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[PMID]:28595197
[Au] Autor:Shan J; Lei H; Shi W; Sun X; Tang Y; Ren C
[Ad] Endereço:Department of Gastroenterology, The 3rd People's Hospital of Chengdu, The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, China.
[Ti] Título:High Serum Pepsinogen I and beta Helicobacter pylori Infection Are Risk Factors for Aspirin-Induced Gastroduodenal Injury.
[So] Source:Dig Dis;36(1):66-71, 2018.
[Is] ISSN:1421-9875
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whether gastric hyperchlorhydria and Helicobacter pylori infection contribute to aspirin-induced gastroduodenal injury still lacks evidence. Because serum pepsinogens (PGs) and gastrin-17 (G17) can reflect gastric acid secretion, this study intended to elucidate whether serum PGs, serum G17, and H. pylori infection are associated with aspirin-induced gastrointestinal injury. SUMMARY: A total of 60 patients taking low-dose aspirin for more than 1 month were enrolled in this study. Serum PG I, PG II, and G17 were determined using ELISA. A 14C-urea breath test was used for the detection of an H. pylori infection. The modified Lanza score was used to evaluate the degree of gastroduodenal injury under endoscopy. The median serum PG I level was significantly higher in the intensive gastroduodenal injury (IGI) group compared to that in the mild gastroduodenal injury group (155.0 vs. 116.6 ng/mL, p = 0.006). The H. pylori infection rate was significantly higher in the IGI group (73 vs. 40%, p = 0.037). Receiver operator characteristic curves analysis revealed that the cutoff value of PG I was 123 ng/mL, with 80% sensitivity and 61.4% specificity. H. pylori infection combined with PG I at >123 ng/mL had an OR (95% CI) of 15.8 (2.4 ± 104.5) for the prediction of aspirin-induced gastroduodenal injury. Key Messages: Serum PG I and H. pylori infection could be used to identify potential high-risk aspirin-induced gastroduodenal injury patients.
[Mh] Termos MeSH primário: Aspirina/efeitos adversos
Duodeno/lesões
Infecções por Helicobacter/sangue
Infecções por Helicobacter/microbiologia
Helicobacter pylori/fisiologia
Pepsinogênio A/sangue
Estômago/lesões
[Mh] Termos MeSH secundário: Idoso
Área Sob a Curva
Duodeno/efeitos dos fármacos
Feminino
Gastrinas/sangue
Infecções por Helicobacter/complicações
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Curva ROC
Fatores de Risco
Estômago/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins); 60748-06-3 (gastrin 17); 9001-10-9 (Pepsinogen A); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1159/000477203


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[PMID]:29244926
[Au] Autor:Matveeva LV; Mosina LM
[Ti] Título:Interrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.
[So] Source:Patol Fiziol Eksp Ter;60(4):72-8, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach. Methods: Surveyed in obtaining informed consent 42 patients with gastric ulcer in the acute phase prior to the eradication and antisecretory therapy and 40 healthy volunteers. On the state of function acid- and enzymes production of the gastric mucosa judged by the results of a 2-hour intragastric pH-metry and serum concentration pepsinogen, gastrin before the start of active treatment. Immunophenotype lymphocytes on CD-antigens (CD3, CD4, CD8, CD16, CD19, CD45, CD56) was measured by immunofluorescence, levels immunoglobulin isotype M, G, A, E - ELISA method. Results: When short-term intragastric pH-metry of the stomach hyperacidity patients recorded 6.7 times more likely than healthy, normacidity - 12.3 times less. Reduction of acid production was observed up to 8.6 times more, indicating the development of mucosal atrophy. Basal pH in the antrum was lower by 54.5% than in the control group, with stimulation increased by 33.6%, but remained lower than the values of healthy individuals by 48.7%. When ELISA amount pepsinogen patients showed significant increase in serum levels of PG-I relative to the control group at 33.4%, PG-II - 52%. In assessing the immune status of patients were identified changes in system phagocytes, cellular and humoral links, most pronounced for severe current peptic ulcer disease. Conclusion: The results indicate the presence of positive and negative correlative links mild to moderate force between indicators of secretory activity of gastric mucosal innate and adaptive immunity in patients with acute exacerbation of peptic ulcer disease. The presence and nature of these relationships should be taken into account when appointing antisecretory drugs.
[Mh] Termos MeSH primário: Antígenos CD/sangue
Mucosa Gástrica/secreção
Gastrinas/sangue
Pepsinogênio A/sangue
Úlcera Gástrica/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Mucosa Gástrica/patologia
Seres Humanos
Masculino
Meia-Idade
Úlcera Gástrica/tratamento farmacológico
Úlcera Gástrica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Gastrins); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:29073245
[Au] Autor:Scott I; Umair S; Savoian MS; Simpson HV
[Ad] Endereço:Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
[Ti] Título:Abomasal dysfunction and cellular and mucin changes during infection of sheep with larval or adult Teladorsagia circumcincta.
[So] Source:PLoS One;12(10):e0186752, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This is the first integrated study of the effects on gastric secretion, inflammation and fundic mucins after infection with L3 T. circumcincta and in the very early period following transplantation of adult worms. At 3 months-of-age, 20 Coopworth lambs were infected intraruminally with 35,000 L3; infected animals were killed on Days 5, 10, 15, 20 and 30 post-infection and 6 controls on either Day 0 or 30 post-infection. Another 15 Romney cross lambs received 10,000 adult worms at 4-5 months-of-age though surgically-implanted abomasal cannulae and were killed after 6, 12, 24 and 72 hours; uninfected controls were also killed at 72 hours. Blood was collected at regular intervals from all animals for measurement of serum gastrin and pepsinogen and abomasal fluid for pH measurement from cannulated sheep. Tissues collected at necropsy were fixed in Bouin's fluid for light microscopy, immunocytochemistry and mucin staining and in Karnovsky's fluid for electron microscopy. Nodules around glands containing developing larvae were seen on Day 5 p.i., but generalised effects on secretion occurred only after parasite emergence and within hours after transplantation of adult worms. After L3 infection, there were maximum worm burdens on Days 10-15 post-infection, together with peak tissue eosinophilia, inhibition of gastric acid secretion, hypergastrinaemia, hyperpepsinogenaemia, loss of parietal cells, enlarged gastric pits containing less mucin and increased numbers of mucous neck cells. After adult transplantation, serum pepsinogen was significantly increased after 9 hours and serum gastrin after 18 hours. Parallel changes in host tissues and the numbers of parasites in the abomasal lumen suggest that luminal parasites, but not those in the tissues, are key drivers of the pathophysiology and inflammatory response in animals exposed to parasites for the first time. These results are consistent with initiation of the host response by parasite chemicals diffusing across the surface epithelium, possibly aided by components of ES products which increased permeability. Parietal cells appear to be a key target, resulting in secondary increases in serum gastrin, pit elongation, loss of surface mucins and inhibition of chief cell maturation. Inflammation occurs in parallel, and could either cause the pathology or exacerbate the direct effects of ES products.
[Mh] Termos MeSH primário: Mucinas Gástricas/secreção
Doenças dos Ovinos
Ovinos
Gastropatias
Estômago de Ruminante
Trichostrongyloidea
Tricostrongiloidíase
[Mh] Termos MeSH secundário: Animais
Gastrinas/sangue
Larva
Pepsinogênio A/sangue
Ovinos/sangue
Ovinos/parasitologia
Doenças dos Ovinos/sangue
Doenças dos Ovinos/parasitologia
Gastropatias/sangue
Gastropatias/parasitologia
Estômago de Ruminante/parasitologia
Estômago de Ruminante/secreção
Tricostrongiloidíase/sangue
Tricostrongiloidíase/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastric Mucins); 0 (Gastrins); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186752


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[PMID]:28898235
[Au] Autor:Gao X; Zhang Y; Brenner H
[Ad] Endereço:Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
[Ti] Título:Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults.
[So] Source:Br J Cancer;117(8):1211-1214, 2017 Oct 10.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Helicobacter pylori (HP) infection and chronic atrophic gastritis (CAG) have shown strong associations with the development of gastric cancer. This study aimed to examine whether both risk factors are associated with accelerated epigenetic ageing, as determined by the 'DNA methylation age', in a population-based study of older adults (n=1477). METHODS: Serological measurements of HP antibodies and pepsinogen I and II for CAG definition were obtained by ELISA kits. Whole blood DNA methylation profiles were measured by Illumina Human Methylation450K Beadchip. DNA methylation ages were calculated by two algorithms proposed by Horvath and Hannum et al. RESULTS: After adjusting for potential covariates in linear regression models, we found that HP infection, infection with virulent HP strains (CagA+) and severe CAG were significantly associated with an increase in DNA methylation age by ∼0.4, 0.6 and 1 year (all P-values <0.05), respectively. CONCLUSIONS: Our study indicates that both CagA+ HP infection and CAG go along with accelerated epigenetic ageing.
[Mh] Termos MeSH primário: Envelhecimento/genética
Senescência Celular/genética
Metilação de DNA
Epigênese Genética/genética
Gastrite Atrófica/genética
Infecções por Helicobacter/genética
[Mh] Termos MeSH secundário: Idoso
Anticorpos Antibacterianos/imunologia
Doença Crônica
Ensaio de Imunoadsorção Enzimática
Feminino
Gastrite Atrófica/complicações
Gastrite Atrófica/metabolismo
Infecções por Helicobacter/complicações
Infecções por Helicobacter/imunologia
Infecções por Helicobacter/metabolismo
Helicobacter pylori/imunologia
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Pepsinogênio A/metabolismo
Pepsinogênio C/metabolismo
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 61536-72-9 (Pepsinogen C); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.314


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[PMID]:28854276
[Au] Autor:Osumi H; Fujisaki J; Suganuma T; Horiuchi Y; Omae M; Yoshio T; Ishiyama A; Tsuchida T; Miki K
[Ad] Endereço:Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
[Ti] Título:A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication.
[So] Source:PLoS One;12(8):e0183980, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Helicobacter pylori (H. pylori) eradication is usually assessed using the 13C-urea breath test (UBT), anti-H. pylori antibody and the H. pylori stool antigen test. However, a few reports have used pepsinogen (PG), in particular, the percentage change in the PG I/II ratio. Here, we evaluated the usefulness of the percentage changes in serum PG I/II ratios for determining the success of eradication therapy for H. pylori. MATERIALS AND METHODS: In total, 650 patients received eradication therapy from October 2008 to March 2013 in our Cancer Institute Hospital. We evaluated the relationship between H. pylori eradication and percentage changes in serum PG I/II ratios before and 3 months after treatment with CLEIA® (FUJIREBIO Inc, Tokyo, Japan). The gold standard of H. pylori eradication was defined as negative by the UBT performed 3 months after completion of eradication treatment. Cut-off values for percentage changes in serum PG I/II ratios were set as +40, +25 and +10% when the serum PG I/II ratio before treatment was below 3.0, above 3.0 but below 5.0 and 5.0 or above, respectively. RESULTS: Serum PG I and PG II levels were measured in 562 patients with H. pylori infection before and after eradication therapy. Eradication of H. pylori was achieved in 433 patients studied (77.0%). The ratios of first, second, third-line and penicillin allergy eradication treatment were 73.8% (317/429), 88.3% (99/112), 75% (12/16) and 100% (5/5), respectively. An increasing percentage in the serum levels of the PG I/II ratios after treatment compared with the values before treatment clearly distinguished success from failure of eradication (108.2±57.2 vs. 6.8±30.7, p<0.05). Using the above cut-off values, the sensitivity, specificity and validity for determination of H. pylori were 93.1, 93.8 and 93.2%, respectively. CONCLUSION: In conclusion, the percentage changes in serum PG I/II ratios are useful as evaluation criteria for assessing the success of eradication therapy for H. pylori.
[Mh] Termos MeSH primário: Infecções por Helicobacter/sangue
Infecções por Helicobacter/terapia
Pepsinogênio A/sangue
Pepsinogênio C/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Feminino
Infecções por Helicobacter/diagnóstico
Infecções por Helicobacter/epidemiologia
Helicobacter pylori/isolamento & purificação
Seres Humanos
Japão/epidemiologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 61536-72-9 (Pepsinogen C); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183980


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[PMID]:28723806
[Au] Autor:Cho JH; Jeon SR; Kim HG; Jin SY; Park S
[Ad] Endereço:aDigestive Disease Center bDepartment of Pathology cDepartment of Medical Biostatistics, Soonchunhyang University Hospital, Seoul, Korea.
[Ti] Título:The serum pepsinogen levels for risk assessment of gastric neoplasms: New proposal from a case-control study in Korea.
[So] Source:Medicine (Baltimore);96(29):e7603, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To decrease the gastric cancer related mortality rate, endoscopic screening is widely performed in Korea. However, a precise method for identifying those at a high risk of gastric neoplasms has not been established. This study aims to evaluate serum pepsinogen (PG) levels for risk assessment of gastric neoplasms. Between August 2014 and March 2016, a total of 398 subjects, including 87 with gastric neoplasms, were enrolled in this study. On the basis of the serum PG I/II ratio, the enrolled subjects were classified into 4 groups: group A, PG I/II ratio >4; group B, >3 and ≤4; group C, >2 and ≤3; group D, ≤2. Compared with group A, a stepwise increase in the risk of gastric neoplasm was observed from group B [odds ratio (OR) = 9.9, 95% confidence interval (95% CI) = 4.0-24.4] to group C (OR = 20.9, 95% CI = 8.7-50.5) to group D (OR = 37.3, 95% CI = 14.3-97.4). The optimal cutoff value of the serum PG I/II ratio for predicting gastric neoplasms was 4.5, with a sensitivity of 97.7% and a specificity of 57.6%. A decrease in the serum PG I/II ratio was strongly associated with an increased risk of gastric neoplasms. The serum PG I/II ratio can be used to identify those at a high risk of gastric neoplasms in Korean population.
[Mh] Termos MeSH primário: Pepsinogênio A/sangue
Pepsinogênio C/sangue
Neoplasias Gástricas/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Razão de Chances
República da Coreia
Medição de Risco
Neoplasias Gástricas/epidemiologia
Neoplasias Gástricas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 61536-72-9 (Pepsinogen C); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007603


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[PMID]:28525343
[Au] Autor:Al-Rawashdeh O; Ismail ZB; Talafha A; Al-Momani A
[Ad] Endereço:.
[Ti] Título:Changes of hematological and biochemical parameters and levels of pepsinogen, histamine and prostaglandins in dairy cows affected with left displacement of the abomasum.
[So] Source:Pol J Vet Sci;20(1):13-18, 2017 Mar 28.
[Is] ISSN:1505-1773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aims of this study were to determine the serum levels of pepsinogen, histamine, and prostaglandins F2α and E2 in lactating dairy cows affected with left displacement of the abomasum (LDA). In addition, the hematological and serum biochemical parameters were also determined in cows affected with LDA. A total of 52 adult lactating Holstein-Friesian cows affected with LDA and 30 normal cows (control) were used. In LDA cows, the average age, BCS and body weight were 4.9 ± 1.2 years, 2.5 ± 0.75, and 525 ± 150kg respectively. The average days-in-milk (DIM) in affected cows was 14 ± 6 with a range between 7 to 45 days. There were no significant differences in values of rectal temperature, heart rate and respiration rate between LDA cows and control. Rumen motility was significantly (p≤0.05) decreased in LDA cows. Cows affected with LDA had significantly (p≤0.05) increased glucose levels, and decreased levels of calcium and magnesium. There were significantly (p≤0.05) increased serum levels of pepsinogen and histamine in LDA cows while levels of prostaglandin E2 were significantly decreased in comparison to those in control cows. There were no significant changes in serum levels of prostaglandin F2α. In the hematology analyses, there were no significant changes in cows with LDA when compared to those in control cows. This study provides evidence of a possible role for pepsinogen, histamine and prostaglandin E2 in the etiopathophysiology of LDA in dairy cows.
[Mh] Termos MeSH primário: Abomaso
Doenças dos Bovinos/sangue
Histamina/sangue
Pepsinogênio A/sangue
Prostaglandinas/sangue
Gastropatias/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/metabolismo
Feminino
Gastropatias/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prostaglandins); 820484N8I3 (Histamine); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


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[PMID]:28378553
[Au] Autor:Lee SP; Lee SY; Kim JH; Sung IK; Park HS; Shim CS
[Ad] Endereço:Department of Internal Medicine, Digestive Disease Center, Konkuk University School of Medicine, Seoul, Korea.
[Ti] Título:Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings.
[So] Source:J Korean Med Sci;32(5):796-802, 2017 May.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The serum pepsinogen (PG) assay findings are correlated with the status of Helicobacter pylori infection, but there are controversies on the link with upper gastrointestinal (UGI) endoscopic findings. The aim of this study was to determine the significance of a serum PG assay for correlating with endoscopic findings in H. pylori-seroprevalent adult population. Korean adults who visited for a health check-up were included consecutively. Subjects after gastrectomy or H. pylori eradication were excluded. After completing the serum PG assay and anti-H. pylori immunoglobulin G (IgG) titer on the same day of UGI endoscopy, subjects with equivocal serology test finding or gastric neoplasm were excluded. Of the 4,830 included subjects, 3,116 (64.5%) were seropositive for H. pylori. Seropositive finding was related to high serum PG I (P < 0.001) and PG II (P < 0.001) concentrations, low PG I/II ratio (P < 0.001), old age (P < 0.001), and male gender (P = 0.006). After adjusting age and gender, the serum PG I and II concentrations were positively correlated with the presence of nodular gastritis (NG) (all P = 0.003). The serum PG I was positively correlated with gastric ulcer (P = 0.003), and it was correlated with duodenal ulcer in seropositive subjects (P = 0.008). The PG I/II ratio was positively correlated with erosive esophagitis, while it was inversely related to chronic atrophic gastritis and metaplastic gastritis (all P < 0.001). Our findings suggest that the serum PG assay finding correlates well with the UGI endoscopic finding. A higher serum PG concentration in subjects with NG and peptic ulcer disease suggests that endoscopic findings reflect gastric secreting ability.
[Mh] Termos MeSH primário: Infecções por Helicobacter/patologia
Pepsinogênio A/sangue
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Anticorpos Antibacterianos/sangue
Estudos Transversais
Úlcera Duodenal/complicações
Úlcera Duodenal/diagnóstico
Endoscopia do Sistema Digestório
Ensaio de Imunoadsorção Enzimática
Esofagite/complicações
Esofagite/diagnóstico
Feminino
Gastrite/complicações
Gastrite/diagnóstico
Infecções por Helicobacter/microbiologia
Helicobacter pylori/imunologia
Seres Humanos
Imunoglobulina G/sangue
Masculino
Meia-Idade
Fatores Sexuais
Úlcera Gástrica/complicações
Úlcera Gástrica/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Immunoglobulin G); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2017.32.5.796


  9 / 720 MEDLINE  
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[PMID]:28376132
[Au] Autor:Mitsuishi T; Hamatani S; Hirooka S; Fukasawa N; Aizawa D; Hara Y; Dobashi A; Goda K; Fukuda T; Saruta M; Urashima M; Ikegami M
[Ad] Endereço:Department of Pathology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
[Ti] Título:Clinicopathological characteristics of duodenal epithelial neoplasms: Focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors).
[So] Source:PLoS One;12(4):e0174985, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Epithelial tumors less commonly occur in the duodenum than in the stomach or large intestine. The clinicopathological characteristics of duodenal epithelial tumors remain a matter of debate. We therefore studied resected specimens to investigate the clinicopathological characteristics of duodenal epithelial tumors. MATERIALS AND METHODS: Among duodenal epithelial tumors resected endoscopically or surgically in our hospital, we studied the clinicopathological characteristics of 110 adenomas or intramucosal carcinomas. The grade of atypia of all tumors was classified into 3 groups according to the World Health Organization (WHO) 2010 classification. The tumors were immunohistochemically evaluated to determine the frequency of differentiation toward fundic glands. RESULTS: As for patient characteristics, there were 76 men (75.2%) and 25 women (24.8%), with a median age of 65 years (range, 34 to 84). The tumors most commonly arose in the first to second part of the duodenum. Many lesions were flat, and the median tumor diameter was 8.0 mm. The lesions were classified into 2 types according to mucin phenotype: intestinal-type tumors (98 lesions, 89.1%) and gastric-type tumors (12 lesions, 10.9%). Intestinal-type tumors were subdivided into 2 groups: tubular-type tumors (91 lesions, 82.7%) and tubulovillous-type tumors (7 lesions, 6.4%). Gastric-type tumors were classified into 2 types: foveolar type (3 lesions, 2.7%) and pyloric gland-type (PG) tumors (9 lesions, 8.2%). The grade of atypia was significantly higher in gastric-type tumors (p<0.01). PG tumors were gastric-type tumors characterized by pyloric glands and findings suggesting differentiation toward fundic glands. CONCLUSIONS: About 10% of the duodenal tumors had a gastric-type mucin phenotype. Gastric-type tumors showed high-grade atypia. In particular, PG tumors showed similarities to PG tumors of the stomach, such as differentiation toward fundic glands.
[Mh] Termos MeSH primário: Neoplasias Duodenais/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Mucinoso/metabolismo
Adenocarcinoma Mucinoso/patologia
Adenoma/metabolismo
Adenoma/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma/metabolismo
Carcinoma/patologia
Neoplasias Duodenais/classificação
Neoplasias Duodenais/metabolismo
Feminino
Mucinas Gástricas/metabolismo
Mucosa Gástrica/metabolismo
Mucosa Gástrica/patologia
ATPase Trocadora de Hidrogênio-Potássio/metabolismo
Seres Humanos
Masculino
Meia-Idade
Pepsinogênio A/metabolismo
Neoplasias Gástricas/metabolismo
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastric Mucins); 9001-10-9 (Pepsinogen A); EC 3.6.3.10 (H(+)-K(+)-Exchanging ATPase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174985


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[PMID]:28323271
[Au] Autor:Tu H; Sun L; Dong X; Gong Y; Xu Q; Jing J; Bostick RM; Wu X; Yuan Y
[Ad] Endereço:Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, Liaoning, China.
[Ti] Título:A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study.
[So] Source:Am J Gastroenterol;112(5):704-715, 2017 May.
[Is] ISSN:1572-0241
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We aimed to assess a serological biopsy using five stomach-specific circulating biomarkers-pepsinogen I (PGI), PGII, PGI/II ratio, anti-Helicobacter pylori (H. pylori) antibody, and gastrin-17 (G-17)-for identifying high-risk individuals and predicting risk of developing gastric cancer (GC). METHODS: Among 12,112 participants with prospective follow-up from an ongoing population-based screening program using both serology and gastroscopy in China, we conducted a multi-phase study involving a cross-sectional analysis, a follow-up analysis, and an integrative risk prediction modeling analysis. RESULTS: In the cross-sectional analysis, the five biomarkers (especially PGII, the PGI/II ratio, and H. pylori sero-positivity) were associated with the presence of precancerous gastric lesions or GC at enrollment. In the follow-up analysis, low PGI levels and PGI/II ratios were associated with higher risk of developing GC, and both low (<0.5 pmol/l) and high (>4.7 pmol/l) G-17 levels were associated with higher risk of developing GC, suggesting a J-shaped association. In the risk prediction modeling analysis, the five biomarkers combined yielded a C statistic of 0.803 (95% confidence interval (CI)=0.789-0.816) and improved prediction beyond traditional risk factors (C statistic from 0.580 to 0.811, P<0.001) for identifying precancerous lesions at enrollment, and higher serological biopsy scores based on the five biomarkers at enrollment were associated with higher risk of developing GC during follow-up (P for trend <0.001). CONCLUSIONS: A serological biopsy composed of the five stomach-specific circulating biomarkers could be used to identify high-risk individuals for further diagnostic gastroscopy, and to stratify individuals' risk of developing GC and thus to guide targeted screening and precision prevention.
[Mh] Termos MeSH primário: Adenocarcinoma/sangue
Anticorpos Antibacterianos/sangue
Gastrinas/sangue
Helicobacter pylori/imunologia
Pepsinogênio A/sangue
Pepsinogênio C/sangue
Lesões Pré-Cancerosas/sangue
Neoplasias Gástricas/sangue
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Idoso
Biomarcadores/sangue
Biópsia
Estudos Transversais
Feminino
Seguimentos
Mucosa Gástrica/patologia
Gastroscopia
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Lesões Pré-Cancerosas/patologia
Modelos de Riscos Proporcionais
Curva ROC
Medição de Risco/métodos
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Biomarkers); 0 (Gastrins); 60748-06-3 (gastrin 17); 61536-72-9 (Pepsinogen C); 9001-10-9 (Pepsinogen A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2017.55



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