[PMID]: | 26519781 |
[Au] Autor: | Wilson K; Hawken S; Potter BK; Chakraborty P; Walker M; Ducharme R; Little J |
[Ad] Endereço: | Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute for Clinical Evaluative Sciences, University of Ottawa, Ottawa, Ontario, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada; Departm |
[Ti] Título: | Accurate prediction of gestational age using newborn screening analyte data. |
[So] Source: | Am J Obstet Gynecol;214(4):513.e1-513.e9, 2016 Apr. |
[Is] ISSN: | 1097-6868 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: Identification of preterm births and accurate estimates of gestational age for newborn infants is vital to guide care. Unfortunately, in developing countries, it can be challenging to obtain estimates of gestational age. Routinely collected newborn infant screening metabolic analytes vary by gestational age and may be useful to estimate gestational age. OBJECTIVE: We sought to develop an algorithm that could estimate gestational age at birth that is based on the analytes that are obtained from newborn infant screening. STUDY DESIGN: We conducted a population-based cross-sectional study of all live births in the province of Ontario that included 249,700 infants who were born between April 2007 and March 2009 and who underwent newborn infant screening. We used multivariable linear and logistic regression analyses to build a model to predict gestational age using newborn infant screening metabolite measurements and readily available physical characteristics data (birthweight and sex). RESULTS: The final model of our metabolic gestational dating algorithm had an average deviation between observed and expected gestational age of approximately 1 week, which suggests excellent predictive ability (adjusted R-square of 0.65; root mean square error, 1.06 weeks). Two-thirds of the gestational ages that were predicted by our model were accurate within ±1 week of the actual gestational age. Our logistic regression model was able to discriminate extremely well between term and increasingly premature categories of infants (c-statistic, >0.99). CONCLUSION: Metabolic gestational dating is accurate for the prediction of gestational age and could have value in low resource settings. |
[Mh] Termos MeSH primário: |
Idade Gestacional Triagem Neonatal
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[Mh] Termos MeSH secundário: |
17-alfa-Hidroxiprogesterona/sangue Algoritmos Aminoácidos/sangue Biomarcadores/sangue Biotinidase/sangue Peso ao Nascer Carnitina/análogos & derivados Carnitina/sangue Estudos Transversais Ácidos Graxos/sangue Feminino Seres Humanos Recém-Nascido Modelos Logísticos Masculino Ontário Oxirredução Gravidez Tireotropina/sangue UTP-Hexose-1-Fosfato Uridililtransferase/sangue
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES |
[Nm] Nome de substância:
| 0 (Amino Acids); 0 (Biomarkers); 0 (Fatty Acids); 0 (acylcarnitine); 68-96-2 (17-alpha-Hydroxyprogesterone); 9002-71-5 (Thyrotropin); EC 2.7.7.10 (UTP-Hexose-1-Phosphate Uridylyltransferase); EC 3.5.1.12 (Biotinidase); S7UI8SM58A (Carnitine) |
[Em] Mês de entrada: | 1608 |
[Cu] Atualização por classe: | 170922 |
[Lr] Data última revisão:
| 170922 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 151101 |
[St] Status: | MEDLINE |
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