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[PMID]:28759642
[Au] Autor:Vitale ML; Garcia CJ; Akpovi CD; Pelletier RM
[Ad] Endereço:Département de pathologie et biologie cellulaire, Faculté de Médecine, Université de Montréal, Montreal, Québec, Canada.
[Ti] Título:Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells.
[So] Source:PLoS One;12(7):e0182495, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Folliculostellate cell gap junctions establish a network for the transmission of information within the anterior pituitary. Connexins make up gap junction channels. Changes in connexin (Cx) turnover modify gap junction-mediated intercellular communication. We have reported that cytokines and hormones influence Cx43 turnover and coupling in folliculostellate cells and in the folliculostellate cell line TtT/GF. In addition, the expression of different connexins alters intercellular communication and connexins may have functions besides cell coupling. Here we assessed the expression, turnover and subcellular localization of Cx46 and Cx50 in the anterior pituitary and TtT/GF cells. Then, we assessed the impact of various natural (lactation, annual reproductive cycle, bFGF) and pathological (autoimmune orchitis, diabetes/obesity) conditions associated with altered anterior pituitary hormone secretion on Cx46 and Cx50. Anterior pituitary Cx46 and Cx50 expression and subcellular distribution were cell-dependent. Cx46 was expressed by folliculostellate, TtT/GF and endocrine cells. In the cytoplasm, Cx46 was chiefly associated with lysosomes. Variously sized Cx46 molecules were recovered exclusively in the TtT/GF cell nuclear fraction. In the nucleus, Cx46 co-localized with Nopp-140, a nucleolar factor involved in rRNA processing. Neither cytoplasmic nor nuclear Cx46 and Cx43 co-localized. Cx50 localized to folliculostellate and TtT/GF cells, and to the walls of blood capillaries, not to endocrine cells. Cx50 was cytoplasmic and associated with the cell membrane, not nuclear. Cx50 did not co-localize with Cx46 but it co-localized in the cytoplasm and co-immunoprecipitated with Cx43. Cx46 and Cx50 responses to various physiological and pathological challenges were different, often opposite. Cx46 and Cx43 expression and phosphorylation profiles differed in the anterior pituitary, whereas Cx50 and Cx43 were similar. The data suggest that Cx46 participates to cellular growth and proliferation and that Cx50, together with Cx43, contributes to folliculostellate cell coupling.
[Mh] Termos MeSH primário: Conexinas/metabolismo
Adeno-Hipófise/metabolismo
[Mh] Termos MeSH secundário: Animais
Membrana Celular/metabolismo
Núcleo Celular/metabolismo
Células Cultivadas
Conexinas/genética
Diabetes Mellitus/metabolismo
Células Endócrinas/metabolismo
Células Epiteliais/metabolismo
Feminino
Lactação/metabolismo
Lisossomos/metabolismo
Masculino
Camundongos
Vison
Obesidade/metabolismo
Orquite/metabolismo
Adeno-Hipófise/citologia
Hormônios Adeno-Hipofisários/secreção
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexins); 0 (Pituitary Hormones, Anterior); 0 (connexin 46); 0 (connexin 50)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182495


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[PMID]:28365624
[Au] Autor:Martin-Grace J; Ahmed M; Mulvihill N; Feeney ER; Crowley RK
[Ad] Endereço:St. Vincent's University Hospital, Dublin, Ireland.
[Ti] Título:Getting to the heart of hypopituitarism.
[So] Source:Clin Med (Lond);17(2):140-142, 2017 Apr.
[Is] ISSN:1473-4893
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 53-year-old woman was diagnosed with hypopituitarism following an acute presentation with cardiac tamponade and hyponatraemia, having recently been investigated for a pericardial effusion. Secondary hypothyroidism is a rare cause of pericardial effusion and tamponade, but an important differential to consider. Management requires appropriate hormone replacement and, critically, a low threshold for commencing stress dose steroids. Clinical signs classically associated with cardiac tamponade are frequently absent in cases of tamponade due to primary and secondary hypothyroidism, and the relatively volume deplete state of secondary hypoadrenalism in hypopituitarism may further mask an evolving tamponade, as the rise in right atrial pressure is less marked even in the presence of large effusion. Our case demonstrates the importance of a high index of suspicion for cardiac tamponade in this patient cohort, even in the absence of clinical signs, and for measuring both thyroid-stimulating hormone and thyroxine levels when evaluating a pericardial effusion.
[Mh] Termos MeSH primário: Hipopituitarismo
Hipotireoidismo
Derrame Pericárdico
[Mh] Termos MeSH secundário: Tamponamento Cardíaco
Diagnóstico Diferencial
Eletrocardiografia
Feminino
Seres Humanos
Hiponatremia
Meia-Idade
Hormônios Adeno-Hipofisários
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE
[do] DOI:10.7861/clinmedicine.17-2-140


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[PMID]:28323954
[Au] Autor:Romanò N; McClafferty H; Walker JJ; Le Tissier P; Shipston MJ
[Ad] Endereço:Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom.
[Ti] Título:Heterogeneity of Calcium Responses to Secretagogues in Corticotrophs From Male Rats.
[So] Source:Endocrinology;158(6):1849-1858, 2017 Jun 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heterogeneity in homotypic cellular responses is an important feature of many biological systems, and it has been shown to be prominent in most anterior pituitary hormonal cell types. In this study, we analyze heterogeneity in the responses to hypothalamic secretagogues in the corticotroph cell population of adult male rats. Using the genetically encoded calcium indicator GCaMP6s, we determined the intracellular calcium responses of these cells to corticotropin-releasing hormone and arginine-vasopressin. Our experiments revealed marked population heterogeneity in the response to these peptides, in terms of amplitude and dynamics of the responses, as well as the sensitivity to different concentrations and duration of stimuli. However, repeated stimuli to the same cell produced remarkably consistent responses, indicating that these are deterministic on a cell-by-cell level. We also describe similar heterogeneity in the sensitivity of cells to inhibition by corticosterone. In summary, our results highlight a large degree of heterogeneity in the cellular mechanisms that govern corticotroph responses to their physiological stimuli; this could provide a mechanism to extend the dynamic range of the responses at the population level to allow adaptation to different physiological challenges.
[Mh] Termos MeSH primário: Sinalização do Cálcio/efeitos dos fármacos
Cálcio/metabolismo
Corticosterona/farmacologia
Corticotrofos/efeitos dos fármacos
Corticotrofos/metabolismo
Hormônio Liberador da Corticotropina/farmacologia
Hormônios Adeno-Hipofisários/metabolismo
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/metabolismo
Animais
Arginina Vasopressina/metabolismo
Arginina Vasopressina/farmacologia
Sinalização do Cálcio/genética
Células Cultivadas
Hormônio Liberador da Corticotropina/metabolismo
Hipotálamo/efeitos dos fármacos
Hipotálamo/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Ratos Transgênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior); 113-79-1 (Arginine Vasopressin); 9002-60-2 (Adrenocorticotropic Hormone); 9015-71-8 (Corticotropin-Releasing Hormone); SY7Q814VUP (Calcium); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00107


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[PMID]:27951529
[Au] Autor:Vaiani E; Malossetti C; Vega LM; Zubizarreta P; Braier J; Belgorosky A
[Ad] Endereço:Endocrine Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina.
[Ti] Título:Predictor Variables of Developing Anterior Pituitary Deficiencies in a Group of Paediatric Patients with Central Diabetes Insipidus and Langerhans Cell Histiocytosis.
[So] Source:Horm Res Paediatr;87(1):51-57, 2017.
[Is] ISSN:1663-2826
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Central diabetes insipidus (CDI) is the most frequent endocrine manifestation and is a known risk factor for the development of further anterior pituitary hormone deficiencies (APD). However, not all CDI patients develop APD, as observed during prolonged periods of follow-up. AIM: To find predictors of developing APD in LCH children with CDI followed in our institution. METHODS: We retrospectively analysed 44 patients over a median period (quartiles) of 12.3 years (8.79-14.24). Patients were subdivided into group 1 and group 2, according to absence or presence of APD, respectively. The main variables studied were: (1) chronological age (CA) at LCH diagnosis, (2) the primary site of LCH at diagnosis: low risk (LR) and multisystemic risk organs, and (3) the presence of reactivation. RESULTS: Multivariate Cox regression analysis showed that APD was positively associated with CA at LCH diagnosis [relative risk (RR) 1.14, p < 0.01], the LR clinical form (RR 8.6, p < 0.03), and negatively associated with the presence of reactivations (RR 0.3, p < 0.01). CONCLUSIONS: Patients with older CA at LCH diagnosis, LR clinical forms, and fewer reactivation episodes might represent a subgroup of paediatric LCH CDI patients with a higher risk of developing APD.
[Mh] Termos MeSH primário: Diabetes Insípido
Histiocitose de Células de Langerhans
Hormônios Adeno-Hipofisários/deficiência
[Mh] Termos MeSH secundário: Adolescente
Criança
Diabetes Insípido/sangue
Diabetes Insípido/complicações
Diabetes Insípido/diagnóstico
Feminino
Histiocitose de Células de Langerhans/sangue
Histiocitose de Células de Langerhans/complicações
Histiocitose de Células de Langerhans/diagnóstico
Seres Humanos
Masculino
Fatores de Risco
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1159/000452996


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[PMID]:27845884
[Au] Autor:De Los Santos MA; Águila CM; Rojas MI; Falen JM; Nuñez O; Chávez EM; Espinoza OA; Pinto PM; Calagua MR
[Ti] Título:Central diabetes insipidus: clinical profile that suggests organicity in Peruvian children: Lima - Peru 2001-2013.
[So] Source:J Pediatr Endocrinol Metab;29(12):1353-1358, 2016 Dec 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Central diabetes insipidus (CDI) is a heterogeneous disease caused by arginine vasopressin deficiency; its management implies a profound understanding of the pathophysiology and the clinical spectrum. The aim of the study was to describe the clinical characteristics that indicate organicity in children and adolescents with central diabetes insipidus treated at the Department of Endocrinology from The Child Health's Institute during 2001 to 2013. METHODS: Cross-sectional, retrospective study. 79 cases of patients diagnosed with CDI (51 males and 28 females) from 1 month to 16 years of age were reviewed. For the descriptive analysis, measures of central tendency and dispersion were used; groups of organic and idiopathic CDI were compared using χ2-test and t-test. A p-value<0.05 was considered significant. RESULTS: The average age of patients was 8.1±4.2 years. Organic causes were intracranial tumors, 44 (55.7%), Langerhans cell histiocytosis (LCH), 11 (13.9%) and cerebral malformations in 7 (8.9%) patients, while the idiopathic group was 14 (17.7%) patients. Regarding clinical characteristics suggestive of organicity, headache (p=0.02) and visual disturbances (p=0.01) were found statistically significant. The anterior pituitary hormonal abnormalities were documented in 34 (52.3%) organic CDI patients. Furthermore, we did not find a significant difference in the average daily dose of desmopressin between patients with permanent vs. transitory CDI (0.81±0.65 vs. 0.59±0.62; p=0.363). CONCLUSIONS: The main clinical features suggestive of organicity in pediatric patients with central diabetes insipidus were headache and visual disturbances; furthermore, anterior pituitary hormonal abnormalities suggest an underlying organic etiology.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/complicações
Cérebro/patologia
Diabetes Insípido/etiologia
Histiocitose de Células de Langerhans/complicações
[Mh] Termos MeSH secundário: Adolescente
Neoplasias Encefálicas/patologia
Cérebro/anormalidades
Criança
Pré-Escolar
Estudos Transversais
Diabetes Insípido/patologia
Feminino
Seguimentos
Histiocitose de Células de Langerhans/patologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Peru
Hormônios Adeno-Hipofisários/deficiência
Prognóstico
Estudos Retrospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27534814
[Au] Autor:Mukai K; Kitamura T; Tamada D; Murata M; Otsuki M; Shimomura I
[Ad] Endereço:Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
[Ti] Título:Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients.
[So] Source:Endocr J;63(11):965-976, 2016 Nov 30.
[Is] ISSN:1348-4540
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Non-functioning pituitary adenoma (NFPA) is often associated with hypopituitarism. Diagnosis of hypopituitarism is important because of its poor prognosis and low quality of life. Among hypopituitarism, it is difficult to diagnose secondary adrenocortical insufficiency and GH deficiency without hormone stimulation test. Therefore, the aim of our study was to identify patients with NFPA who require more careful endocrinological examination. We examined the relationship between NFPA size and the prevalence of each hypopituitarism or the response of each anterior pituitary hormone by insulin tolerance test, LHRH test and TRH test. We studied 63 patients with NFPA admitted for evaluation of pituitary function and surgical indication. They were classified three groups by tumor diameter. The prevalence of GH deficiency, male secondary hypogonadism, secondary hypothyroidism and PRL deficiency were higher in the group of larger tumor diameter (p<0.0001, p<0.05, p<0.05 and p<0.05, respectively). However, that of secondary adrenocortical insufficiency only tended to be higher (p=0.07). In the group with small NFPA (less than 20 mm), the prevalence of secondary adrenocortical insufficiency was 38% although those of GH deficiency, male secondary hypogonadism, secondary hypothyroidism and PRL deficiency were 0%, 0% and 8% and 9%, respectively. Anterior pituitary hormone responses except TSH had significantly negative correlation with tumor diameter (ACTH: r=-0.40, GH: r=-0.57, LH: r=-0.69, FSH: r=-0.46, PRL: r=-0.36). The results suggested physicians should proactively suspect GH deficiency, male secondary hypogonadism and secondary hypothyroidism in patients with larger NFPA. On the other hand, adrenocortical function should be examined even in patients with small NFPA.
[Mh] Termos MeSH primário: Adenoma/patologia
Hipopituitarismo/etiologia
Hormônios Adeno-Hipofisários/deficiência
Neoplasias Hipofisárias/patologia
Carga Tumoral
[Mh] Termos MeSH secundário: Adenoma/complicações
Adenoma/epidemiologia
Adenoma/metabolismo
Insuficiência Adrenal/epidemiologia
Insuficiência Adrenal/etiologia
Insuficiência Adrenal/patologia
Idoso
Feminino
Hospitalização
Seres Humanos
Hipogonadismo/epidemiologia
Hipogonadismo/etiologia
Hipogonadismo/patologia
Hipopituitarismo/epidemiologia
Hipopituitarismo/metabolismo
Hipopituitarismo/patologia
Masculino
Meia-Idade
Hormônios Adeno-Hipofisários/metabolismo
Neoplasias Hipofisárias/complicações
Neoplasias Hipofisárias/epidemiologia
Neoplasias Hipofisárias/metabolismo
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


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[PMID]:27041067
[Au] Autor:Higham CE; Johannsson G; Shalet SM
[Ad] Endereço:Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK; Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
[Ti] Título:Hypopituitarism.
[So] Source:Lancet;388(10058):2403-2415, 2016 Nov 12.
[Is] ISSN:1474-547X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hypopituitarism refers to deficiency of one or more hormones produced by the anterior pituitary or released from the posterior pituitary. Hypopituitarism is associated with excess mortality, a key risk factor being cortisol deficiency due to adrenocorticotropic hormone (ACTH) deficiency. Onset can be acute or insidious, and the most common cause in adulthood is a pituitary adenoma, or treatment with pituitary surgery or radiotherapy. Hypopituitarism is diagnosed based on baseline blood sampling for thyroid stimulating hormone, gonadotropin, and prolactin deficiencies, whereas for ACTH, growth hormone, and antidiuretic hormone deficiency dynamic stimulation tests are usually needed. Repeated pituitary function assessment at regular intervals is needed for diagnosis of the predictable but slowly evolving forms of hypopituitarism. Replacement treatment exists in the form of thyroxine, hydrocortisone, sex steroids, growth hormone, and desmopressin. If onset is acute, cortisol deficiency should be replaced first. Modifications in replacement treatment are needed during the transition from paediatric to adult endocrine care, and during pregnancy.
[Mh] Termos MeSH primário: Adenoma/terapia
Terapia de Reposição Hormonal/métodos
Hipofisectomia/efeitos adversos
Hipopituitarismo
Hipófise/secreção
Hormônios Adeno-Hipofisários/administração & dosagem
Hormônios Adeno-Hipofisários/deficiência
Irradiação Hipofisária/efeitos adversos
Neoplasias Hipofisárias/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Adenoma/sangue
Adenoma/radioterapia
Adenoma/cirurgia
Hormônio Adrenocorticotrópico/administração & dosagem
Hormônio Adrenocorticotrópico/deficiência
Doença Crônica
Desamino Arginina Vasopressina/administração & dosagem
Hormônios Esteroides Gonadais/administração & dosagem
Hormônios Esteroides Gonadais/deficiência
Gonadotropinas Hipofisárias/administração & dosagem
Gonadotropinas Hipofisárias/deficiência
Hormônio do Crescimento Humano/administração & dosagem
Hormônio do Crescimento Humano/deficiência
Seres Humanos
Hidrocortisona/administração & dosagem
Hidrocortisona/deficiência
Hipopituitarismo/sangue
Hipopituitarismo/diagnóstico
Hipopituitarismo/tratamento farmacológico
Hipopituitarismo/etiologia
Neoplasias Hipofisárias/sangue
Neoplasias Hipofisárias/radioterapia
Neoplasias Hipofisárias/cirurgia
Prolactina/administração & dosagem
Prolactina/deficiência
Radioterapia/efeitos adversos
Tireotropina/administração & dosagem
Tireotropina/deficiência
Tiroxina/administração & dosagem
Tiroxina/deficiência
Vasopressinas/administração & dosagem
Vasopressinas/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Gonadotropins, Pituitary); 0 (Pituitary Hormones, Anterior); 11000-17-2 (Vasopressins); 12629-01-5 (Human Growth Hormone); 9002-60-2 (Adrenocorticotropic Hormone); 9002-62-4 (Prolactin); 9002-71-5 (Thyrotropin); ENR1LLB0FP (Deamino Arginine Vasopressin); Q51BO43MG4 (Thyroxine); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:27020952
[Au] Autor:Yang J; Zhang X; Liu Z; Yuan Z; Song Y; Shao S; Zhou X; Yan H; Guan Q; Gao L; Zhang H; Zhao J
[Ad] Endereço:Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
[Ti] Título:High-Cholesterol Diet Disrupts the Levels of Hormones Derived from Anterior Pituitary Basophilic Cells.
[So] Source:J Neuroendocrinol;28(3):12369, 2016 Mar.
[Is] ISSN:1365-2826
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging evidence shows that elevated cholesterol levels are detrimental to health. However, it is unclear whether there is an association between cholesterol and the pituitary. We investigated the effects of a high-cholesterol diet on pituitary hormones using in vivo animal studies and an epidemiological study. In the animal experiments, rats were fed a high-cholesterol or control diet for 28 weeks. In rats fed the high-cholesterol diet, serum levels of thyroid-stimulating hormone (TSH; also known as thyrotrophin), luteinising hormone (LH) and follicle-stimulating hormone (FSH) produced by the basophilic cells of the anterior pituitary were elevated in a time-dependent manner. Among these hormones, TSH was the first to undergo a significant change, whereas adrenocorticotrophic hormone (ACTH), another hormone produced by basophilic cells, was not changed significantly. As the duration of cholesterol feeding increased, cholesterol deposition increased gradually in the pituitary. Histologically, basophilic cells, and especially thyrotrophs and gonadotrophs, showed an obvious increase in cell area, as well as a potential increase in their proportion of total pituitary cells. Expression of the ß-subunit of TSH, FSH and LH, which controls hormone specificity and activity, exhibited a corresponding increase. In the epidemiological study, we found a similar elevation of serum TSH, LH and FSH and a decrease in ACTH in patients with hypercholesterolaemia. Significant positive correlations existed between serum total cholesterol and TSH, FSH or LH, even after adjusting for confounding factors. Taken together, the results of the present study suggest that the high-cholesterol diet affected the levels of hormones derived from anterior pituitary basophilic cells. This phenomenon might contribute to the pituitary functional disturbances described in hypercholesterolaemia.
[Mh] Termos MeSH primário: Colesterol na Dieta/farmacologia
Dieta Aterogênica
Adeno-Hipófise/efeitos dos fármacos
Adeno-Hipófise/metabolismo
Hormônios Adeno-Hipofisários/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Endócrinas/efeitos dos fármacos
Células Endócrinas/metabolismo
Hormônio Foliculoestimulante/sangue
Hipercolesterolemia/sangue
Hormônio Luteinizante/sangue
Masculino
Ratos
Ratos Sprague-Dawley
Tireotropina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholesterol, Dietary); 0 (Pituitary Hormones, Anterior); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1111/jne.12369


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[PMID]:26945381
[Au] Autor:Cerina V; Kruljac I; Radosevic JM; Kirigin LS; Stipic D; Pecina HI; Vrkljan M
[Ad] Endereço:From the Department of Neurosurgery (VC, DS), Department of Radiology (HIP), University Hospital Center "Sestre Milosrdnice," and Department of Endocrinology (IK, JMR, LK, MV), Diabetes and Metabolic Diseases "Mladen Sekso," University Hospital Center "Sestre Milosrdnice," University of Zagreb Medical School, Zagreb, Croatia.
[Ti] Título:Diagnostic Accuracy of Perioperative Measurement of Basal Anterior Pituitary and Target Gland Hormones in Predicting Adrenal Insufficiency After Pituitary Surgery.
[So] Source:Medicine (Baltimore);95(9):e2898, 2016 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The insulin tolerance test (ITT) is the gold standard for diagnosing adrenal insufficiency (AI) after pituitary surgery. The ITT is unpleasant for patients, requires close medical supervision and is contraindicated in several comorbidities. The aim of this study was to analyze whether tumor size, remission rate, preoperative, and early postoperative baseline hormone concentrations could serve as predictors of AI in order to increase the diagnostic accuracy of morning serum cortisol. This prospective study enrolled 70 consecutive patients with newly diagnosed pituitary adenomas. Thirty-seven patients had nonfunctioning pituitary adenomas (NPA), 28 had prolactinomas and 5 had somatotropinomas. Thyroxin (T4), thyrotropin (TSH), prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and insulin-like growth factor 1 (IGF-I) were measured preoperatively and on the sixth postoperative day. Serum morning cortisol was measured on the third postoperative day (CORT3) as well as the sixth postoperative day (CORT6). Tumor mass was measured preoperatively and remission was assessed 3 months after surgery. An ITT was performed 3 to 6 months postoperatively. Remission was achieved in 48% of patients and AI occurred in 51%. Remission rates and tumor type were not associated with AI. CORT3 had the best predictive value for AI (area under the curve (AUC) 0.868, sensitivity 82.4%, specificity 83.3%). Tumor size, preoperative T4, postoperative T4, and TSH were also associated with AI in a multivariate regression model. A combination of all preoperative and postoperative variables (excluding serum cortisol) had a sensitivity of 75.0% and specificity of 77.8%. The predictive power of CORT3 substantially improved by adding those variables into the model (AUC 0.921, sensitivity 94.1%, specificity 78.3%, PPV 81.9%, NPV of 92.7%). In a subgroup analysis that included only female patients with NPA, LH had exactly the same predictive value as CORT3. The addition of baseline LH to CORT3, increased sensitivity to 100.0%, specificity to 88.9%, PPV to 90.4%, and NPV to 100.0%. Besides CORT3, tumor size, thyroid hormones, and gonadotropins can serve as predictors of AI. LH in postmenopausal female patients with NPA has similar diagnostic accuracy as CORT3. Further studies are needed in order to validate the scoring system proposed by this study.
[Mh] Termos MeSH primário: Insuficiência Adrenal/sangue
Hipófise/cirurgia
Hormônios Adeno-Hipofisários/sangue
Complicações Pós-Operatórias/sangue
[Mh] Termos MeSH secundário: Adulto
Antropometria
Feminino
Seres Humanos
Masculino
Meia-Idade
Período Perioperatório
Valor Preditivo dos Testes
Estudos Prospectivos
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160325
[Lr] Data última revisão:
160325
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000002898


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[PMID]:26335931
[Au] Autor:Anwar H; Rahman ZU
[Ad] Endereço:Department of Physiology, Government College University, Faisalabad, Pakistan.
[Ti] Título:Dynamics of anterior pituitary immunoreactive gonadotrophs in moulted hens supplemented with protein, symbiotic and probiotics.
[So] Source:J Anim Physiol Anim Nutr (Berl);100(3):448-55, 2016 Jun.
[Is] ISSN:1439-0396
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present work delineates redistribution patterns of the hormone-producing cells of the anterior pituitary, after the phase of moulting. Two hundred single comb White Leghorn hens at the end of their first production cycle (Age = 70 week) were purchased from the commercial poultry farm and were induced to moult by high-dietary zinc (3 g/kg feed/day) after 1 week of acclimatization, at the experimental research station, Department of Physiology and Pharmacology, University of Agriculture, Faisalabad. The moulted birds were equally (n = 50) and randomly allocated to their respective groups as G1 (control; CP (Crude protein) 16%, no supplement), G2 (CP18%, no other supplement), G3 (CP16%, symbiotic at does rate of 85 mg/l in drinking water daily) and G4 (CP16%, probiotic at dose rate of 85 mg/l in drinking water daily). Ten birds were slaughtered in each group at 5% and at peak of post-moult production stage to collect their pituitary glands. An earlier post-moult production recovery, sustained and lengthier production span was seen in the G2 as compared to all other groups. The lowest production and an earlier production decline were seen in G1. The cell diameter and area of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) gonadotroph increased (p ≤ 0.01) in G2 and G3 as compared to G1. The FSH gonadotroph nucleus diameter and area did increase (p ≤ 0.01) in G2 and G3, while LH gonadotroph nucleus diameter and area decreased (p ≤ 0.01) in G2 and G3 as compared to G1. The increased FSH and LH gonadotroph diameter in protein and symbiotic supplemented birds is accountable for the increased egg production in these groups.
[Mh] Termos MeSH primário: Galinhas/fisiologia
Proteínas na Dieta/administração & dosagem
Gonadotropinas/metabolismo
Muda
Hormônios Adeno-Hipofisários/metabolismo
Probióticos
[Mh] Termos MeSH secundário: Ração Animal
Fenômenos Fisiológicos da Nutrição Animal
Animais
Dieta/veterinária
Feminino
Hormônios Adeno-Hipofisários/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Gonadotropins); 0 (Pituitary Hormones, Anterior)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150904
[St] Status:MEDLINE
[do] DOI:10.1111/jpn.12382



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