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[PMID]:29373588
[Au] Autor:Muszynski S; Tomaszewska E; Kwiecien M; Dobrowolski P; Tomczyk-Warunek A
[Ad] Endereço:Department of Physics, Faculty of Production Engineering, University of Life Sciences in Lublin, Lublin, Poland.
[Ti] Título:Subsequent somatic axis and bone tissue metabolism responses to a low-zinc diet with or without phytase inclusion in broiler chickens.
[So] Source:PLoS One;13(1):e0191964, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zinc is required for normal bone development and cartilage formation. The purpose of this study was to assess the effect of with adding organic Zn (alone or phytase inclusion) at the reduced dose to growing male Ross 308 chickens on somatic axis and bone tissue metabolism. 200 one-day old broilers were divided into the negative control group fed diet without Zn or phytase inclusion, positive control group receiving Zn in the 100% of daily recommended dose from ZnO, and two experimental groups fed diet introduced Zn in 25% of daily recommendation as a glycine chelate (Zn-Gly) with or without phytase inclusion (500 FTU·kg-1). Supplemental organic Zn increased bone Zn and Mg content, serum IGF-1, growth hormone and leptin concentration. Additional phytase inclusion increased body weight gain, blood plasma Ca, Fe, Zn and osteocalcin concentration and tibia ash percentage when compared to the Zn-deprived control. Bone geometry, yield and ultimate strengths were enhanced in both organic Zn supplemented groups, and the overall mechanical strength parameters of bone were better in these groups than in the positive control group supplemented with standard dose of inorganic Zn. Also marked improvements in the thickness of articular and the growth plate cartilages as well as real bone volume and thickness of metaphyseal trabeculae were achieved in all broilers fed Zn-supplemented diet irrespective of phytase inclusion, however, the highest cancellous bone mass and the best trabecular structure were noted after ZnO supplementation. In concludion, although dietary organic Zn given to growing broilers in 25% of daily recommended dose improved general bone properties and mechanical strength, the obtained results do not allow to unambiguously state that organic Zn supplementation at this level, even after phytase inclusion, is sufficient for proper bone development.
[Mh] Termos MeSH primário: 6-Fitase/metabolismo
Osso e Ossos/metabolismo
Zinco/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Galinhas
Hormônio do Crescimento/metabolismo
Fator de Crescimento Insulin-Like I/metabolismo
Leptina/metabolismo
Magnésio/metabolismo
Masculino
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 67763-96-6 (Insulin-Like Growth Factor I); 9002-72-6 (Growth Hormone); EC 3.1.3.26 (6-Phytase); I38ZP9992A (Magnesium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191964


  2 / 21177 MEDLINE  
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[PMID]:28460045
[Au] Autor:Lekva T; Roland MCP; Michelsen AE; Friis CM; Aukrust P; Bollerslev J; Henriksen T; Ueland T
[Ad] Endereço:Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
[Ti] Título:Large Reduction in Adiponectin During Pregnancy Is Associated With Large-for-Gestational-Age Newborns.
[So] Source:J Clin Endocrinol Metab;102(7):2552-2559, 2017 Jul 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Fetuses exposed to an obese intrauterine environment are more likely to be born large-for-gestational age (LGA) and are at increased risk of obesity in childhood and cardiovascular disease and/or type 2 diabetes mellitus as adults, but which factors that influence the intrauterine environment is less clear. Objective: To investigate the association between circulating levels of leptin and adiponectin, measured multiple times during pregnancy, and birth weight and prevalence of LGA or small-for-gestational-age infants. The association between birth weight and messenger RNA (mRNA) expression of adiponectin receptors and genes involved in nutrient transport in the placenta was also investigated. Design: Population-based prospective cohort [substudy of the STORK study (STORe barn og Komplikasjoner, translated as Large Babies and Complications)] from 2001 to 2008. Setting: University hospital. Patients or other participants: 300 women. Main Outcome Measures: Oral glucose tolerance test was performed twice along with adiponectin and leptin levels measured four times during pregnancy. Results: Circulating adiponectin was lower in mothers who gave birth to LGA offspring or had fetuses with high intrauterine abdominal circumference late in pregnancy. Adiponectin decreased most from early to late pregnancy in mothers who gave birth to LGA offspring, and the decrease was an independent predictor of birth weight. Adiponectin receptor 2 and system A amino acid transporter mRNA expression in placentas was negatively correlated with birth weight and was lower in placentas from LGA infants. Conclusions: Our findings suggest that maternal adiponectin may be an important predictor of fetal growth and birth weight, independent of body mass index and insulin resistance.
[Mh] Termos MeSH primário: Adiponectina/sangue
Peso ao Nascer
Desenvolvimento Fetal
Macrossomia Fetal/sangue
Resultado da Gravidez
Receptores de Adiponectina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Feminino
Idade Gestacional
Teste de Tolerância a Glucose
Hospitais Universitários
Seres Humanos
Recém-Nascido
Resistência à Insulina/fisiologia
Leptina/sangue
Masculino
Gravidez
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOR2 protein, human); 0 (Adiponectin); 0 (Leptin); 0 (Receptors, Adiponectin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-00289


  3 / 21177 MEDLINE  
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[PMID]:29237528
[Au] Autor:Feng EC; Jiang L
[Ad] Endereço:School of Biological Science & Medical Engineering, Southeast University, Nanjing 210018, China. jiangli77777@126.com.
[Ti] Título:[Effect of leptin on long-term spatial memory of rats with white matter damage in developing brain].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1267-1271, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the neuroprotective effect of leptin by observing its effect on spatial memory of rats with white matter damage in developing brain. METHODS: A total of 80 neonatal rats were randomly divided into 3 groups: sham-operation (n=27), model (n=27) and leptin intervention (n=27). The rats in the model and leptin intervention groups were used to prepare a model of white matter damage in developing brain, and the rats in the leptin intervention group were given leptin (100 µg/kg) diluted with normal saline immediately after modelling for 4 consecutive days. The survival rate of the rats was observed and the change in body weight was monitored. When the rats reached the age of 21 days, the Morris water maze test was used to evaluate spatial memory. RESULTS: There was no significant difference in the survival rate of rats between the three groups (P>0.05). Within 10 days after birth, the leptin intervention group had similar body weight as the sham-operation group and significantly lower body weight than the model group (P<0.05); more than 10 days after birth, the leptin intervention group had rapid growth with higher body weight than the model and sham-operation groups (P>0.05). The results of place navigation showed that from the second day of experiment, there was a significant difference in the latency period between the three groups (P<0.05); from the fourth day of experiment, the leptin intervention group had a similar latency period as the sham-operation and a significantly shorter latency period than the model group (P<0.05). The results of space search experiment showed that compared with the sham-operation group, the model group had a significant reduction in the number of platform crossings and a significantly longer latency period (P<0.05); compared with the model group, the leptin intervention group had a significantly increased number of platform crossings and a significantly shortened latency period (P<0.05), while there was no significant difference between the leptin intervention and sham-operation groups. CONCLUSIONS: Leptin can alleviate spatial memory impairment of rats with white matter damage in developing brain. It thus exerts a neuroprotective effect, and is worthy of further research.
[Mh] Termos MeSH primário: Leptina/farmacologia
Aprendizagem em Labirinto/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Memória Espacial/efeitos dos fármacos
Substância Branca/patologia
[Mh] Termos MeSH secundário: Animais
Feminino
Gravidez
Ratos
Ratos Sprague-Dawley
Tempo de Reação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 0 (Neuroprotective Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  4 / 21177 MEDLINE  
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[PMID]:29348454
[Au] Autor:Krishnan N; Bonham CA; Rus IA; Shrestha OK; Gauss CM; Haque A; Tocilj A; Joshua-Tor L; Tonks NK
[Ad] Endereço:Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA.
[Ti] Título:Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.
[So] Source:Nat Commun;9(1):283, 2018 01 18.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention in diabetes and obesity. Nevertheless, it is a challenging target for inhibitor development. Previously, we generated a recombinant antibody (scFv45) that recognizes selectively the oxidized, inactive conformation of PTP1B. Here, we provide a molecular basis for its interaction with reversibly oxidized PTP1B. Furthermore, we have identified a small molecule inhibitor that mimics the effects of scFv45. Our data provide proof-of-concept that stabilization of PTP1B in an inactive, oxidized conformation by small molecules can promote insulin and leptin signaling. This work illustrates a novel paradigm for inhibiting the signaling function of PTP1B that may be exploited for therapeutic intervention in diabetes and obesity.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/química
Inibidores Enzimáticos/química
Hipoglicemiantes/química
Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores
Anticorpos de Cadeia Única/química
Bibliotecas de Moléculas Pequenas/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Fármacos Antiobesidade/metabolismo
Benzofenantridinas/química
Benzofenantridinas/metabolismo
Sítios de Ligação
Clonagem Molecular
Cristalografia por Raios X
Inibidores Enzimáticos/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Seres Humanos
Hipoglicemiantes/metabolismo
Insulina/química
Insulina/metabolismo
Isoquinolinas/química
Isoquinolinas/metabolismo
Leptina/química
Leptina/metabolismo
Levamisol/química
Levamisol/metabolismo
Simulação de Acoplamento Molecular
Oxirredução
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Proteína Tirosina Fosfatase não Receptora Tipo 1/química
Proteína Tirosina Fosfatase não Receptora Tipo 1/genética
Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Anticorpos de Cadeia Única/genética
Anticorpos de Cadeia Única/metabolismo
Bibliotecas de Moléculas Pequenas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Benzophenanthridines); 0 (Enzyme Inhibitors); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Isoquinolines); 0 (Leptin); 0 (Recombinant Proteins); 0 (Single-Chain Antibodies); 0 (Small Molecule Libraries); 2880D3468G (Levamisole); AV9VK043SS (sanguinarine); E3B045W6X0 (chelerythrine); EC 3.1.3.48 (PTPN1 protein, human); EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02252-2


  5 / 21177 MEDLINE  
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[PMID]:29254298
[Au] Autor:Khawar MB; Sheikh N
[Ad] Endereço:Cell and Molecular Biology Laboratory, Department of Zoology, University of the Punjab, Lahore-Pakistan.
[Ti] Título:Alterations in transaminase activity and serum level of leptin and hepcidin induced by high fat diet in albino rats.
[So] Source:J Biol Regul Homeost Agents;31(4):951-956, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Obesity is a commonly growing life-threatening problem of the modern world. The present study was aimed to assess alterations in transaminase levels as well as leptin and hepcidin levels of sera through ELISA after high fat diet consumption for sixteen weeks by albino rats (n=5). Three groups were established: experimental groups 1 and 2 and a control group. Group 1 was fed on a high fat diet having a composition of 33% rat chow +33% sucrose +33% milk powder. Similarly, group 2 was fed with another high fat diet with a mixture of rat chow and milk powder ad libitum. The control group was fed on normal rat chow and water ad libitum. After sixteen weeks, the rats were euthanized and blood was collected for serum separation. Serum levels of alanine aminotransferase showed a positive significant increase (P=0.0325) while a significant negative change (P=0.0006) was noted in aspartate aminotransferase levels in both the experimental groups compared to the control group. Serum leptin levels were found to be increased up to 10.06-fold in Group 1 and 6.11-fold in Group 2 when compared to controls. On the other hand, serum hepcidin levels showed up to 1-fold and 2.59-fold changes in Group 1 and Group 2, respectively, compared to controls. Taken together, from these results it can be concluded that a high fat diet not only disturbs normal metabolism, but it also leads to liver inflammation which is obvious by the changes in transaminase activity as well as leptin and hepcidin levels.
[Mh] Termos MeSH primário: Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Gorduras na Dieta/efeitos adversos
Hepcidinas/sangue
Leptina/sangue
Obesidade/genética
[Mh] Termos MeSH secundário: Alanina Transaminase/genética
Animais
Aspartato Aminotransferases/genética
Dieta Hiperlipídica
Expressão Gênica
Hepcidinas/genética
Leptina/genética
Fígado/metabolismo
Fígado/patologia
Masculino
Obesidade/sangue
Obesidade/etiologia
Obesidade/patologia
Ratos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Hamp protein, rat); 0 (Hepcidins); 0 (Leptin); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  6 / 21177 MEDLINE  
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[PMID]:29304064
[Au] Autor:Kuo CH; Lin YL; Lee CJ; Wang CH; Lai YH; Liou HH; Hsu BG
[Ad] Endereço:Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
[Ti] Título:Hyperleptinemia positively associated with central arterial stiffness in hemodialysis patients.
[So] Source:PLoS One;13(1):e0190694, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Leptin plays a role in stimulating vascular inflammation, vascular smooth muscle hypertrophy, and augmenting blood pressure, which contributes to the pathogenesis of atherosclerosis and leads to arterial stiffness. This vascular damage, measured by carotid-femoral pulse wave velocity (cfPWV), is recognized as an independent predictor of cardiovascular mortality in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum leptin and arterial stiffness in HD patients. PATIENTS AND METHODS: In 112 of the 126 HD patients were eligible and their biochemical data were collected for analysis. Serum leptin level was measured using a commercial enzyme-linked immunosorbent assay kit. Carotid-femoral pulse wave velocity was measured by a validated tonometry system (SphygmoCor). Those have cfPWV values above 10 m/s are defined as the high arterial stiffness group. RESULTS: Among the participants, thirty-eight of them who were in the high arterial stiffness group, had a higher prevalence of diabetes mellitus (p = 0.002), age (p = 0.029), body mass index (BMI, p = 0.018), body fat mass (p = 0.001), hemoglobin (p = 0.040), and serum leptin levels (P<0.001). Multivariable logistic regression analysis showed that leptin (odds ratio [OR] 1.09; 95% confidence interval [CI] 1.04-1.14; p <0.001), diabetes (OR 7.17; CI 1.39-37.00; p = 0.019), body fat mass (OR 1.16; CI 1.02-1.33; p = 0.027); and hemoglobin (OR 2.11; CI 1.15-3.87; p = 0.015) were independently associated with arterial stiffness in HD patients. CONCLUSION: In our study, hyperleptinemia was positively correlated to the high cfPWV and thus was related to high arterial stiffness in HD patients.
[Mh] Termos MeSH primário: Artérias/fisiopatologia
Leptina/sangue
Diálise Renal
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Leptin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190694


  7 / 21177 MEDLINE  
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[PMID]:29228137
[Au] Autor:Odle AK; Benes H; Melgar Castillo A; Akhter N; Syed M; Haney A; Allensworth-James M; Hardy L; Winter B; Manoharan R; Syed R; MacNicol MC; MacNicol AM; Childs GV
[Ad] Endereço:Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
[Ti] Título:Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
[So] Source:Endocrinology;159(2):883-894, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cyclic expression of pituitary gonadotropin-releasing hormone receptors (GnRHRs) may be an important checkpoint for leptin regulatory signals. Gonadotrope Lepr-null mice have reduced GnRHR levels, suggesting these receptors may be leptin targets. To determine if leptin stimulated GnRHR directly, primary pituitary cultures or pieces were exposed to 1 to 100 nM leptin. Leptin increased GnRHR protein levels and the percentages of gonadotropes that bound biotinylated analogs of gonadotropin-releasing hormone (bio-GnRH) but had no effect on Gnrhr messenger RNA (mRNA). An in silico analysis revealed three consensus Musashi (MSI) binding elements (MBEs) for this translational control protein in the 3' untranslated region (UTR) of Gnrhr mRNA. Several experiments determined that these Gnrhr mRNA MBE were active: (1) RNA electrophoretic mobility shift assay analyses showed that MSI1 specifically bound Gnrhr mRNA 3'-UTR; (2) RNA immunoprecipitation of pituitary fractions with MSI1 antibody pulled down a complex enriched in endogenous MSI protein and endogenous Gnrhr mRNA; and (3) fluorescence reporter assays showed that MSI1 repressed translation of the reporter coupled to the Gnrhr 3'-UTR. In vitro, leptin stimulation of pituitary pieces reduced Msi1 mRNA in female pituitaries, and leptin stimulation of pituitary cultures reduced MSI1 proteins selectively in gonadotropes identified by binding to bio-GnRH. These findings show that leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. We also show MSI1 interaction with the 3'-UTR of Gnrhr mRNA. These findings now open the door to future studies of leptin-modulated posttranscriptional pathways.
[Mh] Termos MeSH primário: Leptina/farmacologia
Proteínas do Tecido Nervoso/metabolismo
Proteínas de Ligação a RNA/metabolismo
Receptores LHRH/genética
Células-Tronco/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem da Célula/efeitos dos fármacos
Linhagem da Célula/genética
Células Cultivadas
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Gonadotrofos/efeitos dos fármacos
Gonadotrofos/metabolismo
Masculino
Camundongos
Camundongos Knockout
Regiões Promotoras Genéticas/efeitos dos fármacos
RNA Mensageiro/metabolismo
Receptores LHRH/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Leptin); 0 (Msi1h protein, mouse); 0 (Nerve Tissue Proteins); 0 (RNA, Messenger); 0 (RNA-Binding Proteins); 0 (Receptors, LHRH)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00586


  8 / 21177 MEDLINE  
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[PMID]:29294325
[Au] Autor:Zheng X; Niu S
[Ad] Endereço:Foreign Trade and Business College, Chongqing Normal University, Chongqing, China. Electronic address: 20130233@cqnu.edu.cn.
[Ti] Título:Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity.
[So] Source:Biochem Biophys Res Commun;496(1):37-43, 2018 01 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physical exercise is an efficient therapeutical tool in the management of insulin resistance (IR) and related metabolic diseases. Leptin, the well-known obesity hormone and the absence of which leads to IR, showed controversial effects on IR as research continues. Thus, in this study, a detailed investigation of the effect of leptin on exercise-mediated improvement of insulin sensitivity and its underlying mechanism was carried out. Using a rat model of chronic or acute swimming exercise training, we found that serum leptin increased 1 h after either acute exercise or the last session of chronic exercise, when impaired insulin action was observed in previous reports. However, chronic exercise reducd basal serum leptin levels and promoted insulin sensitivity compared with sedentary controls or rats subjected to one bout of aerobic exercise. Our animal results indicated the potential linkage between leptin and insulin sensitivity, which is further investigated in the skeletal muscle L6 cells. Leptin treatment in L6 cells promoted the basal levels of insulin signaling as well as glucose uptake, while blocking JAK2 signaling with either pharmacological intervention (JAK2 inhibitor AG490) or genetic manipulation (siRNA knockdown) decreased the basal levels of insulin signaling. Furthermore, leptin treatment inhibited insulin-stimulated insulin signaling and glucose uptake, while blocking JAK2 signaling restored leptin-attenuated insulin sensitivity. Taken together, our results demonstrated that reduced serum leptin, at least in part, contributes to exercise-mediated improvement of insulin sensitivity, indicating JAK2 as a potent therapeutical target of insulin resistance.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Resistência à Insulina/fisiologia
Insulina/metabolismo
Janus Quinase 2/metabolismo
Leptina/sangue
Proteína Oncogênica v-akt/metabolismo
Condicionamento Físico Animal/métodos
[Mh] Termos MeSH secundário: Animais
Masculino
Fosforilação
Esforço Físico/fisiologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Leptin); EC 2.7.10.2 (Jak2 protein, rat); EC 2.7.10.2 (Janus Kinase 2); EC 2.7.11.1 (Oncogene Protein v-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


  9 / 21177 MEDLINE  
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[PMID]:29373573
[Au] Autor:Robles M; Nouveau E; Gautier C; Mendoza L; Dubois C; Dahirel M; Lagofun B; Aubrière MC; Lejeune JP; Caudron I; Guenon I; Viguié C; Wimel L; Bouraima-Lelong H; Serteyn D; Couturier-Tarrade A; Chavatte-Palmer P
[Ad] Endereço:UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
[Ti] Título:Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age.
[So] Source:PLoS One;13(1):e0190309, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Obesity is a growing concern in horses. The effects of maternal obesity on maternal metabolism and low-grade inflammation during pregnancy, as well as offspring growth, metabolism, low-grade inflammation, testicular maturation and osteochondrotic lesions until 18 months of age were investigated. MATERIAL AND METHODS: Twenty-four mares were used and separated into two groups at insemination according to body condition score (BCS): Normal (N, n = 10, BCS ≤4) and Obese (O, n = 14, BCS ≥4.25). BCS and plasma glucose, insulin, triglyceride, urea, non-esterified fatty acid, serum amyloid A (SAA), leptin and adiponectin concentrations were monitored throughout gestation. At 300 days of gestation, a Frequently Sampled Intravenous Glucose Tolerance Test (FSIGT) was performed. After parturition, foals' weight and size were monitored until 18 months of age with plasma SAA, leptin, adiponectin, triiodothyronine (T3), thyroxine (T4) and cortisol concentrations measured at regular intervals. At 6, 12 and 18 months of age, FSIGT and osteoarticular examinations were performed. Males were gelded at one year and expression of genes involved in testicular maturation analysed by RT-qPCR. RESULTS: Throughout the experiment, maternal BCS was higher in O versus N mares. During gestation, plasma urea and adiponectin were decreased and SAA and leptin increased in O versus N mares. O mares were also more insulin resistant than N mares with a higher glucose effectiveness. Postnatally, there was no difference in offspring growth between groups. Nevertheless, plasma SAA concentrations were increased in O versus N foals until 6 months, with O foals being consistently more insulin resistant with a higher glucose effectiveness. At 12 months of age, O foals were significantly more affected by osteochondrosis than N foals. All other parameters were not different between groups. CONCLUSION: In conclusion, maternal obesity altered metabolism and increased low-grade inflammation in both dams and foals. The risk of developing osteochondrosis at 12 months of age was also higher in foals born to obese dams.
[Mh] Termos MeSH primário: Doenças dos Cavalos/patologia
Doenças dos Cavalos/fisiopatologia
Inflamação/veterinária
Resistência à Insulina/fisiologia
Obesidade/veterinária
Osteocondrose/veterinária
Complicações na Gravidez/veterinária
[Mh] Termos MeSH secundário: Adiponectina/sangue
Animais
Animais Recém-Nascidos
Glicemia/metabolismo
Feminino
Teste de Tolerância a Glucose
Cavalos
Inflamação/etiologia
Insulina/sangue
Leptina/sangue
Masculino
Troca Materno-Fetal
Obesidade/complicações
Obesidade/fisiopatologia
Osteocondrose/etiologia
Gravidez
Complicações na Gravidez/patologia
Complicações na Gravidez/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adiponectin); 0 (Blood Glucose); 0 (Insulin); 0 (Leptin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190309


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[PMID]:29327584
[Au] Autor:Si X; Shang W; Zhou Z; Shui G; Lam SM; Blanchard C; Strappe P
[Ad] Endereço:Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology , Tianjin 300457, China.
[Ti] Título:Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids.
[So] Source:J Agric Food Chem;66(4):881-890, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp., and associated synthesizing enzymes. This altered short-chain fatty acid (SCFA) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulating orexigenic factors. Together with the enhanced fatty acid ß-oxidation highlighted by Prkaa2, Ppara, and Scd1 expression via AMPK signaling pathway and nonalcoholic fatty liver disease pathway, energy expenditure was positively modulated. Serum lipid compositions showed ERB supplement exhibited a more efficient effect on lowering serum sphingolipids, which was closely associated with the status of insulin resistance. Consistently, genes of Ppp2r3b and Prkcg, involved in the function of ceramides in blocking insulin action, were also downregulated following ERB intervention. Enriched GABA and phenolic acids were supposed to be responsible for the health-beneficial effects.
[Mh] Termos MeSH primário: Metabolismo Energético/efeitos dos fármacos
Alimentos Fortificados
Microbioma Gastrointestinal/efeitos dos fármacos
Resistência à Insulina
Oryza
Ácido gama-Aminobutírico/administração & dosagem
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Ceramidas/fisiologia
DNA/análise
Dieta
Dieta Hiperlipídica
Ácidos Graxos Voláteis/sangue
Microbioma Gastrointestinal/fisiologia
Peptídeo 1 Semelhante ao Glucagon/sangue
Leptina/sangue
Fígado/metabolismo
Masculino
Síndrome Metabólica/etiologia
Síndrome Metabólica/prevenção & controle
Obesidade/terapia
Ratos
Ratos Sprague-Dawley
Sementes
Esfingolipídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ceramides); 0 (Fatty Acids, Volatile); 0 (Leptin); 0 (Sphingolipids); 56-12-2 (gamma-Aminobutyric Acid); 89750-14-1 (Glucagon-Like Peptide 1); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04994



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