| [PMID]: | 29338022 |
| [Au] Autor: | Schreiber PW; Bischoff-Ferrari HA; Boggian K; Bonani M; van Delden C; Enriquez N; Fehr T; Garzoni C; Hirsch HH; Hirzel C; Manuel O; Meylan P; Saleh L; Weisser M; Mueller NJ; Swiss Transplant Cohort Study (STCS) |
| [Ad] Endereço: | University Hospital Zurich and University Zurich, Division of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland. |
| [Ti] Título: | Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation. |
| [So] Source: | PLoS One;13(1):e0191167, 2018. |
| [Is] ISSN: | 1932-6203 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P<0.001) and median intact parathyroid hormone levels decreased by 68.4% (from 208.7 to 66.0 ng/l; P<0.001). Median ß-Crosslaps (CTx) and total procollagen type 1 amino-terminal propeptide (P1NP) decreased by 65.1% (from 1.32 to 0.46ng/ml; P<0.001) and 60.6% (from 158.2 to 62.3ng/ml; P<0.001), respectively. Kidney recipients with incident fractures had significantly lower levels of 1, 25-(OH)2 vitamin D at time of transplantation and of intact parathyroid hormone 6 months post-transplant. Among 70 liver recipients, 25-OH vitamin D, 1, 25-(OH)2 vitamin D and intact parathyroid hormone levels were not significantly altered between peri-transplant and 6 months post-transplant. Contrary to kidney recipients, median CTx increased by 60.0% (from 0.45 to 0.72 ng/ml; P = 0.002) and P1NP by 49.3% (from 84.0 to 125.4ng/ml; P = 0.001) in the longitudinal course. Assessed biomarkers didn't differ between liver recipients with and without fractures. To conclude, the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period. After kidney transplantation a significant gain in 1, 25-(OH)2 vitamin D combined with a decline in iPTH, CTx and P1NP, whereas after liver transplantation an increase in CTx and P1NP were characteristic. |
| [Mh] Termos MeSH primário: |
Osso e Ossos/metabolismo
Transplante de Rim
Transplante de Fígado
|
| [Mh] Termos MeSH secundário: |
Adulto
Biomarcadores/sangue
Densidade Óssea
Remodelação Óssea/fisiologia
Colágeno Tipo I/sangue
Feminino
Fraturas Ósseas/etiologia
Taxa de Filtração Glomerular
Seres Humanos
Transplante de Rim/efeitos adversos
Transplante de Fígado/efeitos adversos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Fosfatos/sangue
Pró-Colágeno/sangue
Estudos Prospectivos
Vitamina D/análogos & derivados
Vitamina D/sangue
|
| [Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Biomarkers); 0 (Collagen Type I); 0 (PTH protein, human); 0 (Parathyroid Hormone); 0 (Peptide Fragments); 0 (Peptides); 0 (Phosphates); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (procollagen Type I N-terminal peptide); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); 66772-14-3 (1,25-dihydroxyvitamin D) |
| [Em] Mês de entrada: | 1802 |
| [Cu] Atualização por classe: | 180220 |
[Lr] Data última revisão:
| 180220 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 180117 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1371/journal.pone.0191167 |
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