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[PMID]:28659346
[Au] Autor:Heianza Y; Sun D; Wang T; Huang T; Bray GA; Sacks FM; Qi L
[Ad] Endereço:Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
[Ti] Título:Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial.
[So] Source:Diabetes;66(9):2416-2423, 2017 Sep.
[Is] ISSN:1939-327X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salivary and pancreatic amylases (encoded by and genes, respectively) are responsible for digesting starchy foods. and show copy number variations that affect differences in amylase amount and activity, and copies have been associated with adiposity. We investigated whether genetic variants determining amylase gene copies are associated with 2-year changes in adiposity among 692 overweight and obese individuals who were randomly assigned to diets varying in macronutrient content. We found that changes in body weight (BW) and waist circumference (WC) were significantly different according to the rs11185098 genotype. Individuals carrying the A allele (indicating higher amylase amount and activity) showed a greater reduction in BW and WC at 6, 12, 18, and 24 months than those without the A allele ( < 0.05 for all). The association was stronger for long-term changes compared with short-term changes of these outcomes. The genetic effects on these outcomes did not significantly differ across diet groups. In conclusion, the genetic variant determining starch metabolism influences the response to weight-loss dietary intervention. Overweight and obese individuals carrying the rs11185098 genotype associated with higher amylase activity may have greater loss of adiposity during low-calorie diet interventions.
[Mh] Termos MeSH primário: Proteínas de Ligação a DNA/metabolismo
Variação Genética
Obesidade/dietoterapia
Obesidade/genética
alfa-Amilases Pancreáticas/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Adiposidade
Adulto
Biomarcadores
Proteínas de Ligação a DNA/genética
Dieta Redutora
Feminino
Regulação Enzimológica da Expressão Gênica
Genótipo
Seres Humanos
Masculino
Meia-Idade
alfa-Amilases Pancreáticas/genética
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (DNA-Binding Proteins); 0 (MYCBP protein, human); 0 (Transcription Factors); EC 3.2.1.1 (AMY2A protein, human); EC 3.2.1.1 (AMY2B protein, human); EC 3.2.1.1 (Pancreatic alpha-Amylases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.2337/db16-1482


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[PMID]:28537561
[Au] Autor:Baj J; Radzikowska E; Maciejewski M; Dabrowski A; Torres K
[Ad] Endereço:1 Chair and Department of Human Anatomy, Medical University of Lublin, Poland; Head: prof. dr hab. n. med. Ryszard Maciejewski.
[Ti] Título:Prediction of acute pancreatitis in the earliest stages - role of biochemical parameters and histopathological changes.
[So] Source:Pol Przegl Chir;89(2):31-38, 2017 Apr 30.
[Is] ISSN:2299-2847
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:For many years, there has been a search for a set of biochemical parameters that could facilitate the assessment of severity, prognosis, and administration of early and appropriate treatment in acute pancreatitis. Administration of treatment within the first 48 hours since admission is associated with many problems of distinguishing patients with a mild form of acute pancreatitis (AP) from those with a severe form of acute pancreatitis. STUDY AIM: To assess the relationship between the extent of change in the concentration of 10 selected biochemical indicators: amylase, lipase, total bilirubin, creatinine, uric acid, aspartate transaminase, alanine transaminase, glucose, magnesium, and iron and histopathological lesions in the pancreas within 2 and 6 hours since induction of AP. The selected time periods correspond to the first and the second day of the disease in people, respectively. MATERIAL AND METHODS: The experiments were conducted in 110 male Wistar rats weighing from 250 to 300 g. Experimental animals were divided into three groups: Z - a group in which the ranges of the studied factors and histological structure were established; K - a group of animals operated on which were injected with 0.9% NaCl into the biliary-pancreatic duct; E - a group of animals operated on in which acute pancreatitis was induced by an injection of 5% sodium taurocholate into the biliary-pancreatic duct. Animals from the K and E groups were randomly assigned to one of five subgroups from which the material for biochemical and histological examinations was collected at 2 h and 6 h since the induction of AP. Whole pancreases were dissected for histological examinations, and the samples were dyed with hematoxylin and saturated alcoholic eosin solution. The degree of pancreatic lesions was assessed according to the Spormann score. Quantitative variables were characterized by arithmetic means, standard deviations, medians, minimum and maximum values, and 95% CIs. RESULTS: In histological preparations from rats from the E group, after 2 hours, edematous lesions, neutrophilic infiltrations in the pancreatic parenchyma, together with single petechiae started to appear and were observed. After 6 hours, the lesions became more intense, and minor foci of coagulation necrosis and minor foci of purulent inflammation in the fatty tissue appeared. Within 2 hours, statistically significant differences in the amount of four markers: creatinine, ALT, amylase, and magnesium were observed. After six hours, statistically significant differences in the amount of two markers: AST and glucose were seen. The correlations between histological assessments according to the Spormann scale and biochemical indicators were investigated, and it was observed that within 2 hours the intensity of pancreatitis increased together with an increase in AST. In group K, within 6 hours, the intensity of inflammatory infiltration increased together with an increase in creatinine concentration (correlation coefficient 0.95; p=0.0138). In group E, in the period of 2 hours, lesion intensity in the form of inflammatory infiltration increased together with an increase in the AST level (correlation coefficient 0.90; p=0.0063) and an increase in the iron level (correlation coefficient 0.78; p=0.0399). In the same group and in the same period, an increase in the AST level (correlation coefficient 0.79; p=0.0343) was associated with an increase in lesion intensity in the form of ecchymoses. Inflammatory infiltration increased (correlation coefficient -0.87; p=0.0117) within 6 hours, whereas the creatinine level decreased. Interesting results were obtained with the use of regression analysis - forward stepwise regression. In the period of 2 hours, if the creatinine level increased by 1, the intensity of lesions in acute pancreatitis decreased by 9.02, according to the Spormann score, while the other variables remained at a stable level. However, if ALT level increased by 1, the intensity of lesions in acute pancreatitis increased by 0.02, according to the Spormann score; and if the amylase level increased by 1, the intensity of lesions in acute pancreatitis increased by 0.01, according to the Spormann score, while the other variables remained at a stable level. CONCLUSIONS: Histopathological lesions occurred prior to changes in laboratory test results, whereas significant correlations with Spormann scores were seen in the case of changes in AST and creatinine levels. The study results confirm the fact that diagnostics in acute pancreatitis is very difficult and requires monitoring of many laboratory parameters.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Pancreatite Necrosante Aguda/enzimologia
Pancreatite Necrosante Aguda/patologia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Amilases/sangue
Animais
Aspartato Aminotransferases/sangue
Modelos Animais de Doenças
L-Lactato Desidrogenase/sangue
alfa-Amilases Pancreáticas/sangue
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.2.1.- (Amylases); EC 3.2.1.1 (Pancreatic alpha-Amylases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.5604/01.3001.0009.9153


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[PMID]:28428356
[Au] Autor:Carobene A; Røraas T; Sølvik UØ; Sylte MS; Sandberg S; Guerra E; Marino I; Jonker N; Barla G; Bartlett WA; Fernandez-Calle P; Díaz-Garzón J; Tosato F; Plebani M; Coskun A; Serteser M; Unsal I; Ceriotti F; European Biological Variation Study of the EFLM Working Group on Biological Variation
[Ad] Endereço:Servizio Medicina di Laboratorio, Ospedale San Raffaele, Milan, Italy; carobene.anna@hsr.it.
[Ti] Título:Biological Variation Estimates Obtained from 91 Healthy Study Participants for 9 Enzymes in Serum.
[So] Source:Clin Chem;63(6):1141-1150, 2017 Jun.
[Is] ISSN:1530-8561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We sought to develop estimates of biological variation (BV) for 9 enzymes in blood serum as part of the European Biological Variation Study. METHODS: Ninety-one healthy study participants (38 male and 53 female, 21-69 years old) were phlebotomized in each of 10 consecutive weeks at 6 European laboratories. The same preanalytical sample-handling protocol was followed at each center before transport to San Raffaele Hospital, Milan, Italy, for analysis. Sera were stored at -80 °C before analysis in duplicate within a single run on an ADVIA 2400 Clinical Chemistry System (Siemens Healthcare) following a protocol designed to minimize analytical imprecision. Assay traceability was established using frozen sera with target values assigned by reference methods. The results were subjected to outlier analysis before CV-ANOVA to deliver valid BV estimates. Results for 9 enzymes were subsequently partitioned for graphical display allowing visual assessment of the effects of country of origin, sex, and age on BV estimates. RESULTS: We found no effect of country upon the observed variation, but overall sex-related differences were evident for alanine amino transferase (ALT), γ-glutamyl transferase (GGT), and creatine kinase (CK). The following estimates for within-subject BV (CV ) and between-subject BV (CV ), respectively, were obtained: ALT: 9.3%, 28.2%; aspartate aminotransferase: 9.5%, 20.3%; GGT: 8.9%, 41.7%; alkaline phosphatase : 5.3%, 24.9%; lactate dehydrogenase: 5.2%, 12.6%; CK: 14.5%, 31.5%; amylase: 6.8%, 30.4%; pancreatic α-amylase: 6.3%, 24.9%; and lipase (LIP): 7.7%, 23.8%. CONCLUSIONS: All CV and some CV estimates were lower than those reported in the online BV 2014 updated database. Analytical performance specifications derived from BV can be applied internationally.
[Mh] Termos MeSH primário: Ensaios Enzimáticos Clínicos
[Mh] Termos MeSH secundário: Adulto
Idoso
Alanina Transaminase/sangue
Alanina Transaminase/metabolismo
Fosfatase Alcalina/sangue
Fosfatase Alcalina/metabolismo
Amilases/sangue
Amilases/metabolismo
Aspartato Aminotransferases/sangue
Aspartato Aminotransferases/metabolismo
Creatina Quinase/sangue
Creatina Quinase/metabolismo
Feminino
Voluntários Saudáveis
Seres Humanos
L-Lactato Desidrogenase/sangue
L-Lactato Desidrogenase/metabolismo
Lipase/sangue
Lipase/metabolismo
Masculino
Meia-Idade
alfa-Amilases Pancreáticas/sangue
alfa-Amilases Pancreáticas/metabolismo
Adulto Jovem
gama-Glutamiltransferase/sangue
gama-Glutamiltransferase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 2.7.3.2 (Creatine Kinase); EC 3.1.1.3 (Lipase); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.2.1.- (Amylases); EC 3.2.1.1 (Pancreatic alpha-Amylases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1373/clinchem.2016.269811


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[PMID]:28278221
[Au] Autor:Masuda Y; Nakayama Y; Tanaka A; Naito K; Konishi M
[Ad] Endereço:Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
[Ti] Título:Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.
[So] Source:PLoS One;12(3):e0173621, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated with modulation of the host immune system. In this study, we found that oral administration of YM-2A could inhibit tumor growth and improve survival rate in two distinct mouse models of colon-26 carcinoma and B16 melanoma. Orally administered YM-2A enhanced antitumor immune response by increasing INF-γ-expressing CD4+ and CD8+ cells in the spleen and INF-γ-expressing CD8+ cells in tumor-draining lymph nodes. In vitro study showed that YM-2A directly activated splenic CD11b+ myeloid cells, peritoneal macrophages and bone marrow-derived dendritic cells, but did not affect splenic CD11b- lymphocytes or colon-26 tumor cells. YM-2A is more slowly digested by pancreatic α-amylase than are amylopectin and rabbit liver glycogen, and orally administered YM-2A enhanced the expression of MHC class II and CD86 on dendritic cells and the expression of MHC class II on macrophages in Peyer's patches. Furthermore, in vitro stimulation of YM-2A increased the expression of pro-inflammatory cytokines in Peyer's patch CD11c+ cells. These results suggest that orally administered YM-2A can activate dendritic cells and macrophages in Peyer's patches, inducing systemic antitumor T-cell response. Thus, YM-2A might be a candidate for an oral therapeutic agent in cancer immunotherapy.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Neoplasias do Colo/tratamento farmacológico
Glucanos/farmacologia
Grifola/química
Melanoma Experimental/tratamento farmacológico
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos
Administração Oral
Animais
Antineoplásicos/administração & dosagem
Neoplasias do Colo/imunologia
Citocinas/metabolismo
Feminino
Glucanos/administração & dosagem
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Macrófagos/metabolismo
Melanoma Experimental/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
alfa-Amilases Pancreáticas/metabolismo
Baço/efeitos dos fármacos
Baço/imunologia
Baço/metabolismo
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antineoplastic Agents); 0 (Cytokines); 0 (Glucans); EC 3.2.1.1 (Pancreatic alpha-Amylases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173621


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[PMID]:28228143
[Au] Autor:Bonnefond A; Yengo L; Dechaume A; Canouil M; Castelain M; Roger E; Allegaert F; Caiazzo R; Raverdy V; Pigeyre M; Arredouani A; Borys JM; Lévy-Marchal C; Weill J; Roussel R; Balkau B; Marre M; Pattou F; Brousseau T; Froguel P
[Ad] Endereço:University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, 59000, France. amelie.bonnefond@inserm.fr.
[Ti] Título:Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach.
[So] Source:BMC Med;15(1):37, 2017 Feb 23.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. METHODS: We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of AMY1A (encoding AMY1) or AMY2A (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between AMY1A copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index (BMI)-related plasma metabolites and AMY1 or AMY2 activity. RESULTS: We evidenced strong associations between AMY1 or AMY2 activity and lower BMI. However, we found a modest contribution of AMY1A copy number to lower BMI. Mendelian randomization identified a causal negative effect of BMI on AMY1 and AMY2 activities. Yet, we also found a significant negative contribution of AMY1 activity at baseline to the change in BMI during the 9-year follow-up, and a significant contribution of AMY1A copy number to lower obesity risk in children, suggesting a bidirectional relationship between AMY1 activity and adiposity. Metabonomics identified a BMI-independent association between AMY1 activity and lactate, a product of complex carbohydrate fermentation. CONCLUSIONS: These findings provide new insights into the involvement of amylase in adiposity and starch metabolism.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Obesidade/enzimologia
alfa-Amilases Pancreáticas/metabolismo
alfa-Amilases Salivares/metabolismo
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Biologia de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.2.1.1 (AMY1A protein, human); EC 3.2.1.1 (AMY2A protein, human); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.2.1.1 (Salivary alpha-Amylases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1186/s12916-017-0784-x


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[PMID]:27855503
[Au] Autor:Ben Gara A; Ben Abdallah Kolsi R; Jardak N; Chaaben R; El-Feki A; Fki L; Belghith H; Belghith K
[Ad] Endereço:a Laboratory of Plant Biotechnology Applied to the Improvement of Cultures , Faculty of Sciences of Sfax , Sfax , Tunisia.
[Ti] Título:Inhibitory activities of Cystoseira crinita sulfated polysaccharide on key enzymes related to diabetes and hypertension: in vitro and animal study.
[So] Source:Arch Physiol Biochem;123(1):31-42, 2017 Feb.
[Is] ISSN:1744-4160
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study investigated the effect of the Cystoseira crinita sulfated polysaccharide (CCSP) on key enzymes activities related to diabetes in vitro and in diabetic rats. We found that CCSP inhibited pancreatic α-amylase with IC = 39.16 µg/ml and angiotensin I-converting enzyme (ACE) activity with IC = 58.35 µg/ml in vitro. In diabetic rats, the administration of CCSP reduced the activity of α-amylase in serum, pancreas, and intestine by 23%, 44.38%, and 45%, respectively as compared to untreated diabetic rats. Moreover, the administration of CCSP to surviving diabetic rats protects pancreas ß cells from death and damage, which leads to insulin levels. The decrease in α-amylase and the increase in insulin level lead to a decrease in glucose rate by 56% as compared to untreated diabetic rats. The inhibitory action of α-amylase activity and hypoglycemic effect of CCSP were confirmed by oral glucose tolerance test (OGTT). In addition, the administration of CCSP to surviving diabetic rats normalizes lipid profile, stimulates antioxidant capacity, and prevents liver-kidney toxicities, evidenced by decrease in serum indices of liver and kidney toxicity and confirmed by histological analysis. The overall findings presented in this study demonstrate that the administration of CCSP to diabetic rats can make it a potentially strong candidate for industrial application as a pharmacological agent for the treatment of hyperglycemia, hyperlipidemia, and liver-kidney dysfunctions.
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Diabetes Mellitus Tipo 2/tratamento farmacológico
Inibidores Enzimáticos/uso terapêutico
Hipertensão/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Feófitas/química
Polissacarídeos/uso terapêutico
[Mh] Termos MeSH secundário: Inibidores da Enzima Conversora de Angiotensina/química
Inibidores da Enzima Conversora de Angiotensina/isolamento & purificação
Inibidores da Enzima Conversora de Angiotensina/metabolismo
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Animais
Anti-Hipertensivos/química
Anti-Hipertensivos/isolamento & purificação
Anti-Hipertensivos/metabolismo
Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Produtos Biológicos/metabolismo
Produtos Biológicos/uso terapêutico
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/patologia
Diabetes Mellitus Tipo 2/fisiopatologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/metabolismo
Hipertensão/metabolismo
Hipertensão/patologia
Hipertensão/fisiopatologia
Hipoglicemiantes/química
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/metabolismo
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/enzimologia
Mucosa Intestinal/metabolismo
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/enzimologia
Intestino Delgado/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Rim/fisiopatologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Fígado/fisiopatologia
Masculino
Mar Mediterrâneo
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
alfa-Amilases Pancreáticas/antagonistas & inibidores
alfa-Amilases Pancreáticas/sangue
alfa-Amilases Pancreáticas/metabolismo
Peptidil Dipeptidase A/química
Peptidil Dipeptidase A/metabolismo
Feófitas/crescimento & desenvolvimento
Polissacarídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Antihypertensive Agents); 0 (Biological Products); 0 (Enzyme Inhibitors); 0 (Hypoglycemic Agents); 0 (Polysaccharides); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1080/13813455.2016.1232737


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[PMID]:27588327
[Au] Autor:Asha MK; Debraj D; Dethe S; Bhaskar A; Muruganantham N; Deepak M
[Ad] Endereço:a Microbiology Department , Natural Remedies Private Limited , Bangalore , India.
[Ti] Título:Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes.
[So] Source:J Diet Suppl;14(3):323-333, 2017 May 04.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Flavonoid-rich extract prepared from Glycyrrhiza glabra has been found to be beneficial in patients with functional dyspepsia and was reported to possess some gut health-promoting properties such as antioxidant, anti-inflammatory and anti-Helicobacter pylori activities. In the present study, the flavonoid-rich extract of Glycyrrhiza glabra was evaluated for its compatibility with probiotic strains (Lactobacillus casei, Lactobacillus fermentum, Lactobacillus plantarum, and Streptococcus thermophilus), commercial probiotic drinks, and digestive enzymes (pancreatic α-amylase, α-glucosidase, phytase, xylanase, and pancreatic lipase). Results of this study indicated that the flavonoid-rich extract of Glycyrrhiza glabra is compatible with the tested probiotic strains, probiotic drinks and digestive enzymes.
[Mh] Termos MeSH primário: Digestão/efeitos dos fármacos
Flavonoides/farmacologia
Microbioma Gastrointestinal/efeitos dos fármacos
Glycyrrhiza/química
Extratos Vegetais/farmacologia
Probióticos
[Mh] Termos MeSH secundário: 6-Fitase/efeitos dos fármacos
Endo-1,4-beta-Xilanases/efeitos dos fármacos
Seres Humanos
Lactobacillus/efeitos dos fármacos
Lipase/efeitos dos fármacos
alfa-Amilases Pancreáticas/efeitos dos fármacos
Soluções
alfa-Glucosidases/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Solutions); EC 3.1.1.3 (Lipase); EC 3.1.3.26 (6-Phytase); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.2.1.20 (alpha-Glucosidases); EC 3.2.1.8 (Endo-1,4-beta Xylanases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE


  8 / 116 MEDLINE  
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[PMID]:27555294
[Au] Autor:Raja RA; Schmiegelow K; Sørensen DN; Frandsen TL
[Ad] Endereço:Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
[Ti] Título:Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia.
[So] Source:Pediatr Blood Cancer;64(1):32-38, 2017 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: l-Asparaginase is an important drug for treatment of childhood acute lymphoblastic leukemia (ALL), but is associated with serious toxicities, including pancreatitis and hypertriglyceridemia (HTG). Asparaginase-associated pancreatitis (AAP) is a common reason for stopping asparaginase treatment. The aim of this study was to explore if HTG or early elevations in pancreatic enzymes were associated with the subsequent development of AAP. METHOD: Children (1.0-17.9 years) diagnosed with ALL, treated with asparaginase for 30 weeks, according to the NOPHO ALL2008 protocol at the University Hospital Rigshospitalet, Copenhagen, Denmark, were eligible. Pancreatic enzymes, triglycerides, and cholesterol were measured regularly. RESULTS: Thirty-one patients were included. Seven patients were diagnosed with AAP. HTG was most evident when PEG-asparaginase and dexamethasone were administered concomitantly. Overall, there was no significant difference in triglyceride levels in patients who experienced AAP and patients who did not. An increase in triglyceride levels during concomitant dexamethasone therapy in delayed intensification was significantly associated with an increase in pancreas-specific amylase levels two weeks later (P = 0.005). CONCLUSIONS: AAP does not seem to be associated with HTG. Continuous monitoring of pancreas enzymes does not predict AAP.
[Mh] Termos MeSH primário: Asparaginase/efeitos adversos
Biomarcadores Tumorais/metabolismo
Hipertrigliceridemia/epidemiologia
alfa-Amilases Pancreáticas/sangue
Pancreatite/induzido quimicamente
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Dinamarca/epidemiologia
Feminino
Seguimentos
Seres Humanos
Hipertrigliceridemia/diagnóstico
Lactente
Masculino
Estadiamento de Neoplasias
Pancreatite/sangue
Pancreatite/diagnóstico
Leucemia-Linfoma Linfoblástico de Células Precursoras/enzimologia
Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Triglycerides); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.5.1.1 (Asparaginase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26183


  9 / 116 MEDLINE  
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[PMID]:27406651
[Au] Autor:Arendt M; Cairns KM; Ballard JW; Savolainen P; Axelsson E
[Ad] Endereço:Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
[Ti] Título:Diet adaptation in dog reflects spread of prehistoric agriculture.
[So] Source:Heredity (Edinb);117(5):301-306, 2016 Nov.
[Is] ISSN:1365-2540
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shift related to the subsequent development of agriculture. Previous efforts to study this process were based on geographically limited data sets and low-resolution methods, and it is therefore not known to what extent the diet adaptations are universal among dogs and whether there are regional differences associated with alternative human subsistence strategies. Here we use droplet PCR to investigate worldwide AMY2B copy number diversity among indigenous as well as breed dogs and wolves to elucidate how a change in dog diet was associated with the domestication process and subsequent shifts in human subsistence. We find that AMY2B copy numbers are bimodally distributed with high copy numbers (median 2n =11) in a majority of dogs but no, or few, duplications (median 2n =3) in a small group of dogs originating mostly in Australia and the Arctic. We show that this pattern correlates geographically to the spread of prehistoric agriculture and conclude that the diet change may not have been associated with initial domestication but rather the subsequent development and spread of agriculture to most, but not all regions of the globe.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Agricultura
Variações do Número de Cópias de DNA
Dieta
Cães/genética
alfa-Amilases Pancreáticas/genética
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Regiões Árticas
Austrália
Cruzamento
Canidae/genética
Cães/fisiologia
Domesticação
Amido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9005-25-8 (Starch); EC 3.2.1.1 (Pancreatic alpha-Amylases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160714
[St] Status:MEDLINE
[do] DOI:10.1038/hdy.2016.48


  10 / 116 MEDLINE  
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[PMID]:27383890
[Au] Autor:Terra Gde P; Vinícius De Farias M; Trevisan MG; Garcia JS
[Ti] Título:Evaluation of pancreatin stability through enzyme activity determination.
[So] Source:Acta Pharm;66(3):423-31, 2016 Sep 01.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Pancreatin is a biotechnological product containing an enzyme complex, obtained from porcine pancreas, that is employed in treating pancreatic diseases. Experiments regarding the stability of the pharmaceutical formulation containing pancreatin were performed using standard binary mixtures with 6 excipients in a 1:1 ratio (m/m) and a commercial formulation. To accomplish these goals, samples were stored for 1, 3 and 6 months at 40 ± 1 °C and 75 ± 5 % relative humidity (RH) and 40 ± 1 °C and 0 % RH. Stress testing was also performed. All samples were analyzed to evaluate the α-amylase, lipase and protease activities through UV/Vis spectrophotometry. The results revealed that the excipient proprieties and the storage conditions affected enzyme stability. Humidity was a strong influencing factor in the reduction of α-amylase and protease activities. Stress testing indicated that pH 9.0 and UV light did not induce substantial alterations in enzyme activity.
[Mh] Termos MeSH primário: Excipientes/química
Fármacos Gastrointestinais/metabolismo
Pancreatina/metabolismo
[Mh] Termos MeSH secundário: Animais
Brasil
Química Farmacêutica
Estabilidade de Medicamentos
Armazenamento de Medicamentos
Estabilidade Enzimática
Fármacos Gastrointestinais/química
Guias como Assunto
Temperatura Alta/efeitos adversos
Umidade/efeitos adversos
Concentração de Íons de Hidrogênio
Lipase/química
Lipase/metabolismo
Oxirredução
alfa-Amilases Pancreáticas/química
alfa-Amilases Pancreáticas/metabolismo
Pancreatina/química
Peptídeo Hidrolases/química
Peptídeo Hidrolases/metabolismo
Pós
Sus scrofa
Raios Ultravioleta/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Gastrointestinal Agents); 0 (Powders); 8049-47-6 (Pancreatin); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE



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