[PMID]: | 28247204 |
[Au] Autor: | Smaga I; Jastrzebska J; Zaniewska M; Bystrowska B; Gawlinski D; Faron-Górecka A; Broniowska Z; Miszkiel J; Filip M |
[Ad] Endereço: | Department of Toxicology, Faculty of Pharmacy, College of Medicum, Jagiellonian University, Medyczna 9, PL 30-688, Kraków, Poland. |
[Ti] Título: | Changes in the Brain Endocannabinoid System in Rat Models of Depression. |
[So] Source: | Neurotox Res;31(3):421-435, 2017 Apr. |
[Is] ISSN: | 1476-3524 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | A growing body of evidence implicates the endocannabinoid (eCB) system in the pathophysiology of depression. The aim of this study was to investigate the influence of changes in the eCB system, such as levels of neuromodulators, eCB synthesizing and degrading enzymes, and cannabinoid (CB) receptors, in different brain structures in animal models of depression using behavioral and biochemical analyses. Both models used, i.e., bulbectomized (OBX) and Wistar Kyoto (WKY) rats, were characterized at the behavioral level by increased immobility time. In the OBX rats, anandamide (AEA) levels were decreased in the prefrontal cortex, hippocampus, and striatum and increased in the nucleus accumbens, while 2-arachidonoylglycerol (2-AG) levels were increased in the prefrontal cortex and decreased in the nucleus accumbens with parallel changes in the expression of eCB metabolizing enzymes in several structures. It was also observed that CB receptor expression decreased in the hippocampus, dorsal striatum, and nucleus accumbens, and CB receptor expression decreased in the prefrontal cortex and hippocampus. In WKY rats, the levels of eCBs were reduced in the prefrontal cortex (2-AG) and dorsal striatum (AEA) and increased in the prefrontal cortex (AEA) with different changes in the expression of eCB metabolizing enzymes, while the CB receptor density was increased in several brain regions. These findings suggest that dysregulation in the eCB system is implicated in the pathogenesis of depression, although neurochemical changes were linked to the particular brain structure and the factor inducing depression (surgical removal of the olfactory bulbs vs. genetic modulation). |
[Mh] Termos MeSH primário: |
Ácidos Araquidônicos/metabolismo Encéfalo/metabolismo Depressão/metabolismo Endocanabinoides/metabolismo Glicerídeos/metabolismo Alcamidas Poli-Insaturadas/metabolismo Receptor CB1 de Canabinoide/biossíntese Receptor CB2 de Canabinoide/biossíntese
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[Mh] Termos MeSH secundário: |
Amidoidrolases/biossíntese Animais Modelos Animais de Doenças Resposta de Imobilidade Tônica Lipase Lipoproteica/biossíntese Masculino Monoacilglicerol Lipases/biossíntese Bulbo Olfatório/cirurgia Fosfolipase D/biossíntese Ratos Ratos Endogâmicos WKY
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (Glycerides); 0 (Polyunsaturated Alkamides); 0 (Receptor, Cannabinoid, CB1); 0 (Receptor, Cannabinoid, CB2); 8D239QDW64 (glyceryl 2-arachidonate); EC 3.1.1.23 (Monoacylglycerol Lipases); EC 3.1.1.34 (Lipoprotein Lipase); EC 3.1.4.4 (NAPE-PLD protein, rat); EC 3.1.4.4 (Phospholipase D); EC 3.5.- (Amidohydrolases); EC 3.5.1.- (fatty-acid amide hydrolase); UR5G69TJKH (anandamide) |
[Em] Mês de entrada: | 1710 |
[Cu] Atualização por classe: | 171002 |
[Lr] Data última revisão:
| 171002 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170302 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1007/s12640-017-9708-y |
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