Base de dados : MEDLINE
Pesquisa : D08.244.453.499.500 [Categoria DeCS]
Referências encontradas : 1014 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 102 ir para página                         

  1 / 1014 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29088291
[Au] Autor:Jang H; Choi Y; Yoo I; Han J; Hong JS; Kim YY; Ka H
[Ad] Endereço:Department of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
[Ti] Título:Vitamin D-metabolic enzymes and related molecules: Expression at the maternal-conceptus interface and the role of vitamin D in endometrial gene expression in pigs.
[So] Source:PLoS One;12(10):e0187221, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin D is a secosteroid hormone with many varied functions including regulation of blood calcium levels, cell proliferation, immunity, and reproduction in mammals. Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and is degraded by 24-hydroxylase (CYP24A1). Vitamin D is transported by vitamin D-binding protein (group-specific component, GC) through the bloodstream and regulates cellular actions by binding to vitamin D receptor (VDR). In this study, we determined the expression and regulation of vitamin D-related molecules and the role of vitamin D at the maternal-conceptus interface in pigs. Vitamin D-metabolizing enzymes CYP2R1, CYP27B1, and CYP24A1, vitamin D binding protein GC, and vitamin D receptor VDR were expressed in the endometrium in a pregnancy stage-specific manner as well as in conceptus and chorioallantoic tissues during pregnancy. VDR protein was localized to endometrial and trophoblastic cells. Concentrations of calcitriol, the active form of vitamin D, in the endometrial tissues were higher during early pregnancy than in mid- to late pregnancy, while plasma concentrations of calcitriol were highest during late pregnancy. Furthermore, calcitriol affected the expression of several genes related to conceptus implantation, vitamin D metabolism, calcium ion regulation, PG metabolism, and calcium-binding proteins in endometrial tissue explants. These results show that CYP2R1, CYP27B1, CYP24A1, GC, and VDR were expressed at the maternal-conceptus interface, endometrial calcitriol levels were regulated during pregnancy, and calcitriol modulated the expression of endometrial genes, suggesting that calcitriol may play an important role in the establishment and maintenance of pregnancy by regulating endometrial function in pigs.
[Mh] Termos MeSH primário: Endométrio/metabolismo
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Animais
Colestanotriol 26-Mono-Oxigenase/metabolismo
Membrana Corioalantoide/metabolismo
Endométrio/fisiologia
Feminino
Regulação da Expressão Gênica/fisiologia
Gravidez
Receptores de Calcitriol/metabolismo
Suínos
Vitamina D/fisiologia
Proteína de Ligação a Vitamina D/metabolismo
Vitamina D3 24-Hidroxilase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187221


  2 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29055009
[Au] Autor:Christakos S
[Ad] Endereço:From the Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 christak@njms.rutgers.edu.
[Ti] Título:In search of regulatory circuits that control the biological activity of vitamin D.
[So] Source:J Biol Chem;292(42):17559-17560, 2017 Oct 20.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the gene that mediates the basal activity and hormonal regulation of This work provides a novel mechanism indicating differential regulation of in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Rim/metabolismo
Esclerose Múltipla/metabolismo
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
Animais
Seres Humanos
Esclerose Múltipla/genética
Vitamina D/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
1406-16-2 (Vitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.13.13 (CYP27B1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171022
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.H117.806901


  3 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28902929
[Au] Autor:Li N; Wu HM; Hang F; Zhang YS; Li MJ
[Ad] Endereço:Department of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
[Ti] Título:Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface.
[So] Source:Braz J Med Biol Res;50(11):e6527, 2017 Sep 12.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Immunological mechanisms have been proposed to underlie the pathogenesis of recurrent spontaneous abortion (RSA). Vitamin D has a potent immunomodulatory effect, which may affect pregnancy outcome. The objective of this study was to investigate 25-hydroxyvitamin D [25(OH) D] concentration and vitamin D receptor (VDR) expression in the decidual tissues of RSA patients. Thirty women with RSA (RSA group) and thirty women undergoing elective abortion (control group) were recruited during 2016 from gynecology outpatient clinics. We measured 25(OH) D, interleukin (IL)-17, IL-23, transforming growth factor ß (TGF-ß), VDR and 1-α-hydroxylase (CYP27B1) in decidual tissues collected during the abortion procedure. In the RSA group, 25(OH) D and TGF-ß were significantly decreased while IL-17 and IL-23 were significantly increased compared with the control group. VDR expression was significantly decreased in the RSA group compared with the control group. Logistic regression analysis showed a significant negative correlation between 25(OH) D in decidual tissues and RSA. These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/análise
Aborto Habitual/metabolismo
Decídua/química
Receptores de Calcitriol/análise
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Aborto Habitual/etiologia
Adulto
Feminino
Seres Humanos
Interleucina-17/análise
Interleucina-23/análise
Modelos Logísticos
Gravidez
Terceiro Trimestre da Gravidez
Receptores de Calcitriol/metabolismo
Fatores de Risco
Estatísticas não Paramétricas
Fator de Crescimento Transformador beta/análise
Vitamina D/análise
Vitamina D/metabolismo
Deficiência de Vitamina D/complicações
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-17); 0 (Interleukin-23); 0 (Receptors, Calcitriol); 0 (Transforming Growth Factor beta); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


  4 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28808057
[Au] Autor:Meyer MB; Benkusky NA; Kaufmann M; Lee SM; Onal M; Jones G; Pike JW
[Ad] Endereço:From the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and markmeyer@wisc.edu.
[Ti] Título:A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene essential for vitamin D activation.
[So] Source:J Biol Chem;292(42):17541-17558, 2017 Oct 20.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The vitamin D endocrine system regulates mineral homeostasis through its activities in the intestine, kidney, and bone. Terminal activation of vitamin D to its hormonal form, 1α,25-dihydroxyvitamin D (1,25(OH) D ), occurs in the kidney via the cytochrome P450 enzyme CYP27B1. Despite its importance in vitamin D metabolism, the molecular mechanisms underlying the regulation of the gene for this enzyme, , are unknown. Here, we identified a kidney-specific control module governed by a renal cell-specific chromatin structure located distal to that mediates unique basal and parathyroid hormone (PTH)-, fibroblast growth factor 23 (FGF23)-, and 1,25(OH) D -mediated regulation of expression. Selective genomic deletion of key components within this module in mice resulted in loss of either PTH induction or FGF23 and 1,25(OH) D suppression of gene expression; the former loss caused a debilitating skeletal phenotype, whereas the latter conferred a quasi-normal bone mineral phenotype through compensatory homeostatic mechanisms involving We found that is also expressed at low levels in non-renal cells, in which transcription was modulated exclusively by inflammatory factors via a process that was unaffected by deletion of the kidney-specific module. These results reveal that differential regulation of expression represents a mechanism whereby 1,25(OH) D can fulfill separate functional roles, first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses. Furthermore, we conclude that these mouse models open new avenues for the study of vitamin D metabolism and its involvement in therapeutic strategies for human health and disease.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/biossíntese
Calcitriol/metabolismo
Colecalciferol/metabolismo
Regulação Enzimológica da Expressão Gênica/fisiologia
Homeostase/fisiologia
Rim/metabolismo
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
Animais
Calcitriol/genética
Colecalciferol/genética
Deleção de Genes
Camundongos
Especificidade de Órgãos/fisiologia
Vitamina D3 24-Hidroxilase/biossíntese
Vitamina D3 24-Hidroxilase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1C6V77QF41 (Cholecalciferol); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.15.16 (Cyp24a1 protein, mouse); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase); FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.806901


  5 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Cuppari, Lilian
Texto completo
[PMID]:28665937
[Au] Autor:Carvalho JTG; Schneider M; Cuppari L; Grabulosa CC; T Aoike D; Q Redublo BM; C Batista M; Cendoroglo M; Maria Moyses R; Dalboni MA
[Ad] Endereço:Division of Nephrology- Universidade Federal São Paulo, UNIFESP, São Paulo, São Paulo, Brazil.
[Ti] Título:Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial.
[So] Source:PLoS One;12(6):e0179540, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been reported that vitamin D regulates the immune system. However, whether vitamin D repletion modulates inflammatory responses in lymphocytes from dialysis patients is unclear. In the clinical trial, thirty-two (32) dialysis patients with 25 vitamin D ≤ 20ng/mL were randomized to receive either supplementation of cholecalciferol 100,000 UI/week/3 months (16 patients) or placebo (16 patients). In the in vitro study, B and T lymphocytes from 12 healthy volunteers (HV) were incubated with or without uremic serum in the presence or absence of 25 or 1,25 vitamin D. We evaluated the intracellular expression of IL-6, IFN-γ TLR7, TLR9, VDR, CYP27b1 and CYP24a1 by flow cytometry. We observed a reduction in the expression of TLR7, TLR9, INF-γ and CYP24a1 and an increase in VDR and CYP27b1 expression in patients which were supplemented with cholecalciferol, whereas no differences were found in the placebo group. Uremic serum increased the intracellular expression of IL-6, IFN-γ, TLR7, TLR9, VDR, CYP27b1 and CYP24a1. Treatment with 25 or 1,25 vitamin D decreased IL-6 and TLR9. CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-γ, TLR7 and TLR9 expression. This is the first study showing that cholecalciferol repletion has an anti-inflammatory effect and improves vitamin D intracellular regulatory enzymes on lymphocytes from dialysis patients.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/sangue
Colecalciferol/farmacologia
Inflamação/prevenção & controle
Uremia/enzimologia
Vitamina D3 24-Hidroxilase/sangue
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Citocinas/sangue
Método Duplo-Cego
Seres Humanos
Inflamação/complicações
Mediadores da Inflamação/sangue
Projetos Piloto
Placebos
Receptores de Calcitriol/sangue
Receptores Toll-Like/sangue
Uremia/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cytokines); 0 (Inflammation Mediators); 0 (Placebos); 0 (Receptors, Calcitriol); 0 (Toll-Like Receptors); 1406-16-2 (Vitamin D); 1C6V77QF41 (Cholecalciferol); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.13.13 (CYP27B1 protein, human); EC 1.14.15.16 (CYP24A1 protein, human); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179540


  6 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28590769
[Au] Autor:Zhang Y; Wang Z; Ma T
[Ad] Endereço:1 Department of Neonatal Intensive Care Unit, The First People's Hospital of Shangqiu , Shangqiu City, China .
[Ti] Título:Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma.
[So] Source:DNA Cell Biol;36(8):682-692, 2017 Aug.
[Is] ISSN:1557-7430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was aimed at investigating the correlation between genetic polymorphisms relevant to metabolic pathway of vitamin D3 (VD ) and susceptibility to childhood bronchial asthma. Altogether 143 childhood patients with bronchial asthma and 143 healthy children of Chinese Han ethnicity were enrolled in this study. The key single-nucleotide polymorphisms (SNPs) were identified by HaploView 4.2 software and selected from previous investigations. Genomic DNAs were isolated from peripheral blood samples by using TaqMan Blood DNA kits. The genotyping of SNPs was performed by TaqMan SNPs genotyping assay. Odds ratios and corresponding 95% confidence intervals were calculated to evaluate the association between SNPs and susceptibility to bronchial asthma. Statistical analyses were conducted by using SPSS 13.0 software. Rs10766197 of CYP2R1, rs7041 and rs4588 of CG, rs4646536 of CYP27B1, rs2228570, rs7975232, and rs1544410 of VDR, as well as rs1805192 and rs10865710 of PPAR were shown to be significantly associated with increased risk of bronchial asthma. Besides, prognosis of childhood bronchial asthma, which was represented as Saint George Respiratory Questionnaire (SGRQ) scoring, was closely linked with CYP2R1 rs10766197, CYP27B1 rs4646536, VDR rs7975232, VDR rs1544410, PPAR rs1805192, and PPAR rs10865710. The haplotype analysis suggested that TA and CG of CG rs7041/rs4588, CA and AG of VDR rs7975232/rs1544410, and CC of PPAR rs1805192/rs10865710 were, respectively, correlated with levels of VD, IL-4, and IL-5. And only haplotypes of VDR showed associations with risk of bronchial asthma during childhood, whereas hardly any significance could be observed between the haplotypes and behavior of quality-of-life (SGRQ) scoring. Significant associations were found between rs10766197 of CYP2R1, rs7041 and rs4588 of CG, rs4646536 of CYP27B1, rs2228570, rs7975232, and rs1544410 of VDR, as well as rs1805192 and rs10865710 of PPAR and susceptibility to and prognosis of childhood bronchial asthma, providing novel targets for treating the disorder.
[Mh] Termos MeSH primário: Asma/diagnóstico
Asma/genética
Colecalciferol/genética
Predisposição Genética para Doença
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
Biomarcadores/sangue
Criança
Pré-Escolar
China
Colecalciferol/deficiência
Colestanotriol 26-Mono-Oxigenase/genética
Família 2 do Citocromo P450/genética
Feminino
Genótipo
Haplótipos/genética
Seres Humanos
Interferon gama/biossíntese
Interferon gama/sangue
Interleucina-4/biossíntese
Interleucina-4/sangue
Interleucina-5/biossíntese
Interleucina-5/sangue
Masculino
Subunidade 1 do Complexo Mediador
Redes e Vias Metabólicas/genética
Razão de Chances
Prognóstico
Receptores de Calcitriol/genética
Inquéritos e Questionários
Deficiência de Vitamina D/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Interleukin-5); 0 (Mediator Complex Subunit 1); 0 (Receptors, Calcitriol); 0 (VDR protein, human); 1C6V77QF41 (Cholecalciferol); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.13.13 (CYP27B1 protein, human); EC 1.14.14.1 (Cytochrome P450 Family 2); EC 1.14.14.24 (CYP2R1 protein, human); EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1089/dna.2017.3730


  7 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28539338
[Au] Autor:Beggs MR; Appel I; Svenningsen P; Skjødt K; Alexander RT; Dimke H
[Ad] Endereço:Membrane Protein Disease Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation.
[So] Source:Am J Physiol Renal Physiol;313(3):F629-F640, 2017 Sep 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Significant alterations in maternal calcium (Ca ) and magnesium (Mg ) balance occur during lactation. Ca is the primary divalent cation mobilized into breast milk by demineralization of the skeleton and alterations in intestinal and renal Ca transport. Mg is also concentrated in breast milk, but the underlying mechanisms are not well understood. To determine the molecular alterations in Ca and Mg transport in the intestine and kidney during lactation, three groups of female mice consisting of either nonpregnant controls, lactating mice, or mice undergoing involution were examined. The fractional excretion of Ca , but not Mg , rose significantly during lactation. Renal 1-α hydroxylase and 24-OHase mRNA levels increased markedly, as did plasma 1,25 dihydroxyvitamin D levels. This was accompanied by significant increases in intestinal expression of and in lactating mice. However, no alterations in the expression of cation-permeable claudin-2, claudin-12, or claudins-15 were found in the intestine. In the kidney, increased expression of and was observed during lactation, while no changes in claudins involved in Ca and Mg transport (claudin-2, claudin-14, claudin-16, or claudin-19) were found. Consistent with the mRNA expression, expression of both calbindin-D and transient receptor potential vanilloid 5 (TRPV5) proteins increased. Colonic expression increased during lactation, while renal remained unaltered. In conclusion, proteins involved in transcellular Ca and Mg transport pathways increase during lactation, while expression of paracellular transport proteins remained unchanged. Increased fractional Ca excretion can be explained by vitamin D-dependent intestinal hyperabsorption and bone demineralization, despite enhanced transcellular Ca uptake by the kidney.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Células Epiteliais/metabolismo
Mucosa Intestinal/metabolismo
Rim/metabolismo
Lactação/metabolismo
Magnésio/metabolismo
Glândulas Mamárias Animais/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Adaptação Fisiológica
Animais
Transporte Biológico
Calbindina 1/genética
Calbindina 1/metabolismo
Cálcio/urina
Canais de Cálcio/genética
Canais de Cálcio/metabolismo
Claudinas/genética
Claudinas/metabolismo
Feminino
Absorção Intestinal
Mucosa Intestinal/citologia
Rim/citologia
Proteínas de Membrana Transportadoras/genética
Camundongos
Reabsorção Renal
Proteína G de Ligação ao Cálcio S100/genética
Proteína G de Ligação ao Cálcio S100/metabolismo
Canais de Cátion TRPM/genética
Canais de Cátion TRPM/metabolismo
Canais de Cátion TRPV/genética
Canais de Cátion TRPV/metabolismo
Fatores de Tempo
Vitamina D/análogos & derivados
Vitamina D/sangue
Vitamina D3 24-Hidroxilase/genética
Vitamina D3 24-Hidroxilase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calb1 protein, mouse); 0 (Calbindin 1); 0 (Calcium Channels); 0 (Claudins); 0 (Membrane Transport Proteins); 0 (S100 Calcium Binding Protein G); 0 (S100g protein, mouse); 0 (TRPM Cation Channels); 0 (TRPV Cation Channels); 0 (Trpm6 protein, mouse); 0 (Trpv5 protein, mouse); 0 (Trpv6 protein, mouse); 1406-16-2 (Vitamin D); 66772-14-3 (1,25-dihydroxyvitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.15.16 (Cyp24a1 protein, mouse); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase); I38ZP9992A (Magnesium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00680.2016


  8 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28536085
[Au] Autor:Somjen D; Knoll E; Sharon O; Many A; Stern N
[Ad] Endereço:Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 64239, Israel. Electronic address: dsomjen10@gmail.com.
[Ti] Título:Interaction between the effects of the selective estrogen modulator femarelle and a vitamin D analog in human umbilical artery vascular smooth muscle cells.
[So] Source:J Steroid Biochem Mol Biol;174:9-13, 2017 Nov.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To further investigate the interaction between vitamin D system and estrogen-mimetic compounds in the human vasculature we studied the effect of the "less- calcemic" analog of 1,25(OH) D (1,25D); JK 1624F -2 (JKF) in the presence of selective estrogen modulator femarelle (F), the phytoestrogen daidzein (D) and estradiol-17b (E ) on [H] thymidine incorporation (DNA synthesis) and creatine kinase specific activity (CK) in human umbilical artery vascular smooth muscle cells (VSMC). F, D and E , stimulated DNA synthesis at low concentrations, and inhibited it at high concentrations. All estrogen-related compounds increased CK dose- dependently. Daily treatment with JKF (1nM for 3days) resulted in decreased DNA synthesis, increased CK and up- regulation of the stimulation of DNA synthesis by low estrogen-related hormones whereas D- and E - mediated inhibition of cell proliferation was abolished by JKF. In contrast, inhibition of cell proliferation by F could not be blocked by JKF. JKF also up-regulated the stimulatory effects on CK by F, E and D. VSMC expressed Estrogen Receptor (ER)a and ERb mRNA at a relative ratio of 2.7:1.0, respectively. JKF pretreatment increased ERa (∼50%) and decreased ERb (∼25%) expression. E did not affect ERs whereas both D and F up-regulated ERb (∼100%) and ERa (∼50%). Additionally, JKF increased the intracellular competitive binding of F (from ∼70 to ∼310%), of D (from ∼60 to ∼250%) and of E from (from∼70 to ∼320%). F reciprocally modulated the vitamin D system by up-regulating VDR- and 25 hydroxyy vitamin D 1-a hydroxylase (1OHase) mRNA expression (∼120%). F also stimulated 1OHase activity as indicated by an increase in the production of 1, 25D (∼250%). A similar increase was elicited by D (∼90%) but not by E . In conclusion, F has unique effects on human VSMC in that it can sustain inhibition of cell growth even in the presence of the vitamin D analog JKF. That JKF increases ER expression and F increased the endogenous production of 1, 25D and VDR expression offer new opportunities to modulate VSMC growth. Whether or not these mutual effects of F and JKF can be exploited to promote vascular health, particularly in estrogen-deficient states (e.g., menopause) is under investigation.
[Mh] Termos MeSH primário: Calcitriol/análogos & derivados
Moduladores de Receptor Estrogênico/farmacologia
Miócitos de Músculo Liso/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Calcitriol/farmacologia
Células Cultivadas
Creatina Quinase/metabolismo
DNA/metabolismo
Interações Medicamentosas
Estradiol/farmacologia
Receptor alfa de Estrogênio/genética
Receptor beta de Estrogênio/genética
Estrogênios/farmacologia
Seres Humanos
Isoflavonas/farmacologia
Músculo Liso Vascular/citologia
Miócitos de Músculo Liso/metabolismo
RNA Mensageiro/metabolismo
Receptores de Calcitriol/genética
Artérias Umbilicais/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DT56a); 0 (Estrogen Receptor Modulators); 0 (Estrogen Receptor alpha); 0 (Estrogen Receptor beta); 0 (Estrogens); 0 (Isoflavones); 0 (JK 1624F2-1); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Receptors, Calcitriol); 0 (estrogen receptor alpha, human); 4TI98Z838E (Estradiol); 6287WC5J2L (daidzein); 9007-49-2 (DNA); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 2.7.3.2 (Creatine Kinase); FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


  9 / 1014 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28363955
[Au] Autor:Li CH; Zhang J; Baylink DJ; Wang X; Goparaju NB; Xu Y; Wasnik S; Cheng Y; Berumen EC; Qin X; Lau KW; Tang X
[Ad] Endereço:Division of Regenerative Medicine, Department of Medicine, Loma Linda University, Loma Linda, California, USA.
[Ti] Título:Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis.
[So] Source:FASEB J;31(7):2996-3006, 2017 Jul.
[Is] ISSN:1530-6860
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiple sclerosis (MS) is caused by immune-mediated damage of myelin sheath. Current therapies aim to block such immune responses. However, this blocking is not sufficiently specific and hence compromises immunity, leading to severe side effects. In addition, blocking medications usually provide transient effects and require frequent administration, which further increases the chance to compromise immunity. In this regard, myelin-specific therapy may provide the desired specificity and a long-lasting therapeutic effect by inducing myelin-specific regulatory T (T ) cells. Tolerogenic dendritic cells (TolDCs) are one such therapy. However, generated TolDCs may be converted into immunogenic DCs in a proinflammatory environment. In this study, we identified a potential novel myelin-specific therapy that works with immunogenic DCs, hence without the conversion concern. We showed that immunization with DCs, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase for synthesis of a focally high 1,25-dihydroxyvitamin D concentration in the peripheral lymphoid tissues, induced T cells. In addition, such engineered DCs, when pulsed with a myelin antigen, led to myelin-specific suppression of ongoing experimental allergic encephalomyelitis (an MS animal model), and the disease suppression depended on forkhead-box-protein-P3(foxp3) T cells. Our data support a novel concept that immunogenic DCs can be engineered for myelin-specific therapy for MS.-Li, C.-H., Zhang, J., Baylink, D. J., Wang, X., Goparaju, N. B., Xu, Y., Wasnik, S., Cheng, Y., Berumen, E. C., Qin, X., Lau, K.-H. W., Tang, X. Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Células Dendríticas/metabolismo
Encefalomielite Autoimune Experimental/terapia
Bainha de Mielina
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
25-Hidroxivitamina D3 1-alfa-Hidroxilase/uso terapêutico
Animais
Antígenos
Células da Medula Óssea
Linhagem Celular
Células Cultivadas
Feminino
Fatores de Transcrição Forkhead/genética
Fatores de Transcrição Forkhead/metabolismo
Regulação Enzimológica da Expressão Gênica/imunologia
Tecido Linfoide
Camundongos
Camundongos Endogâmicos C57BL
Linfócitos T Reguladores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Forkhead Transcription Factors); 0 (Foxp3 protein, mouse); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1096/fj.201601243R


  10 / 1014 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28362172
[Au] Autor:Yang J; Wang H; Ji A; Ma L; Wang J; Lian C; Wei Z; Wang L
[Ad] Endereço:a School of Public Health, Central South University , Changsha , Hunan , China.
[Ti] Título:Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.
[So] Source:Nutr Cancer;69(4):593-600, 2017 May-Jun.
[Is] ISSN:1532-7914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experimental studies have determined the chemopreventive effects of vitamin D against the esophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies are not yet well established. The current study aimed to evaluate the associations between plasma vitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. A hospital-based case-control study was performed. Five hundred eighty-two ESCC patients and 569 controls were recruited in a Northern Chinese population. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Higher plasma 25(OH)D was associated with a reduced risk for ESCC, especially for rs2296241, rs11568820, and rs4646536. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/genética
Neoplasias Esofágicas/genética
Polimorfismo de Nucleotídeo Único
Vitamina D/sangue
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
Idoso
Grupo com Ancestrais do Continente Asiático/genética
Estudos de Casos e Controles
Proteínas de Ligação a DNA/genética
Feminino
Predisposição Genética para Doença
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/genética
Receptores de Calcitriol/genética
Transdução de Sinais/genética
Fatores de Transcrição/genética
Vitamina D/análogos & derivados
Vitamina D/genética
Vitamina D/metabolismo
Vitamina D3 24-Hidroxilase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DBP protein, human); 0 (DNA-Binding Proteins); 0 (Receptors, Calcitriol); 0 (Transcription Factors); 0 (VDR protein, human); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.13.13 (CYP27B1 protein, human); EC 1.14.15.16 (CYP24A1 protein, human); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.1.21 (7-dehydrocholesterol reductase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1080/01635581.2017.1299873



página 1 de 102 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde