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[PMID]:28448987
[Au] Autor:Weitekamp CA; Solomon-Lane TK; Del Valle P; Triki Z; Nugent BM; Hofmann HA
[Ad] Endereço:Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.
[Ti] Título:A Role for Oxytocin-Like Receptor in Social Habituation in a Teleost.
[So] Source:Brain Behav Evol;89(3):153-161, 2017.
[Is] ISSN:1421-9743
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oxytocin (OT) mediates social habituation in rodent model systems, but its role in mediating this effect in other vertebrates is unknown. We used males of the African cichlid fish, Astatotilapia burtoni, to investigate two aspects of isotocin (IT; an OT homolog) signaling in social habituation. First, we examined the expression of IT receptor 2 (ITR2) as well as two immediate early genes in brain regions implicated in social recognition. Next, we examined IT neuron activity using immunohistochemistry. Patterns of gene expression in homologs of the amygdala and hippocampus implicate IT signaling in these regions in social habituation to a territorial neighbor. In the preoptic area, the expression of the ITR2 subtype and IT neuron activity respond to the presence of a male, independent of familiarity. Our results implicate IT in mediating social habituation in a teleost.
[Mh] Termos MeSH primário: Ciclídeos/genética
Ocitocina/análogos & derivados
[Mh] Termos MeSH secundário: Agressão/fisiologia
Tonsila do Cerebelo
Animais
Comportamento Animal/fisiologia
Encéfalo/metabolismo
Ciclídeos/fisiologia
Feminino
Hibridização In Situ
Masculino
Ocitocina/metabolismo
Ocitocina/fisiologia
Área Pré-Óptica/metabolismo
Receptores de Ocitocina/fisiologia
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Oxytocin); 50-56-6 (Oxytocin); 550-21-0 (isotocin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1159/000464098


  2 / 16662 MEDLINE  
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[PMID]:28749705
[Au] Autor:Lara-Cinisomo S; McKenney K; Di Florio A; Meltzer-Brody S
[Ad] Endereço:1 Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign , Urbana, Illinois.
[Ti] Título:Associations Between Postpartum Depression, Breastfeeding, and Oxytocin Levels in Latina Mothers.
[So] Source:Breastfeed Med;12(7):436-442, 2017 09.
[Is] ISSN:1556-8342
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postpartum depression (PPD), often comorbid with anxiety, is the leading medical complication among new mothers. Latinas have elevated risk of PPD, which has been associated with early breastfeeding cessation. Lower plasma oxytocin (OT) levels have also been associated with PPD in non-Latinas. This pilot study explores associations between PPD, anxiety, breastfeeding, and OT in Latinas. MATERIALS AND METHODS: Thirty-four Latinas were enrolled during their third trimester of pregnancy and followed through 8 weeks postpartum. Demographic data were collected at enrollment. Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at each time point (third trimester of pregnancy, 4 and 8 weeks postpartum). The Spielberger State-Trait Anxiety Inventory (STAI) was administered postpartum and EPDS anxiety subscale was used to assess anxiety at each time point. Breastfeeding status was assessed at 4 and 8 weeks postpartum. At 8 weeks, OT was collected before, during, and after a 10-minute breast/bottle feeding session from 28 women who completed the procedures. Descriptive statistics are provided and comparisons by mood and breastfeeding status were conducted. Analyses of variance were used to explore associations between PPD, anxiety, breastfeeding status, and OT. RESULTS: Just under one-third of women were depressed at enrollment. Prenatal depression, PPD, and anxiety were significantly associated with early breastfeeding cessation (i.e., stopped breastfeeding before 2 months) (p < 0.05). There was a significant interaction between early breastfeeding cessation and depression status on OT at 8 weeks postpartum (p < 0.05). CONCLUSIONS: Lower levels of OT were observed in women who had PPD at 8 weeks and who had stopped breastfeeding their infant by 8 weeks postpartum. Future studies should investigate the short- and long-term effects of lower OT levels and early breastfeeding cessation on maternal and child well-being.
[Mh] Termos MeSH primário: Aleitamento Materno/psicologia
Depressão Pós-Parto/sangue
Hispano-Americanos
Mães
Ocitocina/sangue
[Mh] Termos MeSH secundário: Adulto
Ansiedade/sangue
Ansiedade/complicações
Ansiedade/psicologia
Depressão Pós-Parto/complicações
Depressão Pós-Parto/psicologia
Escolaridade
Feminino
Hispano-Americanos/psicologia
Seres Humanos
Lactente
Recém-Nascido
Estado Civil
Mães/psicologia
Projetos Piloto
Escalas de Graduação Psiquiátrica
Apoio Social
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1089/bfm.2016.0213


  3 / 16662 MEDLINE  
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[PMID]:28452807
[Au] Autor:Kim J; Kang SM; Lee HJ; Choi SY; Hong SH
[Ad] Endereço:Departments of aOral Microbiology and Immunology bOral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, South Korea.
[Ti] Título:Oxytocin inhibits head and neck squamous cell carcinoma cell migration by early growth response-1 upregulation.
[So] Source:Anticancer Drugs;28(6):613-622, 2017 07.
[Is] ISSN:1473-5741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of oxytocin (OXT) on cancer invasion is controversial. Few studies have examined the effect of early growth response-1 (EGR1) on the invasion of head and neck squamous cell carcinoma (HNSCC). Here, we evaluated how EGR1 affects HNSCC cell migration through the molecular mechanism of OXT in exerting anti-invasion activity. Matrigel invasion and wound-healing assays were used to measure the in-vitro cell migration. The molecular mechanism of OXT was assessed by knockdown or overexpression of EGR1 in HNSCC cells. Three-dimensional (3-D) spheroids formation, followed by the image analysis for quantification was performed. OXT at 500 nmol/l increased mRNA and protein expression of E-cadherin without cytotoxicity. OXT upregulated mRNA and protein expression of EGR1 in 6 h. p53, phosphatase and tensin, and p21 expression was increased in an EGR1-dependent manner with OXT treatment. In addition, OXT significantly downregulated 3-D spheroids' formation according to spheroids' number and size. Our data showed that OXT downregulated HNSCC cell migration by EGR1 upregulation. OXT inhibited spheroids' formation of HNSCC cells under 3-D culture conditions.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/tratamento farmacológico
Movimento Celular/efeitos dos fármacos
Proteína 1 de Resposta de Crescimento Precoce/biossíntese
Neoplasias de Cabeça e Pescoço/tratamento farmacológico
Ocitocina/farmacologia
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/patologia
Transição Epitelial-Mesenquimal/efeitos dos fármacos
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Neoplasias de Cabeça e Pescoço/metabolismo
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Invasividade Neoplásica
Metástase Neoplásica
Receptor do Fator de Crescimento Epidérmico/metabolismo
Esferoides Celulares
Células Tumorais Cultivadas
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (EGR1 protein, human); 0 (Early Growth Response Protein 1); 50-56-6 (Oxytocin); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1097/CAD.0000000000000501


  4 / 16662 MEDLINE  
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[PMID]:29346405
[Au] Autor:Palanisamy A; Kannappan R; Xu Z; Martino A; Friese MB; Boyd JD; Crosby G; Culley DJ
[Ad] Endereço:Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
[Ti] Título:Oxytocin alters cell fate selection of rat neural progenitor cells in vitro.
[So] Source:PLoS One;13(1):e0191160, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Synthetic oxytocin (sOT) is widely used during labor, yet little is known about its effects on fetal brain development despite evidence that it reaches the fetal circulation. Here, we tested the hypothesis that sOT would affect early neurodevelopment by investigating its effects on neural progenitor cells (NPC) from embryonic day 14 rat pups. NPCs expressed the oxytocin receptor (OXTR), which was downregulated by 45% upon prolonged treatment with sOT. Next, we examined the effects of sOT on NPC death, apoptosis, proliferation, and differentiation using antibodies to NeuN (neurons), Olig2 (oligodendrocytes), and GFAP (astrocytes). Treated NPCs were analysed with unbiased high-throughput immunocytochemistry. Neither 6 nor 24 h exposure to 100 pM or 100 nM sOT had an effect on viability as assessed by PI or CC-3 immunocytochemistry. Similarly, sOT had negligible effect on NPC proliferation, except that the overall rate of NPC proliferation was higher in the 24 h compared to the 6 h group regardless of sOT exposure. The most significant finding was that sOT exposure caused NPCs to select a predominantly neuronal lineage, along with a concomitant decrease in glial cells. Collectively, our data suggest that perinatal exposure to sOT can have neurodevelopmental consequences for the fetus, and support the need for in vivo anatomical and behavioral studies in offspring exposed to sOT in utero.
[Mh] Termos MeSH primário: Células-Tronco Neurais/efeitos dos fármacos
Ocitocina/toxicidade
[Mh] Termos MeSH secundário: Animais
Astrócitos/citologia
Astrócitos/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Linhagem da Célula/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Regulação para Baixo/efeitos dos fármacos
Feminino
Seres Humanos
Células-Tronco Neurais/citologia
Células-Tronco Neurais/metabolismo
Neurogênese/efeitos dos fármacos
Neuroglia/citologia
Neuroglia/efeitos dos fármacos
Neurônios/citologia
Neurônios/efeitos dos fármacos
Oligodendroglia/citologia
Oligodendroglia/efeitos dos fármacos
Ocitocina/administração & dosagem
Ocitocina/metabolismo
Placenta/metabolismo
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Ratos
Ratos Sprague-Dawley
Receptores de Ocitocina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Oxytocin); 0 (oxytocin receptor, rat); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191160


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[PMID]:29300770
[Au] Autor:Eisenberg Y; Dugas LR; Akbar A; Reddivari B; Layden BT; Barengolts E
[Ad] Endereço:Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States of America.
[Ti] Título:Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.
[So] Source:PLoS One;13(1):e0190301, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors. DESIGN AND METHODS: A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected including oral glucose tolerance testing and urinary OT (measured by ELISA). Subjects also completed questionnaires on social and lifestyle factors. RESULTS: OT levels were found to be significantly lower in subjects with type 2 diabetes mellitus (T2DM) compared to normal glucose tolerance (p<0.05). When stratified by OT tertiles, subjects with higher OT had lower weight, body mass index (BMI) and hemoglobin A1c, but higher eGFR which remained significant after BMI adjustment. The highest OT tertile also had more smokers and more users of psychiatric medications. A stepwise ordered logistic regression supported these findings and could account for 21% of the variation in OT categories (pseudoR2 = 0.21). CONCLUSIONS: In this unique population, OT was found lower in subjects with diabetes but higher with better renal function, cigarette smoking and use of psychiatric medications. Future studies are needed to confirm these findings and examine the potential therapeutic role of OT.
[Mh] Termos MeSH primário: Afroamericanos
Diabetes Mellitus Tipo 2/urina
Ocitocina/urina
[Mh] Termos MeSH secundário: Adulto
Idoso
Glicemia/metabolismo
Estudos de Casos e Controles
Estudos Transversais
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/psicologia
Ensaio de Imunoadsorção Enzimática
Hemoglobina A Glicada/metabolismo
Seres Humanos
Masculino
Meia-Idade
Obesidade/complicações
Sobrepeso/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190301


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[PMID]:27776060
[Au] Autor:Mandel HC
[Ad] Endereço:Los Angeles, California.
[Ti] Título:Duration of Oxytocin and Rupture of the Membranes Before Diagnosing a Failed Induction of Labor.
[So] Source:Obstet Gynecol;128(5):1183, 2016 11.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Trabalho de Parto Induzido
Ocitocina
[Mh] Termos MeSH secundário: Feminino
Ruptura Prematura de Membranas Fetais
Seres Humanos
Trabalho de Parto
Ocitócicos
Gravidez
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Oxytocics); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29300752
[Au] Autor:Schumacher S; Oe M; Wilhelm FH; Rufer M; Heinrichs M; Weidt S; Moergeli H; Martin-Soelch C
[Ad] Endereço:Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[Ti] Título:Does trait anxiety influence effects of oxytocin on eye-blink startle reactivity? A randomized, double-blind, placebo-controlled crossover study.
[So] Source:PLoS One;13(1):e0190809, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous research has demonstrated that the neuropeptide oxytocin modulates social behaviors and reduces anxiety. However, effects of oxytocin on startle reactivity, a well-validated measure of defense system activation related to fear and anxiety, have been inconsistent. Here we investigated the influence of oxytocin on startle reactivity with particular focus on the role of trait anxiety. METHODS: Forty-four healthy male participants attended two experimental sessions. They received intranasal oxytocin (24 IU) in one session and placebo in the other. Startle probes were presented in combination with pictures of social and non-social content. Eye-blink startle magnitude was measured by electromyography over the musculus orbicularis oculi in response to 95 dB noise bursts. Participants were assigned to groups of high vs. low trait anxiety based on their scores on the trait form of the Spielberger State-Trait Anxiety Inventory (STAI). RESULTS: A significant interaction effect of oxytocin with STAI confirmed that trait anxiety moderated the effect of oxytocin on startle reactivity. Post-hoc tests indicated that for participants with elevated trait anxiety, oxytocin increased startle magnitude, particularly when watching non-social pictures, while this was not the case for participants with low trait anxiety. CONCLUSION: Results indicate that effects of oxytocin on defense system activation depend on individual differences in trait anxiety. Trait anxiety may be an important moderator variable that should be considered in human studies on oxytocin effects.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Ocitocina/fisiologia
Reflexo de Sobressalto/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Piscadela/efeitos dos fármacos
Piscadela/fisiologia
Estudos Cross-Over
Método Duplo-Cego
Seres Humanos
Masculino
Meia-Idade
Ocitocina/farmacologia
Personalidade/fisiologia
Reflexo de Sobressalto/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190809


  8 / 16662 MEDLINE  
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[PMID]:29215519
[Au] Autor:Mackeen AD; Durie DE; Lin M; Huls CK; Qureshey E; Paglia MJ; Sun H; Sciscione A
[Ad] Endereço:Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Biostatistics Core, Geisinger, Danville, Pennsylvania; the Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania; the University of Colorado School of Medicine, Aurora, Colorado; the University of Arizona College of Medicine, Phoenix at Banner University Medical Center, Phoenix, Arizona; and Christiana Care Health System, Newark, Delaware.
[Ti] Título:Foley Plus Oxytocin Compared With Oxytocin for Induction After Membrane Rupture: A Randomized Controlled Trial.
[So] Source:Obstet Gynecol;131(1):4-11, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the use of a transcervical Foley catheter plus oxytocin infusion compared with oxytocin infusion alone for labor induction and cervical ripening in women 34 weeks of gestation or greater with prelabor rupture of membranes. METHODS: This is a randomized, multicenter trial of women with a live, singleton gestation at 34 weeks of gestation or greater with prelabor rupture of membranes, an unfavorable cervical examination (less than 2 cm or 80% effaced), and no contraindication to labor. Participants were randomly allocated to a transcervical Foley catheter inflated to 30 cc with concurrent oxytocin infusion or oxytocin infusion alone. Oxytocin administration was standardized across sites. The primary study outcome was interval from induction to delivery. To detect a 2.5-hour difference in the interval from induction to delivery, we required outcome data on 194 women, assuming 80% power and a two-tailed α of 5%. Analysis was by intent to treat. RESULTS: We enrolled 201 women: 93 were allocated to Foley and 108 to oxytocin. Demographics were similar between the groups. Time to delivery was not significantly different between groups: in the Foley group, it was 13.9 hours (±6.9 SD) compared with 14.4 hours (±7.9 SD) in the oxytocin group (P=.69). There were more cases of clinical chorioamnionitis (8% compared with 0%, P<.01) in the Foley group compared with the oxytocin group. There were no differences for other infectious morbidities or any other variable studied. CONCLUSION: In patients with prelabor rupture of membranes, the use of a transcervical Foley catheter in addition to oxytocin does not shorten the time to delivery compared with oxytocin alone, but may increase the incidence of intraamniotic infection. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01973036.
[Mh] Termos MeSH primário: Ruptura Prematura de Membranas Fetais/tratamento farmacológico
Trabalho de Parto Induzido/métodos
Ocitocina/administração & dosagem
Resultado da Gravidez
Cateterismo Urinário/métodos
[Mh] Termos MeSH secundário: Adulto
Maturidade Cervical/efeitos dos fármacos
Terapia Combinada
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Infusões Intravenosas
Gravidez
Medição de Risco
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
50-56-6 (Oxytocin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002374


  9 / 16662 MEDLINE  
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[PMID]:28747407
[Au] Autor:Roberts ZS; Wolden-Hanson T; Matsen ME; Ryu V; Vaughan CH; Graham JL; Havel PJ; Chukri DW; Schwartz MW; Morton GJ; Blevins JE
[Ad] Endereço:Veterans Affairs Puget Sound Health Care System, Office of Research and Development, Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, Washington.
[Ti] Título:Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats.
[So] Source:Am J Physiol Regul Integr Comp Physiol;313(4):R357-R371, 2017 Oct 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxytocin (OT) administration elicits weight loss in diet-induced obese (DIO) rodents, nonhuman primates, and humans by reducing energy intake and increasing energy expenditure. Although the neurocircuitry underlying these effects remains uncertain, OT neurons in the paraventricular nucleus are positioned to control both energy intake and sympathetic nervous system outflow to interscapular brown adipose tissue (BAT) through projections to the hindbrain nucleus of the solitary tract and spinal cord. The current work was undertaken to examine whether central OT increases BAT thermogenesis, whether this effect involves hindbrain OT receptors (OTRs), and whether such effects are associated with sustained weight loss following chronic administration. To assess OT-elicited changes in BAT thermogenesis, we measured the effects of intracerebroventricular administration of OT on interscapular BAT temperature in rats and mice. Because fourth ventricular (4V) infusion targets hindbrain OTRs, whereas third ventricular (3V) administration targets both forebrain and hindbrain OTRs, we compared responses to OT following chronic 3V infusion in DIO rats and mice and chronic 4V infusion in DIO rats. We report that chronic 4V infusion of OT into two distinct rat models recapitulates the effects of 3V OT to ameliorate DIO by reducing fat mass. While reduced food intake contributes to this effect, our finding that 4V OT also increases BAT thermogenesis suggests that increased energy expenditure may contribute as well. Collectively, these findings support the hypothesis that, in DIO rats, OT action in the hindbrain evokes sustained weight loss by reducing energy intake and increasing BAT thermogenesis.
[Mh] Termos MeSH primário: Tecido Adiposo Marrom/fisiopatologia
Obesidade/tratamento farmacológico
Obesidade/fisiopatologia
Ocitocina/farmacologia
Rombencéfalo/fisiopatologia
Termogênese/efeitos dos fármacos
Perda de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo Marrom/efeitos dos fármacos
Animais
Depressores do Apetite/farmacologia
Dieta Hiperlipídica/efeitos adversos
Relação Dose-Resposta a Droga
Infusões Intraventriculares
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/etiologia
Ratos
Ratos Long-Evans
Ratos Sprague-Dawley
Rombencéfalo/efeitos dos fármacos
Especificidade da Espécie
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Appetite Depressants); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00169.2017


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Texto completo
[PMID]:29227596
[Au] Autor:Veklich TO
[Ti] Título:The inhibitory influence of calix[4]Arene of C-90 on the activity of Ca2+,Mg2+-ATPases in plasma membrane and sarcoplasmic reticulum in myometrium cells.
[So] Source:Ukr Biochem J;88(2):5-15, 2016 Mar-Apr.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Our study on the plasma membrane vesicles and myometrium cells treated with 0.1% digitonin showed that inhibitory effect of calix[4]arene C-90 (5,11,17,23-tetra(trifluoro)methyl(phenylsulphonylimino)-methylamino- 25,26,27,28-tetrapropoxy-calix[4]arene) on the plasma membrane Ca2+,Mg2+-ATPase was more significant than on the Ca2+,Mg2+-ATPase in sarcoplasmic reticulum (the inhibition coefficient I0.5 values were 20.2 ± 0.5 µM and 57.0 ± 1.4 µM for the plasma membrane Ca2+,Mg2+-ATPase and Ca2+,Mg2+-ATPase in sarcoplasmic reticulum, respectively (n = 5)). Inhibition kinetics of calix[4]arene C-90 effect on the Ca2+,Mg2+- ATPase activities in plasma membrane and sarcoplasmic reticulum were studied. This substance inhibited both pumps as complete noncompetitive inhibitor. Calix[4]arene C-90 caused the increase of intracellular Ca2+ concentration and decrease of hydrodynamic diameter in smooth muscle cells similar to the action of uterotonic drug oxytocin.
[Mh] Termos MeSH primário: ATPase de Ca(2+) e Mg(2+)/antagonistas & inibidores
Calixarenos/farmacologia
Membrana Celular/efeitos dos fármacos
Inibidores Enzimáticos/farmacologia
Miócitos de Músculo Liso/efeitos dos fármacos
Fenóis/farmacologia
Retículo Sarcoplasmático/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
ATPase de Ca(2+) e Mg(2+)/metabolismo
Cálcio/metabolismo
Membrana Celular/enzimologia
Tamanho Celular
Feminino
Transporte de Íons/efeitos dos fármacos
Cinética
Miócitos de Músculo Liso/enzimologia
Miométrio/efeitos dos fármacos
Miométrio/enzimologia
Ocitocina/farmacologia
Ligação Proteica
Retículo Sarcoplasmático/enzimologia
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Phenols); 0 (calix(4)arene); 130036-26-9 (Calixarenes); 50-56-6 (Oxytocin); EC 3.6.1.- (Ca(2+) Mg(2+)-ATPase); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.02.005



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