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Pesquisa : D06.472.445.573.666.500 [Categoria DeCS]
Referências encontradas : 530 [refinar]
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[PMID]:28750998
[Au] Autor:Liu H; Li HM; Yue Y; Song ZH; Wang JJ; Dou W
[Ad] Endereço:Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400715, China; Academy of Agricultural Sciences, Southwest University, Chongqing 400715, China.
[Ti] Título:The alternative splicing of BdTai and its involvement in the development of Bactrocera dorsalis (Hendel).
[So] Source:J Insect Physiol;101:132-141, 2017 Aug.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Interest in insect metamorphosis has primarily focused on juvenile hormone (JH) and ecdysone. Compared to ecdysone signaling, the molecular action of JH is less well established because Methoprene-tolerant (Met) as the JH receptor has been identified until recently. In vitro studies have indicated that Met forms an active JH-dependent complex with one partner protein, Taiman (Tai). However, the related studies on Tai's role in insect metamorphosis are very limited. In this study, five Tai isoforms differing in C-terminal region are identified from the oriental fruit fly Bactrocera dorsalis, an important worldwide pest infesting fruits and vegetables. The spatiotemporal expression pattern analysis indicates that BdTai-A and BdTai-B are highly expressed in early larvae while BdTai-D is more abundant in middle-late larvae. Meanwhile, in vivo methoprene stress leads to dramatic expression pattern fluctuation of BdTai isoforms. The subsequent reverse genetic study reveal that all Tai isoforms (denoted as "Tai-core") depletion in larvae stage of B. dorsalis produce precocious larvae-pupae development, i.e. shortened pupation process and miniature pupae. Further knockdown of individual Tai isoform show that silence of BdTai-E causes the same phenotype as of BdTai-core RNAi. The current data suggest that BdTai-E is involved in transducing the JH signal that represses metamorphosis. Besides, isoforms should be considered when studying Tai functions.
[Mh] Termos MeSH primário: Processamento Alternativo
Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Insetos/genética
Tephritidae/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Clonagem Molecular
DNA Complementar/genética
DNA Complementar/metabolismo
Proteínas de Insetos/química
Proteínas de Insetos/metabolismo
Hormônios Juvenis/metabolismo
Larva/genética
Larva/crescimento & desenvolvimento
Larva/metabolismo
Metoprene/metabolismo
Filogenia
Isoformas de Proteínas/química
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Pupa/genética
Pupa/crescimento & desenvolvimento
Pupa/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Alinhamento de Sequência
Transdução de Sinais
Tephritidae/crescimento & desenvolvimento
Tephritidae/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Insect Proteins); 0 (Juvenile Hormones); 0 (Protein Isoforms); 0 (RNA, Messenger); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


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[PMID]:28679117
[Au] Autor:Zhu L; Yin TY; Sun D; Liu W; Zhu F; Lei CL; Wang XP
[Ad] Endereço:Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
[Ti] Título:Juvenile hormone regulates the differential expression of putative juvenile hormone esterases via methoprene-tolerant in non-diapause-destined and diapause-destined adult female beetle.
[So] Source:Gene;627:373-378, 2017 Sep 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Juvenile hormone (JH) plays an essential role in regulating molting, metamorphosis, reproduction, and diapause (dormancy), in many insects and crustaceans. JH esterases (JHEs) can control JH titer by regulating JH degradation. Although the biochemistry and structure of JHEs have been well studied, regulation of their expression remains unclear. We identified three putative JHEs (JHE1, JHE2, JHE3) in the cabbage beetle Colaphellus bowringi, and investigated the regulation of their expression by JH signaling in non-diapause-destined (NDD, reproductive) and diapause-destined (DD) female adults. Sequence and phylogenetic tree analyses indicate that the three putative JHEs shared conserved motifs with the JHEs of other insects and one crustacean, and were similar to Coleopteran, Dipteran, Orthopteran, Hymenopteran, and Decapodan JHEs. They were, however, less closely related to Hemipteran and Lepidopteran JHEs. JHEs were more highly expressed in NDD female adults than in DD female adults. JH analog induction in DD female adults significantly upregulated the expression of JHE1 and JHE2, but had no effect on the expression of JHE3. Knockdown of the JH candidate receptor methoprene-tolerant (Met) in NDD female adults downregulated the expression of all three JHEs. These results suggest that JHE expression is positively correlated with JH signaling, and that Met may be involved in the JH-mediated differential expression of JHE in DD and NDD adult female C. bowringi.
[Mh] Termos MeSH primário: Hidrolases de Éster Carboxílico/genética
Coleópteros/genética
Diapausa de Inseto
Regulação da Expressão Gênica no Desenvolvimento
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Hidrolases de Éster Carboxílico/química
Hidrolases de Éster Carboxílico/metabolismo
Coleópteros/efeitos dos fármacos
Coleópteros/enzimologia
Coleópteros/crescimento & desenvolvimento
Sequência Conservada
Feminino
Metoprene/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sesquiterpenes); 3Q8213U4LQ (juvenile hormone I); 8B830OJ2UX (Methoprene); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (juvenile hormone esterase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


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[PMID]:28623148
[Au] Autor:Bachmann GE; Devescovi F; Nussenbaum AL; Cladera JL; Fernández PC; Vera MT; Teal PEA; Segura DF
[Ad] Endereço:Instituto de Genética "E.A. Favret", Instituto Nacional de Tecnología Agropecuaria (INTA), Nicolas Repetto y de los Reseros s/n, Hurlingham, 1686 Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Ciudad Autónoma de Buenos Aires C1425FQB,
[Ti] Título:Male sexual enhancement after methoprene treatment in Anastrepha fraterculus (Diptera: Tephritidae): A sustained response that does not fade away after sexual maturation.
[So] Source:J Insect Physiol;101:7-14, 2017 Aug.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The juvenile hormone (JH) of insects triggers physiological changes related to reproduction in adults of both sexes. Methoprene is a sesquiterpene with some effects that are analogous to those of JH. Treatments with methoprene accelerate sexual maturation in males of the South American fruit fly Anastrepha fraterculus, giving young males a mating advantage over non-treated males of the same age. Here, we evaluated the effects of methoprene treatment on A. fraterculus males after the sexual maturation phase and tested whether this compound provides a long-term mating advantage. Moreover, we took the first step to unravel the mechanisms that underlie male sexual enhancement. We treated males 1day or 8days after adult emergence and compared mate choice between recently matured (young) females and females that had been mature for ca. 10days (aged females). We also addressed methoprene treatment effects on male sexual signalling. We found that methoprene treatment enhanced male sexual competitiveness even after the sexual maturation phase, and the effect did not decrease until males were older than 20days. However, when methoprene treatment was carried out close to sexual maturity, the mating enhancement was no longer observed, suggesting a non-immediate effect and excluding the possibility that methoprene acts as a pheromonal compound. Young and aged females tended to mate more frequently with treated-males. This might indicate that in a context of sexual selection, the potential benefits associated with reproductive success would be similar for females of both ages. Treated males released larger amounts of pheromonal compounds than non-treated males, but their courtship behaviour was not altered to the same extent, suggesting that methoprene treatment may accelerate differently the components of male courtship. We discuss potential benefits of using methoprene to increase the efficiency of the sterile insect technique, which is an environmentally safe method to control this important South American fruit pest.
[Mh] Termos MeSH primário: Hormônios Juvenis/farmacologia
Metoprene/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
Maturidade Sexual
Tephritidae/efeitos dos fármacos
Tephritidae/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Juvenile Hormones); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE


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[PMID]:28490635
[Au] Autor:Zeng B; Huang Y; Xu J; Shiotsuki T; Bai H; Palli SR; Huang Y; Tan A
[Ad] Endereço:From the Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
[Ti] Título:The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, .
[So] Source:J Biol Chem;292(28):11659-11669, 2017 Jul 14.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. However, how FOXO interacts with hormone signaling to modulate insect growth and development is largely unknown. Here, using the transgene-based CRISPR/Cas9 system, we generated and characterized mutants of the silkworm FOXO ( ) to elucidate its physiological functions during development of this lepidopteran insect. The mutant (FOXO-M) exhibited growth delays from the first larval stage and showed precocious metamorphosis, pupating at the end of the fourth instar (trimolter) rather than at the end of the fifth instar as in the wild-type (WT) animals. However, different from previous reports on precocious metamorphosis caused by juvenile hormone (JH) deficiency in silkworm mutants, the total developmental time of the larval period in the FOXO-M was comparable with that of the WT. Exogenous application of 20-hydroxyecdysone (20E) or of the JH analog rescued the trimolter phenotype. RNA-seq and gene expression analyses indicated that genes involved in JH degradation but not in JH biosynthesis were up-regulated in the FOXO-M compared with the WT animals. Moreover, we identified several FOXO-binding sites in the promoter of genes coding for JH-degradation enzymes. These results suggest that FOXO regulates JH degradation rather than its biosynthesis, which further modulates hormone homeostasis to control growth and development in In conclusion, we have uncovered a pivotal role for FOXO in regulating JH signaling to control insect development.
[Mh] Termos MeSH primário: Bombyx/metabolismo
Hidrolases de Éster Carboxílico/metabolismo
Epóxido Hidrolases/metabolismo
Proteína Forkhead Box O1/metabolismo
Hormônios Juvenis/metabolismo
Metamorfose Biológica
Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Bombyx/efeitos dos fármacos
Bombyx/crescimento & desenvolvimento
Sistemas CRISPR-Cas
Hidrolases de Éster Carboxílico/genética
Ecdisterona/farmacologia
Indução Enzimática/efeitos dos fármacos
Epóxido Hidrolases/genética
Feminino
Proteína Forkhead Box O1/genética
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Hidrólise/efeitos dos fármacos
Proteínas de Insetos/genética
Proteínas de Insetos/metabolismo
Hormônios Juvenis/química
Masculino
Metamorfose Biológica/efeitos dos fármacos
Metoprene/farmacologia
Muda/efeitos dos fármacos
Mutação
Fosfotransferases (Aceptor do Grupo Álcool)/genética
Regiões Promotoras Genéticas/efeitos dos fármacos
Elementos de Resposta/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Forkhead Box Protein O1); 0 (Insect Proteins); 0 (Juvenile Hormones); 5289-74-7 (Ecdysterone); 8B830OJ2UX (Methoprene); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.- (juvenile hormone diol kinase); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (juvenile hormone esterase); EC 3.3.2.- (Epoxide Hydrolases); EC 3.3.2.- (juvenile hormone epoxide hydrolase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.777797


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[PMID]:28369111
[Au] Autor:Suang S; Manaboon M; Singtripop T; Hiruma K; Kaneko Y; Tiansawat P; Neumann P; Chantawannakul P
[Ad] Endereço:Endocrinology Research Laboratory, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Título:Larval diapause termination in the bamboo borer, Omphisa fuscidentalis.
[So] Source:PLoS One;12(4):e0174919, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In insects, juvenile hormone (JH) and 20-hydroxyecdysone (20E) regulate larval growth and molting. However, little is known about how this cooperative control is terminating larval diapause especially in the bamboo borer, Omphisa fuscidentalis. In both in vivo and in vitro experiments, we here measured the expression levels of genes which were affected by juvenile hormone analogue (JHA: S-methoprene) and 20-hydroxyecdysone (20E) in diapausing O. fuscidentalis larvae. Corresponding mRNA expression changes in the subesophageal ganglion (SG) and prothoracic gland (PG) were evaluated using qRT-PCR. The data showed similar response patterns of JH receptor gene (OfMet), diapause hormone gene (OfDH-PBAN), ecdysone receptor genes (OfEcR-A and OfEcR-B1) and ecdysone inducible genes (OfBr-C, OfE75A, OfE75B, OfE75C and OfHR3). JHA induced the expressions of OfMet and OfDH-PBAN in both SG and PG, whereas ecdysone receptor genes and ecdysone inducible genes were induced by JHA only in PG. For 20E treatment group, expressions of ecdysone receptor genes and ecdysone inducible genes in both SG and PG were increased by 20E injection. In addition, the in vitro experiments showed that OfMet and OfDH-PBAN were up-regulated by JHA alone, but ecdysone receptor genes and ecdysone inducible genes were up-regulated by JHA and 20E. However, OfMet and OfDH-PBAN in the SG was expressed faster than OfMet and OfDH-PBAN in the PG and the expression of ecdysone receptor genes and ecdysone inducible genes induced by JHA was much later than observed for 20E. These results indicate that JHA might stimulate the PG indirectly via factors (OfMet and OfDH-PBAN) in the SG, which might be a regulatory mechanism for larval diapause termination in O. fuscidentalis.
[Mh] Termos MeSH primário: Ecdisona/genética
Ecdisterona/metabolismo
Regulação da Expressão Gênica/genética
Hormônios Juvenis/metabolismo
Metamorfose Biológica/fisiologia
Receptores de Esteroides/genética
[Mh] Termos MeSH secundário: Animais
Ecdisona/metabolismo
Hemolinfa/metabolismo
Larva/crescimento & desenvolvimento
Metamorfose Biológica/genética
Metoprene/metabolismo
Mariposas/embriologia
RNA Mensageiro/genética
Receptores de Esteroides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Juvenile Hormones); 0 (RNA, Messenger); 0 (Receptors, Steroid); 0 (ecdysone receptor); 3604-87-3 (Ecdysone); 5289-74-7 (Ecdysterone); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174919


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[PMID]:28187397
[Au] Autor:Lawler SP
[Ad] Endereço:Department of Entomology and Nematology, University of California, Davis One Shields Avenue, Davis, CA 95616, USA. Electronic address: splawler@ucdavis.edu.
[Ti] Título:Environmental safety review of methoprene and bacterially-derived pesticides commonly used for sustained mosquito control.
[So] Source:Ecotoxicol Environ Saf;139:335-343, 2017 May.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Some pesticides are applied directly to aquatic systems to reduce numbers of mosquito larvae (larvicides) and thereby reduce transmission of pathogens that mosquitoes vector to humans and wildlife. Sustained, environmentally-safe control of larval mosquitoes is particularly needed for highly productive waters (e.g., catchment basins, water treatment facilities, septic systems), but also for other habitats to maintain control and reduce inspection costs. Common biorational pesticides include the insect juvenile hormone mimic methoprene and pesticides derived from the bacteria Bacillus thuringiensis israelensis, Lysinibacillus sphaericus and Saccharopolyspora spinosa (spinosad). Health agencies, the public and environmental groups have especially debated the use of methoprene because some studies have shown toxic effects on non-target organisms. However, many studies have demonstrated its apparent environmental safety. This review critically evaluates studies pertinent to the environmental safety of using methoprene to control mosquito larvae, and provides concise assessments of the bacterial larvicides that provide sustained control of mosquitoes. The review first outlines the ecological and health effects of mosquitoes, and distinguishes between laboratory toxicity and environmental effects. The article then interprets non-target toxicity findings in light of measured environmental concentrations of methoprene (as used in mosquito control) and field studies of its non-target effects. The final section evaluates information on newer formulations of bacterially-derived pesticides for sustained mosquito control. Results show that realized environmental concentrations of methoprene were usually 2-5µg/kg (range 2-45µg/kg) and that its motility is limited. These levels were not toxic to the vast majority of vertebrates and invertebrates tested in laboratories, except for a few species of zooplankton, larval stages of some other crustaceans, and small Diptera. Studies in natural habitats have not documented population reductions except in small Diptera. Bacterial larvicides showed good results for sustained control with similarly limited environmental effects, except for spinosad, which had broader effects on insects in mesocosms and temporary pools. These findings should be useful to a variety of stakeholders in informing decisions on larvicide use to protect public and environmental health in a 'One Health' framework.
[Mh] Termos MeSH primário: Bacillaceae
Bacillus thuringiensis
Inseticidas/toxicidade
Larva/efeitos dos fármacos
Macrolídeos/toxicidade
Metoprene/toxicidade
Controle de Mosquitos
[Mh] Termos MeSH secundário: Animais
Culicidae/efeitos dos fármacos
Dípteros/efeitos dos fármacos
Combinação de Medicamentos
Saúde Ambiental
Inseticidas/análise
Metoprene/análise
Poluentes da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); 0 (Water Pollutants); 8B830OJ2UX (Methoprene); XPA88EAP6V (spinosad)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:27530057
[Au] Autor:Zhao B; Hou Y; Wang J; Kokoza VA; Saha TT; Wang XL; Lin L; Zou Z; Raikhel AS
[Ad] Endereço:Department of Entomology, University of California, Riverside, CA, 92521, USA.
[Ti] Título:Determination of juvenile hormone titers by means of LC-MS/MS/MS and a juvenile hormone-responsive Gal4/UAS system in Aedes aegypti mosquitoes.
[So] Source:Insect Biochem Mol Biol;77:69-77, 2016 Oct.
[Is] ISSN:1879-0240
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In anautogenous mosquitoes, juvenile hormone III (JH) plays an essential role in female post-eclosion (PE) development, preparing them for subsequent blood feeding and egg growth. We re-examined the JH titer during the reproductive cycle of female Aedes aegypti mosquitoes. Using liquid chromatography coupled with triple tandem mass spectrometry (LC-MS/MS/MS), we have shown that it reaches its peak at 48-54 h PE in the female hemolymph and at 72 h PE in whole body extracts. This method represents an effective assay for determination of JH titers. The 2.1-kb 5' promoter region of the Early Trypsin (ET) gene, which is specifically expressed in the female midgut under the control of JH during the PE phase, was utilized to genetically engineer the Ae. aegypti mosquito line with the ET-Gal4 activator. We then established the ET-GAL4>UAS-enhanced green fluorescent protein (EGFP) system in Ae. aegypti. In ET-Gal4>UAS-EGFP female mosquitoes, the intensity of the midgut-specific EGFP signal was observed to correspond to the ET gene transcript level and follow the JH titer during the PE phase. The EGFP signal and the EGFP transcript level were significantly diminished in midguts of transgenic female mosquitoes after RNA interference depletion of the JH receptor Methoprene-tolerant (Met), providing evidence of the control of ET gene expression by Met. Topical JH application caused premature enhancement of the EGFP signal and the EGFP transcript level in midguts of newly eclosed ET-Gal4>UAS-EGFP female mosquitoes, in which endogenous JH titer is still low. Hence, this novel ET-Gal4>UAS system permits JH-dependent gene overexpression in the midgut of Ae. aegypti female mosquitoes prior to a blood meal.
[Mh] Termos MeSH primário: Aedes/fisiologia
Proteínas de Insetos/genética
Hormônios Juvenis/genética
Metoprene/metabolismo
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Aedes/genética
Animais
Animais Geneticamente Modificados
Cromatografia Líquida
Feminino
Expressão Gênica
Proteínas de Insetos/metabolismo
Hormônios Juvenis/metabolismo
Espectrometria de Massas em Tandem
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Proteins); 0 (Juvenile Hormones); 0 (Transcription Factors); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160818
[St] Status:MEDLINE


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[PMID]:27263969
[Au] Autor:Lin HH; Cao DS; Sethi S; Zeng Z; Chin JSR; Chakraborty TS; Shepherd AK; Nguyen CA; Yew JY; Su CY; Wang JW
[Ad] Endereço:Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
[Ti] Título:Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success.
[So] Source:Neuron;90(6):1272-1285, 2016 Jun 15.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During the lifespans of most animals, reproductive maturity and mating activity are highly coordinated. In Drosophila melanogaster, for instance, male fertility increases with age, and older males are known to have a copulation advantage over young ones. The molecular and neural basis of this age-related disparity in mating behavior is unknown. Here, we show that the Or47b odorant receptor is required for the copulation advantage of older males. Notably, the sensitivity of Or47b neurons to a stimulatory pheromone, palmitoleic acid, is low in young males but high in older ones, which accounts for older males' higher courtship intensity. Mechanistically, this age-related sensitization of Or47b neurons requires a reproductive hormone, juvenile hormone, as well as its binding protein Methoprene-tolerant in Or47b neurons. Together, our study identifies a direct neural substrate for juvenile hormone that permits coordination of courtship activity with reproductive maturity to maximize male reproductive fitness.
[Mh] Termos MeSH primário: Fatores de Transcrição Hélice-Alça-Hélice Básicos/fisiologia
Corte
Proteínas de Drosophila/fisiologia
Drosophila melanogaster/fisiologia
Hormônios Juvenis/fisiologia
Feromônios/fisiologia
Receptores Odorantes/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Copulação/efeitos dos fármacos
Copulação/fisiologia
Proteínas de Drosophila/genética
Drosophila melanogaster/efeitos dos fármacos
Ácidos Graxos Monoinsaturados/farmacologia
Feminino
Ácido Linoleico/farmacologia
Masculino
Metoprene/farmacologia
Mutação
Feromônios/análise
Receptores Odorantes/genética
Células Receptoras Sensoriais/efeitos dos fármacos
Células Receptoras Sensoriais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Drosophila Proteins); 0 (Fatty Acids, Monounsaturated); 0 (Juvenile Hormones); 0 (Or47b protein, Drosophila); 0 (Pheromones); 0 (Receptors, Odorant); 0 (Resistance to Juvenile Hormone protein, Drosophila); 209B6YPZ4I (palmitoleic acid); 8B830OJ2UX (Methoprene); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE


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[PMID]:27189592
[Au] Autor:Dryden MW; Smith V; Davis WL; Settje T; Hostetler J
[Ad] Endereço:Deptartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA. Dryden@vet.k-state.edu.
[Ti] Título:Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatments of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months.
[So] Source:Parasit Vectors;9(1):287, 2016 05 17.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This controlled laboratory study was designed to evaluate the efficacy of the 10 % imidacloprid/4.5 % flumethrin collar (Seresto®, Bayer Animal Health) against fleas (Ctenocephalides f. felis) on cats, when compared to fipronil (9.8 %w/w)/(s)-methoprene (11.8 % w/w) topical spot-on formulation (Frontline® Plus for Cats and Kittens, Merial). METHODS: Thirty cats were randomized into three groups of ten animals based on pre-treatment flea counts: Group 1: imidacloprid/flumethrin collar; Group 2: fipronil/(s)-methoprene topical spot-on and Group 3: non-treated controls. The imidacloprid/flumethrin collars were applied one time on Day 0, while the fipronil/(s)-methoprene spot-on was administered every 30 days from Day 0 through Day 210. Cats were infested with 100 fleas on study days 0, 7, 14, 29, 59, 89, 119, 149, 179, 209 and 239. All flea counts were conducted by combing to remove fleas on post-treatment days 2, 8, 15, 30, 60, 90, 120, 150, 180, 210 and 240. RESULTS: The efficacy of the imidacloprid/flumethrin collar ranged from 98.2 to 100 % for eight months. The efficacy of fipronil/(s)-methoprene spot-on ranged from 68.2 to 99.9 %. Efficacy was < 85 % for fipronil/(s)-methoprene on Days 90, 150 and 210. The flea counts in both treatment groups were significantly fewer than those in the non-treated control group at every post-treatment study day (P < 0.0001). In addition, there were significantly fewer fleas in the imidacloprid/flumethrin collar group when compared to the fipronil/(s)-methoprene group on Days 90, 150 and 210 (P < 0.0001). CONCLUSIONS: This study demonstrated that the imidacloprid/flumethrin collar (Seresto®, Bayer Animal Health) maintained excellent ( > 98.2 %) efficacy against fleas on cats for the entire 8 month study. Monthly applications of fipronil/(s)-methoprene (Frontline® Plus for Cats and Kittens, Merial) generally had high, but variable (68.2 to 99.9 %) efficacy over the course of the eight month study. Based on the very high residual efficacy achieved by the imidacloprid/flumethrin collar in this study, veterinarians should expect that this collar will control and eliminate existing flea infestations on cats and in their in-home premises as long as every flea infested host is treated.
[Mh] Termos MeSH primário: Doenças do Gato/prevenção & controle
Ctenocephalides/efeitos dos fármacos
Infestações por Pulgas/veterinária
Inseticidas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Gatos
Quimioterapia Combinada
Feminino
Infestações por Pulgas/prevenção & controle
Imidazóis/administração & dosagem
Masculino
Metoprene/administração & dosagem
Neonicotinoides
Nitrocompostos/administração & dosagem
Pirazóis/administração & dosagem
Piretrinas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Pyrazoles); 0 (Pyrethrins); 2O051W13LH (flumethrin); 3BN7M937V8 (imidacloprid); 8B830OJ2UX (Methoprene); QGH063955F (fipronil)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-016-1575-5


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[PMID]:27180724
[Au] Autor:Liu W; Li Y; Zhu L; Zhu F; Lei CL; Wang XP
[Ad] Endereço:Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
[Ti] Título:Juvenile hormone facilitates the antagonism between adult reproduction and diapause through the methoprene-tolerant gene in the female Colaphellus bowringi.
[So] Source:Insect Biochem Mol Biol;74:50-60, 2016 Jul.
[Is] ISSN:1879-0240
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In insects, the process whereby juvenile hormone (JH) regulates short-day (SD)-induced reproductive diapause has been previously investigated. However, we still do not understand the mechanism by which JH regulates long-day (LD)-induced reproductive diapause. In this study, we use a cabbage beetle, Colaphellus bowringi, which is a serious pest of cruciferous vegetables in Asia capable of entering reproductive diapause under LD conditions, as a model to test whether JH regulates female reproductive diapause similar to the mechanism of SD-induced diapause. Our results showed that the JH analog (JHA) methoprene significantly induced ovarian development but inhibited lipid accumulation of diapause-destined adults. Meanwhile, the transcripts of the vitellogenin (Vg) genes were upregulated, whereas the expression of the fat synthesis and stress tolerance genes were downregulated. RNA interference of the JH candidate receptor gene methoprene-tolerant (Met) blocked JH-induced ovarian development and Vg transcription, suggesting a positive regulatory function for JH-Met signaling in reproduction. Furthermore, under reproduction-inducing conditions, Met depletion promoted a diapause-like phenotype, including arrested ovarian development and increased lipid storage, and stimulated the expression of diapause-related genes involved in lipid synthesis and stress tolerance, suggesting JH-Met signaling plays an important role in the inhibition of diapause. Accordingly, our data indicate that JH acts through Met to facilitate development of the reproductive system by upregulating Vg expression while inhibiting diapause by suppressing lipid synthesis and stress tolerance in the cabbage beetle. Combined with previous studies in SD-induced reproductive diapause, we conclude that JH may regulate female reproductive diapause using a conserved Met-dependent pathway, regardless of the length of the photoperiod inducing diapause in insects.
[Mh] Termos MeSH primário: Coleópteros/fisiologia
Diapausa de Inseto
Hormônios Juvenis/genética
Metoprene/metabolismo
[Mh] Termos MeSH secundário: Animais
Coleópteros/genética
Feminino
Hormônios Juvenis/metabolismo
Fotoperíodo
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Juvenile Hormones); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160517
[St] Status:MEDLINE



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