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[PMID]: 28942280 [Au] Autor: Edwards TM; Hamlin HJ; Freymiller H; Green S; Thurman J; Guillette LJ [Ad] Endereço: Department of Biology, University of the South, Sewanee, TN, USA; Department of Biology, University of Florida, Gainesville, FL, USA; School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA. Electronic address: theamedwards@gmail.com. [Ti] Título: Nitrate induces a type 1 diabetic profile in alligator hatchlings. [So] Source: Ecotoxicol Environ Saf;147:767-775, 2018 Jan. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology. One potential factor, supported primarily by epidemiological studies, is the presence of nitrate and nitrite in drinking water. To test this hypothesis, female hatchling alligators were exposed to environmentally relevant concentrations of nitrate in their tank water (reference, 10mg/L, or 100mg/L NO -N) from hatch through 5 weeks or 5 months of age. At each time point, endpoints related to T1D were investigated: plasma levels of glucose, triglycerides, testosterone, estradiol, and thyroxine; pancreas, fat body, and thyroid weights; weight gain or loss; presence of immune cells in the pancreas; and pancreatic beta cell number, assessed by antibody staining of nkx6.1 protein. Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin. Cluster analysis indicated that high nitrate exposure (most animals exposed to 100mg/L NO3-N and one alligator exposed to 10mg/L NO3-N) induced a profile of endpoints consistent with early T1D that could be detected after 5 weeks and was more strongly present after 5 months. Our study supports epidemiological data correlating elevated nitrate with T1D onset in humans, and highlights nitrate as a possible environmental contributor to the etiology of T1D, possibly through its role as a nitric oxide precursor. [Mh] Termos MeSH primário: Jacarés e Crocodilos/sangue Diabetes Mellitus Experimental/induzido quimicamente Diabetes Mellitus Tipo 1/induzido quimicamente Disruptores Endócrinos/toxicidade Nitratos/toxicidade Poluentes Químicos da Água/toxicidade [Mh] Termos MeSH secundário: Jacarés e Crocodilos/crescimento & desenvolvimento Animais Glicemia/análise Diabetes Mellitus Experimental/sangue Diabetes Mellitus Tipo 1/sangue Relação Dose-Resposta a Droga Disruptores Endócrinos/farmacocinética Monitoramento Ambiental/métodos Feminino Hormônios Esteroides Gonadais/sangue Nitratos/farmacocinética Tamanho do Órgão/efeitos dos fármacos Tiroxina/sangue Triglicerídeos/sangue Poluentes Químicos da Água/farmacocinética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Blood Glucose); 0 (Endocrine Disruptors); 0 (Gonadal Steroid Hormones); 0 (Nitrates); 0 (Triglycerides); 0 (Water Pollutants, Chemical); Q51BO43MG4 (Thyroxine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170925 [St] Status: MEDLINE

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[PMID]: 29237526 [Au] Autor: Sun LF; Li YY; Huang BX; Fu XY; Yang FH; Ma DL; Zhang Q [Ad] Endereço: Department of Clinical Laboratory, Children's Hospital of Shenzhen, Shenzhen, Guangdong 518038, China. 771369652@qq.com. [Ti] Título: [Establishment of reference ranges of sex hormones for healthy children in Shenzhen, China based on chemiluminescence]. [So] Source: Zhongguo Dang Dai Er Ke Za Zhi;19(12):1257-1262, 2017 Dec. [Is] ISSN: 1008-8830 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVE: To study the reference ranges of six sex hormones, i.e., luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone, for healthy children aged 0-18 years in Shenzhen, China. METHODS: Stratified cluster sampling was performed to select 2 178 healthy children aged 0-18 years in the districts of Futian, Luohu, Nanshan, Bao'an, and Longgang in Shenzhen between September 2015 and September 2016. There were 1 219 boys and 959 girls, including 81 neonates, 335 infants, 346 young children, 469 preschool children, 419 school-aged children, and 528 adolescents. The American Beckman DXI800 chemiluminescence meter was used to measure the levels of luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone. RESULTS: There were significant differences in the levels of luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone between different age groups (P<0.05). There were also significant differences in the levels of these sex hormones between boys and girls in the same age group (P<0.05). The reference ranges of six sex hormones were established for healthy children aged 0-18 years in Shenzhen based on the levels of these hormones in different age groups. CONCLUSIONS: There are significant differences in sex hormones between different age groups or sex groups. The reference ranges of six sex hormones established for different sexes or ages have great significance in the diagnosis and treatment of endocrine diseases in children. [Mh] Termos MeSH primário: Hormônios Esteroides Gonadais/sangue [Mh] Termos MeSH secundário: Adolescente Fatores Etários Criança Pré-Escolar Estradiol/sangue Feminino Hormônio Foliculoestimulante/sangue Seres Humanos Lactente Recém-Nascido Medições Luminescentes Hormônio Luteinizante/sangue Masculino Progesterona/sangue Valores de Referência Testosterona/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Gonadal Steroid Hormones); 3XMK78S47O (Testosterone); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171215 [St] Status: MEDLINE

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[PMID]: 29385171 [Au] Autor: Aguayo A; Martin CS; Huddy TF; Ogawa-Okada M; Adkins JL; Steele AD [Ad] Endereço: Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America. [Ti] Título: Sex differences in circadian food anticipatory activity are not altered by individual manipulations of sex hormones or sex chromosome copy number in mice. [So] Source: PLoS One;13(1):e0191373, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Recent studies in mice have demonstrated a sexual dimorphism in circadian entrainment to scheduled feeding. On a time restricted diet, males tend to develop food anticipatory activity (FAA) sooner than females and with a higher amplitude of activity. The underlying cause of this sex difference remains unknown. One study suggests that sex hormones, both androgens and estrogens, modulate food anticipatory activity in mice. Here we present results suggesting that the sex difference in FAA is unrelated to gonadal sex hormones. While a sex difference between males and females in FAA on a timed, calorie restricted diet was observed there were no differences between intact and gonadectomized mice in the onset or magnitude of FAA. To test other sources of the sex difference in circadian entrainment to scheduled feeding, we used sex chromosome copy number mutants, but there was no difference in FAA when comparing XX, XY-, XY-;Sry Tg, and XX;Sry Tg mice, demonstrating that gene dosage of sex chromosomes does not mediate the sex difference in FAA. Next, we masculinized female mice by treating them with 17-beta estradiol during the neonatal period; yet again, we saw no difference in FAA between control and masculinized females. Finally, we observed that there was no longer a sex difference in FAA for older mice, suggesting that the sex difference in FAA is age-dependent. Thus, our study demonstrates that singular manipulations of gonadal hormones, sex chromosomes, or developmental patterning are not able to explain the difference in FAA between young male and female mice. [Mh] Termos MeSH primário: Antecipação Psicológica/fisiologia Ritmo Circadiano/efeitos dos fármacos Ritmo Circadiano/genética Alimentos Hormônios Esteroides Gonadais/farmacologia Caracteres Sexuais Cromossomos Sexuais/genética [Mh] Termos MeSH secundário: Animais Antecipação Psicológica/efeitos dos fármacos Estradiol/farmacologia Feminino Dosagem de Genes Masculino Camundongos Camundongos Endogâmicos C57BL [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Gonadal Steroid Hormones); 4TI98Z838E (Estradiol) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191373

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[PMID]: 29399864 [Au] Autor: Amendolagine L; Schoffner T; Koscielny L; Schook M; Copeland D; Casteel J; Duff B; Koester D [Ad] Endereço: Department of Conservation and Science, Cleveland Metroparks Zoo, Cleveland, Ohio. [Ti] Título: In-house monitoring of steroid hormone metabolites in urine informs breeding management of a giant anteater (Myrmechophaga tridactyla). [So] Source: Zoo Biol;37(1):40-45, 2018 Jan. [Is] ISSN: 1098-2361 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Although numbers of giant anteaters within North American facilities have been steadily increasing for the last 15 years, the population now exhibits an unstable age distribution with genetically valuable individuals nearing reproductive senescence. Contributing to this issue is the Association of Zoos and Aquariums (AZA) described lack of standardization of breeding introduction practices and high risk of female injury occurring during such pairings. This report describes the development of a successful breeding protocol at Cleveland Metroparks Zoo based on hormone monitoring and efficient communication between science and animal management teams that minimizes risk of female injury. By training a female giant anteater for urine sample and body weight data collection, staff members accurately predicted estrus, and timed breeding introductions to facilitate positive interactions between the male and female. Such training also allowed for careful monitoring of two pregnancies through parturition (169-184 days from breeding) and post-partum return to estrus (114-129 days from parturition). Urinary hormone monitoring revealed a sharp progestogen increase averaging >five-fold over basal levels (0.52 ± 0.05 ng/mg creatinine) which was sustained throughout the second half of pregnancy. Mean regular estrous cycle length (n = 14 cycles), was calculated as 46.17 ± 1.39 days, measured as days between estrogen peaks of mean concentration 2.27 ± 0.19 ng/mg creatinine. This report summarizes impressive collaborative efforts among multiple zoological departments to achieve extensive hormonal and body weight monitoring from a female giant anteater, adding valuable information on reproductive parameters, and specifics for novel hormone assay techniques. [Mh] Termos MeSH primário: Animais de Zoológico Cruzamento Hormônios Esteroides Gonadais/urina Xenartros/fisiologia Xenartros/urina [Mh] Termos MeSH secundário: Animais Feminino Reprodução/fisiologia Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Gonadal Steroid Hormones) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180206 [St] Status: MEDLINE [do] DOI: 10.1002/zoo.21396

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[PMID]: 29300865 [Au] Autor: Fan J; Wang K; Zirkin B; Papadopoulos V [Ad] Endereço: Research Institute of the McGill University Health Centre and Department of Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. [Ti] Título: CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells. [So] Source: Endocrinology;159(2):1130-1146, 2018 02 01. [Is] ISSN: 1945-7170 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The outer mitochondrial membrane translocator protein (TSPO) binds cholesterol with high affinity and is involved in mediating its delivery into mitochondria, the rate-limiting step in hormone-induced steroidogenesis. Specific ligand binding to TSPO has been shown to initiate steroid formation. However, recent studies of the genetic deletion of Tspo have provided conflicting results. Here, we address and extend previous studies by examining the effects of Tspo-specific mutations on steroid formation in hormone- and cyclic adenosine monophosphate (cAMP)-responsive MA-10 cells, using the CRISPR/Cas9 system. Two mutant subcell lines, nG1 and G2G, each carrying a Tspo exon2-specific genome modification, and two control subcell lines, G1 and HH, each carrying a wild-type Tspo, were produced. In response to dibutyryl cAMP, the nG1 and G2G cells produced progesterone at levels significantly lower than those produced by the corresponding control cells G1 and HH. Neutral lipid homeostasis, which provides free cholesterol for steroid biosynthesis, was altered significantly in the Tspo mutant cells. Interestingly, the mitochondrial membrane potential (ΔΨm) of the Tspo mutant cells was significantly reduced compared with that of the control cells, likely because of TSPO interactions with the voltage-dependent anion channel and tubulin at the outer mitochondrial membrane. Steroidogenic acute regulatory protein (STAR) expression was induced in nG1 cells, suggesting that reduced TSPO affected STAR synthesis and/or processing. Taken together, these results provide further evidence for the critical role of TSPO in steroid biosynthesis and suggest that it may function at least in part via its regulation of ΔΨm and effects on STAR. [Mh] Termos MeSH primário: Sistemas CRISPR-Cas/genética Hormônios Esteroides Gonadais/biossíntese Células Intersticiais do Testículo/metabolismo Potencial da Membrana Mitocondrial/genética Mutagênese Sítio-Dirigida Mutação Receptores de GABA/genética [Mh] Termos MeSH secundário: Animais Linhagem Celular Tumoral Tumor de Células de Leydig/genética Tumor de Células de Leydig/metabolismo Tumor de Células de Leydig/patologia Masculino Camundongos Mutagênese Sítio-Dirigida/métodos Fosfoproteínas/genética Fosfoproteínas/metabolismo Esteroides/biossíntese Neoplasias Testiculares/genética Neoplasias Testiculares/metabolismo Neoplasias Testiculares/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Bzrp protein, mouse); 0 (Gonadal Steroid Hormones); 0 (Phosphoproteins); 0 (Receptors, GABA); 0 (Steroids); 0 (steroidogenic acute regulatory protein) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180105 [St] Status: MEDLINE [do] DOI: 10.1210/en.2017-03065

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[PMID]: 29197623 [Au] Autor: Ommati MM; Heidari R; Jamshidzadeh A; Zamiri MJ; Sun Z; Sabouri S; Wang J; Ahmadi F; Javanmard N; Seifi K; Mousapour S; Yeganeh BS [Ad] Endereço: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Animal Sciences, School of Agriculture, Shiraz University, Shiraz, Iran; Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi, Agricultural University, Taigu, [Ti] Título: Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models. [So] Source: Toxicol Lett;284:46-55, 2018 Mar 01. [Is] ISSN: 1879-3169 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: There are reports of sulfasalazine (Salazosulfapyridine; SASP)-induced reproductive toxicity, but there it is not known whether the SASP molecule or its intestinal metabolites are responsible for this effect. Rats received SASP (150, 300, and 600mg/kg) for 60 consecutive days (in vivo). Additionally, epididymal sperm was isolated and incubated with SASP (10µM-1600µM) (in vitro). Markers of oxidative stress, mitochondrial function, and sperm functionality, along with testis histopathology as well as several steroidogenic genes and proteins, including steroidogenic acute regulatory (StAR) protein, cytochrome P450 side chain cleavage enzyme (P450scc; Cyp11a), 3ß-hydroxysteroid dehydrogenase (3ß-HSD), 17ß-hydroxysteroid dehydrogenase (17ß-HSD) were measured. SASP toxicity was evident as shown by severe testicular histopathological alterations, along with poor sperm parameters and increased markers of oxidative stress. Plasma testosterone level and steroidogenesis-related gene and protein (StAR, 3-beta-HSD, 17-beta-HSD) expressions, as well as mitochondrial membrane potential, were significantly decreased at high doses of SASP (in vivo). Interestingly, in vitro treatment of sperm with SASP not only caused no significant detrimental effect on rat sperm but also increased parameters of sperm functionality and decreased markers of oxidative stress. SASP had paradoxical actions on the rat sperm in these experimental models. The findings might be useful in understanding the mechanism(s) of SASP-induced reproductive toxicity. The present findings have opened a new molecular window into the relationship between disrupted steroidogenesis and mammalian reproduction indices and also are vital regarding clinical administration of SASP and human reproductive health. [Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/toxicidade Hormônios Esteroides Gonadais/metabolismo Espermatogênese/efeitos dos fármacos Espermatozoides/efeitos dos fármacos Sulfassalazina/toxicidade Testículo/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Biomarcadores/metabolismo Relação Dose-Resposta a Droga Masculino Estresse Oxidativo/efeitos dos fármacos Ratos Sprague-Dawley Espermatozoides/metabolismo Espermatozoides/patologia Testículo/metabolismo Testículo/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biomarkers); 0 (Gonadal Steroid Hormones); 3XC8GUZ6CB (Sulfasalazine) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171204 [St] Status: MEDLINE

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[PMID]: 29324824 [Au] Autor: Leary CJ; Ralicki HF; Laurencio D; Crocker-Buta S; Malone JH [Ad] Endereço: University of Mississippi, Department of Biology, University, Mississippi, United States of America. [Ti] Título: Assessing the links among environmental contaminants, endocrinology, and parasites to understand amphibian declines in montane regions of Costa Rica. [So] Source: PLoS One;13(1):e0191183, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Amphibians inhabiting montane riparian zones in the Neotropics are particularly vulnerable to decline, but the reasons are poorly understood. Because environmental contaminants, endocrine disruption, and pathogens often figure prominently in amphibian declines it is imperative that we understand how these factors are potentially interrelated to affect montane populations. One possibility is that increased precipitation associated with global warming promotes the deposition of contaminants in montane regions. Increased exposure to contaminants, in turn, potentially elicits chronic elevations in circulating stress hormones that could contribute to montane population declines by compromising resistance to pathogens and/or production of sex steroids regulating reproduction. Here, we test this hypothesis by examining contaminant levels, stress and sex steroid levels, and nematode abundances in male drab treefrogs, Smilisca sordida, from lowland and montane populations in Costa Rica. We found no evidence that montane populations were more likely to possess contaminants (i.e., organochlorine, organophosphate and carbamate pesticides or benzidine and chlorophenoxy herbicides) than lowland populations. We also found no evidence of elevational differences in circulating levels of the stress hormone corticosterone, estradiol or progesterone. However, montane populations possessed lower androgen levels, hosted more nematode species, and had higher nematode abundances than lowland populations. Although these results suggested that nematodes contributed to lower androgens in montane populations, we were unable to detect a significant inverse relationship between nematode abundance and androgen level. Our results suggest that montane populations of this species are not at greater risk of exposure to contaminants or chronic stress, but implicate nematodes and compromised sex steroid levels as potential threats to montane populations. [Mh] Termos MeSH primário: Anuros/parasitologia Disruptores Endócrinos/toxicidade Poluentes Ambientais/toxicidade [Mh] Termos MeSH secundário: Animais Anuros/sangue Anuros/fisiologia Corticosterona/sangue Costa Rica Disruptores Endócrinos/metabolismo Glândulas Endócrinas/efeitos dos fármacos Glândulas Endócrinas/fisiopatologia Poluentes Ambientais/metabolismo Aquecimento Global Hormônios Esteroides Gonadais/sangue Interações Hospedeiro-Parasita Masculino Nematoides/isolamento & purificação Nematoides/patogenicidade Dinâmica Populacional Estresse Fisiológico Clima Tropical/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Endocrine Disruptors); 0 (Environmental Pollutants); 0 (Gonadal Steroid Hormones); W980KJ009P (Corticosterone) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191183

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[PMID]: 29342161 [Au] Autor: Petrick JL; Falk RT; Hyland PL; Caron P; Pfeiffer RM; Wood SN; Dawsey SM; Abnet CC; Taylor PR; Guillemette C; Murray LJ; Anderson LA; Cook MB [Ad] Endereço: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, United States of America. [Ti] Título: Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study. [So] Source: PLoS One;13(1):e0190325, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Esophageal adenocarcinoma (EA) is characterized by a strong male predominance. Sex steroid hormones have been hypothesized to underlie this sex disparity, but no population-based study to date has examined this potential association. METHODS: Using mass spectrometry and ELISA, we quantitated sex steroid hormones and sex hormone binding globulin, respectively, in plasma from males- 172 EA cases and 185 controls-within the Factors Influencing the Barrett/Adenocarcinoma Relationship (FINBAR) Study, a case-control investigation conducted in Northern Ireland and Ireland. Multivariable adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between circulating hormones and EA. RESULTS: Higher androgen:estrogen ratio metrics were associated with increased odds of EA (e.g., testosterone:estradiol ratio ORQ4 v. Q1 = 2.58, 95%CI = 1.23-5.43; Ptrend = 0.009). All estrogens and androgens were associated with significant decreased odds of EA. When restricted to individuals with minimal to no decrease in body mass index, the size of association for the androgen:estrogen ratio was not greatly altered. CONCLUSIONS: This first study of sex steroid hormones and EA provides tentative evidence that androgen:estrogen balance may be a factor related to EA. Replication of these findings in prospective studies is needed to enhance confidence in the causality of this effect. [Mh] Termos MeSH primário: Adenocarcinoma/sangue Neoplasias Esofágicas/sangue Hormônios Esteroides Gonadais/sangue [Mh] Termos MeSH secundário: Feminino Seres Humanos Masculino [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Gonadal Steroid Hormones) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180215 [Lr] Data última revisão: 180215 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180118 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190325

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[PMID]: 29281666 [Au] Autor: Watts EL; Appleby PN; Albanes D; Black A; Chan JM; Chen C; Cirillo PM; Cohn BA; Cook MB; Donovan JL; Ferrucci L; Garland CF; Giles GG; Goodman PJ; Habel LA; Haiman CA; Holly JMP; Hoover RN; Kaaks R; Knekt P; Kolonel LN; Kubo T; Le Marchand L; Luostarinen T; MacInnis RJ; Mäenpää HO; Männistö S; Metter EJ; Milne RL; Nomura AMY; Oliver SE; Parsons JK; Peeters PH; Platz EA; Riboli E; Ricceri F; Rinaldi S; Rissanen H; Sawada N; Schaefer CA; Schenk JM; Stanczyk FZ; Stampfer M; Stattin P; Stenman UH; Tjønneland A; Trichopoulou A; Thompson IM; Tsugane S; Vatten L [Ad] Endereço: Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. [Ti] Título: Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men. [So] Source: PLoS One;12(12):e0187741, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin. METHODS: Statistical analyses of individual participant data from 12,330 male controls aged 25-85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates. RESULTS: Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones. CONCLUSION: Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption. [Mh] Termos MeSH primário: Antropometria Comportamento Conjuntos de Dados como Assunto Hormônios Esteroides Gonadais/sangue Classe Social [Mh] Termos MeSH secundário: Adulto Seres Humanos Masculino Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Gonadal Steroid Hormones) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171228 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0187741

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[PMID]: 29364611 [Au] Autor: Matosyan KA; Oranskaya AN; Pustovalov DA; Cherepkova EV; Skotnikova UV; Burdyukova EV; Anishchenko AP; Gurevich KG; Khanferyan RA [Ti] Título: [Adipose tissue composition in puberty and postpuberty according to age, sex (gender), physical activity and alimentary behavior]. [So] Source: Vopr Pitan;84(5):88-94, 2015. [Is] ISSN: 0042-8833 [Cp] País de publicação: Russia (Federation) [La] Idioma: rus [Ab] Resumo: The study involved 110 adolescents from 15 to 22 years (35 boys, 75 girls). To assess eating habits and physical activity we used WHO questionnaires. We also analyzed anthropometry, bioimpedance data, parameters of the cardiovascular system: systolic and diastolic blood pressure, heart rate. It has been shown, that body mass index (BMI) in adolescents didn't correlate with the content of both total and visceral adipose tissue in the body and shoud not be used as a major diagnostic criterion of obesity. An excessive content of total adipose tissue was shown in 15% of the puberty and postpuberty teens. Visceral fat content was significantly higher in male, than female (3.03±3.31 vs 2.11±1.57%), independently of the total fat percentage (18.91±16.83 and 31.72±19.24% respectively). The visceral fat in the body begins to increase in age of 16. According to the authors, such an effect in boys and girls is associated with the final changes of puberty (concentration of sex steroids). Such hormons like testosterone and progesterone and estradiol have different effects on the white adipose tissue and play a key role in proceses of its differentiation and metabolism. Percentage of total adipose tissue depends on dietary habits in the first place ­ the predominance of fast food. A significant relationship of physical activity and the percentage of visceral fat was shown. [Mh] Termos MeSH primário: Gordura Abdominal/metabolismo Adiposidade/fisiologia Comportamento Alimentar Hormônios Esteroides Gonadais/metabolismo Puberdade/metabolismo Caracteres Sexuais [Mh] Termos MeSH secundário: Adolescente Adulto Feminino Seres Humanos Masculino [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Gonadal Steroid Hormones) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180205 [Lr] Data última revisão: 180205 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE

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