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[PMID]:27788702
[Au] Autor:Li X; Zhang XT; Zhang MY; Wang GC; Feng H; Zhang CQ
[Ad] Endereço:Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan 250021, China.
[Ti] Título:[Effects of desmopressin acetate and pituitrin on proliferation, contraction, and secretion of hepatic stellate cells].
[So] Source:Zhonghua Gan Zang Bing Za Zhi;24(8):569-574, 2016 Aug 20.
[Is] ISSN:1007-3418
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the effects of desmopressin acetate and pituitrin on the proliferation, contraction, and secretion of hepatic stellate cells (HSCs). The human HSC cell line LX-2 was selected as the research model. And three groups were designed: blank control group, desmopressin acetate group (three subgroups: 1×10 mol/L, 1×10 mol/L, and 1×10 mol/L desmopressin acetate), and pituitrin group (three subgroups: 0.1 U/L, 1.0 U/L, and 10.0 U/L pituitrin). Water-soluble tetrazolium salt (WST)-1 assay was used to evaluate cell proliferation; collagen gel contraction assay was used to assess cell contraction; enzyme-linked immunosorbent assay (ELISA) was used to identify cell secretion. The data was subjected to one-way analysis of variance. (1) The results of WST-1 assay showed that the values of A in three desmopressin acetate subgroups (1×10 mol/L, 1×10 mol/L, and 1×10 mol/L) were 0.459±0.017, 0.467±0.024, and 0.436±0.015, respectively. And the values of A450 in three pituitrin subgroups (0.1 U/L, 1.0 U/L, and 10.0 U/L) were 0.495±0.011, 0.507±0.015, and 0.501±0.009, respectively. Compared with the control group, the desmopressin acetate at high concentration significantly inhibited the cell proliferation ( < 0.05), but the pituitrin at three different concentrations significantly promoted the cell proliferation ( < 0.05). (2) The collagen gel area ratios in three desmopressin acetate subgroups (1×10 mol/L, 1×10 mol/L, and 1×10 mol/L) were 77.07±4.42, 75.85±3.70, and 72.74±3.92, respectively. And the collagen gel area ratios in three pituitrin subgroups (0.1 U/L, 1.0 U/L, and 10.0 U/L) were 57.83±3.96, 50.28±6.69, and 43.56±7.68, respectively. Compared with the control group, the pituitrin at three different concentrations significantly reduced the collagen gel area ( < 0.01). (3) The matrix metalloproteinase(MMP)-2 concentrations in three desmopressin acetate subgroups (1×10 mol/L, 1×10 mol/L, and 1×10 mol/L) were 13.321±0.098, 12.230±0.153, and 12.061±0.126, respectively. And the MMP-2 concentrations in three pituitrin subgroups (0.1 U/L, 1.0 U/L, and 10.0 U/L) were 12.899±0.150, 13.662±0.152, and 13.698±0.119, respectively. Compared with the control group, the desmopressin acetate at low concentration significantly increased the secretion of MMP-2 ( < 0.01); the desmopressin acetate at high concentration significantly decreased the MMP-2 concentration ( < 0.05); the pituitrin at three different concentrations significantly increased the MMP-2 concentration ( < 0.01). The transforming growth factor-beta 1 (TGF-ß1) concentrations in three desmopressin acetate subgroups (1×10 mol/L, 1×10 mol/L, and 1×10 mol/L) were 5.233±0.102, 17.749±0.188, and 36.060±0.227, respectively. And the TGF-ß1 concentrations in three pituitrin subgroups (0.1 U/L, 1.0 U/L, and 10.0 U/L) were 15.615±0.099, 38.460±0.209, and 49.053±0.115, respectively. Compared with the control group, desmopressin acetate and pituitrin significantly promoted the secretion of TGF-ß1 in a concentration-dependent manner ( < 0.01) and pituitrin had a stronger effect than desmopressin acetate ( < 0.01). Desmopressin acetate and pituitrin had no effect on the secretion of the collagenase type I and III ( > 0.05). Desmopressin acetate and pituitrin can induce the changes in the function and morphology of HSCs and may increase vascular resistance in the hepatic sinus. However, desmopressin acetate has less influence on HSCs than pituitrin.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Desamino Arginina Vasopressina/farmacologia
Células Estreladas do Fígado/efeitos dos fármacos
Hormônios Neuro-Hipofisários/farmacologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Células Cultivadas
Colágeno
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Fígado
Fator de Crescimento Transformador beta1/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); 0 (Transforming Growth Factor beta1); 9007-34-5 (Collagen); ENR1LLB0FP (Deamino Arginine Vasopressin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1007-3418.2016.08.003


  2 / 1110 MEDLINE  
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[PMID]:27725243
[Au] Autor:Guo T; Ren L; Wang Q; Li K
[Ad] Endereço:Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China.
[Ti] Título:A network meta-analysis of updated haemostatic strategies for hysterectomy.
[So] Source:Int J Surg;35:187-195, 2016 Nov.
[Is] ISSN:1743-9159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the best haemostatic strategy for hysterectomy through a network meta-analysis. METHODS: We conducted a systematic literature search of the PubMed, Embase, and Cochrane Library databases and extracted data from randomized controlled trials comparing haemostatic strategies for hysterectomy. Direct comparisons and network meta-analyses were conducted in RevMan and ADDIS. Consistency models were established to identify the differences among different haemostatic strategies, and cumulative probability was used to rank the included strategies. Inconsistencies were also tested using node-splitting models. RESULTS: Twenty studies from 16 articles (2 articles contained 3 studies each) comprising 1392 patients were included. Direct meta-analysis showed that the LigaSure (SMD = -1.42 [-2.39, -0.44], P = 0.004), bipolar vessel sealing systems (BVSS) (SMD = -0.35 [-0.66, -0.03], P = 0.03), and pituitrin (SMD = -2.13 [-4.14, -0.13], P = 0.04) applications were effective haemostatic strategies. Based on the network meta-analysis and related subgroup analysis of different surgical procedures, the results showed that the application of pituitrin seemed to be the best haemostatic method for hysterectomy (Rank P = 0.64), especially for vaginal hysterectomy (Rank P = 0.72). The application of LigaSure was the best strategy for abdominal hysterectomy (Rank P = 0.54) but was not effective for laparoscopic hysterectomy (direct comparison with BVSS, MD = -31.39 [-146.61, 83.83], P = 0.59). The node-splitting models test revealed that no significant inconsistencies existed in this research. CONCLUSIONS: Pituitrin application seemed to be the most effective haemostatic strategy for hysterectomy and was especially suitable for vaginal hysterectomy. The best method for reducing blood loss in abdominal hysterectomy was the application of LigaSure.
[Mh] Termos MeSH primário: Perda Sanguínea Cirúrgica/prevenção & controle
Eletrocoagulação/métodos
Técnicas Hemostáticas
Hemostáticos/administração & dosagem
Histerectomia
Hormônios Neuro-Hipofisários/administração & dosagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Histerectomia Vaginal
Metanálise em Rede
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Hemostatics); 0 (Pituitary Hormones, Posterior)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170125
[Lr] Data última revisão:
170125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  3 / 1110 MEDLINE  
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[PMID]:26517776
[Au] Autor:Ottenhausen M; Bodhinayake I; Banu MA; Stieg PE; Schwartz TH
[Ad] Endereço:Department of Neurosurgery, Sackler Brain and Spine Center;
[Ti] Título:Vincent du Vigneaud: following the sulfur trail to the discovery of the hormones of the posterior pituitary gland at Cornell Medical College.
[So] Source:J Neurosurg;124(5):1538-42, 2016 May.
[Is] ISSN:1933-0693
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 1955, Vincent du Vigneaud (1901-1978), the chairman of the Department of Biochemistry at Cornell University Medical College, was awarded the Nobel Prize for Chemistry for his research on insulin and for the first synthesis of the posterior pituitary hormones-oxytocin and vasopressin. His tremendous contribution to organic chemistry, which began as an interest in sulfur-containing compounds, paved the way for a better understanding of the pituitary gland and for the development of diagnostic and therapeutic tools for diseases of the pituitary. His seminal research continues to impact neurologists, endocrinologists, and neurosurgeons, and enables them to treat patients who had no alternatives prior to du Vigneaud's breakthroughs in peptide structure and synthesis. The ability of neurosurgeons to aggressively operate on parasellar pathology was directly impacted and related to the ability to replace these hormones after surgery. The authors review the life and career of Vincent du Vigneaud, his groundbreaking discoveries, and his legacy of the understanding and treatment of the pituitary gland in health and disease.
[Mh] Termos MeSH primário: Prêmio Nobel
Hormônios Neuro-Hipofisários/história
Compostos de Enxofre/história
[Mh] Termos MeSH secundário: História do Século XX
Faculdades de Medicina/história
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:du Vigneaud V
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); 0 (Sulfur Compounds)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE
[do] DOI:10.3171/2015.5.JNS141952


  4 / 1110 MEDLINE  
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[PMID]:25740269
[Au] Autor:Xu DH; Yuan M; Wang JW; Hu YZ
[Ti] Título:Osmotic demyelination syndrome after correction of severe hyponatremia associated with pituitrin.
[So] Source:Int J Clin Pharmacol Ther;53(5):408-11, 2015 May.
[Is] ISSN:0946-1965
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Osmotic demyelination syndrome (ODS) may be precipitated by aggressive correction of a hypoosmolar state. We report the case of a 24-year-old woman who developed ODS during rapid correction of asymptomatic hyponatremia caused by pituitrin prescribed for hemoptysis. After hyponatremia correction by NaCl supplementation, the patient developed limb weakness, blurred vision, hand and perioral numbness, and lisp. Magnetic resonance imaging (MRI) revealed bilateral signal hyperintensity of the globus pallidus and caudate nucleus, compatible with extra-pontine ODS. These symptoms improved gradually with treatment, and brain MRI ~ 3 months later indicated substantial resolution of ODS. This case serves as a warning to physicians that hypoosmotic correction must be achieved at a controlled rate.
[Mh] Termos MeSH primário: Doenças Desmielinizantes/induzido quimicamente
Hemoptise/tratamento farmacológico
Hiponatremia/tratamento farmacológico
Osmose
Hormônios Neuro-Hipofisários/efeitos adversos
Cloreto de Sódio/efeitos adversos
[Mh] Termos MeSH secundário: Doenças Desmielinizantes/diagnóstico
Doenças Desmielinizantes/fisiopatologia
Doenças Desmielinizantes/terapia
Feminino
Seres Humanos
Hiponatremia/induzido quimicamente
Hiponatremia/diagnóstico
Imagem por Ressonância Magnética
Modalidades de Fisioterapia
Índice de Gravidade de Doença
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE
[do] DOI:10.5414/CP202320


  5 / 1110 MEDLINE  
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[PMID]:25294308
[Au] Autor:Zhuang L; Xu Z; Li Y; Luo B
[Ad] Endereço:Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. zhuangliying43205409@126.com.
[Ti] Título:Extrapontine myelinolysis associated with pituitrin: case report and literature review.
[So] Source:BMC Neurol;14:189, 2014 Oct 09.
[Is] ISSN:1471-2377
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hyponatremia is the most common electrolyte abnormality encountered in hospitalized patients, resulting from a varied spectrum of conditions. Both the primary disturbance and its correction can result in life-threatening neurological consequences. Extrapontine myelinolysis is one such complication that is associated with the rapid correction of hyponatremia. Here we describe a patient who developed extrapontine myelinolysis unexpectedly after the correction of hyponatremia, which involved the drug pituitrin. CASE PRESENTATION: A 24-year-old Chinese woman was transferred to our neurology department with the symptoms of dysarthria and quadriparesis developing one day after the correction of hyponatremia (from 118 mmol/L to 140 mmol/L), which followed with a continuous intravenous drip of pituitrin used to control hemoptysis in the emergency room. During the course, she developed involuntary movement. Magnetic resonance imaging changes were consistent with extrapontine myelinolysis. CONCLUSION: This present case describes the mechanism of profound hyponatremia involving pituitrin, and the subsequent development of extrapontine myelinolysis. Physicians may approach effective clinical management of patients through awareness of the adverse effect of pituitrin on serum sodium levels, and avoid rapid correction of hyponatremia in clinical practice.
[Mh] Termos MeSH primário: Hiponatremia/terapia
Mielinólise Central da Ponte/induzido quimicamente
Hormônios Neuro-Hipofisários/efeitos adversos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Hiponatremia/etiologia
Imagem por Ressonância Magnética
Hormônios Neuro-Hipofisários/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150427
[Lr] Data última revisão:
150427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141009
[St] Status:MEDLINE
[do] DOI:10.1186/s12883-014-0189-9


  6 / 1110 MEDLINE  
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[PMID]:25190061
[Au] Autor:Iovino M; Guastamacchia E; Giagulli VA; Licchelli B; Iovino E; Triggiani V
[Ti] Título:Molecular mechanisms involved in the control of neurohypophyseal hormones secretion.
[So] Source:Curr Pharm Des;20(42):6702-13, 2014.
[Is] ISSN:1873-4286
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The regulation of neurohypophyseal peptides secretion reflects the convergence of a large number of afferent neural pathways on vasopressinergic and oxytocinergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). In addition to afferent input, vasopressin and oxytocin can also exert an autocrine regulation of neuronal activity. In fact, magnocellular neurons (MCNs) of SON and PVN are able to secrete these hormones not only at the endings of their terminal axons, but also from their dendrites and this local release, by activating a range of ion gated, ion channel and G protein coupled receptors, participate in pre- and post-synaptic modulation of neural activity of MCNs. In this review we analyzed the molecular mechanisms involved in the control of neurohypophyseal hormones secretion and related possible pharmacological targets.
[Mh] Termos MeSH primário: Hormônios Neuro-Hipofisários/secreção
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neurônios/metabolismo
Ocitocina/metabolismo
Vasopressinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); 11000-17-2 (Vasopressins); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141024
[Lr] Data última revisão:
141024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140906
[St] Status:MEDLINE


  7 / 1110 MEDLINE  
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[PMID]:25150000
[Au] Autor:Xu L; Wang CY; Lv L; Liu KX; Sun HJ; Han GZ
[Ad] Endereço:Department of Medical Affairs, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
[Ti] Título:Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium.
[So] Source:Pharmacol Rep;66(5):908-14, 2014 Oct.
[Is] ISSN:1734-1140
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The pharmacokinetic (PK) studies of phosphocreatine (PCr) and its active metabolite creatine (Cr) are considerably lacking. This study is to comparatively investigate the PK profiles of PCr and Cr in mice plasma and myocardium as well as the ATP level. METHODS: After iv administration of equimolar PCr and preformed Cr to healthy and Pit-induced myocardial ischemic mice, plasma and myocardium samples were analyzed for exogenous PCr, Cr and related ATP concentrations using a specific ion-pair reversed-phase HPLC-UV assay. RESULTS: The plasma C-T data of iv PCr and Cr were well fitted to two-compartment model. Following iv PCr, Cr appeared in plasma as early as 1.0 min postdose with a longer t1/2 than PCr and had a fm of 72%. The mice dosed iv PCr preceded 5 min by ip Pit 30 U/kg showed longer t1/2ß PCr and t1/2 Cr in plasma and elevated Cmax, Cr and Cmax, ATP in myocardium compared with mice dosed iv PCr alone, and it was estimated that about 40% ATP produced by iv PCr was from Cr. CONCLUSION: The PCr in plasma is converted to Cr rapidly and mostly, and shows an elimination rate limited (ERL) metabolite disposition. Iv PCr caused a significantly elevated and long-lasing myocardial ATP and Cr levels. The Pit-induced myocardial ischemia brings slower elimination of PCr and Cr and higher peak concentrations of Cr and ATP in myocardium. The metabolite Cr at least partially mediates PCr-caused rise in myocardial ATP level and also possibly the cardio-protective effects of PCr.
[Mh] Termos MeSH primário: Creatina/metabolismo
Isquemia Miocárdica/fisiopatologia
Miocárdio/metabolismo
Fosfocreatina/farmacocinética
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Animais
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Meia-Vida
Masculino
Camundongos
Hormônios Neuro-Hipofisários/administração & dosagem
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); 020IUV4N33 (Phosphocreatine); 8L70Q75FXE (Adenosine Triphosphate); MU72812GK0 (Creatine)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140823
[Lr] Data última revisão:
140823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140824
[St] Status:MEDLINE


  8 / 1110 MEDLINE  
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[PMID]:24731501
[Au] Autor:Gao Y; Du G; Wu Y; Wang Q; Li R
[Ad] Endereço:Intensive Care Unit, First Affiliated Hospital, Dalian Medical University, Dalian 116021, China. Email: gaoyanguo2008@sina.com.
[Ti] Título:[Protective effect and mechanisms of pituitrin on acute paraquat-induced lung injury in rats].
[So] Source:Zhonghua Yi Xue Za Zhi;94(4):306-9, 2014 Jan 28.
[Is] ISSN:0376-2491
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the protective effect of pituitrin on the development of paraquat-induced lung injury in rats. METHODS: Sixty healthy Sprague Dawley female rats were randomized into 3 groups of control, paraquat and treatment (80 mg/kg, intragastric) groups (n = 20 each) Each group was divided into 4, 6, 12 and 24 h subgroups (n = 5 each). The treatment group received pituitrin, injection via internal jugular vein 30 minutes after paraquat dosing. As controls, control and paraquat groups were injected with an equal volume of saline. The paraquat content in serum and lung tissue was measured by high-performance liquid chromatography-mass spectrometry (HPLC-MS). And the levels of tumor necrosis factor-alpha (TNF-α) in sera and nuclear factor-kappa B (NF-κB) in lung tissue and the content of protein in bronchoalveolar lavage (BAL) fluid were detected at various timepoints. Lung wet-to-dry weight ratio (W/D) was recorded after pituitrin dosing. In addition, pathological changes were also observed. RESULTS: The highest drug concentration of paraquat in lung tissue was far lower in the treatment group than that in the paraquat group ((7.67 ± 0.91) vs (13.27 ± 0.95) µg/g, P = 0.002). There were the same result in sera ((1 695 ± 274) vs (5 377 ± 576) ng/ml, P = 0.003). The area under the concentration-time curve in the treatment group was significantly lower than that in the paraquat group (10 482 vs 43 441, P = 0.000). The levels of NF-κB in lung tissue and TNF-α in sera in the treatment group were lower than those in the paraquat group (TNF-α: 24 h: (1.85 ± 0.22) vs (2.59 ± 0.13) ng/ml, P = 0.020; NF-κB: 24 h: (88.0 ± 2.7) vs (101.8 ± 2.8) ng/g, P = 0.003). And there was a decrease in the content of protein in BAL fluid in the treatment group versus the paraquat group (BALF protein: 24 h: (125.9 ± 4.2) vs (192.7 ± 6.5)µg/ml, P = 0.003), lung W/D significantly decreased in the treatment group versus the paraquat group (12 h: 3.50 ± 0.14 vs 3.73 ± 0.15, P = 0.043; 24 h: 3.41 ± 0.06 vs 3.61 ± 0.09, P = 0.047). In addition, when compared with the paraquat group, the pituitrin-treated rats showed a mitigation of inflammatory response in lungs and reduced pulmonary edema. CONCLUSION: Pituitrin treatment decreases the content of paraquat in sera and lung homogenate in intoxicated rats and alleviates lung injury so that it may become a useful adjuvant in the treatment of acute lung injury.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/tratamento farmacológico
Paraquat/envenenamento
Hormônios Neuro-Hipofisários/uso terapêutico
[Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/induzido quimicamente
Animais
Feminino
Hormônios Neuro-Hipofisários/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pituitary Hormones, Posterior); PLG39H7695 (Paraquat)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140415
[Lr] Data última revisão:
140415
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140416
[St] Status:MEDLINE


  9 / 1110 MEDLINE  
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[PMID]:24644276
[Au] Autor:Lubecka EA; Sikorska E; Marcinkowska A; Ciarkowski J
[Ad] Endereço:Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-952, Gdansk, Poland.
[Ti] Título:Conformational studies of neurohypophyseal hormones analogues with glycoconjugates by NMR spectroscopy.
[So] Source:J Pept Sci;20(6):406-14, 2014 Jun.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two glycosylated peptides have been studied using NMR spectroscopy supported by molecular modeling. Peptide I is an oxytocin (OT) analogue in which glutamine 4 was replaced by serine with attached α-d-mannose through the oxygen ß atom, whereas peptide II is a lysine-vasopressin (LVP) analogue with lysine 8 side chain modified by the attachment of glucuronic acid through an amide bond. Both peptides exhibit very weak uterotonic effect and are less susceptible to proteolytic degradation than the mother hormones. Additionally, peptide II reveals very weak pressor and antidiuretic activities. Our results have shown that the conformational preferences of glycosylated analogues are highly similar to those of their respective mother hormones. OT glycosylated analogue (I) exhibits a 3,4 ß-turn characteristic of OT-like peptides, and vasopressin-glycosylated analogue (II) exhibits ß-turns typical of vasopressin-like peptides. Therefore, the lack of binding of the glycosylated analogues to the receptors can be attributed to a steric interference between the carbohydrate moieties and the receptors. We also consider this to be the reason of the very low activity of the analyzed glycopeptides. We expect that results from these studies will be helpful in designing new OT-like and vasopressin-like drugs.
[Mh] Termos MeSH primário: Glicoconjugados/química
Hormônios Neuro-Hipofisários/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
Ressonância Magnética Nuclear Biomolecular
Hormônios Neuro-Hipofisários/síntese química
Hormônios Neuro-Hipofisários/isolamento & purificação
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycoconjugates); 0 (Pituitary Hormones, Posterior)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140512
[Lr] Data última revisão:
140512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140320
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2628


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[PMID]:24391112
[Au] Autor:Lolait S
[Ad] Endereço:s.j.lolait@bristol.ac.uk.
[Ti] Título:The hypothalamic-neurohypophysial system: genomes, genes and genetics.
[So] Source:Exp Physiol;99(1):52-4, 2014 Jan.
[Is] ISSN:1469-445X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Genoma/genética
Hipotálamo/fisiologia
Neuropeptídeos/genética
Neuro-Hipófise/fisiologia
Hormônios Neuro-Hipofisários/genética
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuropeptides); 0 (Pituitary Hormones, Posterior)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140106
[Lr] Data última revisão:
140106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140107
[St] Status:MEDLINE
[do] DOI:10.1113/expphysiol.2013.072587



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