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[PMID]:24962945
[Au] Autor:Fleury CA; Andreo VC; Lomba PC; Dionísio TJ; Amaral SL; Santos CF; Faria FA
[Ad] Endereço:Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17012-901, Brazil.
[Ti] Título:Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol.
[So] Source:J Anesth;29(1):56-64, 2015 Feb.
[Is] ISSN:1438-8359
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin's effects. The present study aimed to analyze and compare the effects of these two vasoconstrictors, injected by the intravenous route, on the arterial pressure of normotensive, hypertensive and atenolol-treated hypertensive rats. METHOD: The hypertension model was one-kidney-one-clip (1K1C): the main left renal artery was partially constricted and the right kidney was surgically removed in 45-day-old male Wistar rats. 1K1C hypertensive rats received atenolol (90 mg/kg/day) by gavage for 2 weeks. 28-35 days after hypertension induction, a catheter was inserted into the left carotid artery to record direct blood pressure values. The following parameters were recorded: minimal hypotensive response, maximal hypertensive response, response duration and heart rate. RESULTS: Epinephrine, but not felypressin, exerted an important hypotensive action; non-treated hypertensive rats showed more pronounced vasodilation. Treated and non-treated rats showed hypertensive responses of the same magnitudes in all groups; 1K1C atenolol rats showed reduced hypertensive responses to both vasoconstrictors. Felypressin's response duration was longer than that of epinephrine in all groups. Epinephrine increased heart rate while felypressin reduced this parameter only in the normotensive group. CONCLUSIONS: Our results suggest that felypressin has equipotent pressure responses when compared with epinephrine, showing a greater extent of action. Atenolol's reduction of hypertensive effects surprisingly suggests that atenolol ß-blockade may also be important for felypressin's cardiovascular effect, as is widely known for epinephrine. Our data suggest that felypressin is safe for hypertensive subjects, in particular those receiving atenolol.
[Mh] Termos MeSH primário: Atenolol/farmacologia
Epinefrina/farmacologia
Felipressina/farmacologia
Hipertensão/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Hipertensão/fisiopatologia
Hipotensão/epidemiologia
Masculino
Ratos
Ratos Wistar
Vasoconstritores/farmacologia
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 50VV3VW0TI (Atenolol); 56-59-7 (Felypressin); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140626
[St] Status:MEDLINE
[do] DOI:10.1007/s00540-014-1866-y


  2 / 162 MEDLINE  
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[PMID]:25532729
[Au] Autor:Parekh S; Gardener C; Ashley PF; Walsh T
[Ad] Endereço:Unit of Paediatric Dentistry, Department of Craniofacial Growth and Development, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD, UK. s.parekh@eastman.ucl.ac.uk.
[Ti] Título:Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents.
[So] Source:Cochrane Database Syst Rev;(12):CD009742, 2014 Dec 23.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whilst carrying out dental procedures under general anaesthesia (GA), practitioners routinely give local anaesthetics (LA) intraoperatively to children. Local anaesthetics are used to help manage postoperative pain and reduce bleeding and the physiological response to procedures. Studies of effectiveness of intraoperative LA to date have reported contradictory results. OBJECTIVES: To assess the effects of intraoperative local anaesthesia for reducing postoperative pain following general anaesthesia for dental treatment in children and young people aged 17 years or younger. SEARCH METHODS: We searched the following electronic databases: the Cochrane Oral Health Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2013, Issue 12), MEDLINE via OVID (1946 to 02 January 2014), EMBASE via OVID (1980 to 02 January 2014) and Web of Science Conference Proceedings (1990 to 02 January 2014). We searched for ongoing trials in the US National Institutes of Health Register, the metaRegister of Controlled Trials (mRCT) and the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Clinical Trials Portal. We did not place any restrictions on the language or date of publication when searching the electronic databases. SELECTION CRITERIA: Randomised controlled trials in which local anaesthetic was given intraoperatively under general anaesthesia for dental treatment of children and young people aged 17 years or younger. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by The Cochrane Collaboration. We performed data extraction and assessment of risk of bias independently and in duplicate. We contacted authors to clarify omissions in trial reports. In the 'Summary of findings' tables, we elected to report the outcomes pain, distress, postoperative bleeding, and physiological parameters related to the general anaesthetic, as we considered these to be the outcomes of greatest importance to readers of the review. MAIN RESULTS: We included 14 trials in this review, with 1152 randomised participants. The studies were published between 1990 and 2009 and were conducted in the United Kingdom, Egypt, Saudi Arabia, and the United States. The age of participants ranged from 2 to 40 years. Three studies were at an overall high risk of bias, seven studies were at an unclear risk of bias, and we judged four studies to be at low risk of bias. The clinical heterogeneity of the included studies precluded pooling of studies in terms of method of administration of LA (e.g., intraligamental injection, infiltration injection, or topical delivery) and variation in the use of supplementary analgesics and follow-up time.Of the seven studies where administration of LA was by infiltration injection, six studies (very low-quality body of evidence, 542 participants analysed, 1 study had overall high risk of bias, 4 studies had overall unclear risk of bias, 1 study had overall low risk of bias) measured postoperative pain. The results were equivocal. There was a decrease in bleeding and increase in soft tissue damage in the LA groups, but we did not judge this to be clinically significant.In the 2 studies where administration of LA was by intraligamental injection, there was no difference in mean pain scores, and they did not report any soft tissue damage (very low-quality body of evidence, 115 participants analysed, 1 study had overall high risk of bias, 1 study had overall unclear risk of bias).One 3-armed study (very low-quality body of evidence, 54 participants analysed, overall high risk of bias) compared the effects of intraligamental and infiltration LA injection with no treatment. There was no evidence of a mean difference in pain, distress, or postoperative anxiety among the three groups.Four studies (very low-quality body of evidence, 343 participants analysed, 2 studies had overall low risk of bias, 2 studies had overall unclear risk of bias) evaluated the effects of topical LA compared with no treatment or placebo. One study (overall unclear risk of bias) with a no-treatment comparator reported lower mean pain in the LA group; all other studies reported no difference in mean pain scores. Two studies reported on bleeding (overall unclear risk of bias): One study reported a clinically insignificant increase in bleeding with no treatment; the other reported no difference.None of the studies reported on participant or child satisfaction. AUTHORS' CONCLUSIONS: In this review, it was difficult to reach firm conclusions as to the benefit of using local anaesthetic for dental treatment under general anaesthesia. The information reported in the included studies was comprehensive and applicable to the review question, but ultimately it was not sufficient to address the objective of the review. We were unable to pool the included studies in a meta-analysis because of substantial variation in outcome measures, interventions, and treatment types. The use of supplementary analgesia further obscured the effect of local anaesthetics.Based on the literature review and the results of this review, we recommend further randomised controlled trials that minimise bias through adequate allocation concealment and blinding of participants and assessors, and assess the effect of intraoperative local anaesthetic on the volume and type of anaesthetic used and on the cardiovascular system in participants receiving supplementary analgesics as well. Researchers should give consideration to the impact of any changes on the health and well-being of the participant and report baseline measures of pain or distress, or both, and preoperative anxiety.
[Mh] Termos MeSH primário: Anestesia Geral
Anestesia Local
Anestésicos Locais/administração & dosagem
Assistência Odontológica/efeitos adversos
Dor Pós-Operatória/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Bupivacaína
Criança
Epinefrina
Felipressina
Seres Humanos
Cuidados Intraoperatórios/métodos
Lidocaína
Hemorragia Pós-Operatória/prevenção & controle
Prilocaína
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anesthetics, Local); 046O35D44R (Prilocaine); 56-59-7 (Felypressin); 98PI200987 (Lidocaine); Y8335394RO (Bupivacaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:160602
[Lr] Data última revisão:
160602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141224
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD009742.pub2


  3 / 162 MEDLINE  
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[PMID]:23728226
[Au] Autor:Zeytinoglu M; Tuncay Ü; Akay MC; Soydan I
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Faculty of Medicine, Ege University, Izmir-Turkey. mertzeytinoglu@yahoo.com.
[Ti] Título:Holter ECG assessment of the effects of three different local anesthetic solutions on cardiovascular system in the sedated dental patients with coronary artery disease.
[So] Source:Anadolu Kardiyol Derg;13(5):480-5, 2013 Aug.
[Is] ISSN:1308-0032
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of the study is to compare the effects of lidocaine alone, epinephrine-combined lidocaine and prilocaine with octapressin on the cardiovascular system during minor oral surgery of sedated cardiac dental patients under local anesthesia. METHODS: Connected to a Holter electrocardiogram (ECG) monitor for a total of 5 hours starting 1 hour before the procedure, twenty patients with high risk of coronary artery disease were included in the prospective cohort study. All the patients had three operations at 3 different appointments with at least one-week intervals and each operation was performed under local anesthesia achieved by 3.6 mL of 3% prilocaine with octapressin, 3.6 mL of 2% lidocaine with 1:80.000 epinephrine and 3.6 mL of 2% lidocaine without a vasoconstrictor. Data of the Holter ECG device assessed at the end of every hour and evaluated statistically. Repeated measures ANOVA, Friedman test, and Wilcoxon signed ranks test were used to perform statistical analysis. RESULTS: Heart-rate showed significant differences between lidocaine with epinephrine and pure lidocaine in an hour following the injection (p<0.05 for all). Cardiac rhythm showed significant differences between prilocaine with octapressin and pure lidocaine at the second hour after its administration (p<0.05 for all). There were no significant differences between 3 local anesthetics in terms of ST segment deviation. CONCLUSION: In minor oral operation on the sedated patients with cardiac disease, the use of 3.6 mL or a less amount of local anesthetic injection containing epinephrine appears to be a predictable and safe method.
[Mh] Termos MeSH primário: Anestesia Dentária
Anestésicos Locais/farmacologia
Doença da Artéria Coronariana
Frequência Cardíaca/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Idoso
Anestésicos Locais/efeitos adversos
Estudos de Coortes
Eletrocardiografia
Eletrocardiografia Ambulatorial
Epinefrina/efeitos adversos
Epinefrina/farmacologia
Felipressina/efeitos adversos
Felipressina/farmacologia
Feminino
Seres Humanos
Lidocaína/efeitos adversos
Lidocaína/farmacologia
Masculino
Meia-Idade
Estudos Prospectivos
Extração Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 56-59-7 (Felypressin); 98PI200987 (Lidocaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:130820
[Lr] Data última revisão:
130820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130604
[St] Status:MEDLINE
[do] DOI:10.5152/akd.2013.146


  4 / 162 MEDLINE  
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[PMID]:22735869
[Au] Autor:Bronzo AL; Cardoso CG; Ortega KC; Mion D
[Ad] Endereço:Unidade de Hipertensão, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
[Ti] Título:Felypressin increases blood pressure during dental procedures in hypertensive patients.
[So] Source:Arq Bras Cardiol;99(2):724-31, 2012 Aug.
[Is] ISSN:1678-4170
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:BACKGROUND: Felypressin has been added to local anesthetic to increase the length of the anesthetic effect and reduce toxicity during dental procedures. However, the effect on blood pressure remains uncertain, and this may be highly relevant in the dental treatment of hypertensive patients. OBJECTIVE: To investigate the effect of felypressin on blood pressure in hypertensive patients with controlled BP. METHODS: 71 subjects with these characteristics and in need of periodontal treatment were studied. After 10 minutes of rest, local anesthesia (prilocaine) was infiltrated with and without addition of felypressin. Then, a deep subgingival scaling was performed. Blood pressure was measured by an automated oscillometric device (DIXTAL DX2010). Ten minutes after the administration of the anesthetic, peak anesthetic action was recorded. The State-Trait Anxiety Inventory (STAI) was used to assess the patients' trait anxiety. RESULTS: Systolic blood pressure increased after anesthesia, regardless of association with felypressin, throughout the dental procedure (p<0.05) and this response can be explained, at least in part, by the trait anxiety levels of the subjects. However, a further increase in diastolic blood pressure was observed when prilocaine was associated with felypressin (p<0.05), but this response did not change with trait anxiety levels. CONCLUSION: Felypressin increased the diastolic blood pressure of hypertensive patients with controlled blood pressure. Patients with high trait anxiety presented increases in systolic blood pressure upon some procedures, suggesting that an increase in blood pressure might also be related to fear or anxiety.
[Mh] Termos MeSH primário: Anestesia Dentária/efeitos adversos
Pressão Sanguínea/efeitos dos fármacos
Felipressina/efeitos adversos
Hipertensão/induzido quimicamente
Vasoconstritores/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Ansiedade/psicologia
Feminino
Seres Humanos
Hipertensão/psicologia
Masculino
Meia-Idade
Doenças Periodontais/terapia
Estatísticas não Paramétricas
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 56-59-7 (Felypressin)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:120911
[Lr] Data última revisão:
120911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120628
[St] Status:MEDLINE


  5 / 162 MEDLINE  
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[PMID]:20816815
[Au] Autor:Sekino R; Saigusa T; Aono Y; Uchida T; Takada K; Oi Y; Koshikawa N; Cools AR
[Ad] Endereço:Department of Anaesthesiology, Nihon University School of Dentistry, 1-8-13, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
[Ti] Título:Dopamine D1-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393.
[So] Source:Eur J Pharmacol;648(1-3):80-6, 2010 Dec 01.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We studied the effects of the intra-striatal infusion of Ca(2+)-free medium on the intra-striatal injection of 0.5 µg SKF38393-induced striatal dopamine efflux. It is discussed that the amount of extracellular, striatal dopamine seen after striatally applied SKF38393, is the overall result of the (a) release of dopamine from the alpha-methyl-para-tyrosine-sensitive and Ca(2+)-insensitive pool of newly synthesised dopamine, (b) release of dopamine from the reserpine-sensitive and Ca(2+)-sensitive storage pool, (c) inhibition of uptake of dopamine into nerve terminals and glial cells, and (d) facilitation respectively of the inhibition of uptake into blood vessels: dopamine D1-like receptors play only a very limited role in these processes. The present study underlines our previous notion that the effects of SKF38393 cannot simply be ascribed to the dopamine D1-like receptor stimulation (Saigusa et al., 2009): in fact, the present study clearly reveals that SKF38393 is not at all selective in that respect.
[Mh] Termos MeSH primário: 2,3,4,5-Tetra-Hidro-7,8-Di-Hidroxi-1-Fenil-1H-3-Benzazepina/administração & dosagem
2,3,4,5-Tetra-Hidro-7,8-Di-Hidroxi-1-Fenil-1H-3-Benzazepina/farmacologia
Dopamina/metabolismo
Neostriado/efeitos dos fármacos
Neostriado/metabolismo
Receptores de Dopamina D1/metabolismo
[Mh] Termos MeSH secundário: Animais
Arteríolas/efeitos dos fármacos
Arteríolas/metabolismo
Arteríolas/fisiologia
Benzazepinas/administração & dosagem
Benzazepinas/farmacologia
Espaço Extracelular/efeitos dos fármacos
Espaço Extracelular/metabolismo
Felipressina/farmacologia
Técnicas In Vitro
Injeções
Soluções Isotônicas/administração & dosagem
Soluções Isotônicas/farmacologia
Masculino
Neostriado/irrigação sanguínea
Neostriado/citologia
Oximetazolina/farmacologia
Ratos
Ratos Sprague-Dawley
Receptores de Vasopressinas/metabolismo
Vasoconstrição/efeitos dos fármacos
Vasoconstritores/farmacologia
Vênulas/efeitos dos fármacos
Vênulas/metabolismo
Vênulas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzazepines); 0 (Isotonic Solutions); 0 (Receptors, Dopamine D1); 0 (Receptors, Vasopressin); 0 (SCH 23390); 0 (Vasoconstrictor Agents); 56-59-7 (Felypressin); 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine); 8026-10-6 (Ringer's solution); 8VLN5B44ZY (Oxymetazoline); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1101
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100907
[St] Status:MEDLINE
[do] DOI:10.1016/j.ejphar.2010.08.031


  6 / 162 MEDLINE  
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[PMID]:20031290
[Au] Autor:Inagawa M; Ichinohe T; Kaneko Y
[Ad] Endereço:Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan. motoakick1@mac.com
[Ti] Título:Felypressin, but not epinephrine, reduces myocardial oxygen tension after an injection of dental local anesthetic solution at routine doses.
[So] Source:J Oral Maxillofac Surg;68(5):1013-7, 2010 May.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to evaluate the effect of epinephrine (Epi) or felypressin (Fely) contained in dental local anesthetics on myocardial oxygen balance. MATERIALS AND METHODS: Male Japanese White tracheotomized rabbits were anesthetized with isoflurane. Three doses of 0.18, 0.36, and 0.72 mL of 2% lidocaine hydrochloride containing 1:80,000 Epi or 3% prilocaine hydrochloride containing Fely 0.03 IU/mL were injected into the rabbit tongue muscle. These doses were equivalent to 2, 4, and 8 of dental local anesthetic cartridges in humans weighing 50 kg by body weight correction, respectively. Heart rate, blood pressure, aortic blood flow, myocardial tissue blood flow, and myocardial tissue oxygen tension were continuously monitored. Data were recorded immediately before and 10, 20, 30, and 60 minutes after the injection. RESULTS: Heart rate decreased in the Fely group. Systolic blood pressure increased in the Epi group, and diastolic blood pressure increased in both groups. Aortic blood flow and myocardial tissue blood flow increased, whereas myocardial tissue oxygen tension did not change in the Epi group. In contrast, aortic blood flow, myocardial tissue blood flow, and myocardial tissue oxygen tension decreased in the Fely group. CONCLUSION: It is suggested that Fely, but not Epi, decreases myocardial oxygen tension and aggravates myocardial oxygen demand/supply balance even after an injection of dental local anesthetic solution at routine doses.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Epinefrina/administração & dosagem
Felipressina/administração & dosagem
Coração/efeitos dos fármacos
Consumo de Oxigênio/efeitos dos fármacos
Vasoconstritores/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Circulação Coronária/efeitos dos fármacos
Relação Dose-Resposta a Droga
Frequência Cardíaca/efeitos dos fármacos
Injeções
Lidocaína/administração & dosagem
Masculino
Miocárdio/metabolismo
Prilocaína/administração & dosagem
Coelhos
Fluxo Sanguíneo Regional/efeitos dos fármacos
Língua/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 56-59-7 (Felypressin); 98PI200987 (Lidocaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1005
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:091225
[St] Status:MEDLINE
[do] DOI:10.1016/j.joms.2009.07.080


  7 / 162 MEDLINE  
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[PMID]:19857582
[Au] Autor:Bardou I; Leprince J; Chichery R; Vaudry H; Agin V
[Ad] Endereço:GMPc, Groupe Mémoire et Plasticité Comportementale, EA 4259, University of Caen Basse-Normandie, 14032 Caen Cedex, France.
[Ti] Título:Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish, Sepia officinalis.
[So] Source:Neurobiol Learn Mem;93(2):240-7, 2010 Feb.
[Is] ISSN:1095-9564
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The vasopressin (VP)/oxytocin (OT)-related peptides constitute a large superfamily found in a wide range of both vertebrate and invertebrate species. While intensive literature reports that these neuropeptides influence behavior, especially learning and memory, in numerous species from diverse vertebrate groups, their roles in behavioral regulation have never been studied in invertebrates. Here, we investigated the role of two VP/OT superfamily peptides, octopressin (OP) and cephalotocin (CT), on long-term memory (LTM) formation of a passive avoidance task in a cephalopod mollusc, the cuttlefish, Sepia officinalis. Subadult cuttlefish were intravenously injected, in a dose range of 3-60 microg/kg, 1h after the training phase (consolidation design); retention performance was tested 24h post-training. We found that administration of OP at low dose (3 microg/kg) enhanced LTM, whereas a dose of 60 microg/kg attenuated it. No effect of OP on LTM was observed for the 15 microg/kg dose. Conversely, an enhancement of retention performance was observed at all doses of CT tested. This study is the first to demonstrate the behavioral effects of VP/OT superfamily peptides in an invertebrate species. The valuable role of VP/OT-like peptides on memory processes offers new evolutionary perspectives on peptidergic transmission and neuromodulation.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/fisiologia
Felipressina/metabolismo
Memória/fisiologia
Hormônios Peptídicos/fisiologia
Sepia/fisiologia
Vasopressinas/fisiologia
[Mh] Termos MeSH secundário: Animais
Felipressina/administração & dosagem
Feminino
Masculino
Testes Neuropsicológicos
Ocitocina/metabolismo
Hormônios Peptídicos/administração & dosagem
Distribuição Aleatória
Vasopressinas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Peptide Hormones); 11000-17-2 (Vasopressins); 50-56-6 (Oxytocin); 56-59-7 (Felypressin)
[Em] Mês de entrada:1006
[Cu] Atualização por classe:100301
[Lr] Data última revisão:
100301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091028
[St] Status:MEDLINE
[do] DOI:10.1016/j.nlm.2009.10.004


  8 / 162 MEDLINE  
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[PMID]:19410073
[Au] Autor:Caviedes-Bucheli J; Rojas P; Escalona M; Estrada A; Sandoval C; Rivero C; Lombana N; Muñoz HR
[Ad] Endereço:Department of Endodontics, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia. javiercaviedes@cable.net.co
[Ti] Título:The effect of different vasoconstrictors and local anesthetic solutions on substance P expression in human dental pulp.
[So] Source:J Endod;35(5):631-3, 2009 May.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to quantify the effect of the infiltration injection of different vasoconstrictor and anesthetic solutions on substance P (SP) expression in healthy human dental pulp. Thirty pulp samples were obtained from healthy upper premolars in which extraction was indicated for orthodontic reasons and were randomly assigned into three groups of 10 samples each: 2% lidocaine with 1:80,000 epinephrine (Lido group), 3% Prilocaine with 1:200000 felypressin (Prilo group); and 4% Prilocaine without vasoconstrictor (Prilo-no-VC group). All teeth were extracted 10 minutes after anesthetic application. Pulp samples were processed and SP was measured by radioimmunoassay. SP expression for the Lido, Prilo, and Prilo-no-VC groups were 616.49, 663.76, and 760.79 pmol/mg pulp tissue, respectively. Analysis of variance showed statistically significant differences between groups (p = 0.001). Tukey Honestly Significant Difference (HSD) post hoc tests showed significant statistical differences between the Prilo-no-VC group and the Lido group (p < 0.01) and between the Prilo-no-VC group and the Prilo group (p < 0.05). It can be concluded that infiltration injection of local anesthetics with vasoconstrictor attenuate SP expression in human dental pulp.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Polpa Dentária/efeitos dos fármacos
Neurotransmissores/análise
Substância P/efeitos dos fármacos
Vasoconstritores/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Polpa Dentária/irrigação sanguínea
Epinefrina/administração & dosagem
Felipressina/administração & dosagem
Seres Humanos
Lidocaína/administração & dosagem
Microcirculação/efeitos dos fármacos
Prilocaína/administração & dosagem
Substância P/análise
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Neurotransmitter Agents); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 33507-63-0 (Substance P); 56-59-7 (Felypressin); 98PI200987 (Lidocaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:0908
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:090505
[St] Status:MEDLINE
[do] DOI:10.1016/j.joen.2008.12.020


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[PMID]:19350772
[Au] Autor:Jonsson EW
[Ti] Título:[Suspected allergy to local anesthetics prior to dental treatment].
[Ti] Título:Misstänkt allergi vid lokalbedövning inför tandbehandling..
[So] Source:Lakartidningen;106(7):443, 2009 Feb 11-17.
[Is] ISSN:0023-7205
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Mh] Termos MeSH primário: Anestesia Dentária
Anestésicos Locais/efeitos adversos
Hipersensibilidade Imediata/induzido quimicamente
[Mh] Termos MeSH secundário: Anafilaxia/induzido quimicamente
Contraindicações
Combinação de Medicamentos
Felipressina/efeitos adversos
Seres Humanos
Prilocaína/efeitos adversos
Vasoconstritores/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Drug Combinations); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 56-59-7 (Felypressin)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090409
[St] Status:MEDLINE


  10 / 162 MEDLINE  
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Sosa, Eduardo A
Texto completo SciELO Brasil
[PMID]:18853053
[Au] Autor:Cáceres MT; Ludovice AC; Brito FS; Darrieux FC; Neves RS; Scanavacca MI; Sosa EA; Hachul DT
[Ad] Endereço:Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
[Ti] Título:Effect of local anesthetics with and without vasoconstrictor agent in patients with ventricular arrhythmias.
[So] Source:Arq Bras Cardiol;91(3):128-33, 142-7, 2008 Sep.
[Is] ISSN:1678-4170
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:BACKGROUND: The routine use of local anesthetics associated to vasoconstrictors for the dental treatment of patients with cardiopathies is still controversial, due to the risk of adverse cardiovascular effects. OBJECTIVE: To evaluate and compare the hemodynamic effects of the use of local anesthetics with a non-adrenergic vasoconstrictor in patients with ventricular arrhythmia, when compared to the use of anesthetics without vasoconstrictor. METHODS: A prospective randomized study evaluated 33 patients with positive serology for Chagas' disease and 32 patients with coronary artery disease that presented complex ventricular arrhythmia at Holter monitoring (>10 EV/h and NSVT), of which 21 were females, aged 54.73 + 7.94 years, submitted to routine dental treatment with pterygomandibular anesthesia. These patients were divided in two groups: group I received prilocaine 3% associated with felypressin 0.03 IU/ml and group II received lidocaine 2% without vasoconstrictor. The number and complexity of extrasystoles were analyzed, as well as the heart rate and systemic arterial pressure of the patients on the day before, one hour before, during the procedure and one hour after the dental procedure. RESULTS: No hemodynamic alterations or increase in the number and complexity of the ventricular arrhythmia related to the anesthetic used in the dental procedure were observed in either group. CONCLUSION: The results suggest that prilocaine 3% associated to a felypressin 0.03 IU/ml can be safely used in patients with Chagas' disease or coronariopathy with complex ventricular arrhythmia.
[Mh] Termos MeSH primário: Anestesia Dentária/efeitos adversos
Anestésicos Locais/efeitos adversos
Arritmias Cardíacas/fisiopatologia
Cardiomiopatia Chagásica/fisiopatologia
Vasoconstritores/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Pressão Sanguínea/efeitos dos fármacos
Eletrocardiografia Ambulatorial
Felipressina/efeitos adversos
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Lidocaína/efeitos adversos
Masculino
Meia-Idade
Prilocaína/efeitos adversos
Estudos Prospectivos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Vasoconstrictor Agents); 046O35D44R (Prilocaine); 56-59-7 (Felypressin); 98PI200987 (Lidocaine)
[Em] Mês de entrada:0906
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081015
[St] Status:MEDLINE



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