Base de dados : MEDLINE
Pesquisa : D05.750.716.195 [Categoria DeCS]
Referências encontradas : 281 [refinar]
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[PMID]:28475418
[Au] Autor:Terauchi Y; Kim YK; Tanaka T; Nanatani K; Takahashi T; Abe K
[Ad] Endereço:a Laboratory of Applied Microbiology, Department of Microbial Biotechnology , Graduate School of Agricultural Science, Tohoku University , Sendai , Japan.
[Ti] Título:Asp30 of Aspergillus oryzae cutinase CutL1 is involved in the ionic interaction with fungal hydrophobin RolA.
[So] Source:Biosci Biotechnol Biochem;81(7):1363-1368, 2017 Jul.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aspergillus oryzae hydrophobin RolA adheres to the biodegradable polyester polybutylene succinate-co-adipate (PBSA) and promotes PBSA degradation by interacting with A. oryzae polyesterase CutL1 and recruiting it to the PBSA surface. In our previous studies, we found that positively charged amino acid residues (H32, K34) of RolA and negatively charged residues (E31, D142, D171) of CutL1 are important for the cooperative ionic interaction between RolA and CutL1, but some other charged residues in the triple mutant CutL1-E31S/D142S/D171S are also involved. In the present study, on the basis of the 3D-structure of CutL1, we hypothesized that D30 is also involved in the CutL1-RolA interaction. We substituted D30 with serine and performed kinetic analysis of the interaction between wild-type RolA and the single mutant CutL1-D30S or quadruple mutant CutL1-D30S/E31S/D142S/D171S by using quartz crystal microbalance. Our results indicate that D30 is a novel residue involved in the ionic interaction between RolA and CutL1.
[Mh] Termos MeSH primário: Ácido Aspártico/química
Aspergillus oryzae/química
Plásticos Biodegradáveis/química
Hidrolases de Éster Carboxílico/química
Proteínas Fúngicas/química
Polímeros/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Ácido Aspártico/metabolismo
Aspergillus oryzae/enzimologia
Sítios de Ligação
Plásticos Biodegradáveis/metabolismo
Hidrolases de Éster Carboxílico/genética
Hidrolases de Éster Carboxílico/metabolismo
Clonagem Molecular
Escherichia coli/genética
Escherichia coli/metabolismo
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Expressão Gênica
Interações Hidrofóbicas e Hidrofílicas
Cinética
Modelos Moleculares
Mutação
Polímeros/metabolismo
Ligação Proteica
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Domínios e Motivos de Interação entre Proteínas
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Eletricidade Estática
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biodegradable Plastics); 0 (Fungal Proteins); 0 (Polymers); 0 (Recombinant Proteins); 0 (polybutylene succinate-co-adipate); 30KYC7MIAI (Aspartic Acid); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (cutinase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1321952


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[PMID]:28394518
[Au] Autor:Myltygashev MP; Boyandin AN; Shumilova AA; Kapsargin FP; Shishatskaya EI; Kirichenko AK; Volova TG
[Ad] Endereço:Voino-Yasenetsky Krasnoyarsk State Medical University, Department of Urology, Andrology and Sexology, IPE, Krasnoyarsk, Russia.
[Ti] Título:[The study of effectiveness of polyhydroxyalkanoates based biodegradable stents in ureteropelvic segment pyeloplasty].
[So] Source:Urologiia;(1):16-22, 2017 Apr.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:INTRODUCTION: Among urologic diseases, ureteropelvic segment stenosis with hydronephrosis is a common indication for instrumental or surgical correction. The restriction of urine flow with dilatation proximal to obstruction develops in 6.5-37% of cases at different times after the ureteral reconstruction. All this urges to develop and improve stents and search for effective ways to place stents and control their function. AIM: To investigate the effectiveness of polyhydroxyalkanoates based biodegradable stent compared with a commercial analogue in upper urinary tract drainage after ureteropelvic segment pyeloplasty. MATERIALS AND METHODS: Morphological and functional changes in the stented ureter were investigated in 45 male rabbits of "Soviet chinchilla" breed weighing 4550-5200 g that underwent stenting of ureteropelvic segment (UPS). The study used polymeric stents based on poly-3-hydroxybutyrate, poly-4-gidroksibutirotom P (3GB/4GB) and a mixture of poly-3-hydroxybutyrate with polycaprolactone II (3GB)/PCL with the inclusion of PCL 75%; the control material was polyurethane stents. Morphologic evaluation was conducted on ureteral fragments and UPSs in the area of the stent placement at 7, 14 and 28 days after operation. RESULTS: Throughout the experiment, excretory urography and spiral tomography in experimental groups showed no changes in the pelvicalyceal system after placing polymeric stents. The morphologic examination in the experimental group at day 28 after surgery revealed preserved longitudinal folding of ureteral mucosa and absence of muscle hypertrophy. Transitional epithelium had no signs of atrophy and desquamation, its mean thickness was 112.4+/-8.5 mm, whereas in the control group a productive inflammation resulting in sclerosis was found to develop. CONCLUSIONS: We conducted a comparative study of morphologic and functional changes in rabbit ureters after stenting using polyurethane stents (control group) and polymeric stents made of poly-3-hydroxybutyrate, poly-4-hydroxybutyrate II (3GB /4GB) and a mixture of poly-3-hydroxybutyrate with polycaprolactone II (3Gb)/PCL (experimental group). Despite the difference in physical and mechanical properties of biodegradable PGA-based stents, the tissue response to both types of stent was comparable. Ureteral wall preserved longitudinal folds, there was no muscle layer hypertrophy, and mucous membrane had smooth contours with a uniform thickness of the transitional epithelium, whereas in the control group a productive inflammation resulting in sclerosis was found to develop.
[Mh] Termos MeSH primário: Hidroxibutiratos
Pelve Renal/cirurgia
Poliésteres
Poli-Hidroxialcanoatos
Stents
Ureter/cirurgia
[Mh] Termos MeSH secundário: Animais
Plásticos Biodegradáveis
Masculino
Coelhos
Ureter/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biodegradable Plastics); 0 (Hydroxybutyrates); 0 (Polyesters); 0 (Polyhydroxyalkanoates); 117068-64-1 (poly(3-hydroxybutyrate-co-4-hydroxybutyrate)); 24980-41-4 (polycaprolactone); 26063-00-3 (poly-beta-hydroxybutyrate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28335550
[Au] Autor:Park JH; Lee BK; Park SH; Kim MG; Lee JW; Lee HY; Lee HB; Kim JH; Kim MS
[Ad] Endereço:Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Korea. jhp@ajou.ac.kr.
[Ti] Título:Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 21.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL- -PLA) copolymers (PC L A), which display specific rates of flexibility and elasticity. We synthesize the PC L A copolymers by ring-opening polymerization of ε-caprolactone and l-lactide. PC L A copolymers of various compositions were synthesized with 500,000 molecular weight. The PC L A copolymers mechanical properties were dependent on the mole ratio of the ε-caprolactone and l-lactide components. Cyclic tensile tests were carried out to investigate the resistance to creep of PC L A specimens after up to 20 deformation cycles to 50% elongation. After in vivo implantation, the PC L A implants exhibited biocompatibility, and gradually biodegraded over an eight-week experimental period. Immunohistochemical characterization showed that the PC L A implants provoked in vivo inflammation, which gradually decreased over time. The copolymer was used as a drug carrier for locally implantable drugs, the hydrophobic drug dexamethasone (Dex), and the water-soluble drug dexamethasone 21-phosphate disodium salt (Dex(p)). We monitored drug-loaded PC L A films for in vitro and in vivo drug release over 40 days and observed real-time sustained release of near-infrared (NIR) fluorescence over an extended period from hydrophobic IR-780- and hydrophilic IR-783-loaded PC L A implanted in live animals. Finally, we confirmed that PC L A films are usable as biodegradable, elastic drug carriers.
[Mh] Termos MeSH primário: Plásticos Biodegradáveis/química
Sistemas de Liberação de Medicamentos/efeitos adversos
Poliésteres/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacocinética
Plásticos Biodegradáveis/efeitos adversos
Plásticos Biodegradáveis/síntese química
Dexametasona/administração & dosagem
Dexametasona/farmacocinética
Liberação Controlada de Fármacos
Poliésteres/efeitos adversos
Poliésteres/síntese química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biodegradable Plastics); 0 (Polyesters); 0 (poly(epsilon-caprolactone-co-lactide)); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28277656
[Au] Autor:Oyama HT; Tanishima D; Ogawa R
[Ad] Endereço:Department of Chemistry, College of Science, Rikkyo University , 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.
[Ti] Título:Biologically Safe Poly(l-lactic acid) Blends with Tunable Degradation Rate: Microstructure, Degradation Mechanism, and Mechanical Properties.
[So] Source:Biomacromolecules;18(4):1281-1292, 2017 Apr 10.
[Is] ISSN:1526-4602
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although poly(l-lactic acid) (PLLA) is reputed to be biodegradable in the human body, its hydrophobic nature lets it persist for ca. 5.5 years. This study demonstrates that biologically safe lactide copolymers, poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML), dispersed in the PLLA function as detonators (triggers) for its hydrolytic degradation under physiological conditions. The copolymers significantly enhance hydrolysis, and consequently, the degradation rate of PLLA becomes easily tunable by controlling the amounts of PAL and PML. The present study elucidates the effects of uniaxial drawing on the structural development, mechanical properties, and hydrolytic degradation under physiological conditions of PLLA blend films. At initial degradation stages, the mass loss was not affected by uniaxial drawing; however, at late degradation stages, less developed crystals as well as amorphous chains were degradable at low draw ratio (DR), whereas not only highly developed crystals but also the oriented amorphous chains became insensitive to hydrolysis at high DR. Our work provides important molecular level results that demonstrate that biodegradable materials can have superb mechanical properties and also disappear in a required time under physiological conditions.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Plásticos Biodegradáveis/química
Peptídeos/química
Poliésteres/química
[Mh] Termos MeSH secundário: Cromatografia em Gel
Cristalografia por Raios X
Temperatura Alta
Concentração de Íons de Hidrogênio
Hidrólise
Microscopia Eletrônica de Varredura
Microscopia de Polarização
Estrutura Molecular
Resistência à Tração
Fatores de Tempo
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Biodegradable Plastics); 0 (Peptides); 0 (Polyesters); 0 (poly(aspartic acid-co-lactic acid)); 0 (poly(malic acid-co-lactide)); 459TN2L5F5 (poly(lactide))
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biomac.7b00016


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[PMID]:28187295
[Au] Autor:Tang J; Sisler J; Grishkewich N; Tam KC
[Ad] Endereço:Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, Canada.
[Ti] Título:Functionalization of cellulose nanocrystals for advanced applications.
[So] Source:J Colloid Interface Sci;494:397-409, 2017 05 15.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Replacing the widespread use of petroleum-derived non-biodegradable materials with green and sustainable materials is a pressing challenge that is gaining increasing attention by the scientific community. One such system is cellulose nanocrystal (CNC) derived from acid hydrolysis of cellulosic materials, such as plants, tunicates and agriculture biomass. The utilization of colloidal CNCs can aid in the reduction of carbon dioxide that is responsible for global warming and climate change. CNCs are excellent candidates for the design and development of functional nanomaterials in many applications due to several attractive features, such as high surface area, hydroxyl groups for functionalization, colloidal stability, low toxicity, chirality and mechanical strength. Several large scale manufacturing facilities have been commissioned to produce CNCs of up to 1000kg/day, and this has generated increasing interests in both academic and industrial laboratories. In this feature article, we will describe the recent development of functionalized cellulose nanocrystals for several important applications in ours and other laboratories. We will highlight some challenges and offer perspectives on the potentials of these sustainable nanomaterials.
[Mh] Termos MeSH primário: Plásticos Biodegradáveis/química
Celulose/química
Celulose/síntese química
Nanopartículas/química
Nanoestruturas/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Emulsões
Corantes Fluorescentes/química
Química Verde
Hidrólise
Fenômenos Mecânicos
Tamanho da Partícula
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Biodegradable Plastics); 0 (Emulsions); 0 (Fluorescent Dyes); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:28185962
[Au] Autor:Admane P; Gupta J; I J A; Kumar R; Panda AK
[Ad] Endereço:Product Development Cell, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India. Electronic address: prasad.admane@gmail.com.
[Ti] Título:Design and evaluation of antibiotic releasing self- assembled scaffolds at room temperature using biodegradable polymer particles.
[So] Source:Int J Pharm;520(1-2):284-296, 2017 Mar 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biodegradable polymer-based drug-eluting implants offer many advantages such as predictable drug release kinetics, safety, and acceptable drug loading under ambient conditions. Herein, we describe fabrication and evaluation of antibiotic loaded scaffolds for localized delivery and tissue engineering applications. PDLLA particles entrapping gentamycin were formulated using solvent evaporation method and used for scaffold fabrication. Optimization of formulation parameters such as pH of the internal aqueous phase and combination of excipients like glycerol, polyvinyl alcohol (PVA) resulted in high entrapment efficiencies up to 96% of gentamicin in particles with drug load of 16-18µg/mg of polymer particles. These microparticles were fused in presence of methanol at ambient temperatures to form scaffolds of different geometry having reasonable mechanical strength. Porosity of these scaffolds was found to be more than 80%. Antibiotic released from the scaffolds was found to be bioactive as tested against Staphylococcus aureus and the release pattern was biphasic over a period of one week. The scaffolds were found to be non-toxic to murine fibroblasts cultures in vitro as well as to mice upon subcutaneous implantation. This method provides a novel and easy way of fabricating antibiotic loaded polymer scaffolds for varieties of applications.
[Mh] Termos MeSH primário: Implantes Absorvíveis
Plásticos Biodegradáveis/química
Implantes de Medicamento/química
Gentamicinas/administração & dosagem
Ácido Láctico/química
Ácido Poliglicólico/química
Temperatura Ambiente
Tecidos Suporte/química
[Mh] Termos MeSH secundário: Implantes Absorvíveis/efeitos adversos
Animais
Plásticos Biodegradáveis/efeitos adversos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Implantes de Medicamento/administração & dosagem
Implantes de Medicamento/farmacocinética
Liberação Controlada de Fármacos
Fibroblastos/efeitos dos fármacos
Gentamicinas/farmacocinética
Gentamicinas/farmacologia
Glicerol/química
Ácido Láctico/efeitos adversos
Camundongos
Testes de Sensibilidade Microbiana
Tamanho da Partícula
Poliésteres/química
Ácido Poliglicólico/efeitos adversos
Álcool de Polivinil/química
Tecidos Suporte/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biodegradable Plastics); 0 (Drug Implants); 0 (Gentamicins); 0 (Polyesters); 0 (polylactic acid-polyglycolic acid copolymer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 459TN2L5F5 (poly(lactide)); 9002-89-5 (Polyvinyl Alcohol); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:28182847
[Au] Autor:Lee KY; Song KB
[Ad] Endereço:Dept. of Food Science and Technology, Chungnam Natl. Univ., Daejeon, 34134, Republic of Korea.
[Ti] Título:Preparation and Characterization of an Olive Flounder (Paralichthys olivaceus) Skin Gelatin and Polylactic Acid Bilayer Film.
[So] Source:J Food Sci;82(3):706-710, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Olive flounder skin gelatin (OSG) was used as a film base material. A bilayer film of OSG and polylactic acid (PLA) was prepared using solvent casting method to enhance the film properties. Physical properties of the OSG-PLA film were increased compared with the nonaugmented OSG film. In particular, the PLA lamination decreased water vapor permeability from 2.17 to 0.92 × 10 g·m/m ·s·Pa, as well as of the water solubility from 16.62% to 9.27%, in the bilayer film relative to the OSG film. The oxygen permeability of the OSG-PLA bilayer film was held low by the OSG film, compensating for the high oxygen permeability of the PLA layer. Therefore, the OSG-PLA bilayer film with its enhanced physical properties and high water and oxygen barrier properties can be applied as a food packaging material.
[Mh] Termos MeSH primário: Plásticos Biodegradáveis/química
Linguado
Embalagem de Alimentos/métodos
Gelatina/química
Oxigênio
Poliésteres/química
Água
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Olea
Permeabilidade
Pele/química
Solubilidade
Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biodegradable Plastics); 0 (Polyesters); 0 (Steam); 059QF0KO0R (Water); 459TN2L5F5 (poly(lactide)); 9000-70-8 (Gelatin); S88TT14065 (Oxygen)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13650


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[PMID]:28165665
[Au] Autor:Guven MN; Seckin Altuncu M; Demir Duman F; Eren TN; Yagci Acar H; Avci D
[Ad] Endereço:Department of Chemistry, Bogazici University, 34342 Bebek, Istanbul, Turkey.
[Ti] Título:Bisphosphonate-functionalized poly(ß-amino ester) network polymers.
[So] Source:J Biomed Mater Res A;105(5):1412-1421, 2017 May.
[Is] ISSN:1552-4965
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three novel bisphosphonate-functionalized secondary diamines are synthesized and incorporated into poly(ß-amino ester)s (PBAEs) to investigate the effects of bisphosphonates on biodegradation and toxicity of PBAE polymer networks. These three novel amines, BPA1, BPA2, and BPA3, were prepared from the reactions of 1,4-butanediamine, 1,6-hexanediamine, or 4,9-dioxa-1,12-dodecanediamine with tetraethyl vinylidene bisphosphonate, respectively. The PBAE macromers were obtained from the aza-Michael addition reaction of these amines to 1,6-hexane diol diacrylate (HDDA) and poly(ethylene glycol) diacrylate (PEGDA, M = 575) and photopolymerized to produce biodegradable gels. These gels with different chemistries exhibited similar degradation behavior with mass loss of 53-73% within 24 h, indicating that degradation is mostly governed by the bisphosphonate group. Based on the in vitro cytotoxicity evaluation against NIH 3T3 mouse embryonic fibroblast cells, the degradation products do not exhibit significant toxicity in most cases. It was also shown that PBAE macromers can be used as cross-linkers for the synthesis of 2-hydroxyethyl methacrylate hydrogels, conferring small and customizable degradation rates upon them. The materials reported have potential to be used as nontoxic degradable biomaterials. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1412-1421, 2017.
[Mh] Termos MeSH primário: Plásticos Biodegradáveis
Difosfonatos
Fibroblastos/metabolismo
Teste de Materiais
Polímeros
[Mh] Termos MeSH secundário: Animais
Plásticos Biodegradáveis/síntese química
Plásticos Biodegradáveis/química
Plásticos Biodegradáveis/farmacocinética
Plásticos Biodegradáveis/farmacologia
Difosfonatos/química
Difosfonatos/farmacocinética
Difosfonatos/farmacologia
Fibroblastos/citologia
Camundongos
Células NIH 3T3
Polímeros/química
Polímeros/farmacocinética
Polímeros/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biodegradable Plastics); 0 (Diphosphonates); 0 (Polymers); 0 (poly(beta-amino ester))
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1002/jbm.a.36026


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[PMID]:28161666
[Au] Autor:Heyder RS; Zhong Q; Bazito RC; da Rocha SRP
[Ad] Endereço:Department of Chemical Engineering and Materials Science, Wayne State University, 48202, Detroit, MI, USA; Institute of Chemistry, Department of Fundamental Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
[Ti] Título:Cellular internalization and transport of biodegradable polyester dendrimers on a model of the pulmonary epithelium and their formulation in pressurized metered-dose inhalers.
[So] Source:Int J Pharm;520(1-2):181-194, 2017 Mar 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the effect of generation and surface PEGylation of degradable polyester-based dendrimers nanocarriers on their interactions with an in vitro model of the pulmonary epithelium as well as to assess the ability to formulate such carriers in propellant-based, portable oral-inhalation devices to determine their potential for local and systemic delivery of drugs to and through the lungs. Hydroxyl (-OH) terminated polyester dendrimers of generation 3 and 4 (G3, and G4) were synthesized using a divergent approach. G4 was surface-modified with PEG (1,000Da). All dendrimers and their building blocks were determined to be highly compatible with the model pulmonary epithelium, with toxicity profiles much more favorable than non-degradable polyamidoamine dendrimers (PAMAM). The transport of the species from the apical to basolateral side across polarized Calu-3 monolayers showed to be generation and surface-chemistry (PEGylation) dependent. The extent of the transport is modulated by their interaction with the polarized epithelium and their transient opening of the tight junctions. G3 was the one most efficiently internalized by the epithelium, and had a small impact on the integrity of the monolayer. On the other hand, the PEGylated G4 was the one least internalized by the polarized epithelium, and at the same time had a more pronounced transient impact on the cellular junctions, resulting in more efficient transport across the cell monolayer. PEGylation of the dendrimer surface played other roles as well. PEGylation modulated the degradation profile of the dendrimer, slowing the process in a step-wise fashion - first the PEG layer is shed and then the dendrimer starts degrading. PEGylation also helped increase the solvation of the nanocarriers by the hydrofluoroalkane propellant used in pressurized metered-dose inhalers, resulting in formulations with excellent dispersibility and aerosol quality (deep lung deposition of 88.5%), despite their very small geometric diameter. The combined in vitro and formulation performance results shown here demonstrated that degradable, modified polyester dendrimers may serve as a valuable platform that can be tailored to target the lung tissue for treating local diseases, or the circulation, using the lungs as pathway to the bloodstream.
[Mh] Termos MeSH primário: Dendrímeros/farmacocinética
Composição de Medicamentos/métodos
Epitélio/metabolismo
Pulmão/metabolismo
Inaladores Dosimetrados
Poliésteres/farmacocinética
[Mh] Termos MeSH secundário: Proteínas de Artrópodes
Plásticos Biodegradáveis/química
Plásticos Biodegradáveis/farmacocinética
Plásticos Biodegradáveis/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Dendrímeros/química
Dendrímeros/farmacologia
Seres Humanos
Poliésteres/química
Poliésteres/farmacologia
Polietilenoglicóis/química
Polietilenoglicóis/farmacocinética
Pressão
Venenos de Aranha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arthropod Proteins); 0 (Biodegradable Plastics); 0 (Dendrimers); 0 (GxTX-1E, Plesiophrictus guangxiensis); 0 (PAMAM Starburst); 0 (Polyesters); 0 (Spider Venoms); 30IQX730WE (Polyethylene Glycols); U076Q6Q621 (polyethylene glycol 1000)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:28120754
[Au] Autor:Garric X; Nottelet B; Pinese C; Leroy A; Coudane J
[Ad] Endereço:Département Biopolymères Artificiels : Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université Montpellier, ENSCM, Faculté de Pharmacie, Bâtiment I, 15, avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France.
[Ti] Título:[Biodegradable synthetic polymers for the design of implantable medical devices: the ligamentoplasty case].
[Ti] Título:Polymères synthétiques dégradables pour la conception de dispositifs médicaux implantables - Le cas de la ligamentoplastie..
[So] Source:Med Sci (Paris);33(1):39-45, 2017 Jan.
[Is] ISSN:1958-5381
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The sector of implantable medical devices is a growing sector of health products especially dynamic in the field of research. To improve the management of patients and to meet clinical requirements, researchers are developing new types of medical devices. They use different families of biomaterials presenting various chemical and physical characteristics in order for providing clinicians with health products optimized for biomedical applications. In this article, we aim to show how, starting from a family of biomaterials (degradable polymers), it is possible to design an implantable medical device for the therapeutic management of the failure of anterior cruciate ligament. The main steps leading to the design of a total ligament reinforcement are detailed. They range from the synthesis and characterization of degradable polymer to the shaping of the knitted implant, through the assessment of the study of the impact of sterilization on mechanical properties and checking cytocompatibility.
[Mh] Termos MeSH primário: Implantes Absorvíveis
Plásticos Biodegradáveis
Desenho de Equipamento/métodos
Ligamentos/cirurgia
Polímeros/química
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/síntese química
Materiais Biocompatíveis/química
Materiais Biocompatíveis/uso terapêutico
Plásticos Biodegradáveis/síntese química
Plásticos Biodegradáveis/química
Plásticos Biodegradáveis/uso terapêutico
Seres Humanos
Polímeros/síntese química
Procedimentos Cirúrgicos Reconstrutivos/métodos
Procedimentos Cirúrgicos Reconstrutivos/tendências
Medicina Regenerativa/métodos
Medicina Regenerativa/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Biodegradable Plastics); 0 (Polymers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1051/medsci/20173301007



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