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[PMID]:28451931
[Au] Autor:Casajoana A; Pujol J; Garcia A; Elvira J; Virgili N; de Oca FJ; Duran X; Fernández-Veledo S; Vendrell J; Vilarrasa N
[Ad] Endereço:Bariatric Surgery Unit, Bellvitge University Hospital-IDIBELL, c/ Feixa Llarga s/n, 08907, Barcelona, L'Hospitalet de Llobregat, Spain.
[Ti] Título:Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication.
[So] Source:Obes Surg;27(9):2235-2245, 2017 Sep.
[Is] ISSN:1708-0428
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our aim was to determine the predictive value of gut hormone changes for the improvement of type 2 diabetes (T2D) following metabolic Roux-en-Y gastric bypass (mRYGB), sleeve gastrectomy (SG), and greater curvature plication (GCP) in a randomized controlled trial. Contradictory results have been obtained regarding the role of gastrointestinal hormones (in particular GLP-1) in beneficial metabolic bariatric surgery outcomes. METHODS: Forty-five patients with T2D (mean BMI 39.4 ± 1.9 kg/m ) were randomly assigned to mRYGB, SG, or GCP. Anthropometric and biochemical parameters, fasting concentrations of PYY, ghrelin, glucagon, and area under the curve (AUC) of GLP-1 after a standard meal test were determined prior to and at months 1 and 12 after surgery. RESULTS: Twelve months after surgery, total weight loss percentage was higher and HbA1c lower in the mRYGB group than in the SG and GCP groups (-35.2 ± 8.1 and 5.1 ± 0.6% vs. -27.8 ± 5.4 and 6.2 ± 0.8% vs. -20.5 ± 6.8 and 6.6 ± 1.3%; p = 0.007 and p < 0.001, respectively). Moreover, GLP-1 AUC at months 1 and 12 was greater and T2D remission was higher in mRYGB (80 vs. 53.3 vs. 20%, p < 0.001). Insulin treatment (odds ratio (OR) 0.025, p = 0.018) and the increase in GLP-1 AUC from baseline to month 1 (OR 1.021, p = 0.013) were associated with T2D remission. CONCLUSIONS: mRYGB achieves a superior rate of weight loss and T2D remission at month 12. Enhanced GLP-1 secretion 1 month after surgery was a determinant of glucose metabolism improvement. Registration number ( http://www.clinicaltrials.gov ): NCT14104758.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/cirurgia
Gastrectomia/métodos
Derivação Gástrica/métodos
Gastroplastia/métodos
[Mh] Termos MeSH secundário: Adulto
Diabetes Mellitus Tipo 2/complicações
Feminino
Hormônios Gastrointestinais/metabolismo
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Masculino
Meia-Idade
Obesidade Mórbida/complicações
Obesidade Mórbida/cirurgia
Indução de Remissão
Estômago/cirurgia
Perda de Peso
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11695-017-2669-7


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[PMID]:29293196
[Au] Autor:Barnes JL
[Ad] Endereço:Illinois State University, Department of Family and Consumer Sciences, Normal, Illinois. Jennifer L. Barnes, PhD, RD, LDN, is an assistant professor at Illinois State University in the Department of Family and Consumer Sciences, where she teaches in Food, Nutrition, and Dietetics.
[Ti] Título:Enteral Nutrients and Gastrointestinal Physiology.
[So] Source:J Infus Nurs;41(1):35-42, 2018 Jan/Feb.
[Is] ISSN:1539-0667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The gastrointestinal (GI) tract is a highly efficient organ system with specialized structures to facilitate digestion and absorption of nutrients to meet the body's needs. The presence of nutrients in the GI tract supports optimal structure and function, stimulates regulatory hormones, and supports the microbiota, the population of microorganisms residing in the GI tract. A lack of enteral nutrition (EN) results in impaired GI integrity and serious patient complications, making EN a priority. Normal GI physiology is reviewed, and the regulatory impact of luminal nutrients on GI function is discussed.
[Mh] Termos MeSH primário: Nutrição Enteral/métodos
Trato Gastrointestinal/anatomia & histologia
Trato Gastrointestinal/fisiologia
[Mh] Termos MeSH secundário: Hormônios Gastrointestinais
Seres Humanos
Tecido Linfoide
Necessidades Nutricionais
Nutrição Parenteral/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Hormones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1097/NAN.0000000000000260


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[PMID]:27779102
[Au] Autor:Al Fayi MS; Gou X; Forootan SS; Al-Jameel W; Bao Z; Rudland PR; Cornford PA; Hussain SA; Ke Y
[Ad] Endereço:Molecular Pathology Laboratory, Department of Molecular and Clinical Cancer Medicine, Liverpool University, the Cancer Research Centre Building, Liverpool, United Kingdom.
[Ti] Título:The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance.
[So] Source:Oncotarget;7(50):82783-82797, 2016 Dec 13.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the possible involvement of other FABPs are rare. Here we first measured the mRNA levels of 10 FABPs in benign and malignant prostate cell lines and identified the differentially expressed FABP6 and FABP9 mRNAs whose levels in all malignant cell lines were higher than those in the benign cells. Thereafter we assessed the expression status of FABP6 and FABP9 in both prostate cell lines and in human tissues. FABP6 protein was overexpressed only in 1 of the 5 malignant cell lines and its immunostaining intensities were not significantly different between benign and malignant prostate tissues. In contrast, FABP9 protein was highly expressed in highly malignant cell lines PC-3 and PC3-M, but its level in the benign PNT-2 and other malignant cell lines was not detectable. When analysed in an archival set of human prostate tissues, immunohistochemical staining intensity for FABP9 was significantly higher in carcinomas than in benign cases and the increase in FABP9 was significantly correlated with reduced patient survival times. Moreover, the increased level of staining for FABP9 was significantly associated with the increased joint Gleason scores (GS) and androgen receptor index (AR). Suppression of FABP9 expression in highly malignant PC3-M cells inhibited their invasive potential. Our results suggest that FABP9 is a valuable prognostic marker to predict the outcomes of prostate cancer patients, perhaps by playing an important role in prostate cancer cell invasion.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Proteínas de Ligação a Ácido Graxo/metabolismo
Neoplasias da Próstata/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/genética
Linhagem Celular Tumoral
Movimento Celular
Proteínas de Ligação a Ácido Graxo/genética
Hormônios Gastrointestinais/genética
Hormônios Gastrointestinais/metabolismo
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Masculino
Gradação de Tumores
Invasividade Neoplásica
Valor Preditivo dos Testes
Neoplasias da Próstata/genética
Neoplasias da Próstata/patologia
Neoplasias da Próstata/terapia
Interferência de RNA
RNA Mensageiro/genética
Receptores Androgênicos/metabolismo
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AR protein, human); 0 (Biomarkers, Tumor); 0 (Fatty Acid-Binding Proteins); 0 (Gastrointestinal Hormones); 0 (RNA, Messenger); 0 (Receptors, Androgen); 117849-44-2 (fatty acid-binding protein 6)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.12635


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[PMID]:29191090
[Au] Autor:Moghadam AA; Moran TH; Dailey MJ
[Ad] Endereço:1 Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10591, USA.
[Ti] Título:Alterations in circadian and meal-induced gut peptide levels in lean and obese rats.
[So] Source:Exp Biol Med (Maywood);242(18):1786-1794, 2017 Dec.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alterations in gut hormone signaling are a likely contributing factor to the metabolic disturbances associated with overweight/obesity as they coordinate the timing of feeding behavior, absorption, and utilization of nutrients. These hormones are released in response to food intake, or follow a circadian or anticipatory pattern of secretion that is independent of nutrient stimulation. The aim of this study was to identify the degree to which high-fat diet-induced obesity would alter the daily rhythm of gut peptide plasma levels (glucagon-like peptide-1 [GLP-1], peptide YY [PYY], insulin or amylin [AMY]) or meal-induced levels in the middle of the light or dark cycle. Male Sprague-Dawley rats were fed a high-fat diet (OBESE) or chow (LEAN), implanted with jugular catheters, and blood samples were taken every 2 h throughout the light/dark cycle while freely feeding or after an Ensure liquid meal. We found that even when OBESE and LEAN animals ate the same kcals and have a similar pattern of food intake, there is a difference in both the levels and rhythm of plasma gut peptides. GLP-1 and PYY are higher during the light cycle in LEAN animals and AMY is higher in the OBESE group throughout the light/dark cycle. There was also a differential response of plasma gut signals after the Ensure meal, even though the composition and amount of intake of the meal were the same in both groups. These changes occur prior to the high-fat diet induced loss of glycemic control and may be a target for early intervention. Impact statement The aim of this study was to test if obesity would alter the daily rhythm of gut peptides or meal-induced levels in the middle of the light or dark cycle. We found that even when animals are eating the same amount (in kcal) of food that the obese animals have altered daily rhythms and meal-induced gut peptide levels. In particular, we are the first to show that obesity induces increases in peptide YY levels during the light cycle and amylin remains high throughout the light and dark cycle in obese animals. These changes occurred prior to a loss of glycemic control. Thus, the rhythm of gut peptides could be used as an early indicator of later and more serious metabolic disturbances and may be a target for early intervention.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Ingestão de Alimentos/fisiologia
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Obesidade/metabolismo
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Peso Corporal/fisiologia
Dieta Hiperlipídica
Comportamento Alimentar/fisiologia
Hormônios Gastrointestinais/metabolismo
Masculino
Modelos Animais
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Gastrointestinal Hormones); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217732041


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[PMID]:28916678
[Au] Autor:Li P; Wuthrick E; Rappaport JA; Kraft C; Lin JE; Marszalowicz G; Snook AE; Zhan T; Hyslop TM; Waldman SA
[Ad] Endereço:Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, The University of Florida, Gainesville, Florida.
[Ti] Título:GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
[So] Source:Cancer Res;77(18):5095-5106, 2017 Sep 15.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. Eliminating GUCY2C signaling exacerbated RIGS, amplifying radiation-induced mortality, weight loss, mucosal bleeding, debilitation, and intestinal dysfunction. Durable expression of GUCY2C, guanylin, and uroguanylin mRNA and protein by intestinal epithelial cells was preserved following lethal irradiation inducing RIGS. Oral delivery of the heat-stable enterotoxin (ST), an exogenous GUCY2C ligand, opposed RIGS, a process requiring p53 activation mediated by dissociation from MDM2. In turn, p53 activation prevented cell death by selectively limiting mitotic catastrophe, but not apoptosis. These studies reveal a role for the GUCY2C paracrine hormone axis as a novel compensatory mechanism opposing RIGS, and they highlight the potential of oral GUCY2C agonists (Linzess; Trulance) to prevent and treat RIGS in cancer therapy and nuclear disasters. .
[Mh] Termos MeSH primário: Raios gama/efeitos adversos
Trato Gastrointestinal/efeitos da radiação
Síndrome do Intestino Irritável/prevenção & controle
Lesões Experimentais por Radiação/prevenção & controle
Receptores Acoplados a Guanilato Ciclase/metabolismo
Receptores de Peptídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos da radiação
Proliferação Celular/efeitos da radiação
Neoplasias do Colo/enzimologia
Neoplasias do Colo/patologia
Neoplasias do Colo/radioterapia
Feminino
Hormônios Gastrointestinais/metabolismo
Seres Humanos
Síndrome do Intestino Irritável/enzimologia
Síndrome do Intestino Irritável/etiologia
Linfoma/enzimologia
Linfoma/patologia
Linfoma/radioterapia
Masculino
Melanoma Experimental/enzimologia
Melanoma Experimental/patologia
Melanoma Experimental/radioterapia
Camundongos
Camundongos Endogâmicos C57BL
Peptídeos Natriuréticos/metabolismo
Comunicação Parácrina/efeitos da radiação
Lesões Experimentais por Radiação/enzimologia
Lesões Experimentais por Radiação/etiologia
Receptores de Enterotoxina
Transdução de Sinais/efeitos da radiação
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 0 (Natriuretic Peptides); 0 (Receptors, Peptide); 140653-38-9 (guanylin); 152175-68-3 (uroguanylin); EC 4.6.1.2 (GUCY2C protein, human); EC 4.6.1.2 (Gucy2c protein, mouse); EC 4.6.1.2 (Receptors, Enterotoxin); EC 4.6.1.2 (Receptors, Guanylate Cyclase-Coupled)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-17-0859


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[PMID]:28870887
[Au] Autor:Holliday A; Blannin A
[Ad] Endereço:School of SportExercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK a.j.holliday@leedsbeckett.ac.uk.
[Ti] Título:Appetite, food intake and gut hormone responses to intense aerobic exercise of different duration.
[So] Source:J Endocrinol;235(3):193-205, 2017 Dec.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of the study is to investigate the effect of acute bouts of high-intensity aerobic exercise of differing durations on subjective appetite, food intake and appetite-associated hormones in endurance-trained males. Twelve endurance-trained males (age = 21 ± 2 years; BMI = 21.0 ± 1.6 kg/m ; VO = 61.6 ± 6.0 mL/kg/min) completed four trials, within a maximum 28 day period, in a counterbalanced order: resting (REST); 15 min exercise bout (15-min); 30 min exercise bout (30-min) and 45 min exercise bout (45-min). All exercise was completed on a cycle ergometer at an intensity of ~76% VO Sixty minutes post exercise, participants consumed an meal. Measures of subjective appetite and blood samples were obtained throughout the morning, with plasma analyzed for acylated ghrelin, total polypeptide tyrosine-tyrosine (PYY) and total glucagon-like peptide 1 (GLP-1) concentrations. The following results were obtained: Neither subjective appetite nor absolute food intake differed between trials. Relative energy intake (intake - expenditure) was significantly greater after REST (2641 ± 1616 kJ) compared with both 30-min (1039 ± 1520 kJ) and 45-min (260 ± 1731 kJ), and significantly greater after 15-min (2699 ± 1239 kJ) compared with 45-min (condition main effect, < 0.001). GLP-1 concentration increased immediately post exercise in 30-min and 45-min, respectively (condition × time interaction, < 0.001). Acylated ghrelin was transiently suppressed in all exercise trials (condition × time interaction, = 0.011); the greatest, most enduring suppression, was observed in 45-min. PYY concentration was unchanged with exercise. In conclusion, high-intensity aerobic cycling lasting up to 45 min did not suppress subjective appetite or affect absolute food intake, but did reduce relative energy intake, in well-trained endurance athletes. Findings question the role of appetite hormones in regulating subjective appetite in the acute post-exercise period.
[Mh] Termos MeSH primário: Apetite/fisiologia
Ingestão de Alimentos/fisiologia
Exercício/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos Cross-Over
Ingestão de Energia/fisiologia
Metabolismo Energético/fisiologia
Hormônios Gastrointestinais/metabolismo
Grelina/metabolismo
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Masculino
Peptídeo YY/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 0 (Ghrelin); 106388-42-5 (Peptide YY); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-16-0570


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[PMID]:28701300
[Au] Autor:Poppitt SD; Shin HS; McGill AT; Budgett SC; Lo K; Pahl M; Duxfield J; Lane M; Ingram JR
[Ad] Endereço:Human Nutrition Unit, School of Biological Sciences and Department of Medicine, s.poppitt@auckland.ac.nz.
[Ti] Título:Duodenal and ileal glucose infusions differentially alter gastrointestinal peptides, appetite response, and food intake: a tube feeding study.
[So] Source:Am J Clin Nutr;106(3):725-735, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Activation of the ileal brake through the delivery of nutrients into the distal small intestine to promote satiety and suppress food intake provides a new target for weight loss. Evidence is limited, with support from naso-ileal lipid infusion studies. The objective of the study was to investigate whether glucose infused into the duodenum and ileum differentially alters appetite response, food intake, and secretion of satiety-related gastrointestinal peptides. Fourteen healthy male participants were randomly assigned to a blinded 4-treatment crossover, with each treatment of single-day duration. On the day before the intervention (day 0), a 380-cm multilumen tube (1.75-mm diameter) with independent port access to the duodenum and ileum was inserted, and position was confirmed by X-ray. Subsequently (days 1-4), a standardized breakfast meal was followed midmorning by a 90-min infusion of isotonic glucose (15 g, 235 kJ) or saline to the duodenum or ileum. Appetite ratings were assessed with the use of visual analog scales (VASs), blood samples collected, and ad libitum energy intake (EI) measured at lunch, afternoon snack, and dinner. Thirteen participants completed the 4 infusion days. There was a significant effect of nutrient infused and site (treatment × time, < 0.05) such that glucose-to-ileum altered VAS-rated fullness, satisfaction, and thoughts of food compared with saline-to-ileum (Tukey's post hoc, < 0.05); decreased ad libitum EI at lunch compared with glucose-to-duodenum [-22%, -988 ± 379 kJ (mean ± SEM), Tukey's post hoc, < 0.05]; and increased glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) compared with all other treatments (Tukey's post hoc, < 0.05). Macronutrient delivery to the proximal and distal small intestine elicits different outcomes. Glucose infusion to the ileum increased GLP-1 and PYY secretion, suppressed aspects of VAS-rated appetite, and decreased ad libitum EI at a subsequent meal. Although glucose to the duodenum also suppressed appetite ratings, eating behavior was not altered. This trial was registered at www.anzctr.org.au as ACTRN12612000429853.
[Mh] Termos MeSH primário: Apetite/fisiologia
Duodeno/metabolismo
Ingestão de Energia/fisiologia
Hormônios Gastrointestinais/sangue
Glucose/administração & dosagem
Íleo/metabolismo
Resposta de Saciedade/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ingestão de Alimentos
Nutrição Enteral
Peptídeo 1 Semelhante ao Glucagon/sangue
Seres Humanos
Masculino
Peptídeo YY/sangue
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 106388-42-5 (Peptide YY); 89750-14-1 (Glucagon-Like Peptide 1); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.157248


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[PMID]:28638886
[Au] Autor:Han X; Ji X; Zhao H; Zhang Y; Liu G; Wang Y; Zhao W; Wang S
[Ad] Endereço:College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
[Ti] Título:MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG.
[So] Source:Afr J Tradit Complement Altern Med;14(4):239-246, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions. Previous investigations have revealed that the main compositions of Coix seed are proteins, polysaccharides, oils and starches. The objectives of this study are to explore which is the most effective compositions in fortifying the spleen and examine how Coix seed works in regulating the water transport on the spleen deficiency and wet dampness (SDWD) rat model. MATERIALS AND METHODS: The rats used were divided into (i) control group, (ii) model group, (iii) decoction group, (iv) protein group, (v) polysaccharide group, (vi) oil group and (vii) starch group. The urine volume, the drinking volume and the water loading index in each group were calculated. Agilent 8*60K array was used for microarray-based gene expression analysis. The differential mRNAs related to the transport activity were screened. qRT-PCR was used to validate the mRNA microarray. RESULTS: The results demonstrated that all treatment groups could decrease the dampness of SDWD rats. mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively. CONCLUSION: The compositions of proteins and polysaccharides had the most significant effect in regulating the water transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc and AQP family.
[Mh] Termos MeSH primário: Coix/química
Medicamentos de Ervas Chinesas/administração & dosagem
Baço/efeitos dos fármacos
Esplenopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Aquaporina 3/genética
Aquaporina 3/metabolismo
Proteínas de Ligação a Ácido Graxo/genética
Proteínas de Ligação a Ácido Graxo/metabolismo
Feminino
Hormônios Gastrointestinais/genética
Hormônios Gastrointestinais/metabolismo
Seres Humanos
Masculino
Ratos
Ratos Wistar
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/metabolismo
Sementes/química
Baço/metabolismo
Baço/fisiopatologia
Esplenopatias/genética
Esplenopatias/metabolismo
Esplenopatias/fisiopatologia
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aqp3 protein, rat); 0 (Drugs, Chinese Herbal); 0 (Fatty Acid-Binding Proteins); 0 (Gastrointestinal Hormones); 0 (Receptors, G-Protein-Coupled); 059QF0KO0R (Water); 117849-44-2 (fatty acid-binding protein 6); 158801-98-0 (Aquaporin 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.26


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[PMID]:28566304
[Au] Autor:Wu GJ; Cai XD; Xing J; Zhong GH; Chen JDZ
[Ad] Endereço:Division of Gastroenterology, Wuxi Second Hospital affiliated to Nanjing Medical University, Wuxi, China.
[Ti] Título:Circulating motilin, ghrelin, and GLP-1 and their correlations with gastric slow waves in patients with chronic kidney disease.
[So] Source:Am J Physiol Regul Integr Comp Physiol;313(2):R149-R157, 2017 Aug 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with chronic kidney disease (CKD) commonly complain upper gastrointestinal (GI) symptoms, especially anorexia. Hemodialysis (HD) has been noted to improve GI symptoms; however, the underlying mechanisms are unclear. This study was designed ) to study effects of HD on GI symptoms and gastric slow waves; and ) to investigate possible roles of ghrelin and glucagon-like peptide-1 (GLP-1): the study recruited 13 healthy controls, 20 CKD patients without HD (CKD group), and 18 CKD patients with HD (HD group). Dyspeptic symptoms, autonomic functions, gastric slow waves, and plasma level of ghrelin and GLP-1 were analyzed. First, the CKD patients with HD showed markedly lower scores of anorexia (0.6 ± 0.2 vs. 3.2 ± 0.4, < 0.001) compared with patients without HD. Second, the CKD group but not HD group showed a significant reduction (25.6%) in the percentage of normal gastric slow waves, compared with controls. Third, the CKD group exhibited a significantly lower ghrelin level compared with the HD group (26.8 ± 0.9 vs. 34.1 ± 2.3 ng/l, < 0.02) and a higher GLP-1 level (29.4 ± 2.8 vs. 20.0 ± 2.1 pmol/l, < 0.05) compared with controls. Moreover, the percentage of normal slow waves was positively correlated with ghrelin ( = 0.385, = 0.019) but negatively correlated with GLP-1 ( = -0.558, < 0.001) in all CKD patients. Hemodialysis improves upper GI symptoms and gastric slow waves in CKD patients. An increase in ghrelin and a decrease in GLP-1 might be involved in the HD-induced improvement in gastric slow waves.
[Mh] Termos MeSH primário: Hormônios Gastrointestinais/metabolismo
Motilina/metabolismo
Complexo Mioelétrico Migratório
Diálise Renal
Insuficiência Renal Crônica/fisiopatologia
Insuficiência Renal Crônica/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Trânsito Gastrointestinal
Grelina/metabolismo
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Estômago/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 0 (Ghrelin); 52906-92-0 (Motilin); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00317.2016


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[PMID]:28494926
[Au] Autor:Sharman MJ; Bacci B; Santos L; Mansfield CS
[Ad] Endereço:Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: melloras@alumni.unimelb.edu.au.
[Ti] Título:Gastrokine mRNA expression in gastric tissue from dogs with helicobacter colonisation but without inflammatory change during treatment.
[So] Source:Vet Immunol Immunopathol;187:28-34, 2017 May.
[Is] ISSN:1873-2534
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gastrokines (GKNs) are bioactive substances secreted by gastric cells. Evidence supports functional roles for GKNs in gastric homeostasis, immune responses and tumour suppression. Down-regulation has been reported in Helicobacter pylori associated gastritis and other inflammatory gastrointestinal conditions in mice and people. The aim of this study was to evaluate GKN gene expression in dogs positive for other Helicobacter spp. both before and after treatment. Expression of Gkn-1 and Gkn-2 mRNA was studied in endoscopic biopsy samples collected from seven healthy dogs over three time-points pre- (T0) and at 1 and 18 weeks post-treatment for Helicobacter spp. colonisation (T1 & T2). The relative expression software tool (REST) was used to provide efficiency corrected expression ratios for comparisons between groups and these results were compared to a standard 2ΔΔCT methodology. Compared with T1 Gkn1 and Gkn2 mRNA expression was greater at T0 by a mean factor of 2.53 (SE=1.83-3.54) for Gkn1 (P=0.000) and 2.85 (SE=2.23-3.75) for Gkn2 (P=0.000). This difference was attenuated when comparisons were made between T0 and T2. Histopathological evidence of gastritis was not present in any Helicobacter spp. positive sample. When compared to post-eradication samples Gkn gene expression is increased in the presence of Helicobacter spp. in dogs without evidence for concurrent inflammation. Further evaluation is required to determine the relevance of this finding, however given a suspected role in gastric homeostasis, up-regulation of GKN1 and GKN2 could limit development of gastritis in Helicobacter spp. positive dogs.
[Mh] Termos MeSH primário: Doenças do Cão/microbiologia
Hormônios Gastrointestinais/metabolismo
Infecções por Helicobacter/veterinária
Hormônios Peptídicos/metabolismo
Estômago/metabolismo
[Mh] Termos MeSH secundário: Amoxicilina/uso terapêutico
Animais
Antibacterianos/uso terapêutico
Claritromicina/uso terapêutico
Doenças do Cão/tratamento farmacológico
Doenças do Cão/imunologia
Cães
Gastrite/imunologia
Gastrite/metabolismo
Gastrite/microbiologia
Gastrite/veterinária
Expressão Gênica
Infecções por Helicobacter/tratamento farmacológico
Infecções por Helicobacter/imunologia
Infecções por Helicobacter/microbiologia
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Estômago/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gastrointestinal Hormones); 0 (Peptide Hormones); 804826J2HU (Amoxicillin); H1250JIK0A (Clarithromycin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE



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