Base de dados : MEDLINE
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  1 / 1566 MEDLINE  
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[PMID]:27627572
[Au] Autor:Zdrojewicz Z; Pachura E; Pachura P
[Ad] Endereço:Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
[Ti] Título:The Thymus: A Forgotten, But Very Important Organ.
[So] Source:Adv Clin Exp Med;25(2):369-75, 2016 Mar-Apr.
[Is] ISSN:1899-5276
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Medical science seems to be on the threshold of a revolution: It seems possible that in twenty years, doctors will be able to replace organs in the human body like parts in a car. This is thanks to the recent achievement of a team from the Medical Research Council Center for Regenerative Medicine in Edinburgh, Scotland - the group of researchers tried to regenerate the thymus gland in mice. The thymus gland is an essential organ for the development of the immune system, but very few people have any idea that it exists. In the literature and also in people's awareness, the fact is often that the thymus controls and harmonizes the entire immune system and the immune functioning of the organism. It is the primary donor of cells for the lymphatic system, much as bone marrow is the cell donor for the cardiovascular system. It is within the thymus that progenitor cells are created and then undergo maturation and differentiation into mature T cells. The thymus gland is located in the mediastinum, behind the sternum. It is composed of two identical lobes. Each lobe is divided into a central medulla and a peripheral cortex. The thymus is at its largest and most active during the neonatal and pre-adolescent periods. After this period the organ gradually disappears and is replaced by fat. In elderly individuals the thymus weighs 5 g. The aim of this work is to shed new light on this important immune defense organ, whose function is not confined to the destruction of nonfunctional T cells.
[Mh] Termos MeSH primário: Regeneração
Timócitos/imunologia
Timo/imunologia
[Mh] Termos MeSH secundário: Fatores Etários
Envelhecimento/imunologia
Animais
Seleção Clonal Mediada por Antígeno
Seres Humanos
Linfócitos T/imunologia
Timócitos/transplante
Timo/citologia
Timo/transplante
Hormônios do Timo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Thymus Hormones)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.17219/acem/58802


  2 / 1566 MEDLINE  
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[PMID]:27352969
[Au] Autor:Csaba G
[Ad] Endereço:Department of Genetics, Cell and Immunobiology, Semmelweis University , Budapest, Hungary.
[Ti] Título:The Immunoendocrine Thymus as a Pacemaker of Lifespan.
[So] Source:Acta Microbiol Immunol Hung;63(2):139-58, 2016 Jun.
[Is] ISSN:1217-8950
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:The thymus develops from an endocrine area of the foregut, and retains the ancient potencies of this region. However, later it is populated by bone marrow originated lymphatic elements and forms a combined organ, which is a central part of the immune system as well as an influential element of the endocrine orchestra. Thymus produces self-hormones (thymulin, thymosin, thymopentin, and thymus humoral factor), which are participating in the regulation of immune cell transformation and selection, and also synthesizes hormones similar to that of the other endocrine glands such as melatonin, neuropeptides, and insulin, which are transported by the immune cells to the sites of requests (packed transport). Thymic (epithelial and immune) cells also have receptors for hormones which regulate them. This combined organ, which is continuously changing from birth to senescence seems to be a pacemaker of life. This function is basically regulated by the selection of self-responsive thymocytes as their complete destruction helps the development (up to puberty) and their gradual release in case of weakened control (after puberty) causes the erosion of cells and intercellular material, named aging. This means that during aging, self-destructive and non-protective immune activities are manifested under the guidance of the involuting thymus, causing the continuous irritation of cells and organs. Possibly the pineal body is the main regulator of the pacemaker, the neonatal removal of which results in atrophy of thymus and wasting disease and its later corrosion causes the insufficiency of thymus. The co-involution of pineal and thymus could determine the aging and the time of death without external intervention; however, external factors can negatively influence both of them.
[Mh] Termos MeSH primário: Envelhecimento/imunologia
Timo/imunologia
Hormônios do Timo/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Glândula Pineal/crescimento & desenvolvimento
Glândula Pineal/imunologia
Timo/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Thymus Hormones)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE
[do] DOI:10.1556/030.63.2016.2.1


  3 / 1566 MEDLINE  
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[PMID]:26169108
[Au] Autor:Hirokawa K; Utsuyama M; Kikuchi Y
[Ad] Endereço:Institute for Health and Life Sciences, Tokyo Medical & Dental University Open Laboratory, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. hirokawa@nakanosogo.or.jp.
[Ti] Título:Trade off situation between thymus and growth hormone: age-related decline of growth hormone is a cause of thymic involution but favorable for elongation of lifespan.
[So] Source:Biogerontology;17(1):55-9, 2016 Feb.
[Is] ISSN:1573-6768
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:High level of growth hormone (GH) is necessary for the activation of thymic function to promote T cell differentiation in the early stage of animal life. In the later stage of the life, administration of GH promotes the development of immune system and rejuvenates declined immune function of elderly people. By contraries, GH deficiency is favorable for the longer lifespan, as hypo-pituitary dwarf mice such as Ames and Snell dwarf mice exhibit longer lifespan than control. Furthermore over-expression of heterologous or homologous GH in transgenic mice shortens the lifespan. Ecuadorians carrying mutations of GH receptor gene are short in height, but exhibited low frequency of malignancy and no cases of diabetes. These data indicate that GH is necessary for the development of thymus dependent immune system but GH deficiency is favorable for long life span and decreases occurrence of cancer and DM. This situation is a kind of trade off situation between the immune system and GH. Thus the early decline of high level of GH occurring shortly after the birth is a cause of early decline of thymic functions, but favorable for longer lifespan. This situation could be a kind of trade off situation between thymus and GH.
[Mh] Termos MeSH primário: Envelhecimento/imunologia
Hormônio do Crescimento/imunologia
Imunidade Inata/imunologia
Longevidade/imunologia
Modelos Imunológicos
Timo/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Linfócitos T/imunologia
Hormônios do Timo/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thymus Hormones); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150715
[St] Status:MEDLINE
[do] DOI:10.1007/s10522-015-9590-z


  4 / 1566 MEDLINE  
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[PMID]:26033592
[Au] Autor:Litvinenko GI; Shurlygina AV; Dergacheva TI; Mel'nikova EV; Trufakin VA
[Ad] Endereço:Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia, litv_g_i@mail.ru.
[Ti] Título:Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age.
[So] Source:Bull Exp Biol Med;159(1):62-5, 2015 May.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case.
[Mh] Termos MeSH primário: Cronoterapia Farmacológica
Fatores Imunológicos/administração & dosagem
Subpopulações de Linfócitos/efeitos dos fármacos
Ooforite/tratamento farmacológico
RNA de Cadeia Dupla/administração & dosagem
RNA Fúngico/administração & dosagem
Salpingite/tratamento farmacológico
Succinato Desidrogenase/sangue
Hormônios do Timo/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antibacterianos/uso terapêutico
Doença Crônica
Terapia Combinada
Grânulos Citoplasmáticos/enzimologia
Quimioterapia Combinada
Feminino
Seres Humanos
Fatores Imunológicos/farmacologia
Células Matadoras Naturais/efeitos dos fármacos
Células Matadoras Naturais/enzimologia
Células Matadoras Naturais/imunologia
L-Lactato Desidrogenase/sangue
Subpopulações de Linfócitos/enzimologia
Subpopulações de Linfócitos/imunologia
Monócitos/efeitos dos fármacos
Monócitos/enzimologia
Monócitos/imunologia
Ooforite/imunologia
Ooforite/terapia
Modalidades de Fisioterapia
Medicina de Precisão
RNA de Cadeia Dupla/farmacologia
RNA Fúngico/farmacologia
Salpingite/imunologia
Salpingite/terapia
Hormônios do Timo/farmacologia
Resultado do Tratamento
Vitaminas/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Immunologic Factors); 0 (RNA, Double-Stranded); 0 (RNA, Fungal); 0 (Thymus Hormones); 0 (Vitamins); 112279-02-4 (ridostin); 79621-14-0 (thymalin); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.3.99.1 (Succinate Dehydrogenase)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150609
[Lr] Data última revisão:
150609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150603
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-2890-0


  5 / 1566 MEDLINE  
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[PMID]:24771015
[Au] Autor:Costarelli L; Giacconi R; Malavolta M; Basso A; Piacenza F; DeMartiis M; Giannandrea E; Renieri C; Busco F; Galeazzi R; Mocchegiani E
[Ad] Endereço:Translational Center of Research in Nutrition and Ageing, Scientific and Technologic Pole, INRCA, Ancona, Italy.
[Ti] Título:Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study.
[So] Source:Age (Dordr);36(3):9656, 2014 Jun.
[Is] ISSN:1574-4647
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Zinc is a relevant nutritional factor for the whole life of an organism because it affects the inflammatory/immune response and antioxidant activity, leading to a healthy state. Despite its important function, the dietary intake of zinc is inadequate in elderly. Possible interventions include food fortification because it does not require changes in dietary patterns, the cost is low and it can reach a large portion of the elderly population, including very old subjects. Studies evaluating the impact of Zn-fortified foods on functional parameters in elderly, in particular, in very old individuals, are missing. The objective of this study was to evaluate the efficacy of consumption of a zinc-fortified drinking skim milk (Zn-FMilk) for a period of 2 months in comparison to standard non-fortified milk (No-FMilk) on some biochemical parameters, zinc status, inflammatory/immune response and on a key parameter of the T cell-mediated immunity (thymulin hormone) in healthy very old subjects. The treatment with zinc-fortified milk (Zn-FMilk) is a good omen to increase the cell-mediated immunity in very old age represented by thymulin activity and some cytokine (IL-12p70, IFN-γ) release. At clinical level, a good healthy state occurs in 70 % of the subjects with no hospitalization after 1 year of the follow-up in comparison to very old control subjects that did not participate to crossover design. In conclusion, the Zn-FMilk can be considered a good functional food for elderly, including older people. It might be a good replacement to the zinc tablets or lozenges taking into account the attitude of old people to uptake milk as a preferential food.
[Mh] Termos MeSH primário: Envelhecimento/imunologia
Citocinas/sangue
Alimentos Fortificados
Imunidade Celular/efeitos dos fármacos
Leite
Hormônios do Timo/sangue
Zinco/farmacologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Animais
Estudos Cross-Over
Suplementos Nutricionais
Feminino
Seguimentos
Seres Humanos
Masculino
Estado Nutricional
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Thymus Hormones); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140429
[St] Status:MEDLINE
[do] DOI:10.1007/s11357-014-9656-x


  6 / 1566 MEDLINE  
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[PMID]:24734422
[Au] Autor:Kuznetsova TA; Besednova NN; Zaporozhets TS; Smolina TP; Kazha AK; Ivanushko LA
[Ti] Título:[Comparative study of immunomodulatory activity of peptides, tinrostim and thymalin].
[So] Source:Antibiot Khimioter;58(11-12):8-12, 2013.
[Is] ISSN:0235-2990
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The immunomodulatory activity of peptide drugs i.e. tinrostim (dosage form) prepared of squid optical ganglia and pharmacopoeia thymain was studied. Tinrostim showed a stimulating effect on the humoral and cellular nimmune responses when administered parenterally in experimental animals, as well as on the phagocytic activity of neutrophils, comparable to the effect of thymalin. It was demonstrated that both the peptide drugs increased the production of pro-(TNFa, IL-1) and antiinflammatory (IL- 10) cytokines in the culture of intact cells of peripheral blood in vitro. It is essential that when tinrostim was used in 10-fold different doses (0.005 mg / kg and 0.05 mg /kg) in mice, the effect of the lower dose was comparable to the effect of the higher dose.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Interleucina-10/imunologia
Interleucina-1/imunologia
Neutrófilos/imunologia
Precursores de Proteínas/imunologia
Hormônios do Timo/farmacologia
Fator de Necrose Tumoral alfa/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Relação Dose-Resposta a Droga
Masculino
Camundongos
Neutrófilos/citologia
Fagocitose/efeitos dos fármacos
Fagocitose/imunologia
Hormônios do Timo/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (IL10 protein, mouse); 0 (Interleukin-1); 0 (Protein Precursors); 0 (Thymus Hormones); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 79621-14-0 (thymalin); 94948-60-4 (tumor necrosis factor precursor)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140417
[St] Status:MEDLINE


  7 / 1566 MEDLINE  
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[PMID]:24029339
[Au] Autor:Griebling T
[Ti] Título:Re: Success rates, quality of life, and feasibility of sacral nerve stimulation in elderly patients: 1-year follow-up.
[So] Source:J Urol;190(4):1331, 2013 Oct.
[Is] ISSN:1527-3792
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fibrossarcoma/secundário
Neoplasias Pulmonares/secundário
Fator Tímico Circulante/farmacologia
Timosina/análogos & derivados
Hormônios do Timo/farmacologia
[Mh] Termos MeSH secundário: Animais
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thymus Hormones); 61512-21-8 (Thymosin); 9H198D04WL (Thymic Factor, Circulating)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:130914
[St] Status:MEDLINE


  8 / 1566 MEDLINE  
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[PMID]:23258355
[Au] Autor:Tsybikov MN; Likhanov ID; Borshchevskii VS; Kuznik BI; Tsepelev VL; Maslo EIu; Tsybikov NN
[Ti] Título:[The use of Timalin in the treatment of the acute lung abscess].
[So] Source:Khirurgiia (Mosk);(11):19-23, 2012.
[Is] ISSN:0023-1207
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The study was aimed to research levels of main acute inflammation phase peptides, coagulative and fibrinolitic plasma activity on the background of traditional treatment and with addition of Timalin in patients with acute lung abscess. The study demonstrated that induction of bioregulative therapy leads to faster normalization of main indicators of SIRS and plasma fibrinolitic activity and eliminates hypercoagulation.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/metabolismo
Antibacterianos/uso terapêutico
Coagulação Intravascular Disseminada
Abscesso Pulmonar
Pneumonectomia/métodos
Síndrome de Resposta Inflamatória Sistêmica
Hormônios do Timo/administração & dosagem
[Mh] Termos MeSH secundário: Doença Aguda
Adjuvantes Imunológicos/administração & dosagem
Adulto
Biomarcadores/sangue
Testes de Coagulação Sanguínea
Terapia Combinada/métodos
Coagulação Intravascular Disseminada/etiologia
Coagulação Intravascular Disseminada/metabolismo
Coagulação Intravascular Disseminada/terapia
Feminino
Seres Humanos
Imunomodulação
Pulmão/cirurgia
Abscesso Pulmonar/complicações
Abscesso Pulmonar/metabolismo
Abscesso Pulmonar/fisiopatologia
Abscesso Pulmonar/terapia
Masculino
Síndrome de Resposta Inflamatória Sistêmica/etiologia
Síndrome de Resposta Inflamatória Sistêmica/metabolismo
Síndrome de Resposta Inflamatória Sistêmica/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Adjuvants, Immunologic); 0 (Anti-Bacterial Agents); 0 (Biomarkers); 0 (Thymus Hormones); 79621-14-0 (thymalin)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121222
[St] Status:MEDLINE


  9 / 1566 MEDLINE  
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[PMID]:23045981
[Au] Autor:Low TL; Thurman GB; Chincarini C; McClure JE; Marshall GD; Hu SK; Goldstein AL
[Ti] Título:Current status of thymosin research: evidence for the existence of a family of thymic factors that control T-cell maturation. 1979.
[So] Source:Ann N Y Acad Sci;1269:131-46, 2012 Oct.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Linfócitos T/metabolismo
Timosina/metabolismo
Hormônios do Timo/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Modelos Biológicos
Timosina/química
[Pt] Tipo de publicação:CLASSICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thymus Hormones); 61512-21-8 (Thymosin)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:121010
[Lr] Data última revisão:
121010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121011
[St] Status:MEDLINE
[do] DOI:10.1111/j.1749-6632.2012.06765.x


  10 / 1566 MEDLINE  
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[PMID]:22740766
[Au] Autor:Andreou AY
[Ti] Título:Epsilon waves in right ventricular myocardial infarction.
[So] Source:Tex Heart Inst J;39(2):306, 2012.
[Is] ISSN:1526-6702
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Psicotrópicos/administração & dosagem
Esquizofrenia/tratamento farmacológico
Hormônios do Timo/administração & dosagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Psychotropic Drugs); 0 (Thymus Hormones)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120629
[St] Status:MEDLINE



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