countries. Because of its various therapeutic uses, its requirement is increasing dramatically, while formation of dragon's blood need at least several years, so many researchers tried to induce the formation of dragon's blood artificially, but the chemical constituents of artificially induced dragon's blood were rarely studied. In our research, twenty constituents, including three new ones, were isolated from artificially induced dragon's blood of Dracaena cambodiana, five of which are the same with those from natural dragon's blood. In addition, six compounds exhibited cytotoxic activities, and eleven compounds demonstrated antibacterial activities. Artificially induced dragon's blood is expected to be the substituent of natural dragon's blood.
[Mh] Termos MeSH primário: Dracaena/química
Flavonoides/química
Extratos Vegetais/química
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Flavonoides/isolamento & purificação
Seres Humanos
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (Plant Extracts); 0 (Resins, Plant); M3YJ2C28IC (dragon's blood)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  5 / 3802 MEDLINE  
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Lameira, Osmar Alves
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[PMID]:28615025
[Au] Autor:Teixeira FB; de Brito Silva R; Lameira OA; Webber LP; D'Almeida Couto RS; Martins MD; Lima RR
[Ad] Endereço:Laboratory of Functional and Structural Biology, Institute of Biological Science, Federal University of Pará, Belém, 66075-900, Brazil.
[Ti] Título:Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats' tongues.
[So] Source:BMC Complement Altern Med;17(1):313, 2017 Jun 14.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties. METHODS: Aiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats' tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J. RESULTS: The acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages. CONCLUSIONS: The results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Fabaceae/química
Extratos Vegetais/administração & dosagem
Óleos Vegetais/administração & dosagem
Resinas Vegetais/administração & dosagem
Doenças da Língua/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Masculino
Ratos
Ratos Wistar
Doenças da Língua/imunologia
Doenças da Língua/fisiopatologia
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Plant Oils); 0 (Resins, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1820-2


  6 / 3802 MEDLINE  
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[PMID]:28441359
[Au] Autor:Chen X; Zhu X; Feng M; Zhong Z; Zhou X; Chen X; Ye W; Zhang W; Gao X
[Ad] Endereço:State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. vchenxiaodong0823@163.com.
[Ti] Título:Relationship between Expression of Chalcone Synthase Genes and Chromones in Artificial Agarwood induced by Formic Acid Stimulation Combined with Fusarium sp. A2 Inoculation.
[So] Source:Molecules;22(5), 2017 Apr 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Agarwood (gaharu) is a fragrant resin produced in the heartwood of resinous and species. Artificial agarwood samples were obtained from (Lour.) Gilg using formic acid (FA) stimulation combined with sp. A2 inoculation. The relationship between the expression of chalcone synthase genes ( ) and dynamic changes in chromone content was explored in resin-deposited parts of the trunks of . gene expression levels were detected by qRT-PCR analysis. The chemical composition of agarwood obtained from the heartwood of before and within 1 year after induction was determined by GC-MS. After induction with FA stimulation combined with . sp. A2 inoculation, the 1 gene showed relatively high expression, whereas the 2 gene showed low expression. The relative gene expression level of 1 peaked at 12 months, with a 153.1-fold increase, and the dominant period of the 2 gene expression was 10 months with a 14.13-fold increase. Moreover, chromones were not detected until after 2 months, and a large proportion of chromone compounds were detected after 4 months. Chromone content increased with time and peaked at 12 months. 1 gene expression was significantly correlated with 6-hydroxy-2-(2-phenylethyl)chromone accumulation, and 2 gene expression was significantly correlated with 5-hydroxy-6-methoxy-2-(2-phenylethyl)chromone accumulation. gene expression was extremely sensitive to FA stimulation combined with . sp. A2 inoculation and responded to late-onset injury. genes expression also preceded the chromone accumulation. This work laid the foundation for studies on the mechanism by which genes regulate chromone biosynthesis pathways during the formation of agarwood resin in .
[Mh] Termos MeSH primário: Aciltransferases/genética
Cromonas/metabolismo
Formiatos/farmacologia
Fusarium/fisiologia
[Mh] Termos MeSH secundário: Aciltransferases/biossíntese
Medicamentos de Ervas Chinesas/química
Genes de Plantas
Extratos Vegetais/química
Resinas Vegetais
Thymelaeaceae/química
Thymelaeaceae/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromones); 0 (Drugs, Chinese Herbal); 0 (Formates); 0 (Plant Extracts); 0 (Resins, Plant); 0YIW783RG1 (formic acid); EC 2.3.- (Acyltransferases); EC 2.3.1.74 (flavanone synthetase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  7 / 3802 MEDLINE  
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[PMID]:28415020
[Au] Autor:Li J; Li D; Pan Y; Hu JH; Huang W; Wang ZZ; Xiao W; Wang Y
[Ad] Endereço:School of pharmacy, China Pharmaceutical University, NO.24 Tongjia Rd, Nanjing 210009, China; State Key Lab of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.
[Ti] Título:Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1054:20-26, 2017 Jun 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sanjie Zhentong capsule, a well-known traditional Chinese medicine prescription, are used for the treatment of endometriosis-related diseases. In this study, a simple, rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of ten bioactive constituents, including peimine, peiminine, peimisine, loureirin A, loureirin B, 7,4'-dihydroxyflavone, pterostilbene, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 in rat plasma after oral administration of Sanjie Zhentong capsule. The sample preparations for protein removal was accomplished using a simple methanol precipitation method. The analytes were completely separated from the endogenous compounds on an Agilent Poroshell 120 SB-C18 column (4.6mm×150mm, 2.7µm) using an isocratic elution with methanol - 0.1% formic acid aqueous (4/1, v/v) as a mobile phase. The single-run analysis time was as short as 14.0min. The inter-day and intra-day precision of the quality control samples exhibited relative standard deviations (RSD) <9.5% and the accuracy values ranged from -8.6% to 15.0%. The lower limits of quantification (LLOQ) were 10, 10, 10, 10, 10, 10, 5, 10, 10 and 20ng/mL for peimine, peiminine, peimisine, loureirin A, loureirin B, 7,4'-dihydroxyflavone, pterostilbene, ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1, respectively. The analytical method was successfully applied to a pharmacokinetic study of the multi-components after oral administration of Sanjie Zhentong Capsule in rats.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Alcaloides/sangue
Animais
Cevanas/sangue
Chalconas/sangue
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/administração & dosagem
Feminino
Flavonas/sangue
Ginsenosídeos/sangue
Limite de Detecção
Ratos Sprague-Dawley
Resinas Vegetais/farmacocinética
Estilbenos/sangue
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (7,4'-dihydroxyflavone); 0 (Alkaloids); 0 (Cevanes); 0 (Chalcones); 0 (Drugs, Chinese Herbal); 0 (Flavones); 0 (Ginsenosides); 0 (Resins, Plant); 0 (Stilbenes); 0 (loureirin A); 19773-24-1 (peimisine); 26R60S6A5I (pterostilbene); 34QDF8UFSY (verticine); 7413S0WMH6 (ginsenoside Rb1); JKN43410XZ (peiminine); P47L69798O (loureirin B); PJ788634QY (ginsenoside Rg1); Z62692362Z (notoginsenoside R1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE


  8 / 3802 MEDLINE  
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[PMID]:28407923
[Au] Autor:Sun L; Liu D; Sun J; Yang X; Fu M; Guo Y
[Ad] Endereço:Centre of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, PR China; Centre for Nutrition and Food Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane 4072, Australia.
[Ti] Título:Simultaneous separation and purification of chlorogenic acid, epicatechin, hyperoside and phlorizin from thinned young Qinguan apples by successive use of polyethylene and polyamide resins.
[So] Source:Food Chem;230:362-371, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The method for separating and purifying chlorogenic acid (CA), epicatechin (EC), hyperoside (HY) and phlorizin (PH) simutaneously from young Qinguan apples by successive use of X-5 and polyamide resins has been developed in this study. The order of adsorption capacities of X-5 for the four phenolics was PH>HY>EC>CA, and the adsorption equilibriums of the four phenolics onto X-5 resin conformed to Langmuir isotherms preferentially. The adsorption kinetics of EC and CA onto X-5 conformed to the pseudo-first-order model, while that of HY and PH accorded with the pseudo-second-order model. Interestingly, the values of equilibrium adsorption capacities (Q ) calculated in the preferential kinetics models were closer to that of theoretical maximum adsorption capacities (Q ) calculated by Langmuir isotherms. Through dynamic adsorption and desorption using X-5 and polyamide resins with ethanol solution as strippant, CA, EC, HY and PH were obtained with purities of 96.21%, 95.34%, 95.36% and 97.36%, respectively.
[Mh] Termos MeSH primário: Catequina/química
Ácido Clorogênico/química
Malus/química
Florizina/química
Extratos Vegetais/química
Polietileno/química
Quercetina/análogos & derivados
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Quercetina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Resins, Plant); 318ADP12RI (Chlorogenic Acid); 8O1CR18L82 (hyperoside); 8R1V1STN48 (Catechin); 9002-88-4 (Polyethylene); 9IKM0I5T1E (Quercetin); CU9S17279X (Phlorhizin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  9 / 3802 MEDLINE  
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[PMID]:28398735
[Au] Autor:Kuo PC; Hung HY; Hwang TL; Du WK; Ku HC; Lee EJ; Tai SH; Chen FA; Wu TS
[Ad] Endereço:School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
[Ti] Título:Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco.
[So] Source:J Nat Prod;80(4):783-789, 2017 Apr 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Chalconas/isolamento & purificação
Chalconas/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Chalconas/química
Flavonoides/química
Seres Humanos
Estrutura Molecular
Neutrófilos/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Elastase Pancreática/antagonistas & inibidores
Superóxidos/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Chalcones); 0 (Flavonoids); 0 (Resins, Plant); 11062-77-4 (Superoxides); 35HDD3NRIE (flavan-3-ol); EC 3.4.21.36 (Pancreatic Elastase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00039


  10 / 3802 MEDLINE  
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[PMID]:28381769
[Au] Autor:Morikawa T; Matsuda H; Yoshikawa M
[Ad] Endereço:Pharmaceutical Research and Technology Institute.
[Ti] Título:A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh.
[So] Source:J Oleo Sci;66(8):805-814, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Frankincense and myrrh have been used as incense in religious and cultural ceremonies since the beginning of written history. Their common medicinal properties are used in the treatment for inflammatory conditions, some cancerous diseases, and wound healing. In the course of our characterization of the anti-inflammatory constituents from frankincense and myrrh, several terpenoid constituents were found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Here we review the structure of those terpenoid constituents from the gum resins of frankincense and myrrh and evaluate their anti-inflammatory effects by their nitric oxide production inhibitory activity.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Olíbano/química
Macrófagos Peritoneais/metabolismo
Óxido Nítrico/biossíntese
Resinas Vegetais/química
Terpenos/isolamento & purificação
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Depressão Química
Indução Enzimática/efeitos dos fármacos
Lipopolissacarídeos
Ativação de Macrófagos
Camundongos
Óxido Nítrico Sintase Tipo II/metabolismo
Relação Estrutura-Atividade
Terpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Resins, Plant); 0 (Terpenes); 31C4KY9ESH (Nitric Oxide); 9000-45-7 (myrrh resin); EC 1.14.13.39 (Nitric Oxide Synthase Type II); R9XLF1R1WM (Frankincense)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16149



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