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[PMID]: | 28891849 |
[Au] Autor: | Kallenberg FGJ; Bastiaansen BAJ; Nio CY; Soeters MR; Boermeester MA; Aalfs CM; Bossuyt PMM; Dekker E |
[Ad] Endereço: | 1 Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 2 Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 3 Department of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 4 Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 5 Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 6 Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. |
[Ti] Título: | Adrenal Lesions in Patients With (Attenuated) Familial Adenomatous Polyposis and MUTYH-Associated Polyposis. |
[So] Source: | Dis Colon Rectum;60(10):1057-1064, 2017 Oct. | [Is] ISSN: | 1530-0358 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: The reported proportion of patients with familial adenomatous polyposis who have adrenal lesions varies between 7% and 13% compared with 4% in the general population; the prevalence of adrenal lesions in patients with attenuated familial adenomatous polyposis and MUTYH-associated polyposis is unknown. Data on the clinical relevance and clinical course are limited. OBJECTIVE: We aimed to report on the frequency, characteristics, and progression of adrenal lesions in polyposis patients. DESIGN: This was a historical cohort study. SETTINGS: The study was performed at the Academic Medical Center, Amsterdam. PATIENTS: All of the patients with familial adenomatous polyposis, attenuated familial adenomatous polyposis, and MUTYH-associated polyposis were included. Medical charts and imaging reports were analyzed for data on adrenal lesions. A radiologist reassessed all of the images. Patients had not routinely been screened for adrenal lesions. MAIN OUTCOME MEASURES: The frequency, characteristics, and progression of adrenal lesions in patients with polyposis who underwent abdominal imaging were assessed. Findings were compared with a reference. RESULTS: A total of 39 adrenal lesions were identified in 23 (26%) of 90 patients with familial adenomatous polyposis, 2 (18%) of 11 with attenuated familial adenomatous polyposis, and 5 (24%) of 21 with MUTYH-associated polyposis. Mean age at time of detection was 50.7 years (range, 17.1-83.3 y). Median lesion size at baseline was 1.4 cm (range, 1.0-5.0 cm) versus 1.7 cm (range, 1.0-5.7 cm) after a median of 3.5 years (range, 1.0-11.4 y). Two patients were diagnosed with a hyperfunctioning lesion, and 4 underwent adrenalectomy: 3 lesions appeared benign, and 1 was oncocytic of uncertain malignant potential. The OR for detecting at least 1 lesion in a patient with polyposis versus reference was 6.2 (95% CI, 3.2-12.3), with no significant differences in ORs among the 3 syndromes. LIMITATIONS: The study was limited by its retrospective design. CONCLUSIONS: Adrenal lesions are frequent in patients with polyposis who undergo abdominal imaging. They appear to follow a benign and slowly progressive course and are mostly nonhyperfunctioning. See Abstract Video at http://links.lww.com/DCR/A323. |
[Mh] Termos MeSH primário: |
Neoplasias das Glândulas Suprarrenais Glândulas Suprarrenais/diagnóstico por imagem DNA Glicosilases/genética
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[Mh] Termos MeSH secundário: |
Polipose Adenomatosa do Colo/epidemiologia Polipose Adenomatosa do Colo/genética Polipose Adenomatosa do Colo/patologia Polipose Adenomatosa do Colo/cirurgia Neoplasias das Glândulas Suprarrenais/epidemiologia Neoplasias das Glândulas Suprarrenais/patologia Neoplasias das Glândulas Suprarrenais/fisiopatologia Neoplasias das Glândulas Suprarrenais/cirurgia Adrenalectomia/estatística & dados numéricos Adulto Colectomia/métodos Colectomia/estatística & dados numéricos Feminino Seres Humanos Imagem por Ressonância Magnética/estatística & dados numéricos Masculino Meia-Idade Países Baixos/epidemiologia Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/estatística & dados numéricos Estudos Retrospectivos Estatística como Assunto
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| EC 3.2.2.- (DNA Glycosylases); EC 3.2.2.- (mutY adenine glycosylase) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170921 |
[Lr] Data última revisão:
| 170921 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170912 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1097/DCR.0000000000000809 |
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