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  1 / 3056 MEDLINE  
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[PMID]:28707374
[Au] Autor:Uno T; Furutani M; Sakamoto K; Uno Y; Kanamaru K; Mizoguchi A; Hiragaki S; Takeda M
[Ad] Endereço:Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Hyogo, Japan.
[Ti] Título:Localization and functional analysis of the insect-specific RabX4 in the brain of Bombyx mori.
[So] Source:Arch Insect Biochem Physiol;96(1), 2017 Sep.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rab proteins are small monomeric GTPases/GTP-binding proteins, which form the largest branch of the Ras superfamily. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane trafficking. RabX4 is an insect-specific Rab protein that has no close homolog in vertebrates. There is little information about insect-specific Rab proteins. RabX4 was expressed in Escherichia coli and subsequently purified. Antibodies against Bombyx mori RabX4 were produced in rabbits for western immunoblotting and immunohistochemistry. Western blotting of neural tissues revealed a single band, at approximately 26 kD. RabX4-like immunohistochemical reactivity was restricted to neurons of the pars intercerebralis and dorsolateral protocerebrum in the brain. Further immunohistochemical analysis revealed that RabX4 colocalized with Rab6 and bombyxin in the corpus allatum, a neuronal organ that secretes neuropeptides synthesized in the brain into the hemolymph. RabX4 expression in the frontal ganglion, part of the insect stomatogastric nervous system that is found in most insect orders, was restricted to two neurons on the outer region and did not colocalize with allatotropin or Rab6. Furthermore, RNA interference of RabX4 decreased bombyxin expression levels in the brain. These findings suggest that RabX4 is involved in the neurosecretion of a secretory organ in Bombyx mori.
[Mh] Termos MeSH primário: Bombyx/metabolismo
Corpora Allata/metabolismo
Proteínas de Insetos/metabolismo
Proteínas rab de Ligação ao GTP/metabolismo
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Gânglios dos Invertebrados/metabolismo
Hormônios de Inseto/metabolismo
Neurônios/metabolismo
Neurônios/secreção
Neuropeptídeos/metabolismo
Neuropeptídeos/secreção
Interferência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Insect Proteins); 0 (Neuropeptides); 110098-88-9 (bombyxins); 75831-28-6 (allatotropin); EC 3.6.5.2 (rab GTP-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21404


  2 / 3056 MEDLINE  
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[PMID]:28634987
[Au] Autor:Shi G; Zhan P; Jin W; Fei J; Zhao L
[Ad] Endereço:Huzhou Academy of Agricultural Sciences, Huzhou, Zhejiang, P.R. China.
[Ti] Título:Dietary TiO particles modulate expression of hormone-related genes in Bombyx mori.
[So] Source:Arch Insect Biochem Physiol;95(4), 2017 Aug.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Silkworm (Bombyx mori) is an economically beneficial insect. Its growth and development are regulated by endogenous hormones. In the present study, we found that feeding titanium dioxide nanoparticles (TiO NP) caused a significant increase of body size. TiO NP stimulated the transcription of several genes, including the insulin-related hormone bombyxin, PI3K/Akt/TOR (where PI3K is phosphatidylinositol 3-kinase and TOR is target of rapamycin), and the adenosine 5'-monophosphateactivated protein kinase (AMPK)/target of rapamycin (TOR) pathways. Differentially expressed gene (DEG) analysis documented 26 developmental hormone signaling related genes that were differentially expressed following dietary TiO NP treatment. qPCR analysis confirmed the upregulation of insulin/ecdysteroid signaling genes, such as bombyxin B-1, bombyxin B-4, bombyxin B-7, MAPK, P70S6K, PI3k, eIF4E, E75, ecdysteroid receptor (EcR), and insulin-related peptide binding protein precursor 2 (IBP2). We infer from the upregulated expression of bombyxins and the signaling network that they act in bombyxin-stimulated ecdysteroidogenesis.
[Mh] Termos MeSH primário: Bombyx/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Titânio/farmacologia
[Mh] Termos MeSH secundário: Animais
Bombyx/efeitos dos fármacos
Bombyx/genética
Perfilação da Expressão Gênica
Genes de Insetos
Hormônios de Inseto/metabolismo
Nanopartículas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21397


  3 / 3056 MEDLINE  
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[PMID]:28620971
[Au] Autor:Gäde G; Marco HG
[Ad] Endereço:Department of Biological Sciences, University of Cape Town, Rondebosch, South Africa.
[Ti] Título:The adipokinetic hormone of the coleopteran suborder Adephaga: Structure, function, and comparison of distribution in other insects.
[So] Source:Arch Insect Biochem Physiol;95(3), 2017 Jul.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the current study is to identify the adipokinetic hormone(s) (AKHs) of a basal suborder of the species-rich Coleoptera, the Adephaga, and possibly learn more about the ancestral AKH of beetles. Moreover, we wanted to compare the ancestral AKH with AKHs of more advanced beetles, of which a number are pest insects. This would allow us to assess whether AKH mimetics would be suitable as insecticides, that is, be harmful to the pest species but not to the beneficial species. Nine species of the Adephaga were investigated and all synthesize only one octapeptide in the corpus cardiacum, as revealed by Edman degradation sequencing techniques or by mass spectrometry. The amino acid sequence pGlu-Leu-Asn-Phe-Ser-Thr-Gly-Trp corresponds to Schgr-AKH-II that was first identified in the desert locust. It is assumed that Schgr-AKH-II-the peptide of a basal beetle clade-is the ancestral AKH for beetles. Some other beetle families, as well as some Hymenoptera (including honey bees) also contain this peptide, whereas most of the pest beetle species have different AKHs. This argues that those peptides and their receptors should be explored for developing mimetics with insecticidal properties. A scenario where Schgr-AKH-II (the only AKH of Adephaga) is used as basic molecular structure to derive almost all other known beetle AKHs via single step mutations is very likely, and supports the interpretation that Schgr-AKH-II is the ancestral AKH of Coleoptera.
[Mh] Termos MeSH primário: Coleópteros/genética
Evolução Molecular
Hormônios de Inseto/genética
Neuropeptídeos/genética
Ácido Pirrolidonocarboxílico/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Coleópteros/química
Coleópteros/metabolismo
Hormônios de Inseto/análise
Hormônios de Inseto/biossíntese
Hormônios de Inseto/química
Masculino
Neuropeptídeos/análise
Neuropeptídeos/biossíntese
Neuropeptídeos/química
Periplaneta
Ácido Pirrolidonocarboxílico/análise
Ácido Pirrolidonocarboxílico/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Neuropeptides); 134599-16-9 (adipokinetic hormone, beetle); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21399


  4 / 3056 MEDLINE  
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[PMID]:28440594
[Au] Autor:Park Y; Kim Y
[Ad] Endereço:Department of Bio-Sciences, Andong National University, Andong, Korea.
[Ti] Título:Identification of a hypertrehalosemic factor in Spodoptera exigua.
[So] Source:Arch Insect Biochem Physiol;95(1), 2017 May.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trehalose is a major blood sugar in insects with a range of physiological functions, including an energy source and a cryoprotectant. Hemolymph trehalose concentrations are tightly regulated according to physiological conditions. An insulin-like peptide, SeILP1, downregulates hemolymph trehalose concentrations in Spodoptera exigua. Here, we identified a factor that upregulates hemolymph trehalose concentration in S. exigua. Hemolymph trehalose concentrations were significantly increased after immune challenge or under starvation in a time-dependent manner. To determine endocrine factors responsible for the upregulation, stress-associated mediators, such as octopamine, serotonin, or eicosanoids were injected, but they did not upregulate hemolymph trehalose. On the other hand, injection with Schistocerca gregaria adipokinetic hormone (AKH) significantly increased hemolymph trehalose concentration in S. exigua. During upregulation of hemolymph trehalose by AKH injection, trehalose degradation appeared to be inhibited because expression of trehalase and SeILP1 were significantly suppressed while that of trehalose phosphate synthase was not significantly changed. Interrogation of a Spodoptera genome database identified an S. exigua AKH-like gene and its expression was confirmed. During starvation, its expression concentrations were increased, although RNA interference specific to the AKH-like hypertrehalosemic factor (SeHTF) gene significantly prevented the upregulation of hemolymph trehalose concentrations during starvation. A synthetic peptide of SeHTF was prepared and injected into S. exigua larvae. At nanomolar concentration, the synthetic SeHTF peptide effectively upregulated hemolymph trehalose concentrations. Here we report a novel hypertrehalosemic factor in S. exigua (SeHTF).
[Mh] Termos MeSH primário: Proteínas de Insetos/genética
Proteínas de Insetos/metabolismo
Spodoptera/metabolismo
Trealose/metabolismo
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica/efeitos dos fármacos
Genoma de Inseto
Gafanhotos/química
Hemolinfa/metabolismo
Hormônios de Inseto/farmacologia
Proteínas de Insetos/farmacologia
Oligopeptídeos/farmacologia
Ácido Pirrolidonocarboxílico/análogos & derivados
Ácido Pirrolidonocarboxílico/farmacologia
Interferência de RNA
Spodoptera/efeitos dos fármacos
Spodoptera/genética
Inanição
Trealase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Insect Proteins); 0 (Oligopeptides); 0 (adipokinetic hormone); B8WCK70T7I (Trehalose); EC 3.2.1.28 (Trehalase); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21386


  5 / 3056 MEDLINE  
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[PMID]:28426765
[Au] Autor:Hernández-Martínez S; Sánchez-Zavaleta M; Brito K; Herrera-Ortiz A; Ons S; Noriega FG
[Ad] Endereço:Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
[Ti] Título:Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses.
[So] Source:PLoS One;12(4):e0175759, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Allatotropins (AT) are neuropeptides with pleotropic functions on a variety of insect tissues. They affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. The present work provides experimental evidence that AT elicits immune responses in two important mosquito disease vectors, Anopheles albimanus and Aedes aegypti. Hemocytes and an immune-competent mosquito cell line responded to AT by showing strong morphological changes and increasing bacterial phagocytic activity. Phenoloxidase activity in hemolymph was also increased in Ae. aegypti mosquitoes treated with AT but not in An. albimanus, suggesting differences in the AT-dependent immune activation in the two species. In addition, two important insect immune markers, nitric oxide levels and expression of antimicrobial peptide genes, were increased in An. albimanus guts after AT treatment. AT conjugated to quantum dot nanocrystals (QDots) specifically labeled hemocytes in vivo in both mosquito species, implying molecular interactions between AT and hemocytes. The results of our studies suggest a new role for AT in the modulation of the immune response in mosquitoes.
[Mh] Termos MeSH primário: Aedes/imunologia
Anopheles/imunologia
Hormônios de Inseto/farmacologia
Neuropeptídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Hemócitos/imunologia
Hemolinfa/enzimologia
Imunidade Celular
Monofenol Mono-Oxigenase/sangue
Fagocitose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Neuropeptides); 75831-28-6 (allatotropin); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175759


  6 / 3056 MEDLINE  
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[PMID]:28334024
[Au] Autor:Solari P; Rivelli N; De Rose F; Picciau L; Murru L; Stoffolano JG; Liscia A
[Ad] Endereço:Department of Biomedical Sciences, University of Cagliari, University Campus, S.P. 8, Monserrato (CA), Italy.
[Ti] Título:Opposite effects of 5-HT/AKH and octopamine on the crop contractions in adult Drosophila melanogaster: Evidence of a double brain-gut serotonergic circuitry.
[So] Source:PLoS One;12(3):e0174172, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study showed that in adult Drosophila melanogaster, the type of sugar-either present within the crop lumen or in the bathing solution of the crop-had no effect on crop muscle contraction. What is important, however, is the volume within the crop lumen. Electrophysiological recordings demonstrated that exogenous applications of serotonin on crop muscles increases both the amplitude and the frequency of crop contraction rate, while adipokinetic hormone mainly enhances the crop contraction frequency. Conversely, octopamine virtually silenced the overall crop activity. The present study reports for the first time an analysis of serotonin effects along the gut-brain axis in adult D. melanogaster. Injection of serotonin into the brain between the interocellar area shows that brain applications of serotonin decrease the frequency of crop activity. Based on our results, we propose that there are two different, opposite pathways for crop motility control governed by serotonin: excitatory when added in the abdomen (i.e., directly bathing the crop) and inhibitory when supplied within the brain (i.e., by injection). Finally, our results point to a double brain-gut serotonergic circuitry suggesting that not only the brain can affect gut functions, but the gut can also affect the central nervous system. On the basis of our results, and data in the literature, a possible mechanism for these two discrete serotonergic functions is suggested.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Sistema Digestório/efeitos dos fármacos
Drosophila melanogaster/efeitos dos fármacos
Hormônios de Inseto/farmacologia
Contração Muscular/efeitos dos fármacos
Octopamina/farmacologia
Oligopeptídeos/farmacologia
Ácido Pirrolidonocarboxílico/análogos & derivados
Serotonina/farmacologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiologia
Sistema Digestório/inervação
Drosophila melanogaster/anatomia & histologia
Masculino
Contração Muscular/fisiologia
Ácido Pirrolidonocarboxílico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Oligopeptides); 129204-82-6 (DAKH peptide); 14O50WS8JD (Octopamine); 333DO1RDJY (Serotonin); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174172


  7 / 3056 MEDLINE  
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[PMID]:28257925
[Au] Autor:Shaik HA; Mishra A; Kodrík D
[Ad] Endereço:Institute of Entomology, Biology Centre, CAS, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic.
[Ti] Título:Beneficial effect of adipokinetic hormone on neuromuscular paralysis in insect body elicited by braconid wasp venom.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;196:11-18, 2017 Jun.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of Habrobracon hebetor venom and the role of the adipokinetic hormone (AKH) in poisoned adult females of the firebug Pyrrhocoris apterus were studied 24 and 48h after treatments. Venom application elicited total neuromuscular paralysis in firebugs, but the co-application of venom and Pyrap-AKH significantly reduced paralysis (up to 3.2 times) compared to the application of venom only. Although the mechanisms of their action are unknown, both agents might affect neuromuscular junctions. Venom application significantly increased the expression of both P. apterus Akh genes (Pyrap-Akh 5.4 times and Peram-Cah-II 3.6 times), as well as the level of AKHs in the central nervous system (2.5 times) and haemolymph (3.0 times). In the haemolymph, increased AKH levels might have led to the mobilization of stored lipids, which increased 1.9 times, while the level of free carbohydrates remained unchanged. Total metabolism, monitored by carbon dioxide production, significantly declined in paralysed P. apterus individuals (1.4 times and 1.9 times, 24 and 48h after the treatment, respectively), probably because of a malfunction of the muscular system. The results suggest an active role of AKH in the defence mechanism against the stress elicited by neuromuscular paralysis, and the possible involvement of this hormone in neuronal/neuromuscular signalling.
[Mh] Termos MeSH primário: Sistema Nervoso Central/efeitos dos fármacos
Heterópteros/efeitos dos fármacos
Hormônios de Inseto/agonistas
Neuropeptídeos/fisiologia
Oligopeptídeos/agonistas
Paralisia/veterinária
Ácido Pirrolidonocarboxílico/análogos & derivados
Regulação para Cima/efeitos dos fármacos
Venenos de Vespas/toxicidade
[Mh] Termos MeSH secundário: Alostase
Animais
Biomarcadores/metabolismo
Sistema Nervoso Central/metabolismo
República Tcheca
Relação Dose-Resposta a Droga
Metabolismo Energético/efeitos dos fármacos
Feminino
Hemolinfa/efeitos dos fármacos
Hemolinfa/metabolismo
Heterópteros/fisiologia
Injeções
Hormônios de Inseto/genética
Hormônios de Inseto/fisiologia
Hormônios de Inseto/secreção
Cinética
Junção Neuromuscular/efeitos dos fármacos
Junção Neuromuscular/fisiologia
Neuropeptídeos/agonistas
Neuropeptídeos/análise
Neuropeptídeos/genética
Neuropeptídeos/secreção
Oligopeptídeos/genética
Oligopeptídeos/fisiologia
Oligopeptídeos/secreção
Paralisia/induzido quimicamente
Ácido Pirrolidonocarboxílico/agonistas
Tórax
Venenos de Vespas/antagonistas & inibidores
Venenos de Vespas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Insect Hormones); 0 (Neuropeptides); 0 (Oligopeptides); 0 (Pea-CAH-II neuropeptide); 0 (Wasp Venoms); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  8 / 3056 MEDLINE  
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[PMID]:28254268
[Au] Autor:Ibrahim E; Hejníková M; Shaik HA; Dolezel D; Kodrík D
[Ad] Endereço:Institute of Entomology, Biology Centre, CAS, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Agriculture, University of Cairo, Giza, Egypt.
[Ti] Título:Adipokinetic hormone activities in insect body infected by entomopathogenic nematode.
[So] Source:J Insect Physiol;98:347-355, 2017 Apr.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of adipokinetic hormone (AKH) in the firebug Pyrrhocoris apterus adults infected by the entomopathogenic nematode (EPN) Steinernema carpocapsae was examined in this study. It was found that co-application of EPN and AKH enhanced firebug mortality about 2.5 times within 24h (from 20 to 51% in EPN vs. EPN+AKH treatments), and resulted in metabolism intensification, as carbon dioxide production in firebugs increased about 2.1 and 1.6times compared to control- and EPN-treated insects, respectively. Accordingly, firebugs with reduced expression of AKH receptors showed a significantly lower mortality (by 1.6 to 2.9-folds), and lower general metabolism after EPN+AKH treatments. In addition, EPN application increased Akh gene expression in the corpora cardiaca (1.6times), AKH level in the corpora cardiaca (1.3times) and haemolymph (1.7times), and lipid and carbohydrate amounts in the haemolymph. Thus, the outcomes of the present study demonstrate involvement of AKH into the anti-stress reaction elicited by the nematobacterial infection. The exact mechanism by which AKH acts is unknown, but results suggested that the increase of metabolism and nutrient amounts in haemolymph might play a role.
[Mh] Termos MeSH primário: Heterópteros/metabolismo
Heterópteros/parasitologia
Hormônios de Inseto/metabolismo
Oligopeptídeos/metabolismo
Ácido Pirrolidonocarboxílico/análogos & derivados
Rabditídios/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpora Allata/metabolismo
Hemolinfa/metabolismo
Masculino
Especificidade de Órgãos
Ácido Pirrolidonocarboxílico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Oligopeptides); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  9 / 3056 MEDLINE  
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[PMID]:28225562
[Au] Autor:Gäde G; Marco HG
[Ad] Endereço:Department of Biological Sciences, University of Cape Town, Rondebosch, South Africa.
[Ti] Título:The adipokinetic hormone of Mantodea in comparison to other Dictyoptera.
[So] Source:Arch Insect Biochem Physiol;94(3), 2017 Mar.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six species of the order Mantodea (praying mantises) are investigated for the presence and sequence of putative adipokinetic hormones (AKHs). The selected species span a wide evolutionary range of various families and subfamilies of the clade Mantodea. The corpora cardiaca of the different species are dissected, methanolic extracts prepared, peptides separated by liquid chromatography, and AKHs detected and sequenced by ion trap mass spectrometry. All six species investigated contain an octapeptide with the primary structure pGlu-Val-Asn-Phe-Thr-Pro-Asn-Trp amide, which is code-named Emppe-AKH and had been found earlier in three other species of Mantodea. Conspecific bioassays with the species Creoboter sp. (family Hymenopodidae) reveal an adipokinetic but not a hypertrehalosemic function of Emppe-AKH. Comparison with other members of the Dictyoptera (cockroaches, termites) show that Emppe-AKH is only found in certain termites, which have been recently placed into the Blattaria (cockroaches) as sister group to the family Cryptocercidae. Termites and cockroaches both show biodiversity in the sequence of AKHs, and some cockroach species even contain two AKHs. In contrast, all praying mantises-irrespective of their phylogenetic position-synthesize uniformly only one and the same octapeptide Emppe-AKH.
[Mh] Termos MeSH primário: Hormônios de Inseto/análise
Mantódeos/química
Oligopeptídeos/análise
Ácido Pirrolidonocarboxílico/análogos & derivados
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Substituição de Aminoácidos
Animais
Hemolinfa/química
Hormônios de Inseto/metabolismo
Metabolismo dos Lipídeos
Masculino
Mantódeos/metabolismo
Espectrometria de Massas
Dados de Sequência Molecular
Oligopeptídeos/metabolismo
Ácido Pirrolidonocarboxílico/análise
Ácido Pirrolidonocarboxílico/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Oligopeptides); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21376


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[PMID]:28178568
[Au] Autor:Song W; Cheng D; Hong S; Sappe B; Hu Y; Wei N; Zhu C; O'Connor MB; Pissios P; Perrimon N
[Ad] Endereço:Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: rsong@genetics.med.harvard.edu.
[Ti] Título:Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
[So] Source:Cell Metab;25(2):386-399, 2017 Feb 07.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While high-caloric diet impairs insulin response to cause hyperglycemia, whether and how counter-regulatory hormones are modulated by high-caloric diet is largely unknown. We find that enhanced response of Drosophila adipokinetic hormone (AKH, the glucagon homolog) in the fat body is essential for hyperglycemia associated with a chronic high-sugar diet. We show that the activin type I receptor Baboon (Babo) autonomously increases AKH signaling without affecting insulin signaling in the fat body via, at least, increase of Akh receptor (AkhR) expression. Further, we demonstrate that Activin-ß (Actß), an activin ligand predominantly produced in the enteroendocrine cells (EEs) of the midgut, is upregulated by chronic high-sugar diet and signals through Babo to promote AKH action in the fat body, leading to hyperglycemia. Importantly, activin signaling in mouse primary hepatocytes also increases glucagon response and glucagon-induced glucose production, indicating a conserved role for activin in enhancing AKH/glucagon signaling and glycemic control.
[Mh] Termos MeSH primário: Ativinas/metabolismo
Drosophila melanogaster/metabolismo
Corpo Adiposo/metabolismo
Trato Gastrointestinal/metabolismo
Glucagon/metabolismo
Hiperglicemia/metabolismo
[Mh] Termos MeSH secundário: Receptores de Ativinas/metabolismo
Animais
Metabolismo dos Carboidratos
Proteínas de Transporte/metabolismo
Carboidratos da Dieta/efeitos adversos
Modelos Animais de Doenças
Proteínas de Drosophila/genética
Proteínas de Drosophila/metabolismo
Células Enteroendócrinas/metabolismo
Hepatócitos/metabolismo
Hiperglicemia/patologia
Hormônios de Inseto/metabolismo
Larva/metabolismo
Camundongos
Oligopeptídeos/metabolismo
Ácido Pirrolidonocarboxílico/análogos & derivados
Ácido Pirrolidonocarboxílico/metabolismo
Interferência de RNA
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Receptores de Glucagon/genética
Receptores de Glucagon/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AKHR protein, Drosophila); 0 (Carrier Proteins); 0 (Dietary Carbohydrates); 0 (Drosophila Proteins); 0 (Insect Hormones); 0 (Oligopeptides); 0 (RNA, Messenger); 0 (Receptors, Glucagon); 0 (dawdle protein, Drosophila); 104625-48-1 (Activins); 129204-82-6 (DAKH peptide); 9007-92-5 (Glucagon); EC 2.7.11.30 (Activin Receptors); EC 2.7.11.30 (Babo protein, Drosophila); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE



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