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[PMID]:28972919
[Au] Autor:Liang YQ; Huang GY; Lin Z; Li J; Yang JW; Zhong LY; Ying GG
[Ad] Endereço:Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang, 524088, PR China. Electronic address: liangyanqiu11@126.com.
[Ti] Título:Reproductive effects of synthetic progestin norgestrel in zebrafish (Danio rerio).
[So] Source:Chemosphere;190:17-24, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the adverse effects of synthetic progestin norgestrel (NGT) on the reproduction of zebrafish by measuring the egg production, histology and transcriptional expression profiles along the hypothalamic-pituitary-gonadal (HPG) axis in adult zebrafish. After a pre-exposure period of 7 days, adult zebrafish were exposed to 6, 29 and 69 ng L NGT for 21 days. The results showed that exposure to 69 ng L NGT led to a significant up-regulation of follicle stimulating hormone, beta polypeptide (fshb), luteinizing hormone, beta polypeptide (lhb), progesterone receptor (pgr), estrogen receptor 1 (esr1) and androgen receptor (ar) genes in the brains, as well as significant up-regulation of hydroxysteroid 20-beta dehydrogenase (hsd20b) and hydroxysteroid 11-beta dehydrogenase 2 (hsd11b2) genes and down-regulation of 11-beta-hydroxylase (cyp11b) gene in the ovaries of females. In the testes of males, an overall down-regulation of steroidogenic acute regulatory protein (star), cytochrome P450-mediated side-chain cleavage enzyme (cyp11a1), cyp11b, hsd20b, hydroxysteroid 17-beta dehydrogenase type 3 (hsd17b3), hsd11b2 and ar genes were observed following exposure to different treatments of NGT. These transcriptional alterations imply that NGT could exhibit the potent progestogenic and androgenic activities in zebrafish. Egg production as well as histology in the ovaries and testes was not affected by NGT. Taken together, the overall results demonstrated that NGT could significantly affect transcriptional expression levels of genes related to HPG axis in zebrafish, and whether that change translates to additional physiological effects is needed further research.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica/efeitos dos fármacos
Norgestrel/farmacologia
Reprodução/efeitos dos fármacos
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Anticoncepcionais Orais Sintéticos/farmacologia
Feminino
Gonadotropinas Hipofisárias/genética
Hormônios Hipotalâmicos/genética
Masculino
Norgestrel/metabolismo
Progestinas/fisiologia
Receptores de Progesterona/genética
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptives, Oral, Synthetic); 0 (Gonadotropins, Pituitary); 0 (Hypothalamic Hormones); 0 (Progestins); 0 (Receptors, Progesterone); 3J8Q1747Z2 (Norgestrel)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28486374
[Au] Autor:Rezkalla J; Von Wald T; Hansen KA
[Ad] Endereço:Department of Obstetrics & Gynecology, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
[Ti] Título:Premature Thelarche and the PURA Syndrome.
[So] Source:Obstet Gynecol;129(6):1037-1039, 2017 Jun.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Premature thelarche is a self-limited condition characterized by Tanner stage II-III breast development in girls younger than 8 years of age with no evidence of advancing puberty. Evaluation concentrates on excluding central or peripheral causes of precocious puberty. CASE: A girl aged 2 years 4 months with profound hypotonia and delayed developmental milestones presented with Tanner II breast development, elevated follicle-stimulating hormone levels, suppressed luteinizing hormone level, normal growth and skeletal development, and prepubertal uterine length and ovarian volume. Monitoring until 8 years of age revealed no pubertal progression. Whole exome sequencing at 8 years revealed an autosomal-dominant mutation in the purine-rich element-binding protein A (PURA) gene. Previous patients with PURA syndrome have had pituitary dysfunction and precocious puberty. CONCLUSION: Purine-rich element-binding protein A syndrome can be associated with premature thelarche.
[Mh] Termos MeSH primário: Mama/crescimento & desenvolvimento
Proteínas de Ligação a DNA/sangue
Puberdade Precoce/diagnóstico
Fatores de Transcrição/sangue
[Mh] Termos MeSH secundário: Pré-Escolar
Proteínas de Ligação a DNA/genética
Diagnóstico Diferencial
Feminino
Gonadotropinas Hipofisárias/sangue
Seres Humanos
Puberdade Precoce/sangue
Síndrome
Fatores de Transcrição/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Gonadotropins, Pituitary); 0 (PURA protein, human); 0 (Transcription Factors)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002047


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[PMID]:28049245
[Au] Autor:Shin JJ; Jee BC; Kim H; Kim SH
[Ad] Endereço:Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
[Ti] Título:Major Disease Prevalence and Menstrual Characteristics in Infertile Female Korean Smokers.
[So] Source:J Korean Med Sci;32(2):321-328, 2017 Feb.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:We investigated the prevalence of smoking and factors associated with smoking in infertile Korean women. Smoking status, education, occupation, personal habits, past medical history, current illness, stress level, and menstrual characteristics were collected from self-report questionnaires. The Beck Depression Inventory (BDI) was used to assess the degree of depression. Data on the causes of infertility and levels of six reproductive hormones were collected from medical records. Among 785 women less than 42 years of age, the prevalence of current, secondhand, past, and never smokers were 12.7%, 45.7%, 0.9%, and 40.6%, respectively. Primary infertility was more frequent in secondhand smokers. Causes of infertility were similar among current, secondhand, and never smokers. Current smokers were less educated (P < 0.001) and more likely to consume alcohol than secondhand or never smokers (P < 0.001). Secondhand smokers slept less than current smokers (P = 0.041). Among several major diseases, only the prevalence of diabetes mellitus (4.0%) was significantly higher in current smokers than in secondhand smokers (0.0%, P = 0.002) or never smokers (0.6%, P = 0.031). The self-reported prevalence of depression, and the degree of depression were similar among women with different smoking statuses. There were no differences in menstrual characteristics or serum levels of six reproductive hormones between current, secondhand, and never smokers, even after excluding women with polycystic ovary syndrome. In conclusion, education/employment status, alcohol drinking, and the prevalence of primary infertility and diabetes mellitus were significantly different according to smoking status among infertile women.
[Mh] Termos MeSH primário: Infertilidade Feminina/patologia
Fumar/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Consumo de Bebidas Alcoólicas
Depressão/epidemiologia
Diabetes Mellitus Tipo 2/epidemiologia
Estradiol/sangue
Feminino
Gonadotropinas Hipofisárias/sangue
Seres Humanos
Menstruação
Autorrelato
Estresse Psicológico
Inquéritos e Questionários
Tireotropina/sangue
Poluição por Fumaça de Tabaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins, Pituitary); 0 (Tobacco Smoke Pollution); 4TI98Z838E (Estradiol); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2017.32.2.321


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[PMID]:27916574
[Au] Autor:Shahjahan M; Kitahashi T; Ando H
[Ad] Endereço:Sado Marine Biological Station, Faculty of Science, Niigata University, Sado, Niigata 952-2135, Japan.
[Ti] Título:Temperature affects sexual maturation through the control of kisspeptin, kisspeptin receptor, GnRH and GTH subunit gene expression in the grass puffer during the spawning season.
[So] Source:Gen Comp Endocrinol;243:138-145, 2017 Mar 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Water temperature is an environmental factor of primary importance that influences reproductive function in fish. To understand the molecular and physiological mechanisms underlying the regulation of reproduction by temperature, we examined changes in expression of genes encoding kisspeptin (kiss2), kisspeptin receptor (kiss2r) and three gonadotropin-releasing hormones (gnrh1, gnrh2 and gnrh3) in the brain and genes encoding gonadotropin (GTH) subunits (gpa, fshb and lhb) in the pituitary of grass puffer exposed to a low temperature (14°C), normal temperature (21°C) and high temperature (28°C) for 7days. In addition, the plasma levels of cortisol were examined after exposed to three temperature conditions. The gonadosomatic index was significantly decreased in both low and high temperature conditions. The levels of kiss2 and kiss2r mRNAs were significantly decreased at both low and high temperature conditions compared to normal temperature (control) condition. gnrh1 but not gnrh2 were significantly decreased in both temperature conditions, while gnrh3 showed a decreasing tendency in low temperature. Consequently, the levels of fshb and lhb mRNAs were significantly decreased in both low and high temperature conditions. Interestingly, the plasma levels of cortisol were significantly increased in low temperature but remain unchanged in high temperature, suggesting that the fish were under stress in the low temperature conditions but not in the high temperature conditions. Taken together, the present results indicate that anomalous temperature have an inhibitory effect on reproductive function through suppressing kiss2/kiss2r/gnrh1/fshb and lhb expression and these changes may occur in a normal physiological response as well as in a malfunctional stress response.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
Gonadotropinas Hipofisárias/metabolismo
Kisspeptinas/metabolismo
Receptores Acoplados a Proteínas-G/metabolismo
Estações do Ano
Maturidade Sexual/genética
Tetraodontiformes/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Gonadotropinas Hipofisárias/genética
Kisspeptinas/genética
Hipófise/metabolismo
Receptores Acoplados a Proteínas-G/genética
Reprodução/fisiologia
Temperatura Ambiente
Tetraodontiformes/genética
Tetraodontiformes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (Gonadotropins, Pituitary); 0 (Kisspeptins); 0 (Receptors, G-Protein-Coupled)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27494693
[Au] Autor:Tekin S; Erden Y; Sandal S; Etem Onalan E; Ozyalin F; Ozen H; Yilmaz B
[Ad] Endereço:a Department of Physiology , Faculty of Medicine, Inonu University , Malatya , Turkey.
[Ti] Título:Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism.
[So] Source:Arch Physiol Biochem;123(1):9-15, 2017 Feb.
[Is] ISSN:1744-4160
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 µg/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p < 0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p < 0.05), but caused significant decreases in high-density lipoprotein levels (p < 0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p < 0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.
[Mh] Termos MeSH primário: Ingestão de Energia/efeitos dos fármacos
Metabolismo Energético/efeitos dos fármacos
Comportamento Alimentar/efeitos dos fármacos
Hipercolesterolemia/induzido quimicamente
Infertilidade Masculina/induzido quimicamente
Peptídeos e Proteínas de Sinalização Intercelular/toxicidade
Sobrepeso/induzido quimicamente
[Mh] Termos MeSH secundário: Tecido Adiposo Marrom/efeitos dos fármacos
Tecido Adiposo Marrom/metabolismo
Tecido Adiposo Branco/efeitos dos fármacos
Tecido Adiposo Branco/metabolismo
Animais
Relação Dose-Resposta a Droga
Gonadotropinas Hipofisárias/antagonistas & inibidores
Gonadotropinas Hipofisárias/sangue
Hipercolesterolemia/sangue
Hipercolesterolemia/metabolismo
Infertilidade Masculina/sangue
Infertilidade Masculina/metabolismo
Injeções Intraperitoneais
Masculino
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/metabolismo
Sobrepeso/sangue
Sobrepeso/metabolismo
Distribuição Aleatória
Ratos Sprague-Dawley
Testosterona/antagonistas & inibidores
Testosterona/sangue
Testes de Toxicidade Crônica
Proteína Desacopladora 1/antagonistas & inibidores
Proteína Desacopladora 1/genética
Proteína Desacopladora 1/metabolismo
Proteína Desacopladora 3/antagonistas & inibidores
Proteína Desacopladora 3/genética
Proteína Desacopladora 3/metabolismo
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins, Pituitary); 0 (Intercellular Signaling Peptides and Proteins); 0 (Ucp1 protein, rat); 0 (Ucp3 protein, rat); 0 (Uncoupling Protein 1); 0 (Uncoupling Protein 3); 0 (apelin-13 peptide); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1080/13813455.2016.1211709


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[PMID]:27916832
[Au] Autor:Mao J; Dalvie MA
[Ad] Endereço:Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine, Health Sciences Faculty, University of Cape Town, Anzio Road, Observatory, Cape Town 7729, South Africa. maojunme@gmail.com.
[Ti] Título:Anthropometric Measurements, Serum Reproductive Hormonal Levels and Sexual Development among Boys in the Rural Western Cape, South Africa.
[So] Source:Int J Environ Res Public Health;13(12), 2016 Nov 29.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Data on growth and sexual maturation among boys from the rural Western Cape in South Africa is limited. A cross-sectional study of 269 school boys was conducted testing for serum luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG) and estradiol (E2); height, weight and body mass index (BMI); sexual maturity (using Tanner Stages) and a questionnaire (demographic and medical history). The median age at pubertal onset (Tanner Stage 2) and Tanner Stage 5 was 11.6 and 14.7 years, respectively. The median testicular volume was 5.5 mL at Tanner Stage 2 increasing from 2.5 mL at Tanner Stage 1 to 14.7 mL at Tanner Stage 5. Height and weight measurements were <25th & 50th percentile references at Tanner Stages 1-3. Controlling for confounders, serum FSH and LH increased ( < 0.05) from Tanner Stage 1 to 4 (by 4.1 and 3 mL respectively), and serum testosterone and estradiol increased after Tanner Stage 2 (by 12.7 nmol/L and 59.5 pmol/L respectively). These results indicate some delays in pubertal development of boys in the rural Western Cape when compared to boys from other settings possibly due to nutritional, socio-economic and environmental exposures. Changes in serum hormone levels were consistent with other populations. Initiatives to improve nutrition amongst Western Cape rural communities are recommended.
[Mh] Termos MeSH primário: Hormônios Esteroides Gonadais/sangue
Gonadotropinas Hipofisárias/sangue
Globulina de Ligação a Hormônio Sexual/metabolismo
Maturidade Sexual
Testículo/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Adolescente
Antropometria
Índice de Massa Corporal
Peso Corporal
Criança
Estudos Transversais
Exposição Ambiental
Estradiol/sangue
Hormônio Foliculoestimulante/sangue
Seres Humanos
Hormônio Luteinizante/sangue
Masculino
Puberdade/sangue
População Rural/estatística & dados numéricos
Fatores Socioeconômicos
África do Sul
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Gonadotropins, Pituitary); 0 (Sex Hormone-Binding Globulin); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27697204
[Au] Autor:Kumar TR
[Ad] Endereço:Edgar L. and Patricia M. Makowski Endowed Professor, Department of Obstetrics & Gynecology, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States. Electronic address: raj.kumar@ucdenver.edu.
[Ti] Título:Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins.
[So] Source:Prog Mol Biol Transl Sci;143:49-84, 2016.
[Is] ISSN:1878-0814
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gonadotropins play fundamental roles in reproduction. More than 30years ago, Cga transgenic mice were generated, and more than 20years ago, the phenotypes of Cga null mice were reported. Since then, numerous mouse strains have been generated and characterized to address several questions in reproductive biology involving gonadotropin synthesis, secretion, and action. More recently, extragonadal expression, and in some cases, functions of gonadotropins in nongonadal tissues have been identified. Several genomic and proteomic approaches including novel mouse genome editing tools are available now. It is anticipated that these and other emerging technologies will be useful to build an integrated network of gonadotropin signaling pathways in various tissues. Undoubtedly, research on gonadotropins will continue to provide new knowledge and allow us transcend from benchside to the bedside.
[Mh] Termos MeSH primário: Gonadotropinas Hipofisárias/biossíntese
Gonadotropinas Hipofisárias/secreção
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Modelos Animais
Subunidades Proteicas/metabolismo
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gonadotropins, Pituitary); 0 (Protein Subunits); 0 (Transforming Growth Factor beta)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27622546
[Au] Autor:Yom-Din S; Hollander-Cohen L; Aizen J; Boehm B; Shpilman M; Golan M; Hurvitz A; Degani G; Levavi-Sivan B
[Ad] Endereço:Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
[Ti] Título:Gonadotropins in the Russian Sturgeon: Their Role in Steroid Secretion and the Effect of Hormonal Treatment on Their Secretion.
[So] Source:PLoS One;11(9):e0162344, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the reproduction process of male and female fish, pituitary derived gonadotropins (GTHs) play a key role. To be able to specifically investigate certain functions of Luteinizing (LH) and Follicle stimulating hormone (FSH) in Russian sturgeon (Acipenser gueldenstaedtii; st), we produced recombinant variants of the hormones using the yeast Pichia pastoris as a protein production system. We accomplished to create in vitro biologically active heterodimeric glycoproteins consisting of two associated α- and ß-subunits in sufficient quantities. Three dimensional modelling of both GTHs was conducted in order to study the differences between the two GTHs. Antibodies were produced against the unique ß-subunit of each of the GTHs, in order to be used for immunohistochemical analysis and to develop an ELISA for blood and pituitary hormone quantification. This detection technique revealed the specific localization of the LH and FSH cells in the sturgeon pituitary and pointed out that both cell types are present in substantially higher numbers in mature males and females, compared to immature fish. With the newly attained option to prevent cross-contamination when investigating on the effects of GTH administration, we compared the steroidogeneic response (estradiol and 11-Keto testosterone (11-KT) in female and males, respectively) of recombinant stLH, stFSH, and carp pituitary extract in male and female sturgeon gonads at different developmental stages. Finally, we injected commercially available gonadotropin releasing hormones analog (GnRH) to mature females, and found a moderate effect on the development of ovarian follicles. Application of only testosterone (T) resulted in a significant increase in circulating levels of 11-KT whereas the combination of GnRH + T did not affect steroid levels at all. The response pattern for estradiol demonstrated a similar situation. FSH levels showed significant increases when GnRH + T was administered, while no changes were present in LH levels.
[Mh] Termos MeSH primário: Peixes/fisiologia
Gonadotropinas Hipofisárias/fisiologia
Esteroides/fisiologia
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática
Estradiol/secreção
Feminino
Hormônio Foliculoestimulante/química
Hormônio Foliculoestimulante/farmacologia
Hormônio Liberador de Gonadotropina/análogos & derivados
Hormônio Liberador de Gonadotropina/farmacologia
Gonadotropinas Hipofisárias/química
Hormônio Luteinizante/química
Hormônio Luteinizante/farmacologia
Masculino
Modelos Moleculares
Folículo Ovariano/efeitos dos fármacos
Folículo Ovariano/fisiologia
Hipófise/efeitos dos fármacos
Hipófise/fisiologia
Subunidades Proteicas
Proteínas Recombinantes/química
Proteínas Recombinantes/farmacologia
Testículo/efeitos dos fármacos
Testículo/fisiologia
Testosterona/análogos & derivados
Testosterona/farmacologia
Testosterona/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins, Pituitary); 0 (Protein Subunits); 0 (Recombinant Proteins); 0 (Steroids); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); KF38W1A85U (11-ketotestosterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0162344


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[PMID]:27475653
[Au] Autor:Harding LB; Schultz IR; da Silva DA; Ylitalo GM; Ragsdale D; Harris SI; Bailey S; Pepich BV; Swanson P
[Ad] Endereço:School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA 98195, USA.
[Ti] Título:Wastewater treatment plant effluent alters pituitary gland gonadotropin mRNA levels in juvenile coho salmon (Oncorhynchus kisutch).
[So] Source:Aquat Toxicol;178:118-31, 2016 Sep.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is well known that endocrine disrupting compounds (EDCs) present in wastewater treatment plant (WWTP) effluents interfere with reproduction in fish, including altered gonad development and induction of vitellogenin (Vtg), a female-specific egg yolk protein precursor produced in the liver. As a result, studies have focused on the effects of EDC exposure on the gonad and liver. However, impacts of environmental EDC exposure at higher levels of the hypothalamic-pituitary-gonad axis are less well understood. The pituitary gonadotropins, follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) are involved in all aspects of gonad development and are subject to feedback from gonadal steroids making them a likely target of endocrine disruption. In this study, the effects of WWTP effluent exposure on pituitary gonadotropin mRNA expression were investigated to assess the utility of Lh beta-subunit (lhb) as a biomarker of estrogen exposure in juvenile coho salmon (Oncorhynchus kisutch). First, a controlled 72-h exposure to 17α-ethynylestradiol (EE2) and 17ß-trenbolone (TREN) was performed to evaluate the response of juvenile coho salmon to EDC exposure. Second, juvenile coho salmon were exposed to 0, 20 or 100% effluent from eight WWTPs from the Puget Sound, WA region for 72h. Juvenile coho salmon exposed to 2 and 10ng EE2L(-1) had 17-fold and 215-fold higher lhb mRNA levels relative to control fish. Hepatic vtg mRNA levels were dramatically increased 6670-fold, but only in response to 10ng EE2L(-1) and Fsh beta-subunit (fshb) mRNA levels were not altered by any of the treatments. In the WWTP effluent exposures, lhb mRNA levels were significantly elevated in fish exposed to five of the WWTP effluents. In contrast, transcript levels of vtg were not affected by any of the WWTP effluent exposures. Mean levels of natural and synthetic estrogens in fish bile were consistent with pituitary lhb expression, suggesting that the observed lhb induction may be due to estrogenic activity of the WWTP effluents. These results suggest that lhb gene expression may be a sensitive index of acute exposure to estrogenic chemicals in juvenile coho salmon. Further work is needed to determine the kinetics and specificity of lhb induction to evaluate its utility as a potential indicator of estrogen exposure in immature fish.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Gonadotropinas Hipofisárias/metabolismo
Oncorhynchus kisutch/metabolismo
Hipófise/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Etinilestradiol/toxicidade
Feminino
Hormônio Foliculoestimulante/genética
Hormônio Foliculoestimulante/metabolismo
Expressão Gênica/efeitos dos fármacos
Gonadotropinas Hipofisárias/genética
Hormônio Luteinizante/genética
Hormônio Luteinizante/metabolismo
Oncorhynchus kisutch/crescimento & desenvolvimento
Hipófise/metabolismo
RNA Mensageiro/metabolismo
Acetato de Trembolona/toxicidade
Eliminação de Resíduos Líquidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Gonadotropins, Pituitary); 0 (RNA, Messenger); 0 (Water Pollutants, Chemical); 423D2T571U (Ethinyl Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160801
[St] Status:MEDLINE


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[PMID]:27401261
[Au] Autor:Hou ZS; Wen HS; Li JF; He F; Li Y; Tao YX
[Ad] Endereço:Fisheries College, Ocean University of China, Qingdao 266003, China.
[Ti] Título:Hypothalamus-pituitary-gonad axis of rainbow trout (Oncorhynchus mykiss) during early ovarian development and under dense rearing condition.
[So] Source:Gen Comp Endocrinol;236:131-138, 2016 Sep 15.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to determine the hypothalamus-pituitary-gonad (HPG) axis of female rainbow trout (Oncorhynchus mykiss) during early ovarian development and under high rearing density. Trouts were sampled from 240 (ovarian stage II) to 540 (ovarian stage IV) days following hatching (DFH) as control group (Ctrl, 4.6-31.1kg/m(3)) to determine HPG axis during early ovarian development. Trouts from the same batch of fertilized eggs were reared in two higher densities during 240-540 DFH as stocking density 1 and 2 (SD1, 6.6-40.6kg/m(3); SD2, 8.6-49.3kg/m(3)) to elucidate effects of high density on reproductive parameters. Dopamine, E2 (estradiol), 17α,20ß-P (17α,20ß-dihydroxy4-pregnen-3-one) and P4 (progesterone) were evaluated by radioimmunoassay or ELISA. mRNA expression of hypothalamic gnrh-1, -2 (gonadotropin-releasing hormone-1, -2), pituitary gonadotropins (fsh/lh, follicle-stimulating hormone/luteinizing hormone) and their cognate receptors (fshr/lhr) in ovaries were examined by qRT-PCR. Our findings demonstrated mRNA expression of hypothalamic sgnrh-1, pituitary fsh and ovarian fshr increased in early ovarian development (360 DFH). Serum 17α,20ß-P and pituitary lh mRNA expression first increased when trouts were in ovarian stage III (420 DFH). Ovaries were at different stages when reared in different densities. Long-term high density treatment (over 31.7kg/m(3)) resulted in decreased hypothalamic sgnrh-1, pituitary fsh, ovarian fshr, serum E2, and increased hypothalamus gnrh-2 and serum dopamine during vitellogenin synthesis, suggesting HPG of rainbow trout might be retarded under dense rearing condition.
[Mh] Termos MeSH primário: Hormônios Esteroides Gonadais/metabolismo
Gonadotropinas Hipofisárias/metabolismo
Hipotálamo/metabolismo
Oncorhynchus mykiss/genética
Oncorhynchus mykiss/metabolismo
Ovário/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Oncorhynchus mykiss/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Gonadotropins, Pituitary)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE



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