[PMID]: | 28257417 |
[Au] Autor: | Chicote JU; DeSalle R; García-España A |
[Ad] Endereço: | Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain. |
[Ti] Título: | Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification. |
[So] Source: | PLoS One;12(3):e0172887, 2017. |
[Is] ISSN: | 1932-6203 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Subtype R3 phosphotyrosine phosphatase receptors (R3 RPTPs) are single-spanning membrane proteins characterized by a unique modular composition of extracellular fibronectin repeats and a single cytoplasmatic protein tyrosine phosphatase (PTP) domain. Vertebrate R3 RPTPs consist of five members: PTPRB, PTPRJ, PTPRH and PTPRO, which dephosphorylate tyrosine residues, and PTPRQ, which dephosphorylates phophoinositides. R3 RPTPs are considered novel therapeutic targets in several pathologies such as ear diseases, nephrotic syndromes and cancer. R3 RPTP vertebrate receptors, as well as their known invertebrate counterparts from animal models: PTP52F, PTP10D and PTP4e from the fruitfly Drosophila melanogaster and F44G4.8/DEP-1 from the nematode Caenorhabditis elegans, participate in the regulation of cellular activities including cell growth and differentiation. Despite sharing structural and functional properties, the evolutionary relationships between vertebrate and invertebrate R3 RPTPs are not fully understood. Here we gathered R3 RPTPs from organisms covering a broad evolutionary distance, annotated their structure and analyzed their phylogenetic relationships. We show that R3 RPTPs (i) have probably originated in the common ancestor of animals (metazoans), (ii) are variants of a single ancestral gene in protostomes (arthropods, annelids and nematodes); (iii) a likely duplication of this ancestral gene in invertebrate deuterostomes (echinodermes, hemichordates and tunicates) generated the precursors of PTPRQ and PTPRB genes, and (iv) R3 RPTP groups are monophyletic in vertebrates and have specific conserved structural characteristics. These findings could have implications for the interpretation of past studies and provide a framework for future studies and functional analysis of this important family of proteins. |
[Mh] Termos MeSH primário: |
Evolução Molecular Filogenia Proteínas Tirosina Fosfatases Classe 3 Semelhantes a Receptores/genética
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[Mh] Termos MeSH secundário: |
Animais Caenorhabditis elegans/genética Diferenciação Celular/genética Sequência Conservada/genética Proteínas de Drosophila/genética Drosophila melanogaster/genética Seres Humanos Proteínas Tirosina Fosfatases/genética Proteínas Tirosina Fosfatases Classe 4 Semelhantes a Receptores/genética Transdução de Sinais/genética
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Drosophila Proteins); EC 3.1.3.48 (Protein Tyrosine Phosphatases); EC 3.1.3.48 (Ptp10D protein, Drosophila); EC 3.1.3.48 (Ptp4E protein, Drosophila); EC 3.1.3.48 (Ptp52F protein, Drosophila); EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 3); EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 4) |
[Em] Mês de entrada: | 1708 |
[Cu] Atualização por classe: | 170822 |
[Lr] Data última revisão:
| 170822 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170304 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pone.0172887 |
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