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[PMID]:29505532
[Au] Autor:Li J; Li J; Jiang S; Yu R; Yu Y
[Ad] Endereço:Department of Endocrinology and Metabolism.
[Ti] Título:Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto thyroiditis and infertility.
[So] Source:Medicine (Baltimore);97(1):e9546, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Thyrotropin-secreting adenoma (TSHoma) is rare, diagnosis and treatment are often delayed if the condition coexists with Hashimoto thyroiditis. The enlarged pituitary adenoma may eventually induce panhypopituitarism, infertility, or the compression of optic nerves and optic chiasma. PATIENT CONCERNS: This patient was a 36-year-old man who had been referred to the pituitary disease multidisciplinary team (MDT) of the West China Hospital, due to infertility. DIAGNOSES: Examinations revealed pituitary thyrotropin-secreting macroadenoma. INTERVENTIONS: We conducted trans-sphenoidal surgery. Human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) were used for reproductive reconstruction after surgery. OUTCOMES: This patient successfully fathered a child. LESSONS: To date, the multidisciplinary team treatment of TSHoma was rare, TSHomas are often misdiagnosed as macroadenomas, because the clinical features are varied and it often takes a long time to be diagnosed. So the purpose of this case report is to attract attention to the manifestation of increased thyroid stimulating hormone (TSH) concentration and discuss MDT treatment for TSH-secreting adenoma.
[Mh] Termos MeSH primário: Adenoma/complicações
Doença de Hashimoto/complicações
Infertilidade Masculina/etiologia
Neoplasias Hipofisárias/complicações
Tireotropina/secreção
[Mh] Termos MeSH secundário: Adenoma/diagnóstico
Adenoma/secreção
Adenoma/cirurgia
Adulto
Feminino
Seres Humanos
Infertilidade Masculina/terapia
Masculino
Neoplasias Hipofisárias/diagnóstico
Neoplasias Hipofisárias/secreção
Neoplasias Hipofisárias/cirurgia
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009546


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[PMID]:29431947
[Au] Autor:Lapko IV; Kiryakov VA; Pavlovskaya NA; Oshkoderov OA; Klimkina KV
[Ti] Título:[Choice of informative laboratory biomarkers for the early identification of changes in neurohumoral regulation and carbohydrate exchange in workers of the mining and mechanical engineering industry].
[So] Source:Gig Sanit;95(11):1061-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/sangue
Hormônio Foliculoestimulante/sangue
Insulina/sangue
Doenças Profissionais
Tireotropina/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Metabolismo dos Carboidratos/fisiologia
Indústrias Extrativas e de Processamento/métodos
Indústrias Extrativas e de Processamento/normas
Feminino
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Masculino
Meia-Idade
Doenças Profissionais/sangue
Doenças Profissionais/diagnóstico
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Saúde do Trabalhador
Sistema Hipófise-Suprarrenal/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Insulin); 9002-60-2 (Adrenocorticotropic Hormone); 9002-68-0 (Follicle Stimulating Hormone); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29480822
[Au] Autor:Zhang Q; Zang L; Li YJ; Han BY; Gu WJ; Yan WH; Jin N; Chen K; Du J; Wang XL; Guo QH; Yang GQ; Yang LJ; Ba JM; Lv ZH; Dou JT; Lu JM; Mu YM
[Ad] Endereço:Department of Endocrinology, Chinese PLA General Hospital.
[Ti] Título:Thyrotrophic status in patients with pituitary stalk interruption syndrome.
[So] Source:Medicine (Baltimore);97(2):e9084, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pituitary stalk interruption syndrome (PSIS) is associated with simultaneous or subsequent pituitary hormone deficiencies (PHDs). Although the clinical features of multiple PHDs are well known, the status of the thyrotrophic axis in PSIS has not been thoroughly investigated.The clinical data of 89 PSIS patients and 34 Sheehan syndrome (SS) patients were retrospectively analyzed.The prevalence of central hypothyroidism in the PSIS patients and the SS patients was 79.8% and 70.6%, respectively. The thyroid-stimulating hormone (TSH) levels in the PSIS patients were significantly higher in comparison with the SS patients (5.13 ±â€Š3.40 vs 1.67 ±â€Š1.20 mU/L, P < .05). TSH elevation (8.79 ±â€Š3.17 mU/L) was noticed in 29 of 71 (40.85%) hypothyroid PSIS patients but not in the 24 hypothyroid SS patients. The TSH levels in the hypothyroid PSIS patients were significantly higher in comparison with the euthyroid PSIS patients (5.42 ±â€Š3.67 vs 3.66 ±â€Š1.50 mU/L). Thyroid hormone replacement significantly reduced the TSH levels in the PSIS patients with elevated TSH levels from 7.24 ±â€Š0.98 to 1.67 ±â€Š1.51 mU/L (P < .05). The logistic regression analysis suggested that TSH level was not significantly associated with pituitary stalk status and height of the anterior pituitary gland.PSIS is a newly recognized cause of central hypothyroidism. The proportion and amplitude of TSH elevations are higher in PSIS than in other causes of central hypothyroidism.
[Mh] Termos MeSH primário: Doenças da Hipófise/metabolismo
Tireotropina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Feminino
Terapia de Reposição Hormonal
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Doenças da Hipófise/diagnóstico por imagem
Doenças da Hipófise/tratamento farmacológico
Doenças da Hipófise/epidemiologia
Hipófise/diagnóstico por imagem
Hipófise/efeitos dos fármacos
Hipófise/metabolismo
Prevalência
Estudos Retrospectivos
Tireotropina/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009084


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[PMID]:29390279
[Au] Autor:Yang J; Liu S; Yang Z; Shi YB
[Ad] Endereço:Department of Endocrinology.
[Ti] Título:Ectopic thyrotropin secreting pituitary adenoma concomitant with papillary thyroid carcinoma: Case report.
[So] Source:Medicine (Baltimore);96(50):e8912, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. PATIENT CONCERNS: A 27-year-old female was admitted to the hospital in 2002 for neck enlargement and palpitation. Thyroid function test showed increased thyroid hormones and unrepressed TSH. Thyroid ultrasound examination displayed diffuse goiter. The patient was presumptively diagnosed as primary hyperthyroidism and treated with anti-thyroid drugs. Her condition was then improved, but the serum TSH was persistently unrepressed. Therefore, central hyperthyroidism due to TSH-oma or pituitary resistance to thyroid hormone (PRTH) was suspected. Pituitary magnetic resonance imaging (MRI) examination was deservedly performed to rule out TSH-oma, which turned out to be normal. In addition, T3 suppression test was negative. Thus, PRTH, as an uncommon cause of inappropriate TSH secretion, was regarded as the working diagnosis. Triiodothyroacetic acid, which was reported to be effective for PRTH, was then administrated. But it did not work well. To control the symptoms completely and normalize the level of thyroid hormones, radioiodine therapy was carried out in 2007, followed by levothyroxine replacement therapy. Consequently, the symptoms were relieved, whereas serum TSH remained at high levels even with adequate levothyroxine. Unexpected, thyroid papillary carcinoma and a neoplasm in her nasopharynx were successively detected in 2012, which were then removed by surgery. Somewhat interestingly, the serum TSH declined to normal after the operation. DIAGNOSES: The patient was ultimately diagnosed as an ectopic TSH-secreting pituitary adenoma concomitant with papillary thyroid carcinoma. INTERVENTIONS: Thyroidectomy and removal of the ectopic TSH-secreting pituitary adenoma by surgery were carried out, followed by levothyroxine replacement therapy. OUTCOME: Three years after the surgery, the patient felt well with levothyroxine 125ug daily. Serum thyroid hormones and TSH kept in normal and no signs of neoplasm recurrence. LESSONS: Although extremely rare, ectopic TSH-secreting pituitary adenoma, as an uncommon cause of thyrotoxicosis, should be taken into consideration among those who have a longstanding hyperthyroidism with unsuppressed TSH.
[Mh] Termos MeSH primário: Adenoma/diagnóstico
Carcinoma Papilar/diagnóstico
Neoplasias Hipofisárias/diagnóstico
Neoplasias da Glândula Tireoide/diagnóstico
Tireotropina/secreção
[Mh] Termos MeSH secundário: Adenoma/metabolismo
Adenoma/cirurgia
Adulto
Carcinoma Papilar/cirurgia
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Neoplasias Hipofisárias/metabolismo
Neoplasias Hipofisárias/cirurgia
Doenças Raras
Testes de Função Tireóidea
Neoplasias da Glândula Tireoide/cirurgia
Tireoidectomia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008912


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[PMID]:29246344
[Au] Autor:Kilberg MJ; Rasooly IR; LaFranchi SH; Bauer AJ; Hawkes CP
[Ad] Endereço:Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA; Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.
[Ti] Título:Newborn Screening in the US May Miss Mild Persistent Hypothyroidism.
[So] Source:J Pediatr;192:204-208, 2018 Jan.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine if newborn screening (NBS) programs for congenital hypothyroidism in the US use thyroid-stimulating hormone (TSH) cutoffs that are age adjusted to account for the physiologic 4-fold reduction in TSH concentrations over the first few days of life. STUDY DESIGN: All NBS programs in the US were contacted and asked to provide information on their NBS protocols, TSH cutoffs, and whether these cutoffs were age adjusted. RESULTS: Of 51 NBS programs, 28 request a repeat specimen if the initial eluted serum TSH concentration is mildly increased (between the cutoff and a median upper limit of 50 mU/L), whereas 14 programs perform a routine second screen in all infants. Although these specimens are typically collected between 1 week and 1 month of life, 16 of the 28 programs with a discretionary second test and 8 of 14 programs with a routine second test do not have age-adjusted TSH cutoffs after the first 48 hours of life. CONCLUSIONS: There is variation in NBS practices for screening for congenital hypothyroidism across the US, and many programs do not adjust the TSH cutoff beyond the first 2 days of life. Samples are processed when received from older infants, often to retest borderline initial results. This approach will miss congenital hypothyroidism in infants with persistent mild TSH elevations. We recommend that all NBS programs provide age-adjusted TSH cutoffs, and suggest developing a standard approach to screening for congenital hypothyroidism in the US.
[Mh] Termos MeSH primário: Hipotireoidismo Congênito/diagnóstico
Fidelidade a Diretrizes/estatística & dados numéricos
Disparidades em Assistência à Saúde/estatística & dados numéricos
Triagem Neonatal/normas
Testes de Função Tireóidea/normas
Tireotropina/sangue
[Mh] Termos MeSH secundário: Fatores Etários
Algoritmos
Biomarcadores/sangue
Hipotireoidismo Congênito/sangue
Seres Humanos
Recém-Nascido
Triagem Neonatal/métodos
Guias de Prática Clínica como Assunto
Padrões de Referência
Testes de Função Tireóidea/métodos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:27774839
[Au] Autor:Jeong HS; Choi EK; Song IU; Chung YA; Park JS; Oh JK
[Ad] Endereço:1 Department of Radiology, Incheon St. Mary's Hospital, The Catholic University of Korea , Incheon, South Korea .
[Ti] Título:Differences in Brain Glucose Metabolism During Preparation for I Ablation in Thyroid Cancer Patients: Thyroid Hormone Withdrawal Versus Recombinant Human Thyrotropin.
[So] Source:Thyroid;27(1):23-28, 2017 Jan.
[Is] ISSN:1557-9077
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In preparation for I ablation, temporary withdrawal of thyroid hormone is commonly used in patients with thyroid cancer after total thyroidectomy. The current study aimed to investigate brain glucose metabolism and its relationships with mood or cognitive function in these patients using F-fluoro-2-deoxyglucose positron emission tomography ( F-FDG-PET). METHOD: A total of 40 consecutive adult patients with thyroid carcinoma who had undergone total thyroidectomy were recruited for this cross-sectional study. At the time of assessment, 20 patients were hypothyroid after two weeks of thyroid hormone withdrawal, while 20 received thyroid hormone replacement therapy and were euthyroid. All participants underwent brain F-FDG-PET scans and completed mood questionnaires and cognitive tests. Multivariate spatial covariance analysis and univariate voxel-wise analysis were applied for the image data. RESULTS: The hypothyroid patients were more anxious and depressed than the euthyroid participants. The multivariate covariance analysis showed increases in glucose metabolism primarily in the bilateral insula and surrounding areas and concomitant decreases in the parieto-occipital regions in the hypothyroid group. The level of thyrotropin was positively associated with the individual expression of the covariance pattern. The decreased F-FDG uptake in the right cuneus cluster from the univariate analysis was correlated with the increased thyrotropin level and greater depressive symptoms in the hypothyroid group. CONCLUSIONS: These results suggest that temporary hypothyroidism, even for a short period, may induce impairment in glucose metabolism and related affective symptoms.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Glucose/metabolismo
Neoplasias da Glândula Tireoide/metabolismo
[Mh] Termos MeSH secundário: Adulto
Afeto/fisiologia
Ansiedade/diagnóstico por imagem
Ansiedade/metabolismo
Ansiedade/psicologia
Encéfalo/diagnóstico por imagem
Cognição/fisiologia
Estudos Transversais
Depressão/diagnóstico por imagem
Depressão/metabolismo
Depressão/psicologia
Feminino
Fluordesoxiglucose F18
Seres Humanos
Radioisótopos do Iodo/uso terapêutico
Masculino
Meia-Idade
Tomografia por Emissão de Pósitrons
Neoplasias da Glândula Tireoide/diagnóstico por imagem
Neoplasias da Glândula Tireoide/psicologia
Neoplasias da Glândula Tireoide/radioterapia
Tireoidectomia
Tireotropina/sangue
Tiroxina/sangue
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 06LU7C9H1V (Triiodothyronine); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 9002-71-5 (Thyrotropin); IY9XDZ35W2 (Glucose); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1089/thy.2016.0293


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[PMID]:29385150
[Au] Autor:Metlaine A; Sauvet F; Gomez-Merino D; Boucher T; Elbaz M; Delafosse JY; Leger D; Chennaoui M
[Ad] Endereço:Université Paris Descartes, Sorbonne Paris Cité, Hôtel Dieu, Paris, France.
[Ti] Título:Sleep and biological parameters in professional burnout: A psychophysiological characterization.
[So] Source:PLoS One;13(1):e0190607, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Professional burnout syndrome has been described in association with insomnia and metabolic, inflammatory and immune correlates. We investigated the interest of exploring biological parameters and sleep disturbances in relation to burnout symptoms among white-collar workers. Fifty-four participants with burnout were compared to 86 healthy control participants in terms of professional rank level, sleep, job strain (Karasek questionnaire), social support, anxiety and depression (HAD scale). Fasting concentrations of glycaemia, glycosylated hemoglobin (HbA1C), total-cholesterol, triglycerides, C-reactive protein (CRP), thyroid stimulating hormone (TSH), 25-hydroxyvitamin D (25[OH]D), and white blood cell (WBC) counts were assessed. Analysis of variance and a forward Stepwise Multiple Logistic Regression were made to identify predictive factors of burnout. Besides reporting more job strain (in particular job control p = 0.02), higher levels of anxiety (p<0.001), and sleep disorders related to insomnia (OR = 21.5, 95%CI = 8.8-52.3), participants with burnout presented higher levels of HbA1C, glycaemia, CRP, lower levels of 25(OH)D, higher number of leukocytes, neutrophils and monocytes (P<0.001 for all) and higher total-cholesterol (P = 0.01). In particular, when HbA1c is > 3.5%, the prevalence of burnout increases from 16.6% to 60.0% (OR = 4.3, 95%CI = 2.8-6.9). Strong significant positive correlation existed between HbA1C and the two dimensions (emotional exhaustion and depersonalization (r = 0.79 and r = 0.71, p<0.01)) of burnout. Models including job strain, job satisfaction, anxiety and insomnia did not predict burnout (p = 0.30 and p = 0.50). However, when HbA1C levels is included, the prediction of burnout became significant (P = 0.03). Our findings demonstrated the interest of sleep and biological parameters, in particular HbA1C levels, in the characterization of professional burnout.
[Mh] Termos MeSH primário: Esgotamento Profissional
Psicofísica
Distúrbios do Início e da Manutenção do Sono/etiologia
Sono
[Mh] Termos MeSH secundário: Adulto
Proteína C-Reativa/metabolismo
Calcifediol/sangue
Estudos de Casos e Controles
Feminino
França
Hemoglobina A Glicada/metabolismo
Seres Humanos
Modelos Logísticos
Masculino
Exposição Ocupacional
Apoio Social
Tireotropina/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human); 9002-71-5 (Thyrotropin); 9007-41-4 (C-Reactive Protein); P6YZ13C99Q (Calcifediol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190607


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[PMID]:29305326
[Au] Autor:Fernandez MO; Bourguignon NS; Arocena P; Rosa M; Libertun C; Lux-Lantos V
[Ad] Endereço:Consejo Nacional de Investigaciones Cientificas y Técnicas, Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, CABA, Argentina. Electronic address: mfernandez@dna.uba.ar.
[Ti] Título:Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats.
[So] Source:Toxicol Lett;285:81-86, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500 µg 50 µl oil (B500), or 50 µg 50 µl (B50), or 5 µg 50 µl (B5). Controls were injected with 50 µl vehicle during the same period. Neonatal exposure to BPA did not modify TSH levels in PND13 females, but it increased them in adults in estrus. Serum T4 was lower in B5 and B500 with regards to Control, whereas no difference was seen in T3. No significant differences were observed in TRH, TSHß and TRH receptor expression between groups. TSH release from PPC obtained from adults in estrus was also higher in B50 with regard to Control. In vitro 24 h pre-treatment with BPA or E increased basal TSH as well as prolactin release. On the other hand, both BPA and E lowered the response to TRH. The results presented here show that the neonatal exposure to BPA alters the hypothalamic pituitary-thyroid axis in adult rats in estrus, possibly with effects on the pituitary and thyroid. They also show that BPA alters TSH release from rat PPC through direct actions on the pituitary.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/toxicidade
Disruptores Endócrinos/toxicidade
Hipotálamo/efeitos dos fármacos
Fenóis/toxicidade
Hipófise/efeitos dos fármacos
Glândula Tireoide/efeitos dos fármacos
[Mh] Termos MeSH secundário: Envelhecimento/sangue
Envelhecimento/efeitos dos fármacos
Animais
Animais Recém-Nascidos
Células Cultivadas
Relação Dose-Resposta a Droga
Feminino
Hipotálamo/crescimento & desenvolvimento
Hipotálamo/metabolismo
Hipófise/crescimento & desenvolvimento
Hipófise/metabolismo
Ratos Sprague-Dawley
Receptores do Hormônio Liberador da Tireotropina/genética
Receptores do Hormônio Liberador da Tireotropina/metabolismo
Glândula Tireoide/crescimento & desenvolvimento
Glândula Tireoide/metabolismo
Tireotropina/sangue
Tireotropina/genética
Hormônio Liberador de Tireotropina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Phenols); 0 (Receptors, Thyrotropin-Releasing Hormone); 5Y5F15120W (Thyrotropin-Releasing Hormone); 9002-71-5 (Thyrotropin); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


  9 / 27655 MEDLINE  
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[PMID]:29238947
[Au] Autor:Szczepanek-Parulska E; Hernik A; Ruchala M
[Ti] Título:Thyroid ectopy - diagnostic and therapeutic challenges before and in the era of TSH neonatal screening.
[Ti] Título:Ektopia tarczycy ­ wyzwania diagnostyczne i terapeutyczne przed wprowadzeniem przesiewowego badania TSH noworodków i po nim..
[So] Source:Endokrynol Pol;68(6):708-721, 2017.
[Is] ISSN:2299-8306
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Despite TSH screening in newborns is currently conducted in most developed countries, patients with thyroid ectopy born before the procedure was introduced or those in whom the screening failed to establish diagnosis, might still appear. In the paper we revise the current state of knowledge regarding the clinical presentation, diagnosis and treatment of patients with thyroid ectopy. As an example, we report diagnostic and therapeutic difficulties in our three patients with thyroid ectopy remaining undiagnosed and untreated during early childhood. Introduction of neonatal screening for congenital hypothyroidism does not guarantee that all patients with thyroid ectopy will be correctly diagnosed and properly treated due to the possibility of falsely negative result of TSH screening or lack of compliance from parents. Visualization of an ectopic thyroid on ultrasound examination may be challenging for unexperienced sonographists; muscles in the thyroid bed may be misdiagnosed as heterogeneous and hypoechogenic thyroid gland with features suggesting autoimmune thyroid disease. Thyroid scintiscan is crucial for confirmation of the diagnosis of thyroid ectopy. In conclusion, hypothyroidism due to thyroid developmental anomaly should be taken into consideration in case of hypothyroidism and normal thyroid autoantibodies in a patient at any age.
[Mh] Termos MeSH primário: Hipotireoidismo Congênito/diagnóstico
Triagem Neonatal
Guias de Prática Clínica como Assunto
Disgenesia da Tireoide/diagnóstico
Tireotropina/sangue
[Mh] Termos MeSH secundário: Adulto
Hipotireoidismo Congênito/sangue
Hipotireoidismo Congênito/diagnóstico por imagem
Hipotireoidismo Congênito/tratamento farmacológico
Feminino
Seres Humanos
Recém-Nascido
Cintilografia
Disgenesia da Tireoide/sangue
Disgenesia da Tireoide/diagnóstico por imagem
Disgenesia da Tireoide/tratamento farmacológico
Glândula Tireoide/diagnóstico por imagem
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.5603/EP.a2017.0061


  10 / 27655 MEDLINE  
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[PMID]:29283520
[Au] Autor:Tishevskaya NV; Gevorkyan NM; Kozlova NI
[Ti] Título:Sensitivity of T-Lymphocytes to Hormones of the Anterior Pituitary Gland.
[So] Source:Usp Fiziol Nauk;48(1):80-90, 2017 Jan-Mar.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The review provides information about the features of the sensitivity of thymocytes, lymphoid organs' cells and T-lymphocytes of peripheral blood to the hormones secreted by anterior pituitary gland's cells: growth hormone, thyrotropin, adrenocorticotropic hormone, prolactin and ß-endorphin. Some aspects of the T-lymphocytes's response to humoral signals from the hypophysis are shown in the article. Also the pituitary hormones' role in the regulation of proliferation, differentiation, and cytokine production of T-lymphocytes in normal and pathological conditions of the organism being discussed.
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/farmacologia
Hormônio do Crescimento/farmacologia
Adeno-Hipófise/secreção
Prolactina/farmacologia
Timócitos/efeitos dos fármacos
Tireotropina/farmacologia
beta-Endorfina/farmacologia
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/genética
Hormônio Adrenocorticotrópico/imunologia
Animais
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Regulação da Expressão Gênica
Hormônio do Crescimento/genética
Hormônio do Crescimento/imunologia
Seres Humanos
Leucócitos Mononucleares/citologia
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/imunologia
Cultura Primária de Células
Prolactina/genética
Prolactina/imunologia
Transdução de Sinais
Timócitos/citologia
Timócitos/imunologia
Tireotropina/genética
Tireotropina/imunologia
beta-Endorfina/genética
beta-Endorfina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
60617-12-1 (beta-Endorphin); 9002-60-2 (Adrenocorticotropic Hormone); 9002-62-4 (Prolactin); 9002-71-5 (Thyrotropin); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE



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