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  1 / 12264 MEDLINE  
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[PMID]:29190137
[Au] Autor:Hughes JW; Muegge BD; Tobin GS; Litvin M; Sun L; Saenz JB; Gyawali CP; McGill JB
[Ti] Título:HIGH-RISK GASTRIC PATHOLOGY AND PREVALENT AUTOIMMUNE DISEASES IN PATIENTS WITH PERNICIOUS ANEMIA.
[So] Source:Endocr Pract;23(11):1297-1303, 2017 Nov.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pernicious anemia (PA) develops from atrophic gastritis due to autoimmune destruction of parietal cells and results in achlorhydria, vitamin B12 and iron deficiencies, anemia, neurologic deficits, and premalignant and malignant stomach lesions. We report the presentation, diagnosis and gastric complications of PA in patients from an endocrinology practice. METHODS: Thirty-four patients (31 female, 3 male) with PA who underwent esophagogastroduodenoscopy (EGD) or gastrectomy were identified. Pertinent clinical, laboratory, and pathology findings were reviewed and summarized. RESULTS: The mean age of patients was 58.6 ± 14.2 years; the onset of PA was age 50.2 ± 15.3 years. Anemia reflected vitamin B12 and/or iron deficiencies. Parietal cell antibodies (PCA) were detected in 97% of patients, and intrinsic factor blocking antibody (IFBA) was found in 52%. Fasting gastrin and chromogranin A levels were elevated (1,518.0 ± 1,588.3 pg/mL, and 504.9.1 ± 1,524.9 ng/mL respectively). Autoimmune or immunologic diseases (AIDs) were present in 32/34 patients. Stomach pathology showed premalignant or malignant lesions in 26 patients, including gastric neuroendocrine tumors (GNETs) in 6 and adenocarcinoma in 1. One patient presented with neurologic symptoms and subacute combined degeneration of the posterior column of the spinal cord. CONCLUSION: PA should be suspected in patients with unexplained anemia or neurologic symptoms. The diagnosis of PA relies on fasting gastrin and gastric auto-antibody testing, in addition to hematologic evaluation. EGD with measurement of gastric pH and biopsies of the fundus and antrum identifies patients with achlorhydria, atrophic gastritis, and premalignant and malignant stomach lesions. EGD surveillance of patients with high-risk stomach lesions is recommended. ABBREVIATIONS: AID = autoimmune or immunologic disease; EGD = esophagogastroduodenoscopy; GNET = gastric neuroendocrine tumor; IFBA = intrinsic factor blocking antibody; PA = pernicious anemia; PCA = parietal cell antibody; T1D = type 1 diabetes.
[Mh] Termos MeSH primário: Anemia Perniciosa/etiologia
Doenças Autoimunes/complicações
Mucosa Gástrica/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Endoscopia do Sistema Digestório
Feminino
Gastrectomia
Gastrinas/sangue
Gastrite Atrófica/complicações
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.4158/EP-2017-0056


  2 / 12264 MEDLINE  
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[PMID]:29061367
[Au] Autor:Reid AMA; Dunn IC
[Ad] Endereço:The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland EH25 9RG, UK. Electronic address: angus.reid@roslin.ed.ac.uk.
[Ti] Título:Gastrointestinal distribution of chicken gastrin-cholecystokinin family transcript expression and response to short-term nutritive state.
[So] Source:Gen Comp Endocrinol;255:64-70, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The related peptide hormones cholecystokinin (CCK) and gastrin are conserved throughout vertebrate clades and implicated in energy homeostasis. CCK is generally accepted as a satiety hormone in poultry, but the role of gastrin remains poorly studied. Functional dissection of these ligands is required to characterise the molecular control of growth & satiety in the domestic chicken, for which there is an increasingly pressing mandate. There are limited descriptions of physiological distributions for the two genes in birds, and these are mostly reliant on immunohistochemistry which can prove problematic due to the shared structure of the targets. Therefore, we have defined the tissue distributions of CCK and gastrin in the chicken, focussing on the gastrointestinal tract, by using transcript-dependent techniques to improve reliability by increasing specificity. Though considerably more highly expressed in the brain, gastrointestinal CCK transcripts were dispersed throughout the small intestine and particularly around the proximal ileum. Gastrin expression was strictly limited to the gastric antrum region of the intestinal tract, albeit very highly expressed. We demonstrate that CCK mRNA expression does not respond as expected for a short-term satiety hormone, and that the short-term response of gastrin expression is paradoxical compared to its role in mammals. These results partially corroborate previous peptide distribution studies and initiate exploration of the nutrient-responsive roles of these hormones in avian energy balance.
[Mh] Termos MeSH primário: Galinhas/genética
Colecistocinina/genética
Gastrinas/genética
Trato Gastrointestinal/metabolismo
Regulação da Expressão Gênica
Estado Nutricional
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Colecistocinina/metabolismo
Feminino
Gastrinas/metabolismo
Perfilação da Expressão Gênica
Íleo/metabolismo
Masculino
Estado Nutricional/genética
Antro Pilórico/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins); 0 (RNA, Messenger); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


  3 / 12264 MEDLINE  
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[PMID]:28595197
[Au] Autor:Shan J; Lei H; Shi W; Sun X; Tang Y; Ren C
[Ad] Endereço:Department of Gastroenterology, The 3rd People's Hospital of Chengdu, The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, China.
[Ti] Título:High Serum Pepsinogen I and beta Helicobacter pylori Infection Are Risk Factors for Aspirin-Induced Gastroduodenal Injury.
[So] Source:Dig Dis;36(1):66-71, 2018.
[Is] ISSN:1421-9875
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whether gastric hyperchlorhydria and Helicobacter pylori infection contribute to aspirin-induced gastroduodenal injury still lacks evidence. Because serum pepsinogens (PGs) and gastrin-17 (G17) can reflect gastric acid secretion, this study intended to elucidate whether serum PGs, serum G17, and H. pylori infection are associated with aspirin-induced gastrointestinal injury. SUMMARY: A total of 60 patients taking low-dose aspirin for more than 1 month were enrolled in this study. Serum PG I, PG II, and G17 were determined using ELISA. A 14C-urea breath test was used for the detection of an H. pylori infection. The modified Lanza score was used to evaluate the degree of gastroduodenal injury under endoscopy. The median serum PG I level was significantly higher in the intensive gastroduodenal injury (IGI) group compared to that in the mild gastroduodenal injury group (155.0 vs. 116.6 ng/mL, p = 0.006). The H. pylori infection rate was significantly higher in the IGI group (73 vs. 40%, p = 0.037). Receiver operator characteristic curves analysis revealed that the cutoff value of PG I was 123 ng/mL, with 80% sensitivity and 61.4% specificity. H. pylori infection combined with PG I at >123 ng/mL had an OR (95% CI) of 15.8 (2.4 ± 104.5) for the prediction of aspirin-induced gastroduodenal injury. Key Messages: Serum PG I and H. pylori infection could be used to identify potential high-risk aspirin-induced gastroduodenal injury patients.
[Mh] Termos MeSH primário: Aspirina/efeitos adversos
Duodeno/lesões
Infecções por Helicobacter/sangue
Infecções por Helicobacter/microbiologia
Helicobacter pylori/fisiologia
Pepsinogênio A/sangue
Estômago/lesões
[Mh] Termos MeSH secundário: Idoso
Área Sob a Curva
Duodeno/efeitos dos fármacos
Feminino
Gastrinas/sangue
Infecções por Helicobacter/complicações
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Curva ROC
Fatores de Risco
Estômago/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins); 60748-06-3 (gastrin 17); 9001-10-9 (Pepsinogen A); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1159/000477203


  4 / 12264 MEDLINE  
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[PMID]:29244926
[Au] Autor:Matveeva LV; Mosina LM
[Ti] Título:Interrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.
[So] Source:Patol Fiziol Eksp Ter;60(4):72-8, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach. Methods: Surveyed in obtaining informed consent 42 patients with gastric ulcer in the acute phase prior to the eradication and antisecretory therapy and 40 healthy volunteers. On the state of function acid- and enzymes production of the gastric mucosa judged by the results of a 2-hour intragastric pH-metry and serum concentration pepsinogen, gastrin before the start of active treatment. Immunophenotype lymphocytes on CD-antigens (CD3, CD4, CD8, CD16, CD19, CD45, CD56) was measured by immunofluorescence, levels immunoglobulin isotype M, G, A, E - ELISA method. Results: When short-term intragastric pH-metry of the stomach hyperacidity patients recorded 6.7 times more likely than healthy, normacidity - 12.3 times less. Reduction of acid production was observed up to 8.6 times more, indicating the development of mucosal atrophy. Basal pH in the antrum was lower by 54.5% than in the control group, with stimulation increased by 33.6%, but remained lower than the values of healthy individuals by 48.7%. When ELISA amount pepsinogen patients showed significant increase in serum levels of PG-I relative to the control group at 33.4%, PG-II - 52%. In assessing the immune status of patients were identified changes in system phagocytes, cellular and humoral links, most pronounced for severe current peptic ulcer disease. Conclusion: The results indicate the presence of positive and negative correlative links mild to moderate force between indicators of secretory activity of gastric mucosal innate and adaptive immunity in patients with acute exacerbation of peptic ulcer disease. The presence and nature of these relationships should be taken into account when appointing antisecretory drugs.
[Mh] Termos MeSH primário: Antígenos CD/sangue
Mucosa Gástrica/secreção
Gastrinas/sangue
Pepsinogênio A/sangue
Úlcera Gástrica/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Mucosa Gástrica/patologia
Seres Humanos
Masculino
Meia-Idade
Úlcera Gástrica/tratamento farmacológico
Úlcera Gástrica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Gastrins); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  5 / 12264 MEDLINE  
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[PMID]:28455381
[Au] Autor:Blair S
[Ti] Título:Eric Lewis Blair.
[So] Source:BMJ;357:j2021, 2017 04 28.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Colecistocinina/imunologia
Gastrinas/imunologia
Fisiologia/história
Secretina/imunologia
[Mh] Termos MeSH secundário: Bioensaio/métodos
Colecistocinina/isolamento & purificação
Gastrinas/isolamento & purificação
História do Século XX
Seres Humanos
Imunoensaio/métodos
Secretina/isolamento & purificação
Reino Unido
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Blair EL
[Nm] Nome de substância:
0 (Gastrins); 1393-25-5 (Secretin); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j2021


  6 / 12264 MEDLINE  
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[PMID]:29073245
[Au] Autor:Scott I; Umair S; Savoian MS; Simpson HV
[Ad] Endereço:Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
[Ti] Título:Abomasal dysfunction and cellular and mucin changes during infection of sheep with larval or adult Teladorsagia circumcincta.
[So] Source:PLoS One;12(10):e0186752, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This is the first integrated study of the effects on gastric secretion, inflammation and fundic mucins after infection with L3 T. circumcincta and in the very early period following transplantation of adult worms. At 3 months-of-age, 20 Coopworth lambs were infected intraruminally with 35,000 L3; infected animals were killed on Days 5, 10, 15, 20 and 30 post-infection and 6 controls on either Day 0 or 30 post-infection. Another 15 Romney cross lambs received 10,000 adult worms at 4-5 months-of-age though surgically-implanted abomasal cannulae and were killed after 6, 12, 24 and 72 hours; uninfected controls were also killed at 72 hours. Blood was collected at regular intervals from all animals for measurement of serum gastrin and pepsinogen and abomasal fluid for pH measurement from cannulated sheep. Tissues collected at necropsy were fixed in Bouin's fluid for light microscopy, immunocytochemistry and mucin staining and in Karnovsky's fluid for electron microscopy. Nodules around glands containing developing larvae were seen on Day 5 p.i., but generalised effects on secretion occurred only after parasite emergence and within hours after transplantation of adult worms. After L3 infection, there were maximum worm burdens on Days 10-15 post-infection, together with peak tissue eosinophilia, inhibition of gastric acid secretion, hypergastrinaemia, hyperpepsinogenaemia, loss of parietal cells, enlarged gastric pits containing less mucin and increased numbers of mucous neck cells. After adult transplantation, serum pepsinogen was significantly increased after 9 hours and serum gastrin after 18 hours. Parallel changes in host tissues and the numbers of parasites in the abomasal lumen suggest that luminal parasites, but not those in the tissues, are key drivers of the pathophysiology and inflammatory response in animals exposed to parasites for the first time. These results are consistent with initiation of the host response by parasite chemicals diffusing across the surface epithelium, possibly aided by components of ES products which increased permeability. Parietal cells appear to be a key target, resulting in secondary increases in serum gastrin, pit elongation, loss of surface mucins and inhibition of chief cell maturation. Inflammation occurs in parallel, and could either cause the pathology or exacerbate the direct effects of ES products.
[Mh] Termos MeSH primário: Mucinas Gástricas/secreção
Doenças dos Ovinos
Ovinos
Gastropatias
Estômago de Ruminante
Trichostrongyloidea
Tricostrongiloidíase
[Mh] Termos MeSH secundário: Animais
Gastrinas/sangue
Larva
Pepsinogênio A/sangue
Ovinos/sangue
Ovinos/parasitologia
Doenças dos Ovinos/sangue
Doenças dos Ovinos/parasitologia
Gastropatias/sangue
Gastropatias/parasitologia
Estômago de Ruminante/parasitologia
Estômago de Ruminante/secreção
Tricostrongiloidíase/sangue
Tricostrongiloidíase/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastric Mucins); 0 (Gastrins); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186752


  7 / 12264 MEDLINE  
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[PMID]:28902909
[Au] Autor:Vange P; Bruland T; Doseth B; Fossmark R; Sousa MML; Beisvag V; Sørdal Ø; Qvigstad G; Waldum HL; Sandvik AK; Bakke I
[Ad] Endereço:Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
[Ti] Título:The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival.
[So] Source:PLoS One;12(9):e0184514, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated spasmolytic polypeptide-expressing metaplasia (SPEM). The hormone gastrin is important for normal function and maturation of the gastric oxyntic mucosa and hypergastrinemia might be involved in gastric carcinogenesis. Gastrin induces expression of clusterin in adenocarcinoma cells. In the present study, we examined the expression patterns and gastrin-mediated regulation of clusterin in gastric tissue from: humans; rats treated with proton pump (H+/K+-ATPase) inhibitors and/or a gastrin receptor (CCK2R) antagonist; H+/K+-ATPase ß-subunit knockout (H/K-ß KO) mice; and Mongolian gerbils infected with Helicobacter pylori and given a CCK2R antagonist. Biological function of secretory clusterin was studied in human gastric cancer cells. Clusterin was highly expressed in neuroendocrine cells in normal oxyntic mucosa of humans and rodents. In response to hypergastrinemia, expression of clusterin increased significantly and its localization shifted to basal groups of proliferative cells in the mucous neck cell-chief cell lineage in all animal models. That shift was partially inhibited by antagonizing the CCK2R in rats and gerbils. The oxyntic mucosa of H/K-ß KO mice contained areas with clusterin-positive mucous cells resembling SPEM. In gastric adenocarcinomas, clusterin mRNA expression was higher in diffuse tumors containing signet ring cells compared with diffuse tumors without signet ring cells, and clusterin seemed to be secreted by tumor cells. In gastric cancer cell lines, gastrin increased secretion of clusterin, and both gastrin and secretory clusterin promoted survival after starvation- and chemotherapy-induced stress. Overall, our results indicate that clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and stimulates gastric cancer cell survival.
[Mh] Termos MeSH primário: Clusterina/fisiologia
Regulação Neoplásica da Expressão Gênica
Células Parietais Gástricas/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Animais
Carcinogênese/genética
Carcinogênese/metabolismo
Linhagem Celular Tumoral
Clusterina/genética
Clusterina/metabolismo
Feminino
Gastrinas/metabolismo
Gastrinas/fisiologia
Perfilação da Expressão Gênica
Gerbillinae
Seres Humanos
Masculino
Camundongos Knockout
Meia-Idade
Células Parietais Gástricas/metabolismo
Inibidores da Bomba de Prótons/farmacologia
Ratos
Ratos Sprague-Dawley
Receptor de Colecistocinina B/antagonistas & inibidores
Neoplasias Gástricas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Clusterin); 0 (Gastrins); 0 (Proton Pump Inhibitors); 0 (Receptor, Cholecystokinin B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184514


  8 / 12264 MEDLINE  
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[PMID]:28739697
[Au] Autor:Shiomi Y; Yoshimura M; Kuki K; Hori Y; Tanaka T
[Ad] Endereço:Central Research Laboratories, ZERIA Pharmaceutical Co., Ltd., Kumagaya, Japan yoshihiro-shiomi@zeria.co.jp.
[Ti] Título:Z-360 Suppresses Tumor Growth in MIA PaCa-2-bearing Mice Inhibition of Gastrin-induced Anti-Apoptotic Effects.
[So] Source:Anticancer Res;37(8):4127-4137, 2017 08.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: The aim of the study was to evaluate the anti-tumor mechanism of Z-360, a gastrin/cholecystokinin-2 receptor (CCK2R) antagonist, in MIA PaCa-2 cells and in a subcutaneous xenograft mice model. MATERIALS AND METHODS: The anti-tumor effects of Z-360 and/or gemcitabine were monitored using a MIA PaCa-2 xenograft model. The effect of Z-360 on apoptosis in the model was examined by TUNEL staining and real-time PCR analysis and the effect in MIA PaCa-2 cells stably expressing human CCK2R was also evaluated by caspase-3/7 activity. RESULTS: In this xenograft model, Z-360 significantly reduced the tumor weight, increased TUNEL-positive cells and suppressed the expression of anti-apoptosis factors such as survivin, XIAP and Mcl-1, and these effects of Z-360 combined with gemcitabine were more effective. Furthermore, gastrin-17 and gastrin-34 inhibited apoptosis in vitro and Z-360 dose-dependently abrogated this effect. CONCLUSION: These results suggest that Z-360 exerts an anti-tumor effect through a reduction in anti-apoptosis factors by blocking CCK2R.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Benzodiazepinonas/administração & dosagem
Neoplasias Pancreáticas/tratamento farmacológico
Receptor de Colecistocinina B/genética
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Desoxicitidina/administração & dosagem
Desoxicitidina/análogos & derivados
Endopeptidases/administração & dosagem
Gastrinas/administração & dosagem
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Proteínas Inibidoras de Apoptose/biossíntese
Camundongos
Proteína de Sequência 1 de Leucemia de Células Mieloides/biossíntese
Neoplasias Pancreáticas/genética
Neoplasias Pancreáticas/patologia
Receptor de Colecistocinina B/antagonistas & inibidores
Receptor de Colecistocinina B/biossíntese
Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X/biossíntese
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BIRC5 protein, human); 0 (Benzodiazepinones); 0 (Gastrins); 0 (Inhibitor of Apoptosis Proteins); 0 (MCL1 protein, human); 0 (Myeloid Cell Leukemia Sequence 1 Protein); 0 (Receptor, Cholecystokinin B); 0 (X-Linked Inhibitor of Apoptosis Protein); 0 (XIAP protein, human); 0 (Z-360); 0W860991D6 (Deoxycytidine); 60748-06-3 (gastrin 17); B76N6SBZ8R (gemcitabine); EC 3.4.- (Endopeptidases); EC 3.4.99.- (gastrinase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  9 / 12264 MEDLINE  
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[PMID]:28509371
[Au] Autor:Konze SA; Cajic S; Oberbeck A; Hennig R; Pich A; Rapp E; Buettner FFR
[Ad] Endereço:Institute of Clinical Biochemistry, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
[Ti] Título:Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells.
[So] Source:Chembiochem;18(13):1317-1331, 2017 Jul 04.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC CMs) may be used in regenerative medicine for individualized tissue transplants in the future. For application in patients, the generated CMs have to be highly pure and well characterized. In order to overcome the prevalent scarcity of CM-specific markers, we quantitatively assessed cell-surface-exposed sialo-glycoproteins and N-glycans of hiPSCs, CM progenitors, and CMs. Applying a combination of metabolic labeling and specific sialo-glycoprotein capture, we could highly enrich and quantify membrane proteins during cardiomyogenic differentiation. Among them we identified a number of novel, putative biomarkers for hiPSC CMs. Analysis of the N-glycome by capillary gel electrophoresis revealed three novel structures comprising ß1,3-linked galactose, α2,6-linked sialic acid and complex fucosylation; these were highly specific for hiPSCs. Bisecting GlcNAc structures strongly increased during differentiation, and we propose that they are characteristic of early, immature CMs.
[Mh] Termos MeSH primário: Membrana Celular/química
Glicômica/métodos
Células-Tronco Pluripotentes Induzidas/química
Miócitos Cardíacos/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Acetilglucosamina/química
Acetilglucosamina/metabolismo
Sequência de Carboidratos
Diferenciação Celular
Membrana Celular/metabolismo
Subunidade alfa do Receptor do Fator Neutrófico Ciliar/genética
Subunidade alfa do Receptor do Fator Neutrófico Ciliar/metabolismo
Fucose/química
Fucose/metabolismo
Galactose/química
Galactose/metabolismo
Gastrinas/genética
Gastrinas/metabolismo
Regulação da Expressão Gênica
Seres Humanos
Células-Tronco Pluripotentes Induzidas/citologia
Células-Tronco Pluripotentes Induzidas/metabolismo
Laminina/genética
Laminina/metabolismo
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Miócitos Cardíacos/citologia
Miócitos Cardíacos/metabolismo
Polissacarídeos/metabolismo
Receptor EphA7/genética
Receptor EphA7/metabolismo
Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores/genética
Proteínas Tirosina Fosfatases Classe 2 Semelhantes a Receptores/metabolismo
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/metabolismo
Ácidos Siálicos/química
Ácidos Siálicos/metabolismo
Coloração e Rotulagem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CNTFR protein, human); 0 (Ciliary Neurotrophic Factor Receptor alpha Subunit); 0 (Gastrins); 0 (HEPH protein, human); 0 (LGR4 protein, human); 0 (Laminin); 0 (Membrane Proteins); 0 (Polysaccharides); 0 (Receptors, G-Protein-Coupled); 0 (Sialic Acids); 151186-83-3 (laminin A); 28RYY2IV3F (Fucose); EC 2.7.10.1 (Receptor, EphA7); EC 3.1.3.48 (PTPRD protein, human); EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 2); V956696549 (Acetylglucosamine); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700100


  10 / 12264 MEDLINE  
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[PMID]:28446479
[Au] Autor:Abu Ghanimeh M; Abuamr K; Sadeddin E; Yousef O
[Ad] Endereço:Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
[Ti] Título:Severe chronic diarrhoea secondary to primary lymph node gastrinoma.
[So] Source:BMJ Case Rep;2017, 2017 Apr 26.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The existence of primary lymph node (LN) gastrinoma is questionable and controversial. In fact, the presence of gastrinoma in such uncommon site raises the possibility of metastasis from another occult primary site. An extensive evaluation and careful follow-up is always warranted. A female aged 48 years presented with chronic abdominal pain and watery diarrhoea. Her serum gastrin and chromogranin were elevated, and an underlying gastrinoma was suspected. Further evaluation with an octreotide scan, an endoscopic ultrasound and a secretin stimulation test confirmed the diagnosis. Further evaluation for multiple endocrine neoplasia-1 syndrome was negative. She underwent a surgical enucleation near the head of the pancreas. No other lesions were found after careful exploration of the gastrinoma triangle. Histology showed a LN with a neuroendocrine tumour that tested positively with gastrin and chromogranin stains. Her symptoms resolved postoperatively, her serum gastrin normalised and a repeated octreotide scan was negative.
[Mh] Termos MeSH primário: Diarreia/etiologia
Gastrinoma/diagnóstico
Linfonodos/patologia
Tumores Neuroendócrinos/diagnóstico
[Mh] Termos MeSH secundário: Cromograninas/sangue
Feminino
Gastrinoma/metabolismo
Gastrinoma/cirurgia
Gastrinas/sangue
Seres Humanos
Linfonodos/cirurgia
Meia-Idade
Tumores Neuroendócrinos/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromogranins); 0 (Gastrins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE



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