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[PMID]:28300875
[Au] Autor:Khadivi B; Peirouvi T; JavanmardI MZ; Rasmi Y
[Ad] Endereço:Department of Histology, Faculty of Medicine, Urmia University of Medical Sciences, Iran.
[Ti] Título:Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes.
[So] Source:Acta Cir Bras;32(2):140-147, 2017 Feb.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the effect of buserelin on gonadal structure and function in adult male rats. METHODS: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. RESULTS: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. CONCLUSION: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Busserrelina/administração & dosagem
Fármacos para a Fertilidade Masculina/administração & dosagem
Túbulos Seminíferos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Busserrelina/efeitos adversos
Fármacos para a Fertilidade Masculina/efeitos adversos
Marcação In Situ das Extremidades Cortadas
Masculino
Modelos Animais
Ratos
Ratos Wistar
Túbulos Seminíferos/patologia
Testículo/anatomia & histologia
Testículo/efeitos dos fármacos
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertility Agents, Male); 3XMK78S47O (Testosterone); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


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[PMID]:27888394
[Au] Autor:Sahoo JK; Das SK; Sethy K; Mishra SK; Swain RK; Mishra PC; Sahoo SP
[Ad] Endereço:Department of Animal Nutrition, C.V.Sc. & A.H., OUAT, Bhubaneswar, India. jatinsahoo43@gmail.com.
[Ti] Título:Comparative evaluation of hormonal protocol on the performance of crossbred cattle.
[So] Source:Trop Anim Health Prod;49(2):259-263, 2017 Feb.
[Is] ISSN:1573-7438
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A total of 60 animals (38 cows, 22 heifers) were selected and were divided into three groups of 20 animals each (containing both anoestrus and repeat breeder) in which treatment was performed for 60 days. Group I: control (farmer practice), T group: group I + hormone (double synch), and T group: group I + hormone (Estra double synch). The growth performances were measured in terms of body weight and average daily gain (ADG). Blood collection was done at the start and end of the experiment for assessment of blood biochemical, hematological, and reproductive status of the animals. Results revealed significant improvement in growth and reproductive performances in treatment group as compared to control group. Higher percentage of conception was achieved in group III (60%) followed by group II (55%). The least percentage was in group I (15%), i.e., in control group. So it was found that the effect of treating the reproductive-disordered animals with Estra double synch gave comparatively better result than double synch hormonal application.
[Mh] Termos MeSH primário: Busserrelina/farmacologia
Bovinos/fisiologia
Indústria de Laticínios/métodos
Dinoprosta/análogos & derivados
Estradiol/análogos & derivados
Sincronização do Estro/efeitos dos fármacos
Substâncias para o Controle da Reprodução/farmacologia
[Mh] Termos MeSH secundário: Animais
Bovinos/crescimento & desenvolvimento
Dinoprosta/farmacologia
Estradiol/farmacologia
Feminino
Índia
Inseminação Artificial/veterinária
Reprodução
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reproductive Control Agents); 1S4CJB5ZGN (estradiol 3-benzoate); 4TI98Z838E (Estradiol); B7IN85G1HY (Dinoprost); CT6BBQ5A68 (dinoprost tromethamine); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE
[do] DOI:10.1007/s11250-016-1186-3


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[PMID]:27743689
[Au] Autor:Carvalho NA; Soares JG; Souza DC; Maio JR; Sales JN; Martins Júnior B; Macari RC; D'Occhio MJ; Baruselli PS
[Ad] Endereço:Unidade de Pesquisa e Desenvolvimento de Registro-Polo Regional do D.S.A. do Vale do Ribeira/APTA, Registro, São Paulo, Brazil. Electronic address: nelcio@apta.sp.gov.br.
[Ti] Título:Ovulation synchronization with estradiol benzoate or GnRH in a timed artificial insemination protocol in buffalo cows and heifers during the nonbreeding season.
[So] Source:Theriogenology;87:333-338, 2017 Jan 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare estradiol benzoate (EB) and GnRH for the induction of ovulation in a TAI protocol in buffalo during the nonbreeding season. In experiment 1, 141 buffaloes (56 cows and 85 heifers) received an intravaginal P4 device (1.0 g) plus EB (2.0-mg, intramuscular [im]) at random stage of the estrous cycle (Day 0). On Day 9, the P4 device was removed, and buffaloes were given PGF (0.53-mg im sodium cloprostenol) plus eCG (400-IU im). Buffaloes were then randomly allocated to one of three groups and treated as follows: EB24 (n = 47), EB (1.0 mg im) 24 hours after P4 device removal; EB36 (n = 50), EB 36 hours after P4 device removal; GnRH48 (n = 44), GnRH (10 µg im buserelin acetate) 48 hours after P4 device removal. Ultrasound examinations were performed on Day 0 to ascertain ovarian follicular status, Day 9 to measure follicular diameter, and from Day 11 to Day 14 (every 12 hours for 60 hours) to establish the time of ovulation. There were no significant differences between EB24, EB36, and GnRH48 for diameter of the ovulatory follicle (13.1 ± 0.3, 13.7 ± 0.3, and 13.7 ± 0.3 mm; P = 0.26) and ovulation rate (78.7%, 82.0%, and 84.1%; P = 0.93). When compared with heifers, cows had a greater diameter of the dominant follicle on Day 9 (10.3 ± 0.3 and 8.6 ± 0.2 mm; P = 0.0001), diameter of the ovulatory follicle (14.1 ± 0.3 and 13.1 ± 0.2 mm; P = 0.01), ovulation rate (91.1% and 75.3%; P = 0.02), and interval from P4 device removal to ovulation (76.3 ± 1.3 and 72.5 ± 1.4 hours; P = 0.05). In experiment 2, 511 buffaloes (354 cows and 157 heifers) were assigned to the same treatments described in experiment 1 (EB24, n = 168; EB36, n = 172; and GnRH48, n = 171), and all animals were submitted to timed artificial insemination (TAI) 64 hours after P4 device removal. Pregnancy diagnosis was undertaken 30 days after TAI. There were no significant differences between EB24, EB36, and GnRH48 for pregnancy rate (45.2%, 43.0%, and 49.7%; P = 0.46), and the pregnancy rate did not differ (P = 0.31) for cows (47.5%) and heifers (42.7%). The findings from the two experiments indicated that EB (24 or 36 hours) and GnRH (48 hours) induce comparable follicular responses, ovulation, and pregnancy rates in buffalo cows and heifers. Although there were some differences in the follicular responses between cows and heifers, the pregnancy rate to TAI was nonetheless similar.
[Mh] Termos MeSH primário: Búfalos/fisiologia
Busserrelina/farmacologia
Gonadotropina Coriônica/farmacologia
Cloprostenol/farmacologia
Estradiol/análogos & derivados
Sincronização do Estro/métodos
[Mh] Termos MeSH secundário: Animais
Busserrelina/administração & dosagem
Gonadotropina Coriônica/administração & dosagem
Cloprostenol/administração & dosagem
Esquema de Medicação
Estradiol/administração & dosagem
Estradiol/farmacologia
Feminino
Inseminação Artificial/veterinária
Ovário/diagnóstico por imagem
Ovário/efeitos dos fármacos
Ovário/fisiologia
Gravidez
Progesterona/farmacologia
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chorionic Gonadotropin); 1S4CJB5ZGN (estradiol 3-benzoate); 4208238832 (Cloprostenol); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161017
[St] Status:MEDLINE


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[PMID]:27696569
[Au] Autor:Baroncello E; Bernardi ML; Kummer AD; Wentz I; Bortolozzo FP
[Ad] Endereço:Setor de Suínos, Faculdade de Veterinária, Universidade Federal do Rio Grande Do Sul- UFRGS, Porto Alegre, RS, Brazil.
[Ti] Título:Fixed-time post-cervical artificial insemination in weaned sows following buserelin use combined with/without eCG.
[So] Source:Reprod Domest Anim;52(1):76-82, 2017 Feb.
[Is] ISSN:1439-0531
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Fixed-time post-cervical artificial insemination (FTAI) drastically reduces labour requirements and increases the use of boars with higher genetic merit. This study evaluated the efficiency of eCG administration combined with/without the GnRH agonist buserelin for the induction and synchronization of ovulation in weaned sows submitted to FTAI. The sows were allocated into three groups. In the control group, the first artificial insemination was performed at the onset of oestrus and repeated every 24 hr. In the eCG+GnRH group, sows received 600 IU eCG at weaning and buserelin (10 µg) after 86-89 hr of eCG, and in the GnRH group, sows received only buserelin after 86-89 hr of weaning. The hormone-treated sows received a single FTAI after 30-33 hr of buserelin application. All the sows were inseminated with homospermic doses (1.5 × 10  sperm cells/50 ml). The interval between weaning and ovulation was shorter (p < .05) in the eCG+GnRH (133.3 hr) and GnRH (135.9 hr) groups than the control (141.5 hr) group. In the eCG+GnRH group, the sows ovulated earlier (p < .05) than those in the GnRH group (44.5 vs. 48.2 hr after buserelin administration). The reproductive performance of GnRH sows was not compromised when only sows exhibiting oestrus at the time of insemination were considered, but lower farrowing rate and smaller litter size were observed in eCG+GnRH sows. The reproductive performance of eCG+GnRH sows was primarily compromised because the insemination was performed outside the optimal time relative to ovulation; therefore, it is advisable to inseminate them before 116-122 hr after weaning.
[Mh] Termos MeSH primário: Busserrelina/farmacologia
Estro/efeitos dos fármacos
Gonadotropinas Equinas/farmacologia
Inseminação Artificial/veterinária
Indução da Ovulação/veterinária
Ovulação/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Quimioterapia Combinada
Detecção do Estro
Feminino
Tamanho da Ninhada de Vivíparos/efeitos dos fármacos
Modelos Logísticos
Masculino
Ovário/diagnóstico por imagem
Gravidez
Taxa de Gravidez
Suínos
Ultrassonografia
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins, Equine); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1111/rda.12805


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[PMID]:27180066
[Au] Autor:Suszka-Switek A; Ryszka F; Dolinska B; Dec R; Danch A; Filipczyk L; Wiaderkiewicz R
[Ad] Endereço:Department of Histology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland.
[Ti] Título:Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn -Suspension After Single Subcutaneous Injection in Female Rats.
[So] Source:Eur J Drug Metab Pharmacokinet;42(2):251-259, 2017 Apr.
[Is] ISSN:2107-0180
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Although many synthetic gonadoliberin analogs have been developed, only a few of them, including buserelin, were introduced into clinical practice. Dalarelin, which differs from buserelin by just one aminoacid in the position 6 (D-Ala), is not widely used so far. Gonadotropin-releasing hormone (GnRH) analogs are used to treat many different illnesses and are available in different forms like solution for injection, nasal spray, microspheres, etc. Unfortunately, none of the above drug formulations can release the hormones for 24 h. We assumed that classical suspension could solve this problem. METHODS: Two sets of experiments were performed. In the first one, buserelin and dalarelin were injected into mature female rats in two forms: suspension, in which the analogs are bounded by Zn ions and solution. The pharmacokinetic parameters and bioavailability of the analogs were calculated, based on their concentration in the plasma measured by high-performance liquid chromatography method (HPLC). In the second experiment, the hormones in two different forms were injected into superovulated immature female rats and then the concentration of Luteinizing hormone (LH), Follicle-stimulating hormone (FSH) and 17ß-estradiol in the serum was measured by radioimmunological method. RESULTS: The Extent of Biological Availability (EBA), calculated on the base of AUC , showed that in the form of solution buserelin and dalarelin display, respectively, only 13 and 8 % of biological availability of their suspension counterparts. Comparing both analogs, the EBA of dalarelin was half (53 %) that of buserelin delivered in the form of solution and 83 % when they were delivered in the form of suspension. The injection of buserelin or dalarelin, in the form of solution or suspension, into superovulated female rats increased LH, FSH and estradiol concentration in the serum. However, after injection of the analogs in the form of suspension, the high concentration of LH and FSH in the serum persisted longer. CONCLUSION: Performed studies indicate that GnRH analogs in the form of suspension have higher bioavailability than their solution counterparts. It influences the effects of their action, especially in relation to LH and FSH.
[Mh] Termos MeSH primário: Busserrelina/administração & dosagem
Hormônio Liberador de Gonadotropina/análogos & derivados
Zinco/química
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Disponibilidade Biológica
Busserrelina/farmacocinética
Busserrelina/farmacologia
Cromatografia Líquida de Alta Pressão/métodos
Estradiol/sangue
Feminino
Hormônio Foliculoestimulante/sangue
Hormônio Liberador de Gonadotropina/administração & dosagem
Hormônio Liberador de Gonadotropina/farmacocinética
Hormônio Liberador de Gonadotropina/farmacologia
Injeções Subcutâneas
Hormônio Luteinizante/sangue
Soluções Farmacêuticas
Ratos
Ratos Wistar
Suspensões
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Solutions); 0 (Suspensions); 0 (dalarelin); 33515-09-2 (Gonadotropin-Releasing Hormone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); J41CSQ7QDS (Zinc); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE
[do] DOI:10.1007/s13318-016-0342-5


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[PMID]:27667750
[Au] Autor:Geyer A; Poth T; Otzdorff C; Daub L; Reese S; Braun J; Walter B
[Ad] Endereço:Clinic of Small Animal Surgery and Reproduction, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig Maximilian University, Munich, Germany. Electronic address: anja.geyernd@web.de.
[Ti] Título:Histopathologic examination of the genital tract in rabbits treated once or twice with a slow-release deslorelin implant for reversible suppression of ovarian function.
[So] Source:Theriogenology;86(9):2281-2289, 2016 Dec.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A total of 13 rabbits were treated with a subcutaneous deslorelin long-term release implant (4.7 mg) to study the effect on ovarian function and histologic features of the uterus. Seven rabbits (group 1) were implanted with a slow-release deslorelin implant before onset of puberty for 273 days as a part of a previous study. After resumption of ovarian function had been confirmed, they were implanted again at the age of 430 days. Six adult rabbits (>177 days old; group 2) were implanted with a slow-release deslorelin implant for 273 days. Ovarian function before, during, and after treatment with the implant was assessed by measuring serum progesterone levels 10 days after a challenge injection of a short-acting GnRH (0.8 µg buserelin intramuscularly) on progesterone levels in peripheral blood. Values more than 4 ng/mL progesterone were considered to verify ovarian function. Animals in group 1 underwent ovariohysterectomy during the second treatment with the implant and the uteri, and ovaries were subjected to histopathologic examination. Endometrial hyperplasia and endometritis were observed in 5 of 7 animals. Nonatretic and atretic follicles at different developmental stages, but no active corpora lutea, were present in the ovaries. Ovariohysterectomy of group 2 animals was performed 2 to 12 months after implant removal. The histopathologic examination of the uterus and ovary of four animals neutered during induced pseudopregnancy showed no signs of uterine disorders. In two animals undergoing ovariohysterectomy 12 months after implant removal, endometritis was present. Their ovaries contained follicles at different developmental stages and corpora albicantia. Reversible suppression of ovarian function can be achieved in female rabbits by the use of GnRH slow-release implants administered before or after puberty. The findings of endometrial hyperplasia and endometritis in seven out of 13 rabbits treated once or twice with the implant may indicate that the development of age-related pathologies of the uterus cannot be prevented by the suppression of ovarian function with a long-acting GnRH implant.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Genitália Feminina/efeitos dos fármacos
Ovário/efeitos dos fármacos
Pamoato de Triptorrelina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Busserrelina/administração & dosagem
Busserrelina/farmacologia
Preparações de Ação Retardada
Implantes de Medicamento
Inibidores Enzimáticos/administração & dosagem
Feminino
Histerectomia/veterinária
Ovariectomia/veterinária
Ovário/fisiologia
Ovulação/efeitos dos fármacos
Progesterona/sangue
Coelhos
Pamoato de Triptorrelina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Implants); 0 (Enzyme Inhibitors); 4G7DS2Q64Y (Progesterone); 57773-63-4 (Triptorelin Pamoate); PXW8U3YXDV (Buserelin); TKG3I66TVE (deslorelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:27590095
[Au] Autor:Pawlinski B; Domino M; Aniolek O; Ziecik A; Gajewski Z
[Ad] Endereço:Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, WULS-SGGW, Warsaw, Poland; Veterinary Research Centre, Faculty of Veterinary Medicine, WULS-SGGW, Warsaw, Poland.
[Ti] Título:Bioelectrical activity of porcine oviduct and uterus during spontaneous and induced estrus associated with cyclic hormone changes.
[So] Source:Theriogenology;86(9):2312-2322, 2016 Dec.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is widely accepted that uterine contraction is initiated by spontaneous generation of electrical activity at a cellular level in the form of action potentials. Such action potential events, when they involve many myometrial cells and occur in immediate succession, are described by their amplitude and duration. In an effort to improve clinical management of uterine contractions, research has focused on determination of the properties of the reproductive tract's electrical activity under hormonal stimulation. The aim of this study was to evaluate the myoelectric activity (amplitude and duration) of the oviduct and the uterus in relation to plasma concentration of LH, estradiol (E2), and progesterone (P4) during spontaneous and induced estrus in gilts. The course of the experiment was divided into eight periods defined by hormone concentrations (LH, P4, and E2) and time intervals before and after the start of the LH surge. Myoelectric signals were recorded, and the hormone levels were measured during proestrus and estrus in natural and hormone-induced estrus cycle. During the natural estrus, the LH surge was longer than after hormonal stimulation (28 vs. 20 hours) and suggested an inverse relationship between the LH concentration and the duration of myoelectric activity (S = -0.68). Analyses of the records of the amplitudes and durations of the electromyography activity in uterine horns and oviducts showed significant differences between spontaneous and induced estrus (P < 0.05). During induced estrus, the LH surge began earlier (T1 vs. T2) and increased more (7.46 vs. 6.50 ng/mL) than during spontaneous estrus. This observation suggests a direct relationship between the LH concentration and the amplitude of the myoelectric activity (Spearman rank correlation = 0.71). The significantly higher duration and amplitude of the activity in the isthmus of the oviduct and the uterus during induced estrus shortly after the onset of standing heat (4-8 hours after the LH surge) suggested more favorable conditions for effective artificial insemination.
[Mh] Termos MeSH primário: Gonadotropina Coriônica/farmacologia
Fenômenos Eletrofisiológicos/fisiologia
Estro/fisiologia
Tubas Uterinas/fisiologia
Suínos/fisiologia
Útero/fisiologia
[Mh] Termos MeSH secundário: Animais
Busserrelina/administração & dosagem
Busserrelina/farmacologia
Gonadotropina Coriônica/administração & dosagem
Estro/efeitos dos fármacos
Feminino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chorionic Gonadotropin); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE


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[PMID]:27577986
[Au] Autor:Neglia G; Gasparrini B; Salzano A; Vecchio D; De Carlo E; Cimmino R; Balestrieri A; D'Occhio MJ; Campanile G
[Ad] Endereço:Department of Veterinary Medicine and Animal Production, Federico II University, Naples, Italy.
[Ti] Título:Relationship between the ovarian follicular response at the start of an Ovsynch-TAI program and pregnancy outcome in the Mediterranean river buffalo.
[So] Source:Theriogenology;86(9):2328-2333, 2016 Dec.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the relationship between the ovarian follicular response at the start of the OVsynch-fixed-time artificial insemination (TAI) program and pregnancy outcome in the Mediterranean river buffalo. The study involved 116 pluriparous buffaloes at 118 ± 65 days in milk maintained under commercial conditions on a buffalo dairy enterprise in southern Italy. Synchronization of the stage of the estrous cycle in the Ovsynch-TAI program involves an injection of GnRH on Day 0 (GnRH1), PGF on Day 7, and GnRH on Day 9 (GnRH2). Timed artificial insemination is carried out on Day 10. Ovarian ultrasound examinations were undertaken on days 0, 2, 7, 9, 10, and 11 to record total follicles, the dimensions of follicles greater than 0.75 cm, dimensions of the corpus luteum (CL), and the occurrence of ovulation. Blood concentrations of P4 were measured on days 0 and 10 and 10 days after TAI. Pregnancy status was determined on days 27 and 45 after TAI to calculate late embryonic mortality. The data were analyzed by ANOVA and multiple logistic regression. A total of 70 of 116 (60.4%) buffaloes showed ovulation after GnRH1. Buffaloes that ovulated after GnRH1 had a smaller (P < 0.05) area of the ovulatory follicle on Day 0 compared with buffaloes that did not ovulate (1.08 ± 0.1 and 1.29 ± 0.1 cm , respectively). The former buffaloes also had a larger (P < 0.05) CL area (1.81 ± 0.1 and 1.51 ± 0.1 cm , respectively) and greater (P < 0.05) blood concentrations of P4 (1.84 ± 0.2 and 1.34 ± 0.2 ng/mL, respectively) on Day 0. A larger (P < 0.05) proportion of buffaloes that ovulated after GnRH1 showed regression of the CL after the injection of PGF on Day 7 compared with buffaloes that did not ovulate (68 of 69 [98.6%] and 27 of 32 [84.4%], respectively). Buffaloes that ovulated after GnRH1 also had a greater (P < 0.05) ovulation rate after GnRH2 than buffaloes that did not ovulate (65 of 70 [92.8%] and 37 of 46 [80.4%], respectively). Buffaloes that ovulated after GnRH1 had a higher (P < 0.01) pregnancy rate than buffaloes that did not ovulate, both at Day 27 (53 of 70 [75.7%] and 14 of 46 [30.4%], respectively) and Day 45 (46 of 70 [65.7%] and 10 of 46 [21.7%], respectively). The incidence of late embryonic mortality tended to be less for buffaloes that ovulated after GnRH1 than buffaloes that did not ovulate (7 of 53 [13.2%] and 4 of 14 [28.6%], respectively). The present findings have demonstrated a strong direct relationship between the ovarian follicular response at the start of an OVsynch-TAI program and pregnancy outcome in the Mediterranean river buffalo.
[Mh] Termos MeSH primário: Búfalos/fisiologia
Sincronização do Estro/métodos
Inseminação Artificial/veterinária
Folículo Ovariano/efeitos dos fármacos
Resultado da Gravidez
Progesterona/farmacologia
[Mh] Termos MeSH secundário: Animais
Busserrelina/administração & dosagem
Busserrelina/farmacologia
Esquema de Medicação
Feminino
Inseminação Artificial/métodos
Ovulação/efeitos dos fármacos
Gravidez
Resultado da Gravidez/veterinária
Progesterona/administração & dosagem
Prostaglandinas F Sintéticas/administração & dosagem
Prostaglandinas F Sintéticas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prostaglandins F, Synthetic); 4G7DS2Q64Y (Progesterone); HWR60H5GZB (luprostenol); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE


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[PMID]:27170495
[Au] Autor:Pandey AK; Ghuman S; Dhaliwal GS; Agarwal SK; Phogat JB
[Ad] Endereço:Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.
[Ti] Título:Impact of Buserelin Acetate or hCG Administration on the Day of First Artificial Insemination on Subsequent Luteal Profile and Conception Rate in Murrah Buffalo (Bubalus bubalis).
[So] Source:Reprod Domest Anim;51(4):478-84, 2016 Aug.
[Is] ISSN:1439-0531
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study was designed to investigate the impact of buserelin acetate (BA) or human chorionic gonadotropin (hCG) administration on the day of first artificial insemination (AI) on subsequent luteal profile (diameter of corpus luteum (CL) and plasma progesterone) and conception rate in Murrah buffalo. The present experiment was carried out at two locations in 117 buffalo that were oestrus-synchronized using cloprostenol (500 µg) administered (i.m.) 11 days apart followed by AI during standing oestrus. Based on treatment (i.m.) at the time of AI, buffalo were randomly categorized (n = 39 in each group) into control (isotonic saline solution, 5 ml), dAI-BA (buserelin acetate, 20 µg) and dAI-hCG (hCG, 3000 IU) group. Out of these, 14 buffalo of each group were subjected to ovarian ultrasonography on the day of oestrus to monitor the preovulatory follicle and on days 5, 12, 16 and 21 post-ovulation to monitor CL diameter. On the day of each sonography, jugular vein blood samples were collected for the estimation of progesterone concentrations. All the buffalo (n = 117) were confirmed for pregnancy on day 40 post-ovulation. The conception rate was better (p < 0.05) in dAI-BA (51.3%) and dAI-hCG (66.7%) groups as compared to their control counterparts (30.8%). Furthermore, the buffalo of dAI-hCG group had improved (p < 0.05) luteal profile, whereas the buffalo of dAI-BA group failed (p > 0.05) to exhibit stimulatory impact of treatment on luteal profile when compared to control group. In brief, buserelin acetate or hCG treatment on the day of first AI leads to an increase in conception rate; however, an appreciable impact on post-ovulation luteal profile was observed only in hCG-treated Murrah buffalo.
[Mh] Termos MeSH primário: Búfalos
Busserrelina/farmacologia
Gonadotropina Coriônica/farmacologia
Corpo Lúteo/efeitos dos fármacos
Inseminação Artificial/veterinária
[Mh] Termos MeSH secundário: Animais
Feminino
Ovulação/efeitos dos fármacos
Ovulação/fisiologia
Gravidez
Taxa de Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chorionic Gonadotropin); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE
[do] DOI:10.1111/rda.12705


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[PMID]:27089503
[Au] Autor:Ohlsson B
[Ad] Endereço:Division of Internal Medicine, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.
[Ti] Título:Gonadotropin-Releasing Hormone and Its Physiological and Pathophysiological Roles in Relation to the Structure and Function of the Gastrointestinal Tract.
[So] Source:Eur Surg Res;57(1-2):22-33, 2016.
[Is] ISSN:1421-9921
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) are involved in the reproductive cycle and regulate the secretion of sex steroids from the gonads. In mammals, GnRH1 is secreted as a hormone from the hypothalamus, whereas both GnRH1 and GnRH2 are present as neuropeptides in a variety of tissues. This review describes the role of GnRH in the gastrointestinal tract. SUMMARY: GnRH1, GnRH2, and LH receptors in humans and rats, and GnRH receptors in rats, have been described in the gastrointestinal tract, where they affect motility, gastric and hormone secretion, and cell proliferation. GnRH analogs are clinically used in the treatment of sex hormone-dependent diseases, i.e., endometriosis and malignancies, and as pretreatments for in vitro fertilization. Severe gastrointestinal dysmotility has been shown to develop in some women after such treatment, along with a reduction in the number of enteric neurons and autoantibodies against GnRH. Consequently, a rat model of enteric neurodegeneration has been developed based on the administration of the GnRH analog buserelin. Serum IgM antibodies against GnRH1, the GnRH2 precursor progonadoliberin-2, and the GnRH receptor have also been described in patients with irritable bowel syndrome and dysmotility, as well as in patients with gastrointestinal disorders associated with diabetes mellitus, posterior laryngitis, and primary Sjögren's syndrome, although no treatments using GnRH analogs have been administered. CONCLUSION: GnRH and receptors for GnRH and LH are present in the human and rat gastrointestinal tract. Treatment with GnRH analogs may induce severe dysmotility, and a rat model of enteric neurodegeneration has been developed based on stimulation by the GnRH analog buserelin. Autoantibodies against GnRH and its receptor are found in a subgroup of patients with functional bowel disorders and dysmotility, independent of treatment with GnRH analogs.
[Mh] Termos MeSH primário: Trato Gastrointestinal/fisiologia
Hormônio Liberador de Gonadotropina/fisiologia
[Mh] Termos MeSH secundário: Animais
Formação de Anticorpos
Busserrelina/farmacologia
Microbioma Gastrointestinal
Motilidade Gastrointestinal
Hormônio Liberador de Gonadotropina/imunologia
Seres Humanos
Ratos
Receptores LHRH/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Receptors, LHRH); 33515-09-2 (Gonadotropin-Releasing Hormone); PXW8U3YXDV (Buserelin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1159/000445717



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