[PMID]: | 26130238 |
[Au] Autor: | Osugi T; Son YL; Ubuka T; Satake H; Tsutsui K |
[Ad] Endereço: | Bioorganic Research Institute, Suntory Foundation for Life Sciences, 1-1-1 Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan. Electronic address: osugi@sunbor.or.jp. |
[Ti] Título: | RFamide peptides in agnathans and basal chordates. |
[So] Source: | Gen Comp Endocrinol;227:94-100, 2016 Feb 01. |
[Is] ISSN: | 1095-6840 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Since a peptide with a C-terminal Arg-Phe-NH2 (RFamide peptide) was first identified in the ganglia of the venus clam in 1977, RFamide peptides have been found in the nervous system of both invertebrates and vertebrates. In vertebrates, the RFamide peptide family includes gonadotropin-inhibitory hormone (GnIH), neuropeptide FF (NPFF), prolactin-releasing peptide (PrRP), pyroglutamylated RFamide peptide/26RFamide peptide (QRFP/26RFa), and kisspeptins (kiss1 and kiss2). They are involved in important functions such as the release of hormones, regulation of sexual or social behavior, pain transmission, reproduction, and feeding. In contrast to tetrapods and jawed fish, the information available on RFamide peptides in agnathans and basal chordates is limited, thus preventing further insights into the evolution of RFamide peptides in vertebrates. In this review, we focus on the previous research and recent advances in the studies on RFamide peptides in agnathans and basal chordates. In agnathans, the genes encoding GnIH, NPFF, and PrRP precursors and the mature peptides have been identified in lamprey (Petromyzon marinus) and hagfish (Paramyxine atami). Putative kiss1 and kiss2 genes have also been found in the genome database of lamprey. In basal chordates, namely, in amphioxus (Branchiostoma japonicum), a common ancestral form of GnIH and NPFF genes and their mature peptides, as well as the ortholog of the QRFP gene have been identified. The studies revealed that the number of orthologs of vertebrate RFamide peptides present in agnathans and basal chordates is greater than expected, suggesting that the vertebrate RFamide peptides might have emerged and expanded at an early stage of chordate evolution. |
[Mh] Termos MeSH primário: |
Feiticeiras (Peixe)/metabolismo Kisspeptinas/metabolismo Anfioxos/metabolismo Neuropeptídeos/metabolismo Petromyzon/metabolismo
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[Mh] Termos MeSH secundário: |
Animais Evolução Biológica Feiticeiras (Peixe)/genética Kisspeptinas/genética Anfioxos/genética Neuropeptídeos/genética Oligopeptídeos/genética Oligopeptídeos/metabolismo Petromyzon/genética Hormônio Liberador de Prolactina/genética Hormônio Liberador de Prolactina/metabolismo
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW |
[Nm] Nome de substância:
| 0 (Kisspeptins); 0 (Neuropeptides); 0 (Oligopeptides); 0 (Prolactin-Releasing Hormone); 0 (RFamide peptide); 99566-27-5 (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide) |
[Em] Mês de entrada: | 1610 |
[Cu] Atualização por classe: | 161230 |
[Lr] Data última revisão:
| 161230 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 150702 |
[St] Status: | MEDLINE |
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