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[PMID]:26903509
[Au] Autor:Smyth DG
[Ad] Endereço:Department of EndocrinologyWilliam Harvey Research Institute, London, UK derekgsmyth@live.co.uk.
[Ti] Título:60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective.
[So] Source:J Mol Endocrinol;56(4):T13-25, 2016 May.
[Is] ISSN:1479-6813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Many important fields of research had a humble origin. In the distant past, A J P Martin's discovery that amino acids could be separated by paper chromatography and Moore and Stein's use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened the door to reveal the essential relationship that exists between structure and function. In molecular endocrinology, for example, striking advances have been made by chemists with their expertise in the identification of structure working with biologists who contributed valuable knowledge and experience. Advantage was gained from the convergence of different background, and it is notable that the whole is greater than the sum. In the determination of structure, it may be recalled that four of the world's great pioneers (Archibald Martin, Rodney Porter, Fred Sanger and Vincent du Vigneaud) were acknowledged for their fundamental contributions when individually they were awarded the Nobel Prize. They foresaw that the identification of structure would prove of outstanding importance in the future. Indeed, study of the structures of ß-endorphin and enkephalin and the different forms of opiate activity they engender has led to a transformation in our understanding of chemical transmission in the brain.
[Mh] Termos MeSH primário: Pró-Opiomelanocortina/química
Pró-Opiomelanocortina/metabolismo
beta-Endorfina/química
beta-Endorfina/metabolismo
beta-Lipotropina/química
beta-Lipotropina/metabolismo
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Endocrinologia/história
História do Século XX
Seres Humanos
Neuropeptídeos/química
Neuropeptídeos/metabolismo
Neurotransmissores/química
Neurotransmissores/metabolismo
Peptídeos Opioides/metabolismo
Peptídeos Opioides/farmacologia
Especificidade de Órgãos
Hipófise/metabolismo
Ligação Proteica
Transporte Proteico
Proteólise
Receptores Opioides/metabolismo
Relação Estrutura-Atividade
beta-Endorfina/história
beta-Endorfina/farmacologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Neuropeptides); 0 (Neurotransmitter Agents); 0 (Opioid Peptides); 0 (Receptors, Opioid); 60617-12-1 (beta-Endorphin); 66796-54-1 (Pro-Opiomelanocortin); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160224
[St] Status:MEDLINE
[do] DOI:10.1530/JME-16-0033


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[PMID]:23891702
[Au] Autor:Matejec R; Kayser F; Schmal F; Uhle F; Bödeker RH; Maxeiner H; Kolbe JA
[Ad] Endereço:Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Justus-Liebig-University, Rudolf-Buchheim-Str. 7, D-35392 Giessen, Germany. reginald.matejec@chiru.med.uni-giessen.de
[Ti] Título:Effects of corticotropin-releasing hormone on proopiomelanocortin derivatives and monocytic HLA-DR expression in patients with septic shock.
[So] Source:Peptides;47:133-41, 2013 Sep.
[Is] ISSN:1873-5169
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Little is known about interactions between immune and neuro-endocrine systems in patients with septic shock. We therefore evaluated whether the corticotropin-releasing hormone (CRH) and/or proopiomelanocortin (POMC) derivatives [ACTH, ß-endorphin (ß-END), ß-lipotropin (ß-LPH), α-melanocyte stimulating hormone (α-MSH) or N-acetyl-ß-END (Nac-ß-END)] have any influences on monocyte deactivation as a major factor of immunosuppression under septic shock conditions. Sixteen patients with septic shock were enrolled in a double-blind, cross-over and placebo controlled clinical study; 0.5µg/(kgbodyweighth) CRH (or placebo) were intravenously administered for 24h. Using flow cytometry we investigated the immunosuppression in patients as far as related to the loss of leukocyte surface antigen-DR expression on circulating monocytes (mHLA-DR). ACTH, ß-END immunoreacive material (IRM), ß-LPH IRM, α-MSH and Nac-ß-END IRM as well as TNF-α and mHLA-DR expression were determined before, during and after treatment with CRH (or placebo). A significant correlation between plasma concentration of α-MSH and mHLA-DR expression and an inverse correlation between mHLA-DR expression and TNF-α plasma level were found. Additionally, a significant increase of mHLA-DR expression was observed 16h after starting the CRH infusion; 8h later, the mHLA-DR expression had decreased again. Our results indicate that the up-regulation of mHLA-DR expression after CRH infusion is not dependent on the release of POMC derivatives. From the correlation between plasma concentration of α-MSH and mHLA-DR expression, we conclude that in patients with septic shock the down-regulation of mHAL-DR expression is accompanied by the loss of monocytic release of α-MSH into the cardiovascular compartment.
[Mh] Termos MeSH primário: Hormônio Liberador da Corticotropina/administração & dosagem
Antígenos HLA-DR/genética
Monócitos/metabolismo
Choque Séptico/metabolismo
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/sangue
Idoso
Estudos Cross-Over
Método Duplo-Cego
Feminino
Expressão Gênica/efeitos dos fármacos
Antígenos HLA-DR/imunologia
Hospitais Universitários
Seres Humanos
Infusões Intravenosas
Unidades de Terapia Intensiva
Masculino
Meia-Idade
Monócitos/efeitos dos fármacos
Monócitos/imunologia
Monócitos/patologia
Estudos Prospectivos
Choque Séptico/tratamento farmacológico
Choque Séptico/imunologia
Choque Séptico/patologia
alfa-MSH/sangue
beta-Endorfina/análogos & derivados
beta-Endorfina/sangue
beta-Lipotropina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (HLA-DR Antigens); 581-05-5 (alpha-MSH); 60617-12-1 (beta-Endorphin); 75719-50-5 (N-acetyl-beta-endorphin); 9002-60-2 (Adrenocorticotropic Hormone); 9015-71-8 (Corticotropin-Releasing Hormone); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:130902
[Lr] Data última revisão:
130902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130730
[St] Status:MEDLINE


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[PMID]:23821145
[Au] Autor:Weinhofer I; Kunze M; Forss-Petter S; Berger J
[Ad] Endereço:Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria, isabelle.weinhofer@meduniwien.ac.at.
[Ti] Título:Involvement of human peroxisomes in biosynthesis and signaling of steroid and peptide hormones.
[So] Source:Subcell Biochem;69:101-10, 2013.
[Is] ISSN:0306-0225
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although peroxisomes exert essential biological functions, cell type-specific features of this important organelle are still only superficially characterized. An intriguing new aspect of peroxisomal function was recently uncovered by the observation that the peptide hormones ß-lipotropin (ß-LPH) and ß-endorphin are localized to peroxisomes in various human tissues. This suggests a functional link between peptide hormone metabolism and peroxisomes. In addition, because endocrine manifestations that affect steroid hormones are often found in patients suffering from inherited peroxisomal disorders, the question has been raised whether peroxisomes are also involved in steroidogenesis. With this chapter, we will review several crucial aspects concerning peroxisomes and hormone metabolism.
[Mh] Termos MeSH primário: Corticosteroides/biossíntese
Córtex Suprarrenal/metabolismo
Hormônios Esteroides Gonadais/biossíntese
Gônadas/metabolismo
Hormônios Peptídicos/biossíntese
Peroxissomos/metabolismo
[Mh] Termos MeSH secundário: Animais
Ácidos e Sais Biliares/biossíntese
Seres Humanos
beta-Endorfina/biossíntese
beta-Lipotropina/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Bile Acids and Salts); 0 (Gonadal Steroid Hormones); 0 (Peptide Hormones); 60617-12-1 (beta-Endorphin); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:130703
[Lr] Data última revisão:
130703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130704
[St] Status:MEDLINE
[do] DOI:10.1007/978-94-007-6889-5_6


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[PMID]:21236440
[Au] Autor:Gritti F; Guiochon G
[Ad] Endereço:Department of Chemistry, University of Tennessee, Knoxville, TN 37996-1600, USA.
[Ti] Título:The mass transfer kinetics in columns packed with Halo-ES shell particles.
[So] Source:J Chromatogr A;1218(7):907-21, 2011 Feb 18.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The average mesopore size of the new Halo-ES-Peptide shell particles is 160 Å, markedly larger than that of the classical Halo shell particles (90 Å). We found that this change causes a considerable decrease of the film mass transfer resistance measured for columns packed with these particles. We analyze data obtained by systematic measurements of the C term of the van Deemter equation for the peptide ß-lipotropin (MW = 769 Da), the protein insulin (MW = 5800 Da), and a series of non-retained polystyrene standards (MW = 6400 and 13,200). The improvement in column performance is explained by an increase of the fraction of the external surface area of the shell that allows the entrance of the sample molecules inside the particle. The fraction of the shell surface accessible to a probe controls the rate of its external film mass transfer, i.e. its rate of transfer between the interstitial and the stagnant eluent. Although measurable, the increase in sample diffusivity through the porous shells does not account for the better performance of Halo-ES-peptide columns. Furthermore, the analysis of the HETPs data of small molecules (uracil, acetophenone, toluene, and naphthalene, MW< 150) reveals that the eddy diffusion (A) term of these new columns is 25% lower than that of the classical Halo columns. This result is consistent with the impact of intra-particle diffusivity on the eddy diffusion mechanism in packed columns. As shell diffusivity increases, so does the rate of transfer of sample molecules between the eluent stream-paths flowing through the packed particles and across the column diameter. Dispersion through short-range inter-channel and trans-column eddies is reduced.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Modelos Químicos
Peptídeos/química
[Mh] Termos MeSH secundário: Acetofenonas/química
Cromatografia em Gel
Cromatografia Líquida de Alta Pressão/instrumentação
Difusão
Insulina/química
Cinética
Microscopia Eletrônica de Varredura
Peso Molecular
Naftalenos/química
Tamanho da Partícula
Permeabilidade
Poliestirenos/química
Porosidade
Temperatura Ambiente
Tolueno/química
Uracila/química
beta-Lipotropina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Acetophenones); 0 (Insulin); 0 (Naphthalenes); 0 (Peptides); 0 (Polystyrenes); 2166IN72UN (naphthalene); 3FPU23BG52 (Toluene); 56HH86ZVCT (Uracil); 9035-55-6 (beta-Lipotropin); RK493WHV10 (acetophenone)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110118
[St] Status:MEDLINE
[do] DOI:10.1016/j.chroma.2010.12.046


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[PMID]:20980919
[Au] Autor:Matejec R; Löcke G; Kayser F; Lichtenstern C; Weigand MA; Welters ID; Bödeker RH; Harbach HW
[Ad] Endereço:Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy Justus-Liebig-University, Giessen, Germany. reginald.matejec@chiru.med.uni-giessen.de
[Ti] Título:Hemodynamic actions of corticotropin-releasing hormone and proopiomelanocortin derivatives in septic patients.
[So] Source:J Cardiovasc Pharmacol;57(1):94-102, 2011 Jan.
[Is] ISSN:1533-4023
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proopiomelanocortin (POMC) derivatives and mRNA of POMC have been detected in cardiomyocytes and vascular smooth muscle cells. Increased plasma levels of POMC derivatives have been found in septic patients during cardiovascular deregulation; therefore, we evaluated whether corticotroph-type (ACTH, ß-endorphin, ß-lipotropin) or melanotroph-type (α-melanocyte-stimulating hormone and N-acetyl-ß-END) POMC derivatives have influences on patients' hemodynamics during sepsis. Seventeen septic patients were monitored by pulmonary artery catheter and corticotropin-releasing hormone (CRH) tests were performed by intravenous administration of 100 µg CRH. Before, 15, 30, 45, and 60 minutes after CRH administration, hemodynamic variables were measured, and plasma concentrations of POMC derivatives were determined. After CRH administration, heart rate, cardiac index, and stroke index increased, and the systemic vascular resistance index decreased; moreover, a correlation between ACTH concentration and stroke index as well as an inverse correlation between (α-melanocyte-stimulating hormone concentration and systemic vascular resistance index was observed. CRH and ACTH may have opposite effects on the blood pressure (mean arterial pressure). Immediately after CRH injection mean arterial pressure decreased. ACTH (in contrast to ß-endorphin or ß-lipotropin), released into the cardiovascular compartment 15 minutes after CRH injection, might have raised mean arterial pressure as compatible with the correlation between ACTH levels and stroke index. (α-melanocyte-stimulating hormone appears to have a vasodilative effect during sepsis.
[Mh] Termos MeSH primário: Hormônio Liberador da Corticotropina/farmacologia
Hemodinâmica/efeitos dos fármacos
Pró-Opiomelanocortina/farmacologia
Sepse/fisiopatologia
[Mh] Termos MeSH secundário: Hormônio Liberador da Corticotropina/administração & dosagem
Seres Humanos
Injeções Intravenosas
Estudos Prospectivos
Sepse/sangue
Fatores de Tempo
alfa-MSH/sangue
beta-Endorfina/sangue
beta-Lipotropina/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
581-05-5 (alpha-MSH); 60617-12-1 (beta-Endorphin); 66796-54-1 (Pro-Opiomelanocortin); 9015-71-8 (Corticotropin-Releasing Hormone); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:110118
[Lr] Data última revisão:
110118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101029
[St] Status:MEDLINE
[do] DOI:10.1097/FJC.0b013e3181fffe00


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[PMID]:20963870
[Au] Autor:Kato Y
[Ad] Endereço:Division of Endocrinology and Metabolism, Kusaka Hospital.
[Ti] Título:[Lipotropin (lipotropic hormone: LPH) and melanocyte-stimulating hormone (MSH)].
[So] Source:Nihon Rinsho;68 Suppl 7:234-6, 2010 Jul.
[Is] ISSN:0047-1852
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Hormônios Estimuladores de Melanócitos/sangue
beta-Lipotropina/sangue
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-79-3 (Melanocyte-Stimulating Hormones); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1101
[Cu] Atualização por classe:110727
[Lr] Data última revisão:
110727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101022
[St] Status:MEDLINE


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[PMID]:20810565
[Au] Autor:Höftberger R; Kunze M; Voigtländer T; Unterberger U; Regelsberger G; Bauer J; Aboul-Enein F; Garzuly F; Forss-Petter S; Bernheimer H; Berger J; Budka H
[Ad] Endereço:Institute of Neurology, Center for Brain Research, Medical University of Vienna, and Department of Neurology, SMZ-Ost Danube Hospital, AKH 4J, Währinger Gürtel 18-20, P.O. Box 48, A-1097 Vienna, Austria. romana.hoeftberger@meduniwien.ac.at
[Ti] Título:Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin.
[So] Source:Endocrinology;151(10):4801-10, 2010 Oct.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The peptide hormones ACTH, MSHs, ß-lipotropin (ß-LPH), and ß-endorphin are all derived from the precursor molecule proopiomelanocortin (POMC). Using confocal laser microscopy and immunoelectron microscopy in human pituitary gland, we demonstrate a peroxisomal localization of ß-endorphin and ß-LPH in cells expressing the peroxisomal ATP-binding cassette-transporter adrenoleukodystrophy protein (ALDP). The peroxisomal localization of ß-LPH and ß-endorphin was not restricted to the pituitary gland but was additionally found in other human tissues that express high levels of ALDP, such as dorsal root ganglia, adrenal cortex, distal tubules of kidney, and skin. In contrast to the peptide hormones ß-LPH and ß-endorphin, which are derived from the C terminus of POMC, the N-terminal peptides ACTH, α-MSH, and γ-MSH were never detected in peroxisomes. This novel peroxisomal localization of ß-endorphin and ß-LPH in ALDP-positive cells was confirmed by costaining with ALDP and the peroxisomal marker catalase. Moreover, peroxisomal sorting of ß-LPH could be modeled in HeLa cells by ectopic expression of a POMC variant, modified to allow cleavage and release of ß-LPH within the secretory pathway. Although ß-LPH and ß-endorphin were only associated with peroxisomes in cells that normally express ALDP, the transporter activity of ALDP is not necessary for the peroxisomal localization, as demonstrated in tissues of X-linked adrenoleukodystrophy patients lacking functional ALDP. It remains to be elucidated whether and how the peroxisomal localization of POMC-derived hormones has a role in the endocrine dysfunction of peroxisomal disease.
[Mh] Termos MeSH primário: Peroxissomos/metabolismo
beta-Endorfina/metabolismo
beta-Lipotropina/metabolismo
[Mh] Termos MeSH secundário: Membro 1 da Subfamília D de Transportadores de Cassetes de Ligação de ATP
Transportadores de Cassetes de Ligação de ATP/genética
Transportadores de Cassetes de Ligação de ATP/metabolismo
Transportadores de Cassetes de Ligação de ATP/fisiologia
Técnicas de Cultura de Células
Células HeLa
Seres Humanos
Especificidade de Órgãos/genética
Hipófise/metabolismo
Pró-Opiomelanocortina/química
Pró-Opiomelanocortina/genética
Pró-Opiomelanocortina/metabolismo
Transporte Proteico
Distribuição Tecidual
beta-Endorfina/genética
beta-Lipotropina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ABCD1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family D, Member 1); 60617-12-1 (beta-Endorphin); 66796-54-1 (Pro-Opiomelanocortin); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:100903
[St] Status:MEDLINE
[do] DOI:10.1210/en.2010-0249


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[PMID]:18789571
[Au] Autor:Harbach H; Antrecht K; Boedeker RH; Brenck F; Gips H; Hempelmann G; Muehling J; Welters I; Zygmunt M
[Ad] Endereço:University Department of Anaesthesiology, Intensive Care, Pain Therapy, Rudolf-Buchheim-Street 7, D-35385 Giessen, Germany. heinz.harbach@chiru.med.uni-giessen.de
[Ti] Título:Response of proopiomelanocortin and gonado- or lactotroph systems to in-vitro fertilisation procedures stress.
[So] Source:Eur J Obstet Gynecol Reprod Biol;141(2):137-42, 2008 Dec.
[Is] ISSN:1872-7654
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyse for the first time the response of the corticotroph-type and the melanotroph-type pituitary proopiomelanocortin (POMC) system with regard to in-vitro fertilisation (IVF) treatment using self-developed highly specific non-cross-reacting radioimmunoassay. SETTING: University hospital. patients: A total of 28 patients undergoing IVF oocyte retrieval. Cross sectional exploratory study, one factorial design with repeated measurements on one factor, non-parametric tests. Blood was collected before anaesthesia (t(A)) (n=28) and immediately after oocyte retrieval (t(B)) (n=28). MAIN OUTCOME MEASURE(S): beta-endorphin immunoreactive material (IRM), acetyl-N-beta-endorphin IRM, beta-lipotropin IRM, ACTH, cortisol, estradiol, progesterone, prolactin, luteinizing hormone, and follicle-stimulating hormone. For determination of authentic beta-endorphin [beta-endorphin (1-31)] a highly specific two-site fluid phase immunoprecipitation radioimmunoassay was developed, which did not cross-react with any beta-endorphin derivative or any other opioid peptide tested. RESULTS: No response of acetyl-N-beta-endorphin IRM and of authentic beta-endorphin (1-31) was observed to oocyte retrieval in contrast to a significant increase of corticotroph-type proopiomelanocortin derivatives. A significant rise in prolactin plasma concentration indicates a pronounced lactotroph response to oocyte retrieval stress. No significant correlation between POMC derivates and prolactin and between POMC derivatives and gonadotropins or sexual steroids except for ACTH and progesterone and for beta-endorphin IRM and estradiol was observed. CONCLUSION: IVF treatment stress led to significant corticotroph-type POMC and lactotroph responses, but not to responses of authentic beta-endorphin or melanotroph-type POMC in women undergoing oocyte retrieval.
[Mh] Termos MeSH primário: Fertilização In Vitro/efeitos adversos
Lactotrofos/efeitos dos fármacos
Pró-Opiomelanocortina/sangue
Prolactina/sangue
beta-Endorfina/sangue
beta-Lipotropina/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Hidrocortisona/sangue
Recuperação de Oócitos/efeitos adversos
Radioimunoensaio
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
60617-12-1 (beta-Endorphin); 66796-54-1 (Pro-Opiomelanocortin); 9002-62-4 (Prolactin); 9035-55-6 (beta-Lipotropin); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:0903
[Cu] Atualização por classe:140730
[Lr] Data última revisão:
140730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080916
[St] Status:MEDLINE
[do] DOI:10.1016/j.ejogrb.2008.08.001


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[PMID]:18358591
[Au] Autor:Halabe Bucay A
[Ad] Endereço:Department of Pediatrics, Hospital Angeles Lomas, Huixquilucan, Mexico. doctorhalabe@hotmail.com
[Ti] Título:The role of lipotropins as hematopoietic factors and their potential therapeutic use.
[So] Source:Exp Hematol;36(6):752-4, 2008 Jun.
[Is] ISSN:0301-472X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lipotropins are peptides that act as hormones that are released from a common precursor together with other physiologically important peptides; their function is to mobilize the lipids that are stored in adipocytes as an energy reserve. This review will explain the existing scientific evidence on the action of lipotropins in adipocytes and, specifically, when these lipotropins activate bone marrow adipocytes to function as hematopoietic factors and suggest the potential therapeutic use of lipotropins based on these effects.
[Mh] Termos MeSH primário: Doenças Hematológicas/tratamento farmacológico
Hematopoese/fisiologia
beta-Lipotropina/fisiologia
beta-Lipotropina/uso terapêutico
[Mh] Termos MeSH secundário: Síndrome de Imunodeficiência Adquirida/tratamento farmacológico
Adipócitos/citologia
Adipócitos/fisiologia
Células da Medula Óssea/citologia
Células da Medula Óssea/fisiologia
Seres Humanos
Infecção/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:080806
[Lr] Data última revisão:
080806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080325
[St] Status:MEDLINE
[do] DOI:10.1016/j.exphem.2008.02.001


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[PMID]:16457826
[Au] Autor:Naudé R; Oelofsen W; Takahashi A; Amano M; Kawauchi H
[Ad] Endereço:Department of Biochemistry and Microbiology, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031, South Africa. ryno.naude@nmmu.ac.za
[Ti] Título:Molecular cloning and characterization of preproopiomelanocortin (prePOMC) cDNA from the ostrich (Struthio camelus).
[So] Source:Gen Comp Endocrinol;146(3):310-7, 2006 May 01.
[Is] ISSN:0016-6480
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To date proopiomelanocortin (POMC), the precursor protein for melanotropin (MSH), adrenocorticotropin (ACTH), lipotropins (LPH), and beta-endorphin (beta-END) in the pituitary gland, has been studied extensively over a wide spectrum of vertebrate classes. A paucity of information exists, however, with regard to POMC in the avian class, where to date POMC from only one species, the domestic chicken, appears to have been fully characterized. In the present study, we report the use of three clones of cDNA to provide the complete nucleotide sequence of ostrich prePOMC cDNA, consisting of 1072 bp (excluding the poly(A) tail). The deduced amino acid sequence of 253 amino acid residues includes the N-terminal signal peptide of 17 amino acid residues. The predicted amino acid sequence in the overall arrangement of its domains, conforms to that found in other tetrapods. Sequence domains for gamma-MSH, ACTH, alpha-MSH, gamma-LPH, beta-MSH, and beta-END are located at positions 74-85, 134-172, 134-146, 175-220, 203-220, and 223-253, respectively, in ostrich prePOMC, but some of them may not be released in the ostrich pituitary gland, despite the presence of nine potential processing sites consisting of 2-4 dibasic amino acids each. Substitution of glutamic acid for a dibasic amino acid at position 202 in ostrich prePOMC could prevent release of beta-MSH. To date the release of pro-gamma-MSH, beta-LPH, ACTH, gamma-LPH, and beta-END have been confirmed by direct isolation and characterization from ostrich pituitary extracts. In the present study, we have also identified ACTH, gamma-LPH and beta-END in a single frozen ostrich pituitary slice by means of MALDI-TOF mass spectrometry. When compared to a wide range of vertebrate prePOMC molecules, ostrich prePOMC revealed a high level of amino acid sequence identity (77%) with chicken prePOMC, which is the only other avian sequence available. As with other vertebrate classes, considerable intraclass differences were also evident between chicken and ostrich prePOMCs, which belong to different avian orders. Identity of ostrich prePOMC with non-avian tetrapod counterparts is only moderate (53-56%), whereas lower identities (20-49%) are evident over a range of fish prePOMCs.
[Mh] Termos MeSH primário: DNA Complementar/genética
Pró-Opiomelanocortina/genética
Precursores de Proteínas/genética
Struthioniformes/genética
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/genética
Sequência de Aminoácidos
Animais
Sequência de Bases
Clonagem Molecular
Dados de Sequência Molecular
Hipófise/química
Alinhamento de Sequência
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
beta-Endorfina/genética
beta-Lipotropina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Protein Precursors); 60617-12-1 (beta-Endorphin); 66796-54-1 (Pro-Opiomelanocortin); 9002-60-2 (Adrenocorticotropic Hormone); 9035-55-6 (beta-Lipotropin)
[Em] Mês de entrada:0606
[Cu] Atualização por classe:071115
[Lr] Data última revisão:
071115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060207
[St] Status:MEDLINE



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