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[PMID]: 28707374 [Au] Autor: Uno T; Furutani M; Sakamoto K; Uno Y; Kanamaru K; Mizoguchi A; Hiragaki S; Takeda M [Ad] Endereço: Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Hyogo, Japan. [Ti] Título: Localization and functional analysis of the insect-specific RabX4 in the brain of Bombyx mori. [So] Source: Arch Insect Biochem Physiol;96(1), 2017 Sep. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Rab proteins are small monomeric GTPases/GTP-binding proteins, which form the largest branch of the Ras superfamily. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane trafficking. RabX4 is an insect-specific Rab protein that has no close homolog in vertebrates. There is little information about insect-specific Rab proteins. RabX4 was expressed in Escherichia coli and subsequently purified. Antibodies against Bombyx mori RabX4 were produced in rabbits for western immunoblotting and immunohistochemistry. Western blotting of neural tissues revealed a single band, at approximately 26 kD. RabX4-like immunohistochemical reactivity was restricted to neurons of the pars intercerebralis and dorsolateral protocerebrum in the brain. Further immunohistochemical analysis revealed that RabX4 colocalized with Rab6 and bombyxin in the corpus allatum, a neuronal organ that secretes neuropeptides synthesized in the brain into the hemolymph. RabX4 expression in the frontal ganglion, part of the insect stomatogastric nervous system that is found in most insect orders, was restricted to two neurons on the outer region and did not colocalize with allatotropin or Rab6. Furthermore, RNA interference of RabX4 decreased bombyxin expression levels in the brain. These findings suggest that RabX4 is involved in the neurosecretion of a secretory organ in Bombyx mori. [Mh] Termos MeSH primário: Bombyx/metabolismo Corpora Allata/metabolismo Proteínas de Insetos/metabolismo Proteínas rab de Ligação ao GTP/metabolismo [Mh] Termos MeSH secundário: Animais Encéfalo/metabolismo Gânglios dos Invertebrados/metabolismo Hormônios de Inseto/metabolismo Neurônios/metabolismo Neurônios/secreção Neuropeptídeos/metabolismo Neuropeptídeos/secreção Interferência de RNA [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Insect Proteins); 0 (Neuropeptides); 110098-88-9 (bombyxins); 75831-28-6 (allatotropin); EC 3.6.5.2 (rab GTP-Binding Proteins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171003 [Lr] Data última revisão: 171003 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170715 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21404

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[PMID]: 28634987 [Au] Autor: Shi G; Zhan P; Jin W; Fei J; Zhao L [Ad] Endereço: Huzhou Academy of Agricultural Sciences, Huzhou, Zhejiang, P.R. China. [Ti] Título: Dietary TiO particles modulate expression of hormone-related genes in Bombyx mori. [So] Source: Arch Insect Biochem Physiol;95(4), 2017 Aug. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Silkworm (Bombyx mori) is an economically beneficial insect. Its growth and development are regulated by endogenous hormones. In the present study, we found that feeding titanium dioxide nanoparticles (TiO NP) caused a significant increase of body size. TiO NP stimulated the transcription of several genes, including the insulin-related hormone bombyxin, PI3K/Akt/TOR (where PI3K is phosphatidylinositol 3-kinase and TOR is target of rapamycin), and the adenosine 5'-monophosphateactivated protein kinase (AMPK)/target of rapamycin (TOR) pathways. Differentially expressed gene (DEG) analysis documented 26 developmental hormone signaling related genes that were differentially expressed following dietary TiO NP treatment. qPCR analysis confirmed the upregulation of insulin/ecdysteroid signaling genes, such as bombyxin B-1, bombyxin B-4, bombyxin B-7, MAPK, P70S6K, PI3k, eIF4E, E75, ecdysteroid receptor (EcR), and insulin-related peptide binding protein precursor 2 (IBP2). We infer from the upregulated expression of bombyxins and the signaling network that they act in bombyxin-stimulated ecdysteroidogenesis. [Mh] Termos MeSH primário: Bombyx/metabolismo Regulação da Expressão Gênica/efeitos dos fármacos Titânio/farmacologia [Mh] Termos MeSH secundário: Animais Bombyx/efeitos dos fármacos Bombyx/genética Perfilação da Expressão Gênica Genes de Insetos Hormônios de Inseto/metabolismo Nanopartículas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170622 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21397

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[PMID]: 28620971 [Au] Autor: Gäde G; Marco HG [Ad] Endereço: Department of Biological Sciences, University of Cape Town, Rondebosch, South Africa. [Ti] Título: The adipokinetic hormone of the coleopteran suborder Adephaga: Structure, function, and comparison of distribution in other insects. [So] Source: Arch Insect Biochem Physiol;95(3), 2017 Jul. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The aim of the current study is to identify the adipokinetic hormone(s) (AKHs) of a basal suborder of the species-rich Coleoptera, the Adephaga, and possibly learn more about the ancestral AKH of beetles. Moreover, we wanted to compare the ancestral AKH with AKHs of more advanced beetles, of which a number are pest insects. This would allow us to assess whether AKH mimetics would be suitable as insecticides, that is, be harmful to the pest species but not to the beneficial species. Nine species of the Adephaga were investigated and all synthesize only one octapeptide in the corpus cardiacum, as revealed by Edman degradation sequencing techniques or by mass spectrometry. The amino acid sequence pGlu-Leu-Asn-Phe-Ser-Thr-Gly-Trp corresponds to Schgr-AKH-II that was first identified in the desert locust. It is assumed that Schgr-AKH-II-the peptide of a basal beetle clade-is the ancestral AKH for beetles. Some other beetle families, as well as some Hymenoptera (including honey bees) also contain this peptide, whereas most of the pest beetle species have different AKHs. This argues that those peptides and their receptors should be explored for developing mimetics with insecticidal properties. A scenario where Schgr-AKH-II (the only AKH of Adephaga) is used as basic molecular structure to derive almost all other known beetle AKHs via single step mutations is very likely, and supports the interpretation that Schgr-AKH-II is the ancestral AKH of Coleoptera. [Mh] Termos MeSH primário: Coleópteros/genética Evolução Molecular Hormônios de Inseto/genética Neuropeptídeos/genética Ácido Pirrolidonocarboxílico/análogos & derivados [Mh] Termos MeSH secundário: Animais Coleópteros/química Coleópteros/metabolismo Hormônios de Inseto/análise Hormônios de Inseto/biossíntese Hormônios de Inseto/química Masculino Neuropeptídeos/análise Neuropeptídeos/biossíntese Neuropeptídeos/química Periplaneta Ácido Pirrolidonocarboxílico/análise Ácido Pirrolidonocarboxílico/química [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Neuropeptides); 134599-16-9 (adipokinetic hormone, beetle); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170617 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21399

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[PMID]: 28440594 [Au] Autor: Park Y; Kim Y [Ad] Endereço: Department of Bio-Sciences, Andong National University, Andong, Korea. [Ti] Título: Identification of a hypertrehalosemic factor in Spodoptera exigua. [So] Source: Arch Insect Biochem Physiol;95(1), 2017 May. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Trehalose is a major blood sugar in insects with a range of physiological functions, including an energy source and a cryoprotectant. Hemolymph trehalose concentrations are tightly regulated according to physiological conditions. An insulin-like peptide, SeILP1, downregulates hemolymph trehalose concentrations in Spodoptera exigua. Here, we identified a factor that upregulates hemolymph trehalose concentration in S. exigua. Hemolymph trehalose concentrations were significantly increased after immune challenge or under starvation in a time-dependent manner. To determine endocrine factors responsible for the upregulation, stress-associated mediators, such as octopamine, serotonin, or eicosanoids were injected, but they did not upregulate hemolymph trehalose. On the other hand, injection with Schistocerca gregaria adipokinetic hormone (AKH) significantly increased hemolymph trehalose concentration in S. exigua. During upregulation of hemolymph trehalose by AKH injection, trehalose degradation appeared to be inhibited because expression of trehalase and SeILP1 were significantly suppressed while that of trehalose phosphate synthase was not significantly changed. Interrogation of a Spodoptera genome database identified an S. exigua AKH-like gene and its expression was confirmed. During starvation, its expression concentrations were increased, although RNA interference specific to the AKH-like hypertrehalosemic factor (SeHTF) gene significantly prevented the upregulation of hemolymph trehalose concentrations during starvation. A synthetic peptide of SeHTF was prepared and injected into S. exigua larvae. At nanomolar concentration, the synthetic SeHTF peptide effectively upregulated hemolymph trehalose concentrations. Here we report a novel hypertrehalosemic factor in S. exigua (SeHTF). [Mh] Termos MeSH primário: Proteínas de Insetos/genética Proteínas de Insetos/metabolismo Spodoptera/metabolismo Trealose/metabolismo [Mh] Termos MeSH secundário: Animais Regulação da Expressão Gênica/efeitos dos fármacos Genoma de Inseto Gafanhotos/química Hemolinfa/metabolismo Hormônios de Inseto/farmacologia Proteínas de Insetos/farmacologia Oligopeptídeos/farmacologia Ácido Pirrolidonocarboxílico/análogos & derivados Ácido Pirrolidonocarboxílico/farmacologia Interferência de RNA Spodoptera/efeitos dos fármacos Spodoptera/genética Inanição Trealase/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Insect Proteins); 0 (Oligopeptides); 0 (adipokinetic hormone); B8WCK70T7I (Trehalose); EC 3.2.1.28 (Trehalase); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170720 [Lr] Data última revisão: 170720 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170426 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21386

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[PMID]: 28426765 [Au] Autor: Hernández-Martínez S; Sánchez-Zavaleta M; Brito K; Herrera-Ortiz A; Ons S; Noriega FG [Ad] Endereço: Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México. [Ti] Título: Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses. [So] Source: PLoS One;12(4):e0175759, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Allatotropins (AT) are neuropeptides with pleotropic functions on a variety of insect tissues. They affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. The present work provides experimental evidence that AT elicits immune responses in two important mosquito disease vectors, Anopheles albimanus and Aedes aegypti. Hemocytes and an immune-competent mosquito cell line responded to AT by showing strong morphological changes and increasing bacterial phagocytic activity. Phenoloxidase activity in hemolymph was also increased in Ae. aegypti mosquitoes treated with AT but not in An. albimanus, suggesting differences in the AT-dependent immune activation in the two species. In addition, two important insect immune markers, nitric oxide levels and expression of antimicrobial peptide genes, were increased in An. albimanus guts after AT treatment. AT conjugated to quantum dot nanocrystals (QDots) specifically labeled hemocytes in vivo in both mosquito species, implying molecular interactions between AT and hemocytes. The results of our studies suggest a new role for AT in the modulation of the immune response in mosquitoes. [Mh] Termos MeSH primário: Aedes/imunologia Anopheles/imunologia Hormônios de Inseto/farmacologia Neuropeptídeos/farmacologia [Mh] Termos MeSH secundário: Animais Hemócitos/imunologia Hemolinfa/enzimologia Imunidade Celular Monofenol Mono-Oxigenase/sangue Fagocitose [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Neuropeptides); 75831-28-6 (allatotropin); EC 1.14.18.1 (Monophenol Monooxygenase) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170907 [Lr] Data última revisão: 170907 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170421 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0175759

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[PMID]: 28334024 [Au] Autor: Solari P; Rivelli N; De Rose F; Picciau L; Murru L; Stoffolano JG; Liscia A [Ad] Endereço: Department of Biomedical Sciences, University of Cagliari, University Campus, S.P. 8, Monserrato (CA), Italy. [Ti] Título: Opposite effects of 5-HT/AKH and octopamine on the crop contractions in adult Drosophila melanogaster: Evidence of a double brain-gut serotonergic circuitry. [So] Source: PLoS One;12(3):e0174172, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This study showed that in adult Drosophila melanogaster, the type of sugar-either present within the crop lumen or in the bathing solution of the crop-had no effect on crop muscle contraction. What is important, however, is the volume within the crop lumen. Electrophysiological recordings demonstrated that exogenous applications of serotonin on crop muscles increases both the amplitude and the frequency of crop contraction rate, while adipokinetic hormone mainly enhances the crop contraction frequency. Conversely, octopamine virtually silenced the overall crop activity. The present study reports for the first time an analysis of serotonin effects along the gut-brain axis in adult D. melanogaster. Injection of serotonin into the brain between the interocellar area shows that brain applications of serotonin decrease the frequency of crop activity. Based on our results, we propose that there are two different, opposite pathways for crop motility control governed by serotonin: excitatory when added in the abdomen (i.e., directly bathing the crop) and inhibitory when supplied within the brain (i.e., by injection). Finally, our results point to a double brain-gut serotonergic circuitry suggesting that not only the brain can affect gut functions, but the gut can also affect the central nervous system. On the basis of our results, and data in the literature, a possible mechanism for these two discrete serotonergic functions is suggested. [Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos Sistema Digestório/efeitos dos fármacos Drosophila melanogaster/efeitos dos fármacos Hormônios de Inseto/farmacologia Contração Muscular/efeitos dos fármacos Octopamina/farmacologia Oligopeptídeos/farmacologia Ácido Pirrolidonocarboxílico/análogos & derivados Serotonina/farmacologia [Mh] Termos MeSH secundário: Animais Encéfalo/fisiologia Sistema Digestório/inervação Drosophila melanogaster/anatomia & histologia Masculino Contração Muscular/fisiologia Ácido Pirrolidonocarboxílico/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Oligopeptides); 129204-82-6 (DAKH peptide); 14O50WS8JD (Octopamine); 333DO1RDJY (Serotonin); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170324 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0174172

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[PMID]: 28257925 [Au] Autor: Shaik HA; Mishra A; Kodrík D [Ad] Endereço: Institute of Entomology, Biology Centre, CAS, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic. [Ti] Título: Beneficial effect of adipokinetic hormone on neuromuscular paralysis in insect body elicited by braconid wasp venom. [So] Source: Comp Biochem Physiol C Toxicol Pharmacol;196:11-18, 2017 Jun. [Is] ISSN: 1532-0456 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The effect of Habrobracon hebetor venom and the role of the adipokinetic hormone (AKH) in poisoned adult females of the firebug Pyrrhocoris apterus were studied 24 and 48h after treatments. Venom application elicited total neuromuscular paralysis in firebugs, but the co-application of venom and Pyrap-AKH significantly reduced paralysis (up to 3.2 times) compared to the application of venom only. Although the mechanisms of their action are unknown, both agents might affect neuromuscular junctions. Venom application significantly increased the expression of both P. apterus Akh genes (Pyrap-Akh 5.4 times and Peram-Cah-II 3.6 times), as well as the level of AKHs in the central nervous system (2.5 times) and haemolymph (3.0 times). In the haemolymph, increased AKH levels might have led to the mobilization of stored lipids, which increased 1.9 times, while the level of free carbohydrates remained unchanged. Total metabolism, monitored by carbon dioxide production, significantly declined in paralysed P. apterus individuals (1.4 times and 1.9 times, 24 and 48h after the treatment, respectively), probably because of a malfunction of the muscular system. The results suggest an active role of AKH in the defence mechanism against the stress elicited by neuromuscular paralysis, and the possible involvement of this hormone in neuronal/neuromuscular signalling. [Mh] Termos MeSH primário: Sistema Nervoso Central/efeitos dos fármacos Heterópteros/efeitos dos fármacos Hormônios de Inseto/agonistas Neuropeptídeos/fisiologia Oligopeptídeos/agonistas Paralisia/veterinária Ácido Pirrolidonocarboxílico/análogos & derivados Regulação para Cima/efeitos dos fármacos Venenos de Vespas/toxicidade [Mh] Termos MeSH secundário: Alostase Animais Biomarcadores/metabolismo Sistema Nervoso Central/metabolismo República Tcheca Relação Dose-Resposta a Droga Metabolismo Energético/efeitos dos fármacos Feminino Hemolinfa/efeitos dos fármacos Hemolinfa/metabolismo Heterópteros/fisiologia Injeções Hormônios de Inseto/genética Hormônios de Inseto/fisiologia Hormônios de Inseto/secreção Cinética Junção Neuromuscular/efeitos dos fármacos Junção Neuromuscular/fisiologia Neuropeptídeos/agonistas Neuropeptídeos/análise Neuropeptídeos/genética Neuropeptídeos/secreção Oligopeptídeos/genética Oligopeptídeos/fisiologia Oligopeptídeos/secreção Paralisia/induzido quimicamente Ácido Pirrolidonocarboxílico/agonistas Tórax Venenos de Vespas/antagonistas & inibidores Venenos de Vespas/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Insect Hormones); 0 (Neuropeptides); 0 (Oligopeptides); 0 (Pea-CAH-II neuropeptide); 0 (Wasp Venoms); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170809 [Lr] Data última revisão: 170809 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170305 [St] Status: MEDLINE

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[PMID]: 28254268 [Au] Autor: Ibrahim E; Hejníková M; Shaik HA; Dolezel D; Kodrík D [Ad] Endereço: Institute of Entomology, Biology Centre, CAS, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Agriculture, University of Cairo, Giza, Egypt. [Ti] Título: Adipokinetic hormone activities in insect body infected by entomopathogenic nematode. [So] Source: J Insect Physiol;98:347-355, 2017 Apr. [Is] ISSN: 1879-1611 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The role of adipokinetic hormone (AKH) in the firebug Pyrrhocoris apterus adults infected by the entomopathogenic nematode (EPN) Steinernema carpocapsae was examined in this study. It was found that co-application of EPN and AKH enhanced firebug mortality about 2.5 times within 24h (from 20 to 51% in EPN vs. EPN+AKH treatments), and resulted in metabolism intensification, as carbon dioxide production in firebugs increased about 2.1 and 1.6times compared to control- and EPN-treated insects, respectively. Accordingly, firebugs with reduced expression of AKH receptors showed a significantly lower mortality (by 1.6 to 2.9-folds), and lower general metabolism after EPN+AKH treatments. In addition, EPN application increased Akh gene expression in the corpora cardiaca (1.6times), AKH level in the corpora cardiaca (1.3times) and haemolymph (1.7times), and lipid and carbohydrate amounts in the haemolymph. Thus, the outcomes of the present study demonstrate involvement of AKH into the anti-stress reaction elicited by the nematobacterial infection. The exact mechanism by which AKH acts is unknown, but results suggested that the increase of metabolism and nutrient amounts in haemolymph might play a role. [Mh] Termos MeSH primário: Heterópteros/metabolismo Heterópteros/parasitologia Hormônios de Inseto/metabolismo Oligopeptídeos/metabolismo Ácido Pirrolidonocarboxílico/análogos & derivados Rabditídios/fisiologia [Mh] Termos MeSH secundário: Animais Corpora Allata/metabolismo Hemolinfa/metabolismo Masculino Especificidade de Órgãos Ácido Pirrolidonocarboxílico/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Oligopeptides); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170714 [Lr] Data última revisão: 170714 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170304 [St] Status: MEDLINE

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[PMID]: 28225562 [Au] Autor: Gäde G; Marco HG [Ad] Endereço: Department of Biological Sciences, University of Cape Town, Rondebosch, South Africa. [Ti] Título: The adipokinetic hormone of Mantodea in comparison to other Dictyoptera. [So] Source: Arch Insect Biochem Physiol;94(3), 2017 Mar. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Six species of the order Mantodea (praying mantises) are investigated for the presence and sequence of putative adipokinetic hormones (AKHs). The selected species span a wide evolutionary range of various families and subfamilies of the clade Mantodea. The corpora cardiaca of the different species are dissected, methanolic extracts prepared, peptides separated by liquid chromatography, and AKHs detected and sequenced by ion trap mass spectrometry. All six species investigated contain an octapeptide with the primary structure pGlu-Val-Asn-Phe-Thr-Pro-Asn-Trp amide, which is code-named Emppe-AKH and had been found earlier in three other species of Mantodea. Conspecific bioassays with the species Creoboter sp. (family Hymenopodidae) reveal an adipokinetic but not a hypertrehalosemic function of Emppe-AKH. Comparison with other members of the Dictyoptera (cockroaches, termites) show that Emppe-AKH is only found in certain termites, which have been recently placed into the Blattaria (cockroaches) as sister group to the family Cryptocercidae. Termites and cockroaches both show biodiversity in the sequence of AKHs, and some cockroach species even contain two AKHs. In contrast, all praying mantises-irrespective of their phylogenetic position-synthesize uniformly only one and the same octapeptide Emppe-AKH. [Mh] Termos MeSH primário: Hormônios de Inseto/análise Mantódeos/química Oligopeptídeos/análise Ácido Pirrolidonocarboxílico/análogos & derivados [Mh] Termos MeSH secundário: Sequência de Aminoácidos Substituição de Aminoácidos Animais Hemolinfa/química Hormônios de Inseto/metabolismo Metabolismo dos Lipídeos Masculino Mantódeos/metabolismo Espectrometria de Massas Dados de Sequência Molecular Oligopeptídeos/metabolismo Ácido Pirrolidonocarboxílico/análise Ácido Pirrolidonocarboxílico/metabolismo [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Hormones); 0 (Oligopeptides); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170310 [Lr] Data última revisão: 170310 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170223 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21376

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[PMID]: 28178568 [Au] Autor: Song W; Cheng D; Hong S; Sappe B; Hu Y; Wei N; Zhu C; O'Connor MB; Pissios P; Perrimon N [Ad] Endereço: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: rsong@genetics.med.harvard.edu. [Ti] Título: Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control. [So] Source: Cell Metab;25(2):386-399, 2017 Feb 07. [Is] ISSN: 1932-7420 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: While high-caloric diet impairs insulin response to cause hyperglycemia, whether and how counter-regulatory hormones are modulated by high-caloric diet is largely unknown. We find that enhanced response of Drosophila adipokinetic hormone (AKH, the glucagon homolog) in the fat body is essential for hyperglycemia associated with a chronic high-sugar diet. We show that the activin type I receptor Baboon (Babo) autonomously increases AKH signaling without affecting insulin signaling in the fat body via, at least, increase of Akh receptor (AkhR) expression. Further, we demonstrate that Activin-ß (Actß), an activin ligand predominantly produced in the enteroendocrine cells (EEs) of the midgut, is upregulated by chronic high-sugar diet and signals through Babo to promote AKH action in the fat body, leading to hyperglycemia. Importantly, activin signaling in mouse primary hepatocytes also increases glucagon response and glucagon-induced glucose production, indicating a conserved role for activin in enhancing AKH/glucagon signaling and glycemic control. [Mh] Termos MeSH primário: Ativinas/metabolismo Drosophila melanogaster/metabolismo Corpo Adiposo/metabolismo Trato Gastrointestinal/metabolismo Glucagon/metabolismo Hiperglicemia/metabolismo [Mh] Termos MeSH secundário: Receptores de Ativinas/metabolismo Animais Metabolismo dos Carboidratos Proteínas de Transporte/metabolismo Carboidratos da Dieta/efeitos adversos Modelos Animais de Doenças Proteínas de Drosophila/genética Proteínas de Drosophila/metabolismo Células Enteroendócrinas/metabolismo Hepatócitos/metabolismo Hiperglicemia/patologia Hormônios de Inseto/metabolismo Larva/metabolismo Camundongos Oligopeptídeos/metabolismo Ácido Pirrolidonocarboxílico/análogos & derivados Ácido Pirrolidonocarboxílico/metabolismo Interferência de RNA RNA Mensageiro/genética RNA Mensageiro/metabolismo Receptores de Glucagon/genética Receptores de Glucagon/metabolismo Transdução de Sinais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (AKHR protein, Drosophila); 0 (Carrier Proteins); 0 (Dietary Carbohydrates); 0 (Drosophila Proteins); 0 (Insect Hormones); 0 (Oligopeptides); 0 (RNA, Messenger); 0 (Receptors, Glucagon); 0 (dawdle protein, Drosophila); 104625-48-1 (Activins); 129204-82-6 (DAKH peptide); 9007-92-5 (Glucagon); EC 2.7.11.30 (Activin Receptors); EC 2.7.11.30 (Babo protein, Drosophila); SZB83O1W42 (Pyrrolidonecarboxylic Acid) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170209 [St] Status: MEDLINE

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