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[PMID]:29506497
[Au] Autor:Park SJ; Noh JH; Park KB; Jang SY; Lee JW
[Ad] Endereço:College of medicine, Soonchunhyang University, 204-ho, 31 Soonchunhyang-6-gil, Dongnam-gu, Cheonan, 31151, Choongcheongnam-do, South Korea.
[Ti] Título:A novel surgical technique for punctal stenosis: placement of three interrupted sutures after rectangular three-snip punctoplasty.
[So] Source:BMC Ophthalmol;18(1):70, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We developed a novel surgical technique to treat punctal stenosis involving the placement of three interrupted sutures after rectangular three-snip punctoplasty (TSP). METHODS: Retrospective chart review of forty-eight eyes of 44 patients who underwent rectangular TSP with three interrupted sutures was performed. We investigated whether anatomical recurrences (re-stenosis) occurred during the follow-up period. The subjective symptoms of patients were surveyed. RESULTS: The mean patient age was 64.1 years, and the mean follow-up time was 17.4 months. The placement of three interrupted sutures after rectangular TSP afforded satisfactory outcomes. Regarding subjective symptoms, 91.7% of the eyes (44/48) were reported as improved. Among 4 eyes determined as symptomatic failure, anatomical recurrence (re-stenosis of the punctum) was observed in only one eye. The other three (6.25%, 3/48 eyes) showed functional nasolacrimal obstruction, namely epiphora with patent tear duct. CONCLUSIONS: Placement of three interrupted sutures after rectangular TSP to treat punctal stenosis showed promising results. Notably anatomical success rate was about 98%. Further comparisons between the novel surgical technique and conventional techniques are required.
[Mh] Termos MeSH primário: Doenças Palpebrais/cirurgia
Aparelho Lacrimal/cirurgia
Obstrução dos Ductos Lacrimais/terapia
Procedimentos Cirúrgicos Oftalmológicos
Técnicas de Sutura
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Nylons
Estudos Retrospectivos
Suturas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nylons)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0733-2


  2 / 4405 MEDLINE  
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[PMID]:29205213
[Au] Autor:Zanelli L; Todros S; Carniel EL; Pavan PG; Pavan PG
[Ad] Endereço:Department of Mathematics, University of Padova, Padova, Italy.
[Ti] Título:Mechanical properties variation and constitutive modelling of biomedical polymers after sterilization.
[So] Source:Acta Bioeng Biomech;19(3):3-9, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this work, the mechanical behavior of two block copolymers for biomedical applications is studied with particular regard to the effects induced by a steam sterilization treatment that biomedical devices usually undergo in healthcare facilities. This investigation is aimed at describing the elasto-plastic behavior of the stress-strain response, determining a functional dependence between material constitutive parameters, to obtain an optimal constitutive model. METHODS: The mechanical properties of these polymers are analyzed through uniaxial tensile tests, before and after the sterilization process. The effect of sterilization on the mechanical behavior is evaluated. The Ramberg-Osgood model is used to describe the elasto-plastic behavior of the stress-strain response. RESULTS: Data from uniaxial tensile tests are discussed in the light of previous data on the same polymeric materials, in order to highlight the correlation between physicochemical and mechanical properties variation. The material constitutive parameters are determined and the functional dependence between them is found, thus enabling an optimal constitutive model to be obtained. CONCLUSIONS: The effect of sterilization on the material constitutive parameters is studied, to evaluate the suitability of the model in describing the mechanical response of biomedical polymer before and after sterilization treatment. The same approach can be applied to other biomaterials, under various tensile tests, and for several processes that induce variation in mechanical properties.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Éteres/química
Modelos Químicos
Nylons/química
Esterilização/métodos
[Mh] Termos MeSH secundário: Força Compressiva
Simulação por Computador
Módulo de Elasticidade
Teste de Materiais
Estresse Mecânico
Resistência à Tração
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Ethers); 0 (Nylons); 0 (polyamide-ether-elastomer)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  3 / 4405 MEDLINE  
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[PMID]:29252993
[Au] Autor:Favier V; Zemiti N; Caravaca Mora O; Subsol G; Captier G; Lebrun R; Crampette L; Mondain M; Gilles B
[Ad] Endereço:Montpellier Laboratory of Informatics, Robotics and Microelectonics (LIRMM), ICAR team, French National Centre for Scientific Research (CNRS), Montpellier University, Montpellier, France.
[Ti] Título:Geometric and mechanical evaluation of 3D-printing materials for skull base anatomical education and endoscopic surgery simulation - A first step to create reliable customized simulators.
[So] Source:PLoS One;12(12):e0189486, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Endoscopic skull base surgery allows minimal invasive therapy through the nostrils to treat infectious or tumorous diseases. Surgical and anatomical education in this field is limited by the lack of validated training models in terms of geometric and mechanical accuracy. We choose to evaluate several consumer-grade materials to create a patient-specific 3D-printed skull base model for anatomical learning and surgical training. METHODS: Four 3D-printed consumer-grade materials were compared to human cadaver bone: calcium sulfate hemihydrate (named Multicolor), polyamide, resin and polycarbonate. We compared the geometric accuracy, forces required to break thin walls of materials and forces required during drilling. RESULTS: All materials had an acceptable global geometric accuracy (from 0.083mm to 0.203mm of global error). Local accuracy was better in polycarbonate (0.09mm) and polyamide (0.15mm) than in Multicolor (0.90mm) and resin (0.86mm). Resin and polyamide thin walls were not broken at 200N. Forces needed to break Multicolor thin walls were 1.6-3.5 times higher than in bone. For polycarbonate, forces applied were 1.6-2.5 times higher. Polycarbonate had a mode of fracture similar to the cadaver bone. Forces applied on materials during drilling followed a normal distribution except for the polyamide which was melted. Energy spent during drilling was respectively 1.6 and 2.6 times higher on bone than on PC and Multicolor. CONCLUSION: Polycarbonate is a good substitute of human cadaver bone for skull base surgery simulation. Thanks to short lead times and reasonable production costs, patient-specific 3D printed models can be used in clinical practice for pre-operative training, improving patient safety.
[Mh] Termos MeSH primário: Endoscopia/métodos
Modelos Anatômicos
Impressão Tridimensional
Base do Crânio/anatomia & histologia
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Cadáver
Sulfato de Cálcio/química
Simulação por Computador
Seres Humanos
Nylons/química
Segurança do Paciente
Cimento de Policarboxilato/química
Reprodutibilidade dos Testes
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nylons); 0 (Polycarboxylate Cement); 25766-59-0 (polycarbonate); WAT0DDB505 (Calcium Sulfate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189486


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[PMID]:29224995
[Au] Autor:Kashiwazaki G; Maeda R; Kawase T; Hashiya K; Bando T; Sugiyama H
[Ad] Endereço:Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwake-cho, Sakyo, Kyoto 606-8502, Japan.
[Ti] Título:Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer.
[So] Source:Bioorg Med Chem;26(1):1-7, 2018 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:N-Methylpyrrole-N-methylimidazole (PI) polyamides are a class of DNA minor groove binders with DNA sequence-specificity. DNA-alkylating PI polyamide conjugates are attractive candidates as anticancer drugs acting through DNA damage and its subsequent inhibition of cell proliferation. One example is a chlorambucil-PI polyamide conjugate targeting the runt-related transcription factor (RUNX) family. RUNX1 has pro-oncogenic properties in acute myeloid leukemia, and recently the chlorambucil-PI polyamide conjugate was demonstrated to have anticancer effects. Herein, we apply another DNA-alkylating agent, seco-CBI, to target the consensus sequence of the RUNX family. Two types of CBI conjugates were prepared and their binding properties were characterized by Bind-n-Seq analysis using a high-throughput sequencer. The sequencing data were analyzed by two methods, MERMADE and our new MR (motif identification with a reference sequence), and the resultant binding motif logos were as predicted from the pairing rules proposed by Dervan et al. This is the first report to employ the MR method on alkylating PI polyamide conjugates. Moreover, cytotoxicity of conjugates 3 and 4 against a human non-small cell lung cancer, A549, were examined to show promising IC s of 120 nm and 63 nm, respectively. These findings suggest seco-CBI-PI polyamide conjugates are candidates for oncological therapy.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Ensaios de Triagem em Larga Escala
Imidazóis/farmacologia
Nylons/farmacologia
Pirróis/farmacologia
[Mh] Termos MeSH secundário: Alquilação
Antineoplásicos/síntese química
Antineoplásicos/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Imidazóis/química
Estrutura Molecular
Nylons/química
Pirróis/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Imidazoles); 0 (Nylons); 0 (Pyrroles); 7GBN705NH1 (imidazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  5 / 4405 MEDLINE  
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[PMID]:28934500
[Au] Autor:Taniguchi J; Pandian GN; Hidaka T; Hashiya K; Bando T; Kim KK; Sugiyama H
[Ad] Endereço:Department of Chemistry, Graduate School of Science Kyoto University, Sakyo-Ku, Kyoto 606-8502, Japan.
[Ti] Título:A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm.
[So] Source:Nucleic Acids Res;45(16):9219-9228, 2017 Sep 19.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Targeted differentiation of human induced pluripotent stem cells (hiPSCs) using only chemicals would have value-added clinical potential in the regeneration of complex cell types including cardiomyocytes. Despite the availability of several chemical inhibitors targeting proteins involved in signaling pathways, no bioactive synthetic DNA-binding inhibitors, targeting key cell fate-controlling genes such as SOX2, are yet available. Here, we demonstrate a novel DNA-based chemical approach to guide the differentiation of hiPSCs using pyrrole-imidazole polyamides (PIPs), which are sequence-selective DNA-binding synthetic molecules. Harnessing knowledge about key transcriptional changes during the induction of cardiomyocyte, we developed a DNA-binding inhibitor termed PIP-S2, targeting the 5'-CTTTGTT-3' and demonstrated that inhibition of SOX2-DNA interaction by PIP-S2 triggers the mesoderm induction in hiPSCs. Genome-wide gene expression analyses revealed that PIP-S2 induced mesoderm by targeted alterations in SOX2-associated gene regulatory networks. Also, employment of PIP-S2 along with a Wnt/ß-catenin inhibitor successfully generated spontaneously contracting cardiomyocytes, validating our concept that DNA-binding inhibitors could drive the directed differentiation of hiPSCs. Because PIPs can be fine-tuned to target specific DNA sequences, our DNA-based approach could be expanded to target and regulate key transcription factors specifically associated with desired cell types.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos
Mesoderma/citologia
Miócitos Cardíacos/citologia
Nylons/farmacologia
Pirróis/farmacologia
Fatores de Transcrição SOXB1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Sequência de Bases
Sítios de Ligação
Linhagem Celular
Sequência Consenso
Expressão Gênica
Seres Humanos
Células-Tronco Pluripotentes Induzidas/citologia
Células-Tronco Pluripotentes Induzidas/metabolismo
Mesoderma/efeitos dos fármacos
Mesoderma/metabolismo
Miócitos Cardíacos/metabolismo
Nylons/química
Pirróis/química
Fatores de Transcrição SOXB1/metabolismo
Via de Sinalização Wnt/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nylons); 0 (PIP-S2 compound); 0 (Pyrroles); 0 (SOX2 protein, human); 0 (SOXB1 Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx693


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[PMID]:28759443
[Au] Autor:Coutinho de Paula E; Gomes JCL; Amaral MCS
[Ad] Endereço:Federal University of Itajubá, Itabira, Minas Gerais, Brazil E-mail: ecoutinho.unifei@gmail.com.
[Ti] Título:Recycling of end-of-life reverse osmosis membranes by oxidative treatment: a technical evaluation.
[So] Source:Water Sci Technol;76(3-4):605-622, 2017 Jul.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The adverse impacts caused by the disposal of thousands of tonnes per annum of reverse osmosis (RO) membranes modules have grown dramatically around the world. The objective of this study was to evaluate the technical feasibility of recycling by chemical oxidation of end-of-life RO membranes for applications in other separation processes with specifications less rigorous. The recycling technique consisted in to cause a membrane exposition with oxidant solutions in order to remove its aromatic polyamide layer and subsequent conversion to a porous membrane. The recycling technique was evaluated by water permeability and salt rejection tests before and after the oxidative treatments. Initially, membranes' chemical cleaning and pretreatment procedures were assessed. Among factors evaluated, the oxidizing agent, its concentration and pH, associated with the oxidative treatment time, showed important influence on the oxidation of the membranes. Results showed that sodium hypochlorite and potassium permanganate are efficient agents for the membrane recycling. The great increased permeability and decreased salt rejection indicated changes on membranes' selective properties. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and contact angle characterization techniques revealed marked changes on the main membranes' physical-chemical properties, such as morphology, roughness and hydrophobicity. Reuse of produced effluents and fouling tendency of recycled membranes were also evaluated.
[Mh] Termos MeSH primário: Membranas Artificiais
Reciclagem
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Filtração
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Nylons/química
Osmose
Permeabilidade
Espectrometria por Raios X
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membranes, Artificial); 0 (Nylons); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.238


  7 / 4405 MEDLINE  
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[PMID]:28626142
[Au] Autor:Tanaka M; Kurosawa S
[Ad] Endereço:Health Research Institute, Advanced Industrial Science and Technology (AIST).
[Ti] Título:Surface Modification of PDMS and Plastics with Zwitterionic Polymers.
[So] Source:J Oleo Sci;66(7):699-704, 2017 Jul 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Surface modification of PDMS, polycarbonate, and acrylic resin was examined using various methacryl polymers bearing sulfobetaine, phosphoryl choline, and oligoethylene glycol units. We have found that zwitterionic polymers are adsorbed on the PDMS surface treated with plasma. The surface of PDMS is stable to keep high hydrophilicity after a month of the modification. On the other hand, one of sulfobetaine polymers showed distinguished adsorption behavior in the case of polycarbonate surface treated with plasma. Suppression effect for nonspecific adsorption of BSA was evaluated using polycarbonate and acrylic resin modified with the polymers. The modified surfaces showed suppression effect for nonspecific adsorption of BSA compared with the surface only treated with plasma.
[Mh] Termos MeSH primário: Dimetilpolisiloxanos/química
Nylons/química
Plásticos/química
Polímeros/química
[Mh] Termos MeSH secundário: Resinas Acrílicas/química
Adsorção
Betaína/análogos & derivados
Etilenoglicol
Interações Hidrofóbicas e Hidrofílicas
Metacrilatos/química
Fosforilcolina
Plasma
Cimento de Policarboxilato/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Dimethylpolysiloxanes); 0 (Methacrylates); 0 (Nylons); 0 (Plastics); 0 (Polycarboxylate Cement); 0 (Polymers); 0 (poly(dimethylsiloxane)-polyamide copolymer); 107-73-3 (Phosphorylcholine); 25766-59-0 (polycarbonate); 3SCV180C9W (Betaine); 8CVU22OCJW (sulfobetaine); FC72KVT52F (Ethylene Glycol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17041


  8 / 4405 MEDLINE  
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[PMID]:28610874
[Au] Autor:Xu X; Zhang B; Gan P; Wu J; Dai W; Zhang L; Wang J
[Ad] Endereço:State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.
[Ti] Título:On-nylon membrane detection of nucleic acid molecules by rolling circle amplification.
[So] Source:Anal Biochem;533:26-33, 2017 Sep 15.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Positively-charged nylon membrane (NM) is a general solid-phase support for nucleic acid detection due to its convenient immobilization of nucleic acid materials by direct electrostatic adherence and simple UV crosslinking. Rolling circle amplification (RCA) is a widely used isothermal DNA amplification technique for nucleic acid detection. Near-infrared fluorescence (NIRF) is a new fluorescence technique with high sensitivity due to low background. This study developed a simple method for detecting nucleic acid molecules by combining the advantages of NM, RCA and NIRF, named NIRF-based solid phase RCA on nylon membrane (NM-NIRF-sRCA). The detection system of this method only need two kinds of nucleic acid molecules: target-specific probes with a RCA primer (P) at their 3' end and a rolling circle (RC). The detection procedure consists of four steps: (1) immobilizing detected nucleic acids on NM by UV crosslinking; (2) hybridizing NM with specific probes and RC; (3) amplifying by a RCA reaction containing biotin-dUTP; (4) incubating NM with NIRF-labeled streptavidin and imaging with a NIRF imager. The method was fully testified by detecting oligonucleotides, L1 fragments of various HPV subtypes cloned in plasmid, and E.coli genomic DNA. This study thus provides a new facile method for detecting nucleic acid molecules.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Técnicas de Amplificação de Ácido Nucleico
Ácidos Nucleicos/isolamento & purificação
[Mh] Termos MeSH secundário: Biotina/química
Primers do DNA/genética
Seres Humanos
Membranas/química
Hibridização de Ácido Nucleico
Ácidos Nucleicos/genética
Nylons/química
Estreptavidina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (Nucleic Acids); 0 (Nylons); 6SO6U10H04 (Biotin); 9013-20-1 (Streptavidin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


  9 / 4405 MEDLINE  
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[PMID]:28575703
[Au] Autor:Zeng C; Tanaka S; Suzuki Y; Fujii S
[Ad] Endereço:Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan. Electronic address: zeng.chenghui.35z@st.kyoto-u.ac.jp.
[Ti] Título:Impact of feed water pH and membrane material on nanofiltration of perfluorohexanoic acid in aqueous solution.
[So] Source:Chemosphere;183:599-604, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nanofiltration was thought to be a good option for the recovery of perfluorohexanoic acid (PFHxA) from industrial wastewater. In this study, two commercially available nanofiltration (NF) membranes (NF 270 and NTR-7450) were tested to concentrate the PFHxA in aqueous solution. Filtration test was conducted in crossflow filtration mode. Membrane flux and PFHxA rejection rate were monitored throughout the filtration test. The impact of initial feed water pH on membrane performance was investigated. Results demonstrated that the two NF membranes showed different response to the change of initial feed water pH, which was caused by the intrinsic properties of membrane material. The flux performance of NF 270 was stable, while its rejection rate of PFHxA was very sensitive to the change of initial feed water pH. Opposite result was obtained with NTR-7450. It had a very good stability on rejection rate, while its flux was very sensitive to the change of initial feed water pH. The mechanisms behind these phenomena were also discussed. The results obtained in this study should be very useful for the process design in practical engineering.
[Mh] Termos MeSH primário: Caproatos/análise
Filtração/métodos
Fluorcarbonetos/análise
Membranas Artificiais
Águas Residuais/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio
Nylons/química
Polímeros/química
Sulfonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caproates); 0 (Fluorocarbons); 0 (Membranes, Artificial); 0 (Nylons); 0 (Polymers); 0 (Sulfones); 0 (Waste Water); 0 (Water Pollutants, Chemical); 25667-42-9 (polyether sulfone); ZP34Q2220R (perfluorohexanoic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


  10 / 4405 MEDLINE  
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[PMID]:28530640
[Au] Autor:Morita K; Suzuki K; Maeda S; Matsuo A; Mitsuda Y; Tokushige C; Kashiwazaki G; Taniguchi J; Maeda R; Noura M; Hirata M; Kataoka T; Yano A; Yamada Y; Kiyose H; Tokumasu M; Matsuo H; Tanaka S; Okuno Y; Muto M; Naka K; Ito K; Kitamura T; Kaneda Y; Liu PP; Bando T; Adachi S; Sugiyama H; Kamikubo Y
[Ad] Endereço:Department of Human Health Sciences, Graduate School of Medicine.
[Ti] Título:Genetic regulation of the RUNX transcription factor family has antitumor effects.
[So] Source:J Clin Invest;127(7):2815-2828, 2017 Jun 30.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of evidence suggests that it has pro-oncogenic properties in acute myeloid leukemia (AML). Here we have demonstrated that the antileukemic effect mediated by RUNX1 depletion is highly dependent on a functional p53-mediated cell death pathway. Increased expression of other RUNX family members, including RUNX2 and RUNX3, compensated for the antitumor effect elicited by RUNX1 silencing, and simultaneous attenuation of all RUNX family members as a cluster led to a much stronger antitumor effect relative to suppression of individual RUNX members. Switching off the RUNX cluster using alkylating agent-conjugated pyrrole-imidazole (PI) polyamides, which were designed to specifically bind to consensus RUNX-binding sequences, was highly effective against AML cells and against several poor-prognosis solid tumors in a xenograft mouse model of AML without notable adverse events. Taken together, these results identify a crucial role for the RUNX cluster in the maintenance and progression of cancer cells and suggest that modulation of the RUNX cluster using the PI polyamide gene-switch technology is a potential strategy to control malignancies.
[Mh] Termos MeSH primário: Antineoplásicos Alquilantes/farmacologia
Subunidades alfa de Fatores de Ligação ao Core
Leucemia Mieloide Aguda
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Alquilantes/química
Linhagem Celular Tumoral
Subunidades alfa de Fatores de Ligação ao Core/genética
Subunidades alfa de Fatores de Ligação ao Core/metabolismo
Seres Humanos
Leucemia Mieloide Aguda/tratamento farmacológico
Leucemia Mieloide Aguda/genética
Leucemia Mieloide Aguda/metabolismo
Camundongos
Camundongos Endogâmicos NOD
Nylons/química
Nylons/farmacologia
Pirróis/química
Pirróis/farmacologia
Proteína Supressora de Tumor p53/genética
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (Core Binding Factor alpha Subunits); 0 (Nylons); 0 (Pyrroles); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170930
[Lr] Data última revisão:
170930
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE



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