Base de dados : MEDLINE
Pesquisa : D08 [Categoria DeCS]
Referências encontradas : 6 [refinar]
Mostrando: 1 .. 6   no formato [Detalhado]

página 1 de 1

  1 / 6 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27261887
[Au] Autor:Lalonde J
[Ad] Endereço:Research and Development, Codexis, Inc., United States. Electronic address: jim.lalonde@codexis.com.
[Ti] Título:Highly engineered biocatalysts for efficient small molecule pharmaceutical synthesis.
[So] Source:Curr Opin Biotechnol;42:152-158, 2016 Dec.
[Is] ISSN:1879-0429
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Technologies for the engineering of biocatalysts for efficient synthesis of pharmaceutical targets have advanced dramatically over the last few years. Integration of computational methods for structural modeling, combined with high through put methods for expression and screening of biocatalysts and algorithms for mining experimental data, have allowed the creation of highly engineered biocatalysts for the efficient synthesis of pharmaceuticals. Methods for the synthesis of chiral alcohols and amines have been particularly successful, along with the creation of non-natural activities for such desirable reactions as cyclopropanation and esterification.
[Mh] Termos MeSH primário: Biocatálise
Descoberta de Drogas/métodos
Indústria Farmacêutica
Enzimas e Coenzimas/metabolismo
Engenharia Metabólica
Preparações Farmacêuticas/síntese química
[Mh] Termos MeSH secundário: Álcoois/metabolismo
Aminas/química
Animais
Indústria Farmacêutica/métodos
Indústria Farmacêutica/tendências
Enzimas e Coenzimas/genética
Seres Humanos
Engenharia Metabólica/métodos
Engenharia Metabólica/tendências
Preparações Farmacêuticas/isolamento & purificação
Preparações Farmacêuticas/metabolismo
Bibliotecas de Moléculas Pequenas/isolamento & purificação
Bibliotecas de Moléculas Pequenas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alcohols); 0 (Amines); 0 (Enzymes and Coenzymes); 0 (Pharmaceutical Preparations); 0 (Small Molecule Libraries)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  2 / 6 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:21321550
[Au] Autor:Arcinas AJ; Booker SJ
[Ti] Título:Enzymology: Radical break-up, blissful make-up.
[So] Source:Nat Chem Biol;7(3):133-4, 2011 Mar.
[Is] ISSN:1552-4469
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Enzimas e Coenzimas/metabolismo
Radicais Livres/metabolismo
S-Adenosilmetionina/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/química
Catálise
Ativação Enzimática
Enzimas e Coenzimas/química
Radicais Livres/química
Modelos Químicos
S-Adenosilmetionina/química
Tiazóis/química
Tiazóis/metabolismo
Triptofano/química
Triptofano/metabolismo
[Pt] Tipo de publicação:COMMENT; NEWS
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzymes and Coenzymes); 0 (Free Radicals); 0 (Thiazoles); 7LP2MPO46S (S-Adenosylmethionine); 8DUH1N11BX (Tryptophan); F7YI574GFD (nosiheptide)
[Em] Mês de entrada:1104
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110216
[St] Status:MEDLINE
[do] DOI:10.1038/nchembio.528


  3 / 6 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:21054276
[Au] Autor:Chen L; He ZS; Huang T; Cai YD
[Ad] Endereço:College of Information ENgineering, Shanghai Maritime University, China.
[Ti] Título:Using compound similarity and functional domain composition for prediction of drug-target interaction networks.
[So] Source:Med Chem;6(6):388-95, 2010 Nov.
[Is] ISSN:1875-6638
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Study of interactions between drugs and target proteins is an essential step in genomic drug discovery. It is very hard to determine the compound-protein interactions or drug-target interactions by experiment alone. As supplementary, effective prediction model using machine learning or data mining methods can provide much help. In this study, a prediction method based on Nearest Neighbor Algorithm and a novel metric, which was obtained by combining compound similarity and functional domain composition, was proposed. The target proteins were divided into the following groups: enzymes, ion channels, G protein-coupled receptors, and nuclear receptors. As a result, four predictors with the optimal parameters were established. The overall prediction accuracies, evaluated by jackknife cross-validation test, for four groups of target proteins are 90.23%, 94.74%, 97.80%, and 97.51%, respectively, indicating that compound similarity and functional domain composition are very effective to predict drug-target interaction networks.
[Mh] Termos MeSH primário: Descoberta de Drogas/métodos
[Mh] Termos MeSH secundário: Algoritmos
Biologia Computacional/métodos
Mineração de Dados
Enzimas e Coenzimas/antagonistas & inibidores
Enzimas e Coenzimas/metabolismo
Canais Iônicos/antagonistas & inibidores
Canais Iônicos/metabolismo
Antagonistas de Entorpecentes
Receptores Citoplasmáticos e Nucleares/antagonistas & inibidores
Receptores Citoplasmáticos e Nucleares/metabolismo
Receptores Opioides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzymes and Coenzymes); 0 (Ion Channels); 0 (Narcotic Antagonists); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Receptors, Opioid)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101109
[St] Status:MEDLINE


  4 / 6 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20580938
[Au] Autor:Wollmer MA
[Ad] Endereço:Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland. marcaxel.wollmer@upkbs.ch
[Ti] Título:Cholesterol-related genes in Alzheimer's disease.
[So] Source:Biochim Biophys Acta;1801(8):762-73, 2010 Aug.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Experimental data show that cholesterol can modulate central processes in the pathogenesis of Alzheimer's disease (AD). The epidemiological link between elevated plasma cholesterol at midlife and increased risk for AD and the possibility that 3-hydroxy-3-methylglutaryl-coenzym A reductase inhibitors (statins) may be protective against AD support a role of cholesterol metabolism in AD and have rendered it a potential therapeutic target in the treatment and prevention of the disease. The strong association of AD and AD endophenotypes with the APOE gene provides a genetic link between AD and cholesterol metabolism, because the apolipoprotein E (ApoE) is the most prevalent cholesterol transport protein in the central nervous system. Against this background several other genes with a role in cholesterol metabolism have been investigated for association with AD. In this review a compilation of genes related to cholesterol based on the information of the AmiGo gene ontology database is matched with the AlzGene database of AD candidate genes. 56 out of 149 (37.6%) genes with a relation to cholesterol metabolism have been investigated for association with AD. Given that only 660 out of about 23,000 (2.9%) genes have been assessed in hypothesis-driven candidate gene studies on AD, the cholesterol metabolic pathway is strongly represented among these genes. Among 34 cholesterol-related genes for which association with AD has been described APOE, CH25H, CLU, LDLR, SORL1 outstand with positive meta-analyses. However, it is unclear, if their association with AD is mediated by cholesterol-related mechanisms or by more specific direct effects of the respective proteins on Abeta metabolism.
[Mh] Termos MeSH primário: Doença de Alzheimer/genética
Colesterol/genética
Metabolismo dos Lipídeos/genética
[Mh] Termos MeSH secundário: Doença de Alzheimer/enzimologia
Doença de Alzheimer/metabolismo
Peptídeos beta-Amiloides/genética
Peptídeos beta-Amiloides/metabolismo
Animais
Apolipoproteínas E/genética
Apolipoproteínas E/metabolismo
Encéfalo/metabolismo
Colesterol/metabolismo
Enzimas e Coenzimas/genética
Genes/fisiologia
Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Apolipoproteins E); 0 (Enzymes and Coenzymes); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100629
[St] Status:MEDLINE
[do] DOI:10.1016/j.bbalip.2010.05.009


  5 / 6 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20540107
[Au] Autor:Schuster S; Kreft JU; Brenner N; Wessely F; Theissen G; Ruppin E; Schroeter A
[Ad] Endereço:Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Ernst-Abbe-Platz 2, Jena, Germany.
[Ti] Título:Cooperation and cheating in microbial exoenzyme production--theoretical analysis for biotechnological applications.
[So] Source:Biotechnol J;5(7):751-8, 2010 Jul.
[Is] ISSN:1860-7314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The engineering of microorganisms to produce a variety of extracellular enzymes (exoenzymes), for example for producing renewable fuels and in biodegradation of xenobiotics, has recently attracted increasing interest. Productivity is often reduced by "cheater" mutants, which are deficient in exoenzyme production and benefit from the product provided by the "cooperating" cells. We present a game-theoretical model to analyze population structure and exoenzyme productivity in terms of biotechnologically relevant parameters. For any given population density, three distinct regimes are predicted: when the metabolic effort for exoenzyme production and secretion is low, all cells cooperate; at intermediate metabolic costs, cooperators and cheaters coexist; while at high costs, all cells use the cheating strategy. These regimes correspond to the harmony game, snowdrift game, and Prisoner's Dilemma, respectively. Thus, our results indicate that microbial strains engineered for exoenzyme production will not, under appropriate conditions, be outcompeted by cheater mutants. We also analyze the dependence of the population structure on cell density. At low costs, the fraction of cooperating cells increases with decreasing cell density and reaches unity at a critical threshold. Our model provides an estimate of the cell density maximizing exoenzyme production.
[Mh] Termos MeSH primário: Biotecnologia
Enzimas e Coenzimas/biossíntese
Modelos Biológicos
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Biocombustíveis/microbiologia
Evolução Biológica
Celulose
Teoria do Jogo
Polissacarídeos
Biologia de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biofuels); 0 (Enzymes and Coenzymes); 0 (Polysaccharides); 8024-50-8 (hemicellulose); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:101118
[Lr] Data última revisão:
101118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100612
[St] Status:MEDLINE
[do] DOI:10.1002/biot.200900303


  6 / 6 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:19059103
[Au] Autor:Marletta MA; Stubbe J
[Ti] Título:Catalysis and regulation. Editorial overview.
[So] Source:Curr Opin Struct Biol;18(6):641-3, 2008 Dec.
[Is] ISSN:1879-033X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Enzimas e Coenzimas/química
Enzimas e Coenzimas/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
Fenômenos Bioquímicos
Catálise
Histona Acetiltransferases/química
Histona Acetiltransferases/metabolismo
Seres Humanos
Metaloproteínas/química
Metaloproteínas/metabolismo
Complexos Multiproteicos/química
Complexos Multiproteicos/metabolismo
Fosfotransferases (Aceptor do Grupo Carboxila)/química
Fosfotransferases (Aceptor do Grupo Carboxila)/metabolismo
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Enzymes and Coenzymes); 0 (Metalloproteins); 0 (Multiprotein Complexes); EC 2.3.1.48 (Histone Acetyltransferases); EC 2.7.2.- (Phosphotransferases (Carboxyl Group Acceptor)); EC 2.7.2.8 (acetylglutamate kinase)
[Em] Mês de entrada:0902
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081209
[St] Status:MEDLINE
[do] DOI:10.1016/j.sbi.2008.11.006



página 1 de 1
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde