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[PMID]:29214535
[Au] Autor:Mijangos L; Ziarrusta H; Olivares M; Zuloaga O; Möder M; Etxebarria N; Prieto A
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080, Bilbao, Spain.
[Ti] Título:Simultaneous determination of 41 multiclass organic pollutants in environmental waters by means of polyethersulfone microextraction followed by liquid chromatography-tandem mass spectrometry.
[So] Source:Anal Bioanal Chem;410(2):615-632, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A new procedure using polyethersulfone (PES) microextraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was developed in this work for the simultaneous determination of 41 multiclass priority and emerging organic pollutants including herbicides, hormones, personal care products, and pharmaceuticals, among others, in seawater, wastewater treatment plant (WWTP) effluents, and estuary samples. The optimization of the analysis included two different chromatographic columns and different variables (polarity, fragmentor voltage, collision energy, and collision cell accelerator) of the mass spectrometer. In the case of PES extraction, ion strength of the water, pH, addition of EDTA, and the amount of the polymeric material were thoroughly investigated. The developed procedure was compared with a previously validated one based on a standard solid-phase extraction (SPE). In contrast to the SPE protocol, the PES method allowed a cost-efficient extraction of complex aqueous samples with lower matrix effect from 120 mL of water sample. Satisfactory and comparable apparent recovery values (80-119 and 70-131%) and method quantification limits (MQLs, 0.4-26 and 0.2-23 ng/L) were obtained for PES and SPE procedures, respectively, regardless of the matrix. Repeatability values lower than 27% were obtained. Finally, the developed methods were applied to the analysis of real samples from the Basque Country and irbesartan, valsartan, acesulfame, and sucralose were the analytes most often detected at the highest concentrations (51-1096 ng/L). Graphical abstract Forty-one multiclass pollutant determination in environmental waters by means of PES/SPE-LC-MS/MS.
[Mh] Termos MeSH primário: Herbicidas/análise
Hormônios/análise
Preparações Farmacêuticas/análise
Polímeros/química
Extração em Fase Sólida/métodos
Sulfonas/química
Espectrometria de Massas em Tandem/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida/métodos
Estuários
Limite de Detecção
Água do Mar/análise
Águas Residuais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Herbicides); 0 (Hormones); 0 (Pharmaceutical Preparations); 0 (Polymers); 0 (Sulfones); 0 (Waste Water); 0 (Water Pollutants, Chemical); 25667-42-9 (polyether sulfone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0763-2


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[PMID]:29175396
[Au] Autor:Wang F; Liu F; Chen W; Xu R; Wang W
[Ad] Endereço:School of Biological Science, Luoyang Normal University, Luoyang, 471022, China; Cold Water Fish Breeding Engineering Technology Research Center of Henan Province, Luoyang, 471022, China. Electronic address: wangfan7677@163.com.
[Ti] Título:Effects of triclosan (TCS) on hormonal balance and genes of hypothalamus-pituitary- gonad axis of juvenile male Yellow River carp (Cyprinus carpio).
[So] Source:Chemosphere;193:695-701, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Triclosan (TCS) is a broad spectrum antimicrobial agent which has been widely dispersed and determinated in the aquatic environment. However, the effects of TCS on reproductive endocrine in male fish are poorly understood. In this study, male Yellow River carp (Cyprinus carpio) were exposed to 0, 1/5, 1/10 and 1/20 LC (96 h LC of TCS to carp) TCS under semi-static conditions for 42 d. Vitellogenin (Vtg), 17ß-estradiol (E ), testosterone(T), gonadotropin (GtH), and gonadotropin-releasing hormone (GnRH) levels were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, we also examined the mRNA expressions of aromatase, GtHs-ß, GnRH, estrogen receptor (Er), and androgen receptor (Ar) by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). TCS induced Vtg levels of hepatopancreas, E levels of serum, and inhibited Ar and Er mRNA levels, suggesting that the induction of Vtg production by TCS was indirectly caused by non-Er pathways. TCS-induced Vtg levels by interfering with the reproductive axis at plenty of latent loci of male carps: (a) TCS exposure increased the aromatase mRNA expression of hypothalamus and gonad aromatase, consequently increasing serum concentrations of E to induce Vtg in hepatopancreas; (b) TCS treatment changed GtH-ß and GnRH mRNA expression and secretion, causing the disturbance of reproductive endocrine; (c) TCS exposure decreased Ar mRNA levels, indicating potential Ar-mediated antiandrogen action. These mechanisms showed that TCS may induce Vtg production in male carp by non-Er-mediated pathways.
[Mh] Termos MeSH primário: Carpas/metabolismo
Triclosan/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/toxicidade
Aromatase/genética
Sistema Endócrino/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Estradiol/análise
Hormônio Liberador de Gonadotropina/análise
Hormônio Liberador de Gonadotropina/genética
Gônadas/enzimologia
Gônadas/metabolismo
Hepatopâncreas/metabolismo
Hormônios/metabolismo
Hipotálamo/metabolismo
Masculino
Hipófise/metabolismo
RNA Mensageiro/análise
Reação em Cadeia da Polimerase em Tempo Real
Receptores Estrogênicos/genética
Reprodução/efeitos dos fármacos
Testosterona/análise
Vitelogeninas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Hormones); 0 (RNA, Messenger); 0 (Receptors, Estrogen); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4NM5039Y5X (Triclosan); 4TI98Z838E (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29425002
[Au] Autor:Shaykhelislamova MV; Dikopol'skaya NB; Bilalova GA; Zefirov TL
[Ti] Título:[State of adaptive systems of the body in boys aged of 11-15 years in the process of their age development, pubertal maturation and in the dynamics of the school year].
[So] Source:Gig Sanit;95(7):661-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A comprehensive study of the functional state of the sympathoadrenal system (SAS) and adrenal cortex (AC) in boys aged of 11-15 years, was carried out depending on their age, puberty stage and academic year period, on the basis of indices of the daily adrenaline (A), noradrenaline (NA), 17-ketosteroids (17-KS) and 17-oxyketosteroids (17-OKS) excretion. A certain synchronism of the manifestation offunctional activity of the SAS mediator level, glucocorticoid and androgen AC function is determined as boys grow older and during their pubertal changes. At the same time the different dynamics of the studied indices in boys aged of from 14 to 15 years and by the V puberty stage is marked. During the academic year changes of hormone and hormonal metabolite excretion, having a different focus and intensity in the age groups were observed: a significant decrease of age NA excretion and androgen metabolite indices (at 15) of 14 and 15 year-old teenagers at the end of the academic year is found out, against the backdrop of a substantial and long-term increase of glucocorticoids (February, April), with their dangerous catabolic effect on a child's body and their depressing effect on the immune response.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Desenvolvimento do Adolescente/fisiologia
Desenvolvimento Infantil/fisiologia
Hormônios
Puberdade/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Hormônios/análise
Hormônios/sangue
Seres Humanos
Masculino
Federação Russa/epidemiologia
Serviços de Saúde Escolar/estatística & dados numéricos
Maturidade Sexual/fisiologia
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:29229332
[Au] Autor:Aparicio I; Martín J; Abril C; Santos JL; Alonso E
[Ad] Endereço:Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011 Seville, Spain. Electronic address: iaparicio@us.es.
[Ti] Título:Determination of household and industrial chemicals, personal care products and hormones in leafy and root vegetables by liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr A;1533:49-56, 2018 Jan 19.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A multiresidue method has been developed for the determination of emerging pollutants in leafy and root vegetables. Selected compounds were 6 perfluoroalkyl compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), 3 non-ionic surfactants (nonylphenol and nonylphenolethoxylates), 8 anionic surfactants (4 alkylsulfates and 4 linear alkylbenzene sulfonates), 4 preservatives (parabens), 2 biocides (triclosan and triclocarban), 2 plasticizers (bisphenol A and di-(2-ethylhexyl)phthalate), 6 UV-filters (benzophenones) and 4 hormones. The method is based on ultrasound-assisted extraction, clean-up by dispersive solid-phase extraction (d-SPE) and liquid chromatography-tandem mass spectrometry analysis. Due to the diversity of the physico-chemical properties of the target compounds, and to better evaluate the influence of sample treatment variables in extraction efficiencies, Box-Behnken design was applied to optimize extraction solvent volume, number of extraction cycles and d-SPE sorbent amount. Linearity (R ) higher than 0.992, accuracy (expressed as relative recoveries) in the range from 81 to 126%, precision (expressed as relative standard deviation) lower than 19% and limits of detection between 0.025 and 12.5ngg dry weight were achieved. The method was applied to leafy vegetables (lettuce, spinach and chard) and root vegetables (carrot, turnip and potato) from a local market. The highest concentrations corresponded to the surfactants reaching levels up to 114ngg (dry weight), in one of the lettuce samples analyzed.
[Mh] Termos MeSH primário: Cromatografia Líquida
Poluentes Ambientais/análise
Análise de Alimentos/métodos
Hormônios/análise
Compostos Orgânicos/análise
Espectrometria de Massas em Tandem
Verduras/química
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/análise
Compostos Benzidrílicos/análise
Fluorcarbonetos/análise
Análise de Alimentos/normas
Limite de Detecção
Parabenos/análise
Fenóis/análise
Ácidos Ftálicos/análise
Plastificantes/análise
Conservantes Farmacêuticos/análise
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Benzhydryl Compounds); 0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Hormones); 0 (Organic Chemicals); 0 (Parabens); 0 (Phenols); 0 (Phthalic Acids); 0 (Plasticizers); 0 (Preservatives, Pharmaceutical); 0 (alkylbenzyl sulfonic acid); 6O7F7IX66E (phthalic acid); 79F6A2ILP5 (nonylphenol); 9H2MAI21CL (perfluorooctane sulfonic acid); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:29405681
[Au] Autor:Dolomatov S; Sataieva T; Pazovsky G; Zukow W
[Ti] Título:[Neuroendocrine effects of helminthiases (A review)].
[So] Source:Parazitologiia;51(2):97-103, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Nowadays the number of patients diagnosed with helminthiases shows tendency for steady growth around the world. During last few years, researches in the field of immunology have again turned their attention towards the question of parasitological immunity and tissue response. Helminthiases and other parasitic diseases in some instances can induce central nervous system disorders and violate human behavioral reactions. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. The aim of this review is to reveal details of specific mechanisms of the general helminths' impact on the nervous system and the endocrine control level of physiological functions of the host organism. Finally, we discuss the current gaps in knowledge about the interaction between helminths, immunity, and human endocrine system. Key words: helminths, immunity, hormones, cytokines.
[Mh] Termos MeSH primário: Sistema Endócrino/imunologia
Epilepsia/imunologia
Interações Hospedeiro-Parasita/imunologia
Sistema Nervoso/imunologia
Neurocisticercose/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas/imunologia
Citocinas/metabolismo
Sistema Endócrino/metabolismo
Sistema Endócrino/parasitologia
Epilepsia/complicações
Epilepsia/metabolismo
Epilepsia/parasitologia
Helmintos/patogenicidade
Helmintos/fisiologia
Hormônios/imunologia
Hormônios/metabolismo
Seres Humanos
Imunidade Inata
Sistema Nervoso/metabolismo
Sistema Nervoso/parasitologia
Neurocisticercose/complicações
Neurocisticercose/metabolismo
Neurocisticercose/parasitologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29051074
[Au] Autor:Shero MR; Bergfelt DR; Testa JW; Adams GP
[Ad] Endereço:Department of Biological Sciences, University of Alaska Anchorage, 3101 Science Circle, Anchorage, AK 99508-4614, USA. Electronic address: mrshero@alaska.edu.
[Ti] Título:Pairing ultrasonography with endocrinology to elucidate underlying mechanisms of successful pregnancy in the northern fur seal (Callorhinus ursinus).
[So] Source:Gen Comp Endocrinol;255:78-89, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive success is one of the central tenets of conservation management programs, yet the inability to study underlying physiological processes in a minimally-invasive manner and the unpredictable nature of wild animal populations leaves large gaps in our knowledge of factors critical to successful reproduction in wild species. This study integrated ultrasonography of the reproductive tract and analysis of reproductive hormones in 172 northern fur seals (Callorhinus ursinus) to identify intrinsic factors associated with reinitiating embryonic growth at the end of diapause. Within the first 3-4 weeks of active gestation, pregnant fur seals (n = 126) had a larger corpus luteum and fewer antral follicles than non-pregnant fur seals, or those still in diapause (n = 46). This suggests that the conceptus drives changes in ovarian status to convey its presence to the female. Morphological changes in the reproductive tract associated with pregnancy were not reflected in differences in endocrine profiles (estradiol, estrone, progesterone, and relaxin) between pregnant and non-pregnant individuals. Hormone concentrations correlated more strongly with calendar date than with the presence or size of the conceptus, demonstrating that none of these reproductive hormones were reliable markers for early pregnancy diagnosis. Instead, the northern fur seal's long diestrus may serve to reduce the probability of a temporal mismatch between corpus luteum regression and embryo implantation. Indeed, conception rates were high and confirmed rates of pregnancy loss were relatively low (11%). In this study, minimally-invasive ultrasonography was used in wild pinnipeds to detect very early pregnancy (embryonic vesicles >2 mm) in combination with ovarian and endocrine dynamics at the time of embryo implantation, shedding light on mechanisms for maternal recognition of pregnancy. This study is also the first to track whether these same animals carried the embryo to term, by observing fur seals during the birthing season the following year. Data do not support the notion that decreased pregnancy rates or higher pregnancy loss rates are major contributing factors to the northern fur seal's population decline.
[Mh] Termos MeSH primário: Sistema Endócrino/metabolismo
Otárias/fisiologia
Ultrassonografia
[Mh] Termos MeSH secundário: Animais
Embrião de Mamíferos/fisiologia
Feminino
Otárias/embriologia
Hormônios/metabolismo
Modelos Lineares
Masculino
Ovário/anatomia & histologia
Ovário/diagnóstico por imagem
Gravidez
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


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[PMID]:29237125
[Au] Autor:Suh JH; Wang Y; Ho CT
[Ad] Endereço:Food Science and Human Nutrition, Citrus Research and Education Center, University of Florida , 700 Experiment Station Rd, Lake Alfred, Florida 33850, United States.
[Ti] Título:Natural Dietary Products and Their Effects on Appetite Control.
[So] Source:J Agric Food Chem;66(1):36-39, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural dietary products have been thoroughly studied for their effects of antiadipogenesis to prevent and treat obesity for decades. Nevertheless, in the past few years appetite control for the treatment of obesity has attracted much attention as a new target. Homeostatic control of energy intake involves a complex system that conveys peripheral signals to the central nervous system where multiple signals are integrated and then provide feedback to regulate satiation. This perspective aims at elucidating the neuronal mechanisms of food intake and energy balance as well as providing an alternative pathway of controlling weight using natural dietary products.
[Mh] Termos MeSH primário: Adiposidade/fisiologia
Regulação do Apetite/efeitos dos fármacos
Produtos Biológicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Hormônios/metabolismo
Seres Humanos
Saciação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05104


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[PMID]:29283227
[Au] Autor:Kolesnikov SS; Bystrova MF
[Ti] Título:Cyclic AMP: Second Messenger as the First Messenger.
[So] Source:Usp Fiziol Nauk;47(3):3-16, 2016 Jul-Sep.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Cell-to-cell communications and autocrine/paracrine regulations are mediated by an extracellular signaling network involving secretion of a variety of different factors, hormones, neurotransmitters, and other signaling molecules that are recognized in an extracellular medium by multiple molecular receptors operating in the plasma membrane of cells. Most of plasma membrane receptors belong to the superfamily of heptahelical receptors, many of which are coupled by G-proteins to adenylate cyclase responsible for cAMP production in the cell cytoplasm. The canonical role of cAMP in cell physiology is to serve as a second messenger and universal regulator of intracellular processes. Meanwhile, increasing body of evidence leaves little doubts that stimulated cells can release cAMP into intercellular space, where it may serve as signaling molecule in cell-to-cell communications and autocrine regulations. This review considers the basic concept on mechanisms of intracellular and extracellular signaling with cAMP as the second and first messenger.
[Mh] Termos MeSH primário: Adenilil Ciclases/metabolismo
AMP Cíclico/metabolismo
Células Eucarióticas/metabolismo
Receptores de Superfície Celular/metabolismo
Sistemas do Segundo Mensageiro/genética
[Mh] Termos MeSH secundário: Adenilil Ciclases/genética
Animais
Comunicação Celular
Membrana Celular/metabolismo
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/genética
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/metabolismo
Células Eucarióticas/citologia
Espaço Extracelular/metabolismo
Regulação da Expressão Gênica
Hormônios/genética
Hormônios/metabolismo
Seres Humanos
Neurotransmissores/genética
Neurotransmissores/metabolismo
Receptores de Superfície Celular/genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hormones); 0 (Neurotransmitter Agents); 0 (Receptors, Cell Surface); E0399OZS9N (Cyclic AMP); EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 6); EC 4.6.1.1 (Adenylyl Cyclases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:29176767
[Au] Autor:Littauer EQ; Esser ES; Antao OQ; Vassilieva EV; Compans RW; Skountzou I
[Ad] Endereço:Department of Microbiology & Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
[Ti] Título:H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation.
[So] Source:PLoS Pathog;13(11):e1006757, 2017 Nov.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increased susceptibility to influenza virus infection during pregnancy has been attributed to immunological changes occurring before and during gestation in order to "tolerate" the developing fetus. These systemic changes are most often characterized by a suppression of cell-mediated immunity and elevation of humoral immune responses referred to as the Th1-Th2 shift. However, the underlying mechanisms which increase pregnant mothers' risk following influenza virus infection have not been fully elucidated. We used pregnant BALB/c mice during mid- to late gestation to determine the impact of a sub-lethal infection with A/Brisbane/59/07 H1N1 seasonal influenza virus on completion of gestation. Maternal and fetal health status was closely monitored and compared to infected non-pregnant mice. Severity of infection during pregnancy was correlated with premature rupture of amniotic membranes (PROM), fetal survival and body weight at birth, lung viral load and degree of systemic and tissue inflammation mediated by innate and adaptive immune responses. Here we report that influenza virus infection resulted in dysregulation of inflammatory responses that led to pre-term labor, impairment of fetal growth, increased fetal mortality and maternal morbidity. We observed significant compartment-specific immune responses correlated with changes in hormonal synthesis and regulation. Dysregulation of progesterone, COX-2, PGE2 and PGF2α expression in infected pregnant mice was accompanied by significant remodeling of placental architecture and upregulation of MMP-9 early after infection. Collectively these findings demonstrate the potential of a seasonal influenza virus to initiate a powerful pro-abortive mechanism with adverse outcomes in fetal health.
[Mh] Termos MeSH primário: Hormônios/metabolismo
Vírus da Influenza A Subtipo H1N1/fisiologia
Influenza Humana/fisiopatologia
Complicações na Gravidez/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Dinoprostona/metabolismo
Feminino
Seres Humanos
Influenza Humana/metabolismo
Influenza Humana/mortalidade
Influenza Humana/virologia
Pulmão/metabolismo
Pulmão/virologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Especificidade de Órgãos
Placenta/metabolismo
Placenta/virologia
Gravidez
Complicações na Gravidez/metabolismo
Complicações na Gravidez/mortalidade
Complicações na Gravidez/virologia
Resultado da Gravidez
Progesterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones); 4G7DS2Q64Y (Progesterone); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006757


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[PMID]:29202965
[Au] Autor:Vercellini P; Buggio L; Somigliana E
[Ad] Endereço:Department of Clinical Sciences and Community Health, Università degli Studi; and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: paolo.vercellini@unimi.it.
[Ti] Título:Role of medical therapy in the management of deep rectovaginal endometriosis.
[So] Source:Fertil Steril;108(6):913-930, 2017 Dec.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Defining whether medical therapy is effective in women with deep rectovaginal endometriosis and in which circumstances it can be considered an alternative to surgery is important for patients and physicians. Numerous observational and some randomized controlled studies demonstrated that different hormonal drugs improved pain and other symptoms in approximately two-thirds of women with deep rectovaginal endometriosis. Because major differences in the effect size of various compounds were not observed, much importance should be given to safety, tolerability, and cost of medications when counseling patients. Progestins seem to offer the best therapeutic balance when long-term treatments are planned. Women should be informed that hormonal drugs control but do not cure endometriosis and that, to avoid surgery, they should be used for years. Medical therapy is not an alternative to surgery in women with hydronephrosis, severe subocclusive bowel symptoms, and in those wishing a natural conception. A progestin should systematically be chosen as a comparator in future randomized trials on novel medications for deep endometriosis. In the meantime, the use of existing drugs should be optimized, and medical and surgical treatments could be viewed as subsequent stages of a stepwise approach. In general, there is no absolute "best" choice, and women must be thoroughly informed of potential benefits, potential harms, and costs of different therapeutic options and allowed to choose what they deem is better for them.
[Mh] Termos MeSH primário: Endometriose/tratamento farmacológico
Endométrio/efeitos dos fármacos
Hormônios/uso terapêutico
Doenças Retais/tratamento farmacológico
Doenças Vaginais/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Biópsia
Colposcopia
Endometriose/complicações
Endometriose/diagnóstico
Endometriose/fisiopatologia
Endométrio/patologia
Endométrio/fisiopatologia
Estrogênios/uso terapêutico
Feminino
Hormônios/efeitos adversos
Seres Humanos
Progestinas/uso terapêutico
Doenças Retais/complicações
Doenças Retais/diagnóstico
Doenças Retais/fisiopatologia
Resultado do Tratamento
Doenças Vaginais/complicações
Doenças Vaginais/diagnóstico
Doenças Vaginais/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Estrogens); 0 (Hormones); 0 (Progestins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE



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