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[PMID]: 27470300 [Au] Autor: Chong YH; Pankhurst MW; McLennan IS [Ad] Endereço: Department of Anatomy, Otago School of Medical Sciences, Dunedin, New Zealand. [Ti] Título: The Testicular Hormones AMH, InhB, INSL3, and Testosterone Can Be Independently Deficient in Older Men. [So] Source: J Gerontol A Biol Sci Med Sci;72(4):548-553, 2017 Apr 01. [Is] ISSN: 1758-535X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Late-onset hypogonadism is symptomatically diverse and not fully explained by circulating testosterone level. The adult testes secrete four distinct hormones (testosterone, AMH, INSL3, and InhB) into the circulation. Testosterone and InhB have proven dynamic regulation, with limited information available for AMH and INSL3. During aging, there is cellular senescence, which may underlie the diversity of hypogonadism. This leads to the postulate that the relative levels (profile) of the four testicular hormones in older men are variable and cannot be evaluated by the measurement of one hormone. Methods: 111 men aged 19-50 years and 98 men aged 70-90 years were examined. The circulating levels of the testicular hormones were measured using ELISAs, and the variation in the levels of hormones was analyzed by various correlative analyses. Results: All four hormones were largely or totally independent. Some men were deficient in multiple hormones, but no man had multiple elevated hormones. The average hormonal levels were lower in older men, with diverse profiles of the four testicular hormones. Hence, some men had one or more hormones below the reference range, with testosterone the most conserved. Consequently, testosterone levels were not indicative of the complete state of the endocrine testes. Conclusions: The four hormones vary independently of each other, in younger and older men. This indicates that they are regulated dynamically rather than influenced by endocrine cell number. Older men exhibited diverse profiles of low levels of testicular hormones, suggesting that the testes age differently between men. Testosterone alone inadequately describes gonadal states. [Mh] Termos MeSH primário: Inibinas/deficiência Insulina/deficiência Hormônios Testiculares/deficiência Testosterona/deficiência [Mh] Termos MeSH secundário: Adulto Fatores Etários Idoso Idoso de 80 Anos ou mais Hormônio Antimülleriano/sangue Hormônio Antimülleriano/deficiência Estudos Transversais Seres Humanos Inibinas/sangue Insulina/sangue Masculino Meia-Idade Proteínas Hormônios Testiculares/sangue Testosterona/sangue Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insulin); 0 (Leydig insulin-like protein); 0 (Proteins); 0 (Testicular Hormones); 0 (inhibin B); 3XMK78S47O (Testosterone); 57285-09-3 (Inhibins); 80497-65-0 (Anti-Mullerian Hormone) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170810 [Lr] Data última revisão: 170810 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 160730 [St] Status: MEDLINE [do] DOI: 10.1093/gerona/glw143

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[PMID]: 26280929 [Au] Autor: Adedara IA; Owoeye O; Aiyegbusi MA; Dagunduro JO; Daramola YM; Farombi EO [Ad] Endereço: Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: dedac2001@yahoo.co.uk. [Ti] Título: Kolaviron protects against benzo[a]pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats. [So] Source: Environ Toxicol Pharmacol;40(2):459-70, 2015 Sep. [Is] ISSN: 1872-7077 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Exposure to benzo[a]pyrene (B[a]P) is well reported to be associated with neurological and reproductive dysfunctions. The present study investigated the influence of kolaviron, an isolated biflavonoid from the seed of Garcinia kola, on functional alterations along the brain-pituitary-gonadal axis in male rats exposed to B[a]P. Benzo[a]pyrene was orally administered at a dose of 10mg/kg alone or orally co-administered with kolaviron at 100 and 200mg/kg for 15 consecutive days. Administration of B[a]P significantly (p<0.05) decreased plasma levels of pituitary hormones namely follicle-stimulating hormone (FSH) and prolactin but increased luteinizing hormone (LH) by 47%, 55% and 20.9%, respectively, when compared with the control. The significant decrease in gonadosomatic index (GSI) was accompanied by significant decrease in testosterone production and sperm functional parameters in the B[a]P-treated rats. Moreover, B[a]P-treated rats showed significant elevation in the circulatory concentrations of pro-inflammatory cytokines and oxidative stress indices in the brain, testes and sperm of B[a]P-treated rats. Light microscopy revealed severe necrosis of the Purkinje cells in the cerebellum, neuronal degeneration of the cerebral cortex, neuronal necrosis of the hippocampus and testicular atrophy in B[a]P-treated rats. Kolaviron co-treatment significantly ameliorated B[a]P mediated damages by suppressing pro-inflammatory mediators and enhancing the antioxidant status, neuroendocrine function, sperm characteristics and improving the architecture of the brain and testes in B[a]P-treated rats. The findings in the present investigation highlight that kolaviron may be developed to novel therapeutic agent against toxicity resulting from B[a]P exposure. [Mh] Termos MeSH primário: Benzo(a)pireno/toxicidade Encéfalo/efeitos dos fármacos Flavonoides/administração & dosagem Espermatozoides/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Encéfalo/patologia Flavonoides/farmacologia Masculino Estresse Oxidativo/efeitos dos fármacos Hormônios Hipofisários/sangue Ratos Espermatozoides/fisiologia Hormônios Testiculares/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Flavonoids); 0 (Pituitary Hormones); 0 (Testicular Hormones); 3417WMA06D (Benzo(a)pyrene); PX7M0YV62G (kolaviron) [Em] Mês de entrada: 1606 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150818 [St] Status: MEDLINE

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[PMID]: 26159287 [Au] Autor: Brown GR; Kulbarsh KD; Spencer KA; Duval C [Ad] Endereço: School of Psychology & Neuroscience, University of St Andrews, UK. Electronic address: grb4@st-andrews.ac.uk. [Ti] Título: Peri-pubertal exposure to testicular hormones organizes response to novel environments and social behaviour in adult male rats. [So] Source: Horm Behav;73:135-41, 2015 Jul. [Is] ISSN: 1095-6867 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Previous research has shown that exposure to testicular hormones during the peri-pubertal period of life has long-term, organizational effects on adult sexual behaviour and underlying neural mechanisms in laboratory rodents. However, the organizational effects of peri-pubertal testicular hormones on other aspects of behaviour and brain function are less well understood. Here, we investigated the effects of manipulating peri-pubertal testicular hormone exposure on later behavioural responses to novel environments and on hormone receptors in various brain regions that are involved in response to novelty. Male rodents generally spend less time in the exposed areas of novel environments than females, and this sex difference emerges during the peri-pubertal period. Male Lister-hooded rats (Rattus norvegicus) were castrated either before puberty or after puberty, then tested in three novel environments (elevated plus-maze, light-dark box, open field) and in an object/social novelty task in adulthood. Androgen receptor (AR), oestrogen receptor (ER1) and corticotropin-releasing factor receptor (CRF-R2) mRNA expression were quantified in the hypothalamus, hippocampus and medial amygdala. The results showed that pre-pubertally castrated males spent more time in the exposed areas of the elevated-plus maze and light-dark box than post-pubertally castrated males, and also confirmed that peri-pubertal hormone exposure influences later response to an opposite-sex conspecific. Hormone receptor gene expression levels did not differ between pre-pubertally and post-pubertally castrated males in any of the brain regions examined. This study therefore demonstrates that testicular hormone exposure during the peri-pubertal period masculinizes later response to novel environments, although the neural mechanisms remain to be fully elucidated. [Mh] Termos MeSH primário: Comportamento Exploratório/efeitos dos fármacos Maturidade Sexual/efeitos dos fármacos Comportamento Social Hormônios Testiculares/farmacologia [Mh] Termos MeSH secundário: Animais Hormônio Liberador da Corticotropina/metabolismo Feminino Hipocampo/metabolismo Hipotálamo/efeitos dos fármacos Hipotálamo/metabolismo Masculino Ratos Receptores Androgênicos/metabolismo Receptores de Hormônio Liberador da Corticotropina/metabolismo Receptores Estrogênicos/metabolismo Maturidade Sexual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Receptors, Androgen); 0 (Receptors, Corticotropin-Releasing Hormone); 0 (Receptors, Estrogen); 0 (Testicular Hormones); 9015-71-8 (Corticotropin-Releasing Hormone) [Em] Mês de entrada: 1603 [Cu] Atualização por classe: 171110 [Lr] Data última revisão: 171110 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150711 [St] Status: MEDLINE

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[PMID]: 24844827 [Au] Autor: Chen X; Ma J; Yu H; Leng L; Zhou Q; Sun Z; Tang N [Ad] Endereço: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. [Ti] Título: [Study on the association between maternal urinary phthalate metabolites and testicular steroid hormones in the cord blood in a Chinese population]. [So] Source: Zhonghua Yu Fang Yi Xue Za Zhi;48(3):167-71, 2014 Mar. [Is] ISSN: 0253-9624 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVE: The purposes of our study were to investigate the association between maternal urinary phthalate metabolites and the levels of inhibin B (INHB) and insulin-like factor 3 (INSL3) in the cord blood in a Chinese pregnant population. METHODS: Maternal urine samples in the third trimester of pregnancy of 69 participants were collected and stored, and the samples of cord blood (10 ml) were collected at delivery between June 2011 and September 2012 in a comprehensive hospital of gynecology and obstetrics in Tianjin, China.Four phthalate metabolites, monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), and mono-2-ethylhexyl phthalate (MEHP) were measured in the urine samples using liquid chromatography-tandem mass spectrometry. The levels of INHB, INSL3 in the cord blood were tested by ELISA. Associations of phthalate exposure with INHB and INSL3 levels were determined by spearman correlation and multiple regression model analysis. RESULTS: The median concentrations of observed metabolites in descending order were 49.74 µg/L for MMP, 24.96 µg/L for MEHP, 19.52 µg/L for MEP and 17.73 µg/L for MBP. The median concentrations of INHB and INSL3 were 89.09 and 106.21 ng/L.Significant negative associations between INHB and MMP(ß' = -0.252), MEP(ß' = -0.363) or the sum value (∑PAEs) (ß' = -0.346) were found by the multiple regression model analysis. For INSL3, only the sum value (ß' = -0.313) was inversely significantly associated with the levels of INSL3 in the cord blood. CONCLUSIONS: Maternal urinary phthalate metabolites were associated with INHB and INSL3 in the cord blood in a Chinese population. [Mh] Termos MeSH primário: Subunidades beta de Inibinas/sangue Insulina/sangue Ácidos Ftálicos/urina Hormônios Testiculares/sangue [Mh] Termos MeSH secundário: Adulto Dietilexilftalato/análogos & derivados Dietilexilftalato/urina Feminino Sangue Fetal/química Seres Humanos Recém-Nascido Masculino Exposição Materna Gravidez Proteínas Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Insulin); 0 (Leydig insulin-like protein); 0 (Phthalic Acids); 0 (Proteins); 0 (Testicular Hormones); 0 (monoethyl phthalate); 2STT6D18JR (monomethyl phthalate); 6O7F7IX66E (phthalic acid); 93443-12-0 (Inhibin-beta Subunits); C42K0PH13C (Diethylhexyl Phthalate); FU2EWB60RT (mono-(2-ethylhexyl)phthalate); ZI46LWZ45G (monobutyl phthalate) [Em] Mês de entrada: 1502 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140522 [St] Status: MEDLINE

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[PMID]: 24366307 [Au] Autor: Chen X; Zhang Z; Chang X; Niu Y; Cui H [Ad] Endereço: Gynecologic Oncology Center, Peking University People's Hospital, Beijing 100044, P.R. China. [Ti] Título: Production of transgenic mice expressing tumor virus A under ovarian­specific promoter 1 control using testis­mediated gene transfer. [So] Source: Mol Med Rep;9(3):955-60, 2014 Mar. [Is] ISSN: 1791-3004 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: The aim of the present study was to produce transgenic mice expressing tumor virus A (TVA) in the ovary under ovarian specific promoter 1 (OSP1) control. A transgenic mouse model was established in which TVA, an avian retroviral receptor gene driven by OSP1, was selectively expressed in the ovary. A recombinant plasmid containing TVA cDNA and an OSP1 promoter was constructed. The DNA fragment was repeatedly injected into male mouse testes at multiple sites. At 4­7, 7­10 and 10­13 weeks following the final injection, two DNA­injected male mice were mated with four wild­type female mice to produce transgenic mice. The transgenic positive rate in mouse F1 offspring was 39.69%. When the positive F1 individuals were mated with wild­type Imprinting Control Region mice (PxW) or with positive F1 individuals (PxP), the F2 individuals had a transgenic rate of 12.44%. The transgenic rates in the F1 offspring, produced following mating at the three time intervals, were 55.71 (39/70), 30.77 (4/13) and 18.75% (9/48), respectively. The transgenic rates of the F2 offspring decreased with the age of the F1 offspring, from 26.67% when PxP were mated at 6­8 weeks of age to 6.52% when PxW were mated at 5­6 months of age. The results indicate a high efficiency of gene transfer to F1 offspring using testis­mediated gene transfer (TMGT). The transgenic rate in the F2 offspring was lower than that in the F1 offspring. The results reveal that TMGT is suitable for creating transgenic animals among F1 offspring. Semi­quantitative reverse transcription-polymerase chain reaction results showed that TVA was expressed in the mice ovaries. The results demonstrate the importance of using the replication­competent avian sarcoma­leukosis virus long terminal repeat with a splice acceptor­TVA system in ovarian tumorigenesis research. [Mh] Termos MeSH primário: Técnicas de Transferência de Genes Vírus Oncogênicos/genética Regiões Promotoras Genéticas/genética Hormônios Testiculares/genética Testículo/metabolismo [Mh] Termos MeSH secundário: Animais Feminino Vetores Genéticos/genética Vetores Genéticos/metabolismo Masculino Camundongos Camundongos Transgênicos Hormônios Testiculares/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Testicular Hormones); 0 (germ cell-specific protein 1, mouse) [Em] Mês de entrada: 1409 [Cu] Atualização por classe: 140129 [Lr] Data última revisão: 140129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 131225 [St] Status: MEDLINE [do] DOI: 10.3892/mmr.2013.1876

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[PMID]: 24157129 [Au] Autor: Pilipovic I; Radojevic K; Kosec D; Nanut MP; Stojic-Vukanic Z; Arsenovic-Ranin N; Leposavic G [Ad] Endereço: Immunology Research Centre "Branislav Jankovic", Institute of Virology, Vaccines and Sera "Torlak", 458 Vojvode Stepe, 11221 Belgrade, Serbia. [Ti] Título: Gonadal hormone dependent developmental plasticity of catecholamine:ß2-adrenoceptor signaling complex in male rat thymus: putative implications for thymopoiesis. [So] Source: J Neuroimmunol;265(1-2):20-35, 2013 Dec 15. [Is] ISSN: 1872-8421 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The study was undertaken considering that: i) androgens affect ß2-adrenoceptor (AR)-mediated catecholamine (CA) action in many tissues; and ii) peripubertal changes in both circulating androgen and thymic CA levels are implicated in rat thymic involution. Its aims were to: i) explore putative effects of the late prepubertal orchidectomy on thymic CA:ß2-AR complex in young adult rats, and ii) delineate the direct effects of testicular hormone withdrawal on the CA:ß2-AR complex from those elicited secondarily through altered influence of this complex components on each other's availability. Upon showing that prepubertal orchidectomy augmented the efficacy of thymopoiesis through increasing the thymocyte surface density of Thy-1, whose expression is negatively regulated by ß2-AR-mediated signaling, we examined the effects of orchidectomy and 14-day-long propranolol (PROP) treatment in orchidectomized (ORX) and sham-ORX rats on thymic norepinephrine (NE) concentration and metabolism and ß2-AR expression. Orchidectomy, despite an increase in the average NE amount per thymocyte and total thymocyte NE content, diminished thymic NE concentration. This decrease reflected the diminished density of CA-synthesizing nerve fibers, CD68+ macrophages, cortical (aminopeptidase A+), and medullary (UEA-1+) thymic epithelial cells (TECs) and their CA content (probably due to lessened TH expression accompanied by increased MAO-A expression). Moreover, orchidectomy decreased the surface ß2-AR expression on thymocytes, CD68+ macrophages and OX-62+ dendritic cells, but increased its expression on the TECs. In sham-ORX rats, PROP reduced thymic NE concentration by diminishing TH expression in the thymic cells. Additionally, PROP in thymocytes and thymic stromal cells diminished and enhanced the ß2-AR mRNA expression, respectively. However, in ORX rats PROP did not significantly affect CA(NE):ß2-AR complex components. This indicated that prepubertal orchidectomy affects ability of young adult rats to respond to ß-AR blockade by altering thymic NE and ß2-AR availability. Collectively, the results showed that testicular hormones contribute to alterations in thymus/thymopoiesis during the critical peripubertal period by shaping modulatory sympathetic influence and CA autocrine/paracrine action within the organ. [Mh] Termos MeSH primário: Catecolaminas/metabolismo Receptores Adrenérgicos beta/metabolismo Transdução de Sinais/fisiologia Hormônios Testiculares/metabolismo Timo/metabolismo [Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/farmacologia Animais Diferenciação Celular/efeitos dos fármacos Proliferação Celular/efeitos dos fármacos Células Dendríticas/efeitos dos fármacos Células Dendríticas/metabolismo Células Epiteliais/metabolismo Glutamil Aminopeptidase/metabolismo Macrófagos/efeitos dos fármacos Macrófagos/metabolismo Masculino Fibras Nervosas/efeitos dos fármacos Fibras Nervosas/metabolismo Orquiectomia Lectinas de Plantas/metabolismo Propranolol/farmacologia Ratos Receptores Adrenérgicos beta/genética Transdução de Sinais/efeitos dos fármacos Timócitos/efeitos dos fármacos Timócitos/metabolismo Timo/citologia Timo/efeitos dos fármacos Tirosina 3-Mono-Oxigenase/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Adrenergic beta-Antagonists); 0 (Catecholamines); 0 (Plant Lectins); 0 (Receptors, Adrenergic, beta); 0 (Testicular Hormones); 0 (Ulex europaeus lectins); 9Y8NXQ24VQ (Propranolol); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); EC 3.4.11.7 (Glutamyl Aminopeptidase) [Em] Mês de entrada: 1401 [Cu] Atualização por classe: 131203 [Lr] Data última revisão: 131203 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 131026 [St] Status: MEDLINE

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[PMID]: 23451117 [Au] Autor: Jamsai D; O'Connor AE; Deboer KD; Clark BJ; Smith SJ; Browne CM; Bensley JG; Merriman JA; Yuen WS; Koopman P; Jones KT; O'Bryan MK [Ad] Endereço: Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia. duangporn.jamsai@monash.edu [Ti] Título: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. [So] Source: PLoS One;8(2):e56955, 2013. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells, key components of such pathways remain largely unidentified. Gametogenetin (GGN) is a testis-enriched protein that has been shown to bind to the DNA repair protein FANCL via yeast-two-hybrid assays. This finding and its testis-enriched expression pattern raise the possibility that GGN plays a role in DNA repair during spermatogenesis. Herein we demonstrated that the largest isoform GGN1 interacted with components of DNA repair machinery in the mouse testis. In addition to FANCL, GGN1 interacted with the critical component of the Fanconi Anemia (FA) pathway FANCD2 and a downstream component of the BRCA pathway, BRCC36. To define the physiological function of GGN, we generated a Ggn null mouse line. A complete loss of GGN resulted in embryonic lethality at the very earliest period of pre-implantation development, with no viable blastocysts observed. This finding was consistent with the observation that Ggn mRNA was also expressed in lower levels in the oocyte and pre-implantation embryos. Moreover, pachytene spermatocytes of the Ggn heterozygous knockout mice showed an increased incidence of unrepaired DNA double strand breaks (DSBs). Together, our results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos. [Mh] Termos MeSH primário: Quebras de DNA de Cadeia Dupla Reparo do DNA/fisiologia Hormônios Testiculares/metabolismo [Mh] Termos MeSH secundário: Animais Células Cultivadas Reparo do DNA/genética Desenvolvimento Embrionário/genética Feminino Imunoprecipitação Masculino Camundongos Camundongos Knockout Reação em Cadeia da Polimerase Via Transcriptase Reversa Hormônios Testiculares/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Ggn protein, mouse); 0 (Testicular Hormones) [Em] Mês de entrada: 1309 [Cu] Atualização por classe: 150218 [Lr] Data última revisão: 150218 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130302 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0056955

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[PMID]: 23321184 [Au] Autor: Dong Y; Du RC; Jiang YT; Wu J; Li LL; Liu RZ [Ad] Endereço: Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, The First Hospital, Jilin University, Changchun, Jilin Province, China. [Ti] Título: Impact of chromosomal translocations on male infertility, semen quality, testicular volume and reproductive hormone levels. [So] Source: J Int Med Res;40(6):2274-83, 2012. [Is] ISSN: 1473-2300 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To analyse the relationship between male infertility and chromosomal translocations, and the influence of different types of chromosomal translocations on semen quality, testicular volume and hormone levels. METHODS: A retrospective cohort of infertile men was recruited for chromosomal analysis using standard Giemsa stain banding. Physical examinations, semen analysis, hormonal analysis and the detection of azoospermia factor (AZF) microdeletions were carried out. Men with normal fertility were used as controls. RESULTS: Among the 1056 infertile men, 22 had chromosomal translocations (2.1%), including seven with Robertsonian translocations (0.7%), 11 with autosome-autosome reciprocal translocations (1.0%) and four with gonosome-autosome reciprocal translocations (0.4%). Left and right testicular volumes of patients with chromosomal translocations were significantly smaller than those in the fertile control group. There were no significant differences in hormone levels between patients with chromosomal translocations and fertile controls, except for significantly lower testosterone levels in patients with Robertsonian and gonosome-autosome reciprocal translocations compared with the controls. All AZF microdeletion analyses showed normal results. CONCLUSIONS: Chromosomal translocations may cause reductions in testicular volume and testosterone level, which may impact spermatogenesis, resulting in azoospermia or oligozoospermia and male infertility. [Mh] Termos MeSH primário: Infertilidade Masculina/genética Análise do Sêmen Hormônios Testiculares/sangue Translocação Genética [Mh] Termos MeSH secundário: Adulto Azoospermia/genética Estudos de Coortes Seres Humanos Cariótipo Masculino Meia-Idade Estudos Retrospectivos Espermatogênese/genética Hormônios Testiculares/análise Testículo/fisiologia Testosterona/sangue Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Testicular Hormones); 3XMK78S47O (Testosterone) [Em] Mês de entrada: 1309 [Cu] Atualização por classe: 170214 [Lr] Data última revisão: 170214 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130117 [St] Status: MEDLINE

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[PMID]: 23017989 [Au] Autor: Min KJ; Lee CK; Park HN [Ti] Título: The lifespan of Korean eunuchs. [So] Source: Curr Biol;22(18):R792-3, 2012 Sep 25. [Is] ISSN: 1879-0445 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Eunuquismo Longevidade Orquiectomia [Mh] Termos MeSH secundário: Adoção Família Seres Humanos Masculino República da Coreia Hormônios Testiculares/deficiência Hormônios Testiculares/fisiologia [Pt] Tipo de publicação: LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Testicular Hormones) [Em] Mês de entrada: 1304 [Cu] Atualização por classe: 160401 [Lr] Data última revisão: 160401 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 120929 [St] Status: MEDLINE

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[PMID]: 22417467 [Au] Autor: Das RR [Ti] Título: Antibiotic treatment of acute otitis media in children: which schedule to follow? [So] Source: J Paediatr Child Health;48(3):283, 2012 Mar. [Is] ISSN: 1440-1754 [Cp] País de publicação: Australia [La] Idioma: eng [Mh] Termos MeSH primário: Fator de Crescimento Epidérmico/fisiologia Glicoproteínas Inibidores do Crescimento/fisiologia Ductos Paramesonéfricos Hormônios Testiculares/fisiologia Testículo/embriologia [Mh] Termos MeSH secundário: Seres Humanos Masculino [Pt] Tipo de publicação: COMMENT; LETTER [Nm] Nome de substância: 0 (Glycoproteins); 0 (Growth Inhibitors); 0 (Testicular Hormones); 62229-50-9 (Epidermal Growth Factor) [Em] Mês de entrada: 1208 [Cu] Atualização por classe: 120315 [Lr] Data última revisão: 120315 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 120316 [St] Status: MEDLINE [do] DOI: 10.1111/j.1440-1754.2012.02417.x

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