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[PMID]:29320582
[Au] Autor:Xie S; Yang X; Wang D; Zhu F; Yang N; Hou Z; Ning Z
[Ad] Endereço:National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
[Ti] Título:Thyroid transcriptome analysis reveals different adaptive responses to cold environmental conditions between two chicken breeds.
[So] Source:PLoS One;13(1):e0191096, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Selection for cold tolerance in chickens is important for improving production performance and animal welfare. The identification of chicken breeds with higher cold tolerance and production performance will help to target candidates for the selection. The thyroid gland plays important roles in thermal adaptation, and its function is influenced by breed differences and transcriptional plasticity, both of which remain largely unknown in the chicken thyroid transcriptome. In this study, we subjected Bashang Long-tail (BS) and Rhode Island Red (RIR) chickens to either cold or warm environments for 21 weeks and investigated egg production performance, body weight changes, serum thyroid hormone concentrations, and thyroid gland transcriptome profiles. RIR chickens had higher egg production than BS chickens under warm conditions, but BS chickens produced more eggs than RIRs under cold conditions. Furthermore, BS chickens showed stable body weight gain under cold conditions while RIRs did not. These results suggested that BS breed is a preferable candidate for cold-tolerance selection and that the cold adaptability of RIRs should be improved in the future. BS chickens had higher serum thyroid hormone concentrations than RIRs under both environments. RNA-Seq generated 344.3 million paired-end reads from 16 sequencing libraries, and about 90% of the processed reads were concordantly mapped to the chicken reference genome. Differential expression analysis identified 46-1,211 genes in the respective comparisons. With regard to breed differences in the thyroid transcriptome, BS chickens showed higher cell replication and development, and immune response-related activity, while RIR chickens showed higher carbohydrate and protein metabolism activity. The cold environment reduced breed differences in the thyroid transcriptome compared with the warm environment. Transcriptional plasticity analysis revealed different adaptive responses in BS and RIR chickens to cope with the cold, and showed higher responsiveness in BS compared with RIR chickens, suggesting greater adaptability of the thyroid in BS chickens. Moreover, 10,053 differential splicing events were revealed among the groups, with RNA splicing and processing, gene expression, transport, and metabolism being the main affected biological processes, identifying a valuable alternative splicing repertoire for the chicken thyroid. A short isoform of TPO (encoding thyroid peroxidase) containing multiple open reading frames was generated in both breeds by skipping exons 4 and 5 in the cold environment. These findings provide novel clues for future studies of the molecular mechanisms underlying cold adaptation and/or acclimation in chickens.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Galinhas/genética
Glândula Tireoide/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Galinhas/classificação
Galinhas/fisiologia
Ovos
Hormônios Tireóideos/sangue
Hormônios Tireóideos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Thyroid Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191096


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[PMID]:28964732
[Au] Autor:Pérez JH; Meddle SL; Wingfield JC; Ramenofsky M
[Ad] Endereço:Department of Neurobiology, Physiology and Behavior, University of California, One Shields Avenue, Davis, CA 95616, USA. Electronic address: jonathan.perez@abdn.ac.uk.
[Ti] Título:Effects of thyroid hormone manipulation on pre-nuptial molt, luteinizing hormone and testicular growth in male white-crowned sparrows (Zonotrichia leuchophrys gambelii).
[So] Source:Gen Comp Endocrinol;255:12-18, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most seasonal species rely on the annual change in day length as the primary cue to appropriately time major spring events such as pre-nuptial molt and breeding. Thyroid hormones are thought to be involved in the regulation of both of these spring life history stages. Here we investigated the effects of chemical inhibition of thyroid hormone production using methimazole, subsequently coupled with either triiodothyronine (T3) or thyroxine (T4) replacement, on the photostimulation of pre-nuptial molt and breeding in Gambel's white-crowned sparrows (Zonotrichia leuchophrys gambelii). Suppression of thyroid hormones completely prevented pre-nuptial molt, while both T3 and T4 treatment restored normal patterns of molt in thyroid hormone-suppressed birds. Testicular recrudescence was blocked by methimazole, and restored by T4 but not T3, in contrast to previous findings demonstrating central action of T3 in the photostimulation of breeding. Methimazole and replacement treatments elevated plasma luteinizing hormone levels compared to controls. These data are partially consistent with existing theories on the role of thyroid hormones in the photostimulation of breeding, while highlighting the possibility of additional feedback pathways. Thus we suggest that regulation of the hypothalamic pituitary gonad axis that controls breeding may be more complex than previously considered.
[Mh] Termos MeSH primário: Hormônio Luteinizante/sangue
Muda/efeitos dos fármacos
Pardais/sangue
Pardais/crescimento & desenvolvimento
Testículo/crescimento & desenvolvimento
Hormônios Tireóideos/farmacologia
[Mh] Termos MeSH secundário: Animais
Masculino
Pardais/fisiologia
Testículo/anatomia & histologia
Testículo/efeitos dos fármacos
Tiroxina/sangue
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thyroid Hormones); 06LU7C9H1V (Triiodothyronine); 9002-67-9 (Luteinizing Hormone); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:29253128
[Au] Autor:Mohácsik P; Erdélyi F; Baranyi M; Botz B; Szabó G; Tóth M; Haltrich I; Helyes Z; Sperlágh B; Tóth Z; Sinkó R; Lechan RM; Bianco AC; Fekete C; Gereben B
[Ad] Endereço:Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
[Ti] Título:A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
[So] Source:Endocrinology;159(2):1159-1171, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormone (TH) is present in the systemic circulation and thus should affect all cells similarly in the body. However, tissues have a complex machinery that allows tissue-specific optimization of local TH action that calls for the assessment of TH action in a tissue-specific manner. Here, we report the creation of a TH action indicator (THAI) mouse model to study tissue-specific TH action. The model uses a firefly luciferase reporter readout in the context of an intact transcriptional apparatus and all elements of TH metabolism and transport and signaling. The THAI mouse allows the assessment of the changes of TH signaling in tissue samples or in live animals using bioluminescence, both in hypothyroidism and hyperthyroidism. Beyond pharmacologically manipulated TH levels, the THAI mouse is sufficiently sensitive to detect deiodinase-mediated changes of TH action in the interscapular brown adipose tissue (BAT) that preserves thermal homeostasis during cold stress. The model revealed that in contrast to the cold-induced changes of TH action in the BAT, the TH action in this tissue, at room temperature, is independent of noradrenergic signaling. Our data demonstrate that the THAI mouse can also be used to test TH receptor isoform-specific TH action. Thus, THAI mouse constitutes a unique model to study tissue-specific TH action within a physiological/pathophysiological context and test the performance of thyromimetics. In conclusion, THAI mouse provides an in vivo model to assess a high degree of tissue specificity of TH signaling, allowing alteration of tissue function in health and disease, independently of changes in circulating levels of TH.
[Mh] Termos MeSH primário: Genes Reporter
Elementos de Resposta
Hormônios Tireóideos/farmacologia
Hormônios Tireóideos/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Regulação da Expressão Gênica
Células HEK293
Seres Humanos
Hipertireoidismo/genética
Hipertireoidismo/metabolismo
Hipotireoidismo/genética
Hipotireoidismo/metabolismo
Iodeto Peroxidase/genética
Iodeto Peroxidase/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Modelos Animais
Especificidade de Órgãos/efeitos dos fármacos
Especificidade de Órgãos/genética
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Thyroid Hormones); EC 1.11.1.8 (Iodide Peroxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00582


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[PMID]:29186449
[Au] Autor:van der Spek AH; Jim KK; Karaczyn A; van Beeren HC; Ackermans MT; Darras VM; Vandenbroucke-Grauls CMJE; Hernandez A; Brouwer MC; Fliers E; van de Beek D; Boelen A
[Ad] Endereço:Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
[Ti] Título:The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species.
[So] Source:Endocrinology;159(2):826-835, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neutrophils are essential effector cells of the innate immune system that have recently been recognized as thyroid hormone (TH) target cells. Cellular TH bioavailability is regulated by the deiodinase enzymes, which can activate or inactivate TH. We have previously shown that the TH inactivating enzyme type 3 deiodinase (D3) is present in neutrophils. Furthermore, D3 knockout (D3KO) mice show impaired bacterial killing upon infection. We hypothesized that D3 plays a role in neutrophil function during infection by actively regulating local TH availability. We measured TH concentrations in cerebrospinal fluid (CSF) from patients with bacterial meningitis and controls. Bacterial meningitis resulted in marked changes in CSF TH levels, characterized by a strong increase of thyroxine and reverse-triiodothyronine concentrations. This altered TH profile was consistent with elevated D3 activity in infiltrating neutrophils at the site of infection. D3 knockdown in zebrafish embryos with pneumococcal meningitis resulted in increased mortality and reduced neutrophil infiltration during infection. Finally, stimulated neutrophils from female D3KO mice exhibited impaired NADPH-oxidase activity, an important component of the neutrophil bacterial killing machinery. These consistent findings across experimental models strongly support a critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential.
[Mh] Termos MeSH primário: Iodeto Peroxidase/fisiologia
Neutrófilos/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Estudos de Casos e Controles
Células Cultivadas
Embrião não Mamífero
Iodeto Peroxidase/genética
Meningites Bacterianas/líquido cefalorraquidiano
Meningites Bacterianas/imunologia
Camundongos Knockout
Especificidade da Espécie
Hormônios Tireóideos/líquido cefalorraquidiano
Hormônios Tireóideos/metabolismo
Tri-Iodotironina Reversa/líquido cefalorraquidiano
Peixe-Zebra/embriologia
Peixe-Zebra/genética
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Thyroid Hormones); 5817-39-0 (Triiodothyronine, Reverse); EC 1.11.1.- (iodothyronine deiodinase type III); EC 1.11.1.8 (Iodide Peroxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00666


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[PMID]:29225125
[Au] Autor:Shimada N; Takasawa R; Tanuma SI
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
[Ti] Título:Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
[So] Source:Arch Biochem Biophys;638:1-7, 2018 01 15.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many cancer cells undergo metabolic reprogramming known as the Warburg effect, which is characterized by a greater dependence on glycolysis for ATP generation, even under normoxic conditions. Glyoxalase I (GLO I) is a rate-limiting enzyme involved in the detoxification of cytotoxic methylglyoxal formed in glycolysis and which is known to be highly expressed in many cancer cells. Thus, specific inhibitors of GLO I are expected to be effective anticancer drugs. We previously discovered a novel GLO I inhibitor named TLSC702. Although the strong inhibitory activity of TLSC702 was observed in the in vitro enzyme assay, higher concentrations were required to induce apoptosis at the cellular level. One of the proposed reasons for this difference is that cancer cells alter the energy metabolism leading them to become more dependent on mitochondrial respiration than glycolysis (Metabolic shift) to avoid apoptosis induction. Thus, we assumed that combination of TLSC702 with shikonin-a specific inhibitor of pyruvate kinase M2 (PKM2) that acts as a driver of TCA cycle by supplying pyruvate and which is known to be specifically expressed in cancer cells-would have anticancer effects. We herein show the anticancer effects of combination treatment with TLSC702 and shikonin, and a possible anticancer mechanism.
[Mh] Termos MeSH primário: Apoptose
Proteínas de Transporte/metabolismo
Lactoilglutationa Liase/metabolismo
Proteínas de Membrana/metabolismo
Proteínas de Neoplasias/metabolismo
Neoplasias/enzimologia
Piruvato Quinase/metabolismo
Hormônios Tireóideos/metabolismo
[Mh] Termos MeSH secundário: Butiratos/farmacologia
Proteínas de Transporte/antagonistas & inibidores
Proteínas de Transporte/genética
Linhagem Celular Tumoral
Ciclo do Ácido Cítrico/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Lactoilglutationa Liase/antagonistas & inibidores
Lactoilglutationa Liase/genética
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/genética
Naftoquinonas/farmacologia
Proteínas de Neoplasias/antagonistas & inibidores
Proteínas de Neoplasias/genética
Neoplasias/tratamento farmacológico
Neoplasias/genética
Neoplasias/patologia
Piruvato Quinase/antagonistas & inibidores
Piruvato Quinase/genética
Ácido Pirúvico/metabolismo
Tiazóis/farmacologia
Hormônios Tireóideos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid); 0 (Butyrates); 0 (Carrier Proteins); 0 (Membrane Proteins); 0 (Naphthoquinones); 0 (Neoplasm Proteins); 0 (Thiazoles); 0 (Thyroid Hormones); 0 (thyroid hormone-binding proteins); 3IK6592UBW (shikonin); 8558G7RUTR (Pyruvic Acid); EC 2.7.1.40 (Pyruvate Kinase); EC 4.4.1.5 (GLO1 protein, human); EC 4.4.1.5 (Lactoylglutathione Lyase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29320567
[Au] Autor:Gil-Cayuela C; Ortega A; Tarazón E; Martínez-Dolz L; Cinca J; González-Juanatey JR; Lago F; Roselló-Lletí E; Rivera M; Portolés M
[Ad] Endereço:Cardiocirculatory Unit, Health Research Institute of La Fe University Hospital (IIS La Fe), Valencia, Spain.
[Ti] Título:Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.
[So] Source:PLoS One;13(1):e0190987, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association between dilated cardiomyopathy (DCM) and low thyroid hormone (TH) levels has been previously described. In these patients abnormal thyroid function is significantly related to impaired left ventricular (LV) function and increased risk of death. Although TH was originally thought to be produced exclusively by the thyroid gland, we recently reported TH biosynthesis in the human ischemic heart. OBJECTIVES: Based on these findings, we evaluated whether the genes required for TH production are also altered in patients with DCM. METHODS: Twenty-three LV tissue samples were obtained from patients with DCM (n = 13) undergoing heart transplantation and control donors (n = 10), and used for RNA sequencing analysis. The number of LV DCM samples was increased to 23 to determine total T4 and T3 tissue levels by ELISA. RESULTS: We found that all components of TH biosynthesis are expressed in human dilated heart tissue. Expression of genes encoding thyroperoxidase (-2.57-fold, P < 0.05) and dual oxidase 2 (2.64-fold, P < 0.01), the main enzymatic system of TH production, was significantly altered in patients with DCM and significantly associated with LV remodeling parameters. Thyroxine (T4) cardiac tissue levels were significantly increased (P < 0.01), whilst triiodothyronine (T3) levels were significantly diminished (P < 0.05) in the patients. CONCLUSIONS: Expression of TH biosynthesis machinery in the heart and total tissue levels of T4 and T3, are altered in patients with DCM. Given the relevance of TH in cardiac pathology, our results provide a basis for new gene-based therapeutic strategies for treating DCM.
[Mh] Termos MeSH primário: Autoantígenos/genética
Cardiomiopatia Dilatada/genética
Oxidases Duais/genética
Iodeto Peroxidase/genética
Proteínas de Ligação ao Ferro/genética
Miocárdio/metabolismo
Receptores da Tireotropina/genética
Hormônios Tireóideos/biossíntese
[Mh] Termos MeSH secundário: Autoantígenos/metabolismo
Biomarcadores/metabolismo
Cardiomiopatia Dilatada/patologia
Estudos de Casos e Controles
Oxidases Duais/metabolismo
Feminino
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Iodeto Peroxidase/metabolismo
Proteínas de Ligação ao Ferro/metabolismo
Masculino
Meia-Idade
Receptores da Tireotropina/metabolismo
Remodelação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Autoantigens); 0 (Biomarkers); 0 (Iron-Binding Proteins); 0 (Receptors, Thyrotropin); 0 (Thyroid Hormones); EC 1.11.1.- (Dual Oxidases); EC 1.11.1.7 (TPO protein, human); EC 1.11.1.8 (Iodide Peroxidase); EC 1.6.3.1 (DUOX2 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190987


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[PMID]:29017816
[Au] Autor:Chang J; Wang H; Xu P; Guo B; Li J; Wang Y; Li W
[Ad] Endereço:Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing, 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing, 100049, China.
[Ti] Título:Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus).
[So] Source:Environ Pollut;232:338-346, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kg DFB once a week for 42 days through oral or dermal routes. Their body weight, plasma thyroid hormone levels, thyroid gland histology and the transcription of hypothalamic-pituitary-thyroid (HPT) axis-related genes in different tissues were assessed to explore the effects of DFB on the HPT axis of lizards. The body weight decreased significantly only after the dermal exposure to DFB. Triiodothyronine (T3) to thyroxine (T4) ratio in the male plasma also significantly increased after the dermal exposure. After oral exposure, the activity of thyroid gland was positively related to the thyroid hormone levels. Furthermore, the alterations in thyroid hormone levels affected the HPT axis-related gene expression, which was tissue dependent and sexually selected. The thyroid hormone receptor genes (trα and trß) in the brain and thyroid were more sensitive to oral exposure. However, only the dermal treatment affected the trα, trß and type 2 deiodinase (dio2) genes in the male liver. These results suggest that DFB exposure caused sex-specific changes in the thyroid function of lizards, and the dermal treatment may be an important route for the risk assessment of reptiles.
[Mh] Termos MeSH primário: Diflubenzuron/toxicidade
Disruptores Endócrinos/toxicidade
Hormônios Juvenis/toxicidade
Lagartos/fisiologia
[Mh] Termos MeSH secundário: Animais
Disruptores Endócrinos/metabolismo
Hipotálamo/efeitos dos fármacos
Lagartos/metabolismo
Masculino
Hipófise/efeitos dos fármacos
Glândula Tireoide/metabolismo
Hormônios Tireóideos/metabolismo
Tiroxina/sangue
Testes de Toxicidade
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Juvenile Hormones); 0 (Thyroid Hormones); 06LU7C9H1V (Triiodothyronine); J76U6ZSI8D (Diflubenzuron); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE


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[PMID]:28970022
[Au] Autor:Chang J; Hao W; Xu Y; Xu P; Li W; Li J; Wang H
[Ad] Endereço:Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing 100049, China.
[Ti] Título:Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure.
[So] Source:Environ Pollut;232:300-309, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The disturbance of the thyroid system and elimination of chiral pyrethroid pesticides with respect to enantioselectivity in reptiles have so far received limited attention by research. In this study, bioaccumulation, thyroid gland lesions, thyroid hormone levels, and hypothalamus-pituitary-thyroid axis-related gene expression in male Eremias argus were investigated after three weeks oral administration of lambda-cyhalothrin (LCT) enantiomers. In the lizard liver, the concentration of LCT was negatively correlated with the metabolite-3-phenoxybenzoic acid (PBA) level during 21 days of exposure. (+)-LCT exposure induced a higher thyroid follicular epithelium height than (-)-LCT exposure. The thyroxine levels were increased in both treated groups while only (+)-LCT exposure induced a significant change in the triiodothyronine (T3) level. In addition, the expressions of hypothalamus-pituitary-thyroid axis-related genes including thyroid hormone receptors (trs), deiodinases (dios), uridinediphosphate glucuronosyltransferase (udp), and sulfotransferase (sult) were up-regulated after exposure to the two enantiomers. (+)-LCT treatment resulted in higher expression of trs and (-)-LCT exposure led to greater stimulation of dios in the liver, which indicated PBA-induced antagonism on thyroid hormone receptors and LCT-induced disruption of thyroxine (T4) deiodination. The results suggest the (-)-LCT exposure causes higher residual level in lizard liver while induces less disruption on lizard thyroid activity than (+)-LCT.
[Mh] Termos MeSH primário: Lagartos/fisiologia
Nitrilos/toxicidade
Praguicidas/toxicidade
Piretrinas/toxicidade
Glândula Tireoide/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Benzoatos
Disruptores Endócrinos/metabolismo
Iodeto Peroxidase/metabolismo
Fígado/metabolismo
Lagartos/metabolismo
Masculino
Praguicidas/metabolismo
Receptores dos Hormônios Tireóideos/metabolismo
Estereoisomerismo
Glândula Tireoide/metabolismo
Hormônios Tireóideos/metabolismo
Tiroxina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Endocrine Disruptors); 0 (Nitriles); 0 (Pesticides); 0 (Pyrethrins); 0 (Receptors, Thyroid Hormone); 0 (Thyroid Hormones); 69DC2655VH (3-phenoxybenzoic acid); EC 1.11.1.8 (Iodide Peroxidase); Q51BO43MG4 (Thyroxine); V0V73PEB8M (cyhalothrin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:29244911
[Au] Autor:Karzakova LM; Avtonomova OI; Kudryashov SI; Komelyagina NA; Ukhterova ND
[Ti] Título:The role of circulating cytokines and thyroid hormones in the development of the nephrotic variant of glomerulonephritis.
[So] Source:Patol Fiziol Eksp Ter;60(3):76-82, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose of the research - studying the features of the production of pro- and anti-inflammatory cytokines, as well as indicators of thyroid status in patients with nephrotic variant of glomerulonephritis (GN). Research methods. Methods: The examination involved 78 patients with primary GN, including 30 patients with nephrotic syndrome (NS) and 48 GN patients who had no NS symptoms. Laboratory researches included the determination of the concentration of the main cytokines circulating in the blood - IL-1b, IL-2, IL-4, IL-10, IFN-g and the receptor antagonist of IL-1b - Rа-IL-1b by the method of solid-phase enzyme linked immunosorbent assay enzyme immunoassay (ELISA) in the system of the bideterminant definition of antigen with the use of peroxidase as indicator enzyme using standard sets ("Cytokine", St.-Petersburg) according to the technique attached to a set. The investigation of the basic indicators of thyroid status - free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), anti-thyroid peroxydase antibodies (TPOAb) is carried out by the ELISA using standard sets and NGO techniques «Diagnostic systems¼ (N-Novgorod). The researches were conducted twice - before the hospitalization (1-2 days) and after the end of a stationary stage of treatment (12-14 days). Results: In 90% of patients with nephrotic option of GN there have been identified laboratory signs of hypothyroidism of different degrees of severity accompanied by increasing of production levels of proinflammatory cytokine IL-1b and IL-4, related to the activity of a humoral link of adaptive immunity. The reduction of glomerular, erythropoietic, concentration kidney functions, as well as proteinuria in patients with nephrotic option GN are associated with the decrease of T4 levels in the blood and increased levels of the cytokines circulating in the blood - IL-1b and IL-4. Conclusion: The obtained data demonstrate that the high level of production of IL-1b and IL-4 in GN patients causes hypothyroidism resulting in the formation of NS.
[Mh] Termos MeSH primário: Glomerulonefrite/sangue
Hipotireoidismo/sangue
Interleucina-10/sangue
Interleucina-4/sangue
Síndrome Nefrótica/sangue
Complicações na Gravidez/sangue
Hormônios Tireóideos/sangue
[Mh] Termos MeSH secundário: Feminino
Glomerulonefrite/complicações
Seres Humanos
Hipotireoidismo/complicações
Masculino
Síndrome Nefrótica/complicações
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL10 protein, human); 0 (IL4 protein, human); 0 (Thyroid Hormones); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  10 / 17367 MEDLINE  
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[PMID]:28740583
[Au] Autor:Osuna PM; Udovcic M; Sharma MD
[Ad] Endereço:Houston Methodist Hospital, Houston, Texas.
[Ti] Título:Hyperthyroidism and the Heart.
[So] Source:Methodist Debakey Cardiovasc J;13(2):60-63, 2017 Apr-Jun.
[Is] ISSN:1947-6108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormones have a significant impact on cardiac function and structure. Excess thyroid hormone affects cardiovascular hemodynamics, leading to high-output heart failure and, in late stages, dilated cardiomyopathy. In this review, we discuss how hyperthyroidism affects cardiovascular pathophysiology and molecular mechanisms and examine the complications caused by excess thyroid hormone, such as heart failure and atrial fibrillation.
[Mh] Termos MeSH primário: Cardiopatias/fisiopatologia
Coração/fisiopatologia
Hipertireoidismo/fisiopatologia
Glândula Tireoide/fisiopatologia
[Mh] Termos MeSH secundário: Metabolismo Energético
Cardiopatias/diagnóstico
Cardiopatias/epidemiologia
Cardiopatias/prevenção & controle
Hemodinâmica
Seres Humanos
Hipertireoidismo/diagnóstico
Hipertireoidismo/epidemiologia
Hipertireoidismo/terapia
Prognóstico
Medição de Risco
Fatores de Risco
Glândula Tireoide/metabolismo
Hormônios Tireóideos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Thyroid Hormones)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.14797/mdcj-13-2-60



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