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[PMID]:28457753
[Au] Autor:Sadovnik I; Herrmann H; Eisenwort G; Blatt K; Hoermann G; Mueller N; Sperr WR; Valent P
[Ad] Endereço:Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria.
[Ti] Título:Expression of CD25 on leukemic stem cells in BCR-ABL1 CML: Potential diagnostic value and functional implications.
[So] Source:Exp Hematol;51:17-24, 2017 07.
[Is] ISSN:1873-2399
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chronic myeloid leukemia (CML) is a stem cell-derived leukemia in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1. The disease is characterized by an accumulation of myeloid precursor cells in the peripheral blood and bone marrow (BM). A small fraction of neoplastic cells in the CML clone supposedly exhibits self-renewal and thus long-term disease-propagating ability. However, so far, little is known about the phenotype, function, and target expression profiles of these leukemic stem cells (LSCs). Recent data suggest that CML LSCs aberrantly express the interleukin-2 receptor alpha chain CD25. Whereas normal CD34 /CD38 BM stem cells display only low amounts of CD25 or lack CD25 altogether, CD34 /CD38 LSCs express CD25 strongly in more than 90% of all patients with untreated CML. As a result, CD25 can be used to identify and quantify CML LSCs. In addition, it has been shown that CD25 serves as a negative growth regulator of CML LSCs. Here, we review the value of CD25 as a novel marker and potential drug target in CML LSCs.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/biossíntese
Proteínas de Fusão bcr-abl/metabolismo
Regulação Leucêmica da Expressão Gênica
Subunidade alfa de Receptor de Interleucina-2/biossíntese
Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico
Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo
Proteínas de Neoplasias/metabolismo
Células-Tronco Neoplásicas/metabolismo
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/metabolismo
Antígenos CD34/metabolismo
Células da Medula Óssea/metabolismo
Seres Humanos
Glicoproteínas de Membrana/metabolismo
Células-Tronco Neoplásicas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (BCR-ABL1 fusion protein, human); 0 (Biomarkers, Tumor); 0 (IL2RA protein, human); 0 (Interleukin-2 Receptor alpha Subunit); 0 (Membrane Glycoproteins); 0 (Neoplasm Proteins); EC 2.7.10.2 (Fusion Proteins, bcr-abl); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  2 / 2609 MEDLINE  
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[PMID]:28461108
[Au] Autor:Santaguida MG; Gatto I; Mangino G; Virili C; Stramazzo I; Fallahi P; Antonelli A; Segni M; Romeo G; Centanni M
[Ad] Endereço:Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.
[Ti] Título:BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases.
[So] Source:Clin Immunol;184:42-47, 2017 11.
[Is] ISSN:1521-7035
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT+NEAD. Th17 were higher in patients with isolated HT than in HD but no further changes were seen in patients with HT+NEAD. CD24 CD38 unstimulated Breg cells were similar in HT patients and in HD, but significantly higher in patients with HT+NEAD than in both HT and in HD. CD19 CD24 CD27 Breg memory phenotype was similar in HD and in HT patients, but decreased in patients with HT+NEAD (23.4%vs38.5%). Upon CpG-stimulation, CD24 CD38 IL-10 Breg cells were higher in HT patients than in HD (3.9%vs1.8%) but similar in patients with HT+NEAD (2.4%).
[Mh] Termos MeSH primário: Linfócitos B Reguladores/imunologia
Doença Celíaca/imunologia
Gastrite Atrófica/imunologia
Doença de Hashimoto/imunologia
Células Th17/imunologia
Vitiligo/imunologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/imunologia
Adulto
Antígenos CD19/imunologia
Doenças Autoimunes/complicações
Doenças Autoimunes/imunologia
Antígeno CD24/imunologia
Estudos de Casos e Controles
Doença Celíaca/complicações
Feminino
Gastrite Atrófica/complicações
Doença de Hashimoto/complicações
Seres Humanos
Interleucina-10/imunologia
Masculino
Glicoproteínas de Membrana/imunologia
Meia-Idade
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia
Vitiligo/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD19); 0 (CD19 molecule, human); 0 (CD24 Antigen); 0 (CD24 protein, human); 0 (IL10 protein, human); 0 (Membrane Glycoproteins); 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7); 130068-27-8 (Interleukin-10); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 2609 MEDLINE  
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[PMID]:27778417
[Au] Autor:Martins C; Lima J; Nunes G; Borrego LM
[Ad] Endereço:CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Lisbon, Portugal.
[Ti] Título:Pregnancy alters the circulating B cell compartment in atopic asthmatic women, and transitional B cells are positively associated with the development of allergy manifestations in their progeny.
[So] Source:Am J Reprod Immunol;76(6):465-474, 2016 Dec.
[Is] ISSN:1600-0897
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:PROBLEM: Maternal atopy is a risk factor for allergy. B cells are poorly studied in reproduction and atopy. We aimed to assess how pregnancy affects B cells in atopic women and whether B cells relate to allergic manifestations in offspring. METHOD OF STUDY: Women with and without atopic asthma, pregnant and non-pregnant were enrolled for the study, and circulating B cells were evaluated by flow cytometry, using CD19, CD27, CD38, IgD, and IgM. RESULTS: Compared to healthy non-pregnant, atopic asthmatic non-pregnant (ANP) women presented increased B cell counts, enlarged memory subsets, less transitional cells, and plasmablasts. Atopic asthmatic pregnant (AP) and healthy pregnant (HP) women showed similarities: reduced B cell counts and percentages, fewer memory cells, especially switched, and higher plasmablast percentages. Transitional B cell percentages were increased in AP women with allergic manifestations in their progeny. CONCLUSION: Atopic asthmatic non-pregnant women have a distinctive B cell compartment. B cells change in pregnancy, similarly in AP and HP women. The recognition that AP women with allergy in their progeny have a typical immune profile may help, in the future, the adoption of preventive measures to avoid the manifestation of allergic diseases in their newborns.
[Mh] Termos MeSH primário: Asma/imunologia
Linfócitos B/imunologia
Hipersensibilidade Imediata/imunologia
Memória Imunológica
Herança Materna/imunologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/genética
ADP-Ribosil Ciclase 1/imunologia
Adulto
Antígenos CD19/genética
Antígenos CD19/imunologia
Asma/diagnóstico
Asma/genética
Asma/patologia
Linfócitos B/patologia
Estudos de Casos e Controles
Feminino
Expressão Gênica
Seres Humanos
Hipersensibilidade Imediata/diagnóstico
Hipersensibilidade Imediata/genética
Hipersensibilidade Imediata/patologia
Imunoglobulina D/sangue
Imunoglobulina M/sangue
Imunofenotipagem
Recém-Nascido
Doenças do Recém-Nascido
Contagem de Linfócitos
Glicoproteínas de Membrana/genética
Glicoproteínas de Membrana/imunologia
Gravidez
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD19); 0 (CD19 molecule, human); 0 (Immunoglobulin D); 0 (Immunoglobulin M); 0 (Membrane Glycoproteins); 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/aji.12595


  4 / 2609 MEDLINE  
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[PMID]:28972094
[Au] Autor:Abana CO; Pilkinton MA; Gaudieri S; Chopra A; McDonnell WJ; Wanjalla C; Barnett L; Gangula R; Hager C; Jung DK; Engelhardt BG; Jagasia MH; Klenerman P; Phillips EJ; Koelle DM; Kalams SA; Mallal SA
[Ad] Endereço:Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
[Ti] Título:Cytomegalovirus (CMV) Epitope-Specific CD4 T Cells Are Inflated in HIV CMV Subjects.
[So] Source:J Immunol;199(9):3187-3201, 2017 Nov 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Select CMV epitopes drive life-long CD8 T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4 T cells specific for human CMV (HCMV) are elevated in HIV HCMV subjects. To determine whether HCMV epitope-specific CD4 T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4 T cells in coinfected HLA-DR7 long-term nonprogressor HIV subjects with undetectable HCMV plasma viremia. DYS-specific CD4 T cells were inflated among these HIV subjects compared with those from an HIV HCMV HLA-DR7 cohort or with HLA-DR7-restricted CD4 T cells from the HIV-coinfected cohort that were specific for epitopes of HCMV phosphoprotein-65, tetanus toxoid precursor, EBV nuclear Ag 2, or HIV gag protein. Inflated DYS-specific CD4 T cells consisted of effector memory or effector memory-RA subsets with restricted TCRß usage and nearly monoclonal CDR3 containing novel conserved amino acids. Expression of this near-monoclonal TCR in a Jurkat cell-transfection system validated fine DYS specificity. Inflated cells were polyfunctional, not senescent, and displayed high ex vivo levels of granzyme B, CX CR1, CD38, or HLA-DR but less often coexpressed CD38 and HLA-DR The inflation mechanism did not involve apoptosis suppression, increased proliferation, or HIV gag cross-reactivity. Instead, the findings suggest that intermittent or chronic expression of epitopes, such as DYS, drive inflation of activated CD4 T cells that home to endothelial cells and have the potential to mediate cytotoxicity and vascular disease.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Infecções por Citomegalovirus/imunologia
Citomegalovirus/imunologia
Epitopos de Linfócito T/imunologia
Infecções por HIV/imunologia
HIV-1/imunologia
Proteínas Virais/imunologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/imunologia
Linfócitos T CD4-Positivos/patologia
Infecções por Citomegalovirus/patologia
Feminino
Infecções por HIV/patologia
Antígeno HLA-DR7/imunologia
Seres Humanos
Memória Imunológica
Masculino
Glicoproteínas de Membrana/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epitopes, T-Lymphocyte); 0 (HLA-DR7 Antigen); 0 (Membrane Glycoproteins); 0 (Viral Proteins); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700851


  5 / 2609 MEDLINE  
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[PMID]:28934217
[Au] Autor:Gómez-Mora E; Massanella M; García E; Giles D; Bernadó M; Urrea V; Carrillo J; Ouchi D; Puig J; Negredo E; Clotet B; Blanco J; Cabrera C
[Ad] Endereço:IrsiCaixa AIDS Research Institute, Institut de Recerca Germans Trias i Pujol (IGTP), Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain.
[Ti] Título:Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.
[So] Source:PLoS One;12(9):e0184433, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some HIV-infected c-ART-suppressed individuals show incomplete CD4+ T-cell recovery, abnormal T-cell activation and higher mortality. One potential source of immune activation could be coinfection with cytomegalovirus (CMV). IgG and IgM levels, immune activation, inflammation and T-cell death in c-ART-suppressed individuals with CD4+ T-cell counts >350 cells/µL (immunoconcordant, n = 133) or <350 cells/µL (immunodiscordant, n = 95) were analyzed to evaluate the effect of CMV humoral response on immune recovery. In total, 27 HIV-uninfected individuals were included as controls. In addition, the presence of CMV IgM antibodies was retrospectively analyzed in 58 immunoconcordant individuals and 66 immunodiscordant individuals. Increased CMV IgG levels were observed in individuals with poor immune reconstitution (p = 0.0002). Increased CMV IgG responses were significantly correlated with lower nadir and absolute CD4+ T-cell counts. In contrast, CMV IgG responses were positively correlated with activation (HLA-DR+) and death markers in CD4+ T-cells and activated memory CD8+ T-cells (CD45RA-CD38+). Longitudinal subanalysis revealed an increased frequency of IgM+ samples in individuals with poor CD4+ T-cell recovery, and an association was observed between retrospective IgM positivity and the current level of IgG. The magnitude of the humoral immune response to CMV is associated with nadir CD4+ T-cell counts, inflammation, immune activation and CD4+ T-cell death, thus suggesting that CMV infection may be a relevant driving force in the increased morbidity/mortality observed in HIV+ individuals with poor CD4+ T-cell recovery.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Infecções por Citomegalovirus/imunologia
Infecções por HIV/tratamento farmacológico
Infecções por HIV/imunologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/sangue
Adulto
Fármacos Anti-HIV/uso terapêutico
Anticorpos Antivirais/sangue
Contagem de Linfócito CD4
Coinfecção/tratamento farmacológico
Coinfecção/imunologia
Citomegalovirus
Infecções por Citomegalovirus/complicações
Feminino
Seguimentos
Infecções por HIV/complicações
Antígenos HLA-DR/sangue
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Inflamação/complicações
Inflamação/imunologia
Masculino
Meia-Idade
Estudos Retrospectivos
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antibodies, Viral); 0 (HLA-DR Antigens); 0 (Immunoglobulin G); 0 (Immunoglobulin M); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184433


  6 / 2609 MEDLINE  
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[PMID]:28892514
[Au] Autor:El-Hamoly T; El-Sharawy DM; El Refaye MS; Abd El-Rahman SS
[Ad] Endereço:Drug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
[Ti] Título:L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization.
[So] Source:PLoS One;12(9):e0184157, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the renal cytotoxicity using in vivo and in vitro models. Swiss mice were exposed to gamma radiation (IRR, 6Gy) or treated with cisplatin (CIS, 15 mg/kg, i.p.) for induction of nephrotoxicity. Remarkably, pretreatment with L-TH (1µg/kg) ameliorated the elevated kidney function biomarkers, oxidative stress and protected the renal tissue from the subsequent cellular damage. Likewise, L-TH inhibited the apoptotic cascade by down-regulating the extreme consumption of the cellular energy (ATP), the expression of caspase-3 and Bax, and the stimulation of cyclic ADP ribose (cADPR)/calcium mobilization. Moreover, incubation with L-TH (120nM/4h) significantly blocked the cytotoxicity of CIS on Vero cells and the depletion of NAD+ content as well as modified the ADP-ribose cyclase (CD38) enzymatic activity. High doses of L-TH (up to30 nM/4h) inversely increased the radiosensitivity of Vero cells towards IRR (up to 6Gy). On the other hand, L-TH did not interfere CIS-induced cytotoxicity of colorectal adenocarcinoma (Caco-2) cell line. In conclusion, pretreatment with L-TH could be a promising protective approach to the renal cellular damage induced during either CIS or IRR therapy by regulating the unbalanced oxidative status, the expression of pro-apoptotic biomarkers via modulation of cADPR mediated-calcium mobilization.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Rim/efeitos dos fármacos
Rim/metabolismo
Substâncias Protetoras/farmacologia
Transdução de Sinais/efeitos dos fármacos
Tiroxina/farmacologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase/metabolismo
ADP-Ribosil Ciclase 1/metabolismo
Animais
Biomarcadores
Cálcio/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Cercopithecus aethiops
Fragmentação do DNA/efeitos dos fármacos
Rim/patologia
Rim/efeitos da radiação
Testes de Função Renal
Masculino
Camundongos
Mitocôndrias/metabolismo
Modelos Animais
Estresse Oxidativo/efeitos dos fármacos
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Protective Agents); EC 3.2.2.5 (ADP-ribosyl Cyclase); EC 3.2.2.6 (ADP-ribosyl Cyclase 1); Q51BO43MG4 (Thyroxine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184157


  7 / 2609 MEDLINE  
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[PMID]:28827034
[Au] Autor:Yu S; Qi Y; Wang H; Jiang J; Sun L; Zhou Q
[Ad] Endereço:Department of Ultrasound, The Second Hospital of Xi'an Jiao Tong University, Xi'an 710004, China.
[Ti] Título:Dysfunction of CD24+CD38+ B cells in patients with Hashimoto's thyroiditis is associated with a lack of interleukin 10.
[So] Source:Int J Biochem Cell Biol;90:114-120, 2017 Sep.
[Is] ISSN:1878-5875
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Autoimmune thyroid disease (AITD) is characterized by immune attacks on the person's own thyroid. Hashimoto's thyroiditis (HT) is a subtype of AITD and is a common cause of hypothyroidism and related symptoms. Regulatory B (Breg) cells can express interleukin 10 (IL-10) and have recently emerged as a critical participant in suppression pathogenic inflammation and promoting peripheral tolerance. The role of Breg cells in HT is not yet clear. In this study, we first examined the IL-10 production by B cells in healthy controls and HT patients, and found that the healthy control B cells demonstrated significantly higher IL-10 expression than HT B cells after CpG stimulation. In both groups, the IL-10-producing B cells were highly enriched in the CD24 CD38 compartment. However, compared to healthy controls, HT patients presented higher levels of circulating CD24 CD38 B cells, but lower percentage of IL-10 cells in the CD24 CD38 B cell compartment. In healthy controls, we performed coculture experiments of T cells with autologous total B cells, CD24 CD38 B cells, and non-CD24 CD38 B cells, and found significantly lower T cell proliferation as well as tumor necrosis factor (TNF) and interferon gamma (IFN-γ) production in cell cultures containing CD24 CD38 B cells. In contrast, the HT CD24 CD38 B cells demonstrated reduced capacity in suppressing T cell proliferation and did not suppress TNF and IFN-γ production. This lack of inhibitory activity in HT CD24 CD38 B cells was related to a lack of IL-10, since addition of exogenous IL-10 in CD24 CD38 B cell-T cell coculture significantly suppressed the proliferation of T cells and reduced proinflammatory cytokine secretion. Together, our study identified an upregulation of CD24 CD38 B cells but a downregulation in their regulatory activity in HT patients.
[Mh] Termos MeSH primário: ADP-Ribosil Ciclase 1/metabolismo
Antígenos CD34/metabolismo
Linfócitos B/metabolismo
Linfócitos B/patologia
Doença de Hashimoto/imunologia
Interleucina-10/deficiência
[Mh] Termos MeSH secundário: Adulto
Linfócitos B/secreção
Linfócitos B Reguladores/metabolismo
Linfócitos B Reguladores/patologia
Estudos de Casos e Controles
Proliferação Celular
Regulação para Baixo
Feminino
Doença de Hashimoto/metabolismo
Seres Humanos
Interferon gama/secreção
Interleucina-10/biossíntese
Meia-Idade
Linfócitos T/citologia
Fator de Necrose Tumoral alfa/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (IL10 protein, human); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


  8 / 2609 MEDLINE  
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[PMID]:28759657
[Au] Autor:Li G; Zhao J; Cheng L; Jiang Q; Kan S; Qin E; Tu B; Zhang X; Zhang L; Su L; Zhang Z
[Ad] Endereço:The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America.
[Ti] Título:HIV-1 infection depletes human CD34+CD38- hematopoietic progenitor cells via pDC-dependent mechanisms.
[So] Source:PLoS Pathog;13(7):e1006505, 2017 Jul.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic human immunodeficiency virus-1 (HIV-1) infection in patients leads to multi-lineage hematopoietic abnormalities or pancytopenia. The deficiency in hematopoietic progenitor cells (HPCs) induced by HIV-1 infection has been proposed, but the relevant mechanisms are poorly understood. We report here that both human CD34+CD38- early and CD34+CD38+ intermediate HPCs were maintained in the bone marrow (BM) of humanized mice. Chronic HIV-1 infection preferentially depleted CD34+CD38- early HPCs in the BM and reduced their proliferation potential in vivo in both HIV-1-infected patients and humanized mice, while CD34+CD38+ intermediate HSCs were relatively unaffected. Strikingly, depletion of plasmacytoid dendritic cells (pDCs) prevented human CD34+CD38- early HPCs from HIV-1 infection-induced depletion and functional impairment and restored the gene expression profile of purified CD34+ HPCs in humanized mice. These findings suggest that pDCs contribute to the early hematopoietic suppression induced by chronic HIV-1 infection and provide a novel therapeutic target for the hematopoiesis suppression in HIV-1 patients.
[Mh] Termos MeSH primário: Células Dendríticas/imunologia
Infecções por HIV/imunologia
Células-Tronco Hematopoéticas/citologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/genética
ADP-Ribosil Ciclase 1/imunologia
Animais
Antígenos CD34/imunologia
Células Dendríticas/citologia
Células Dendríticas/virologia
Infecções por HIV/virologia
HIV-1/fisiologia
Hematopoese
Células-Tronco Hematopoéticas/imunologia
Células-Tronco Hematopoéticas/virologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006505


  9 / 2609 MEDLINE  
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[PMID]:28726646
[Au] Autor:Kirtava T; Vatsadze T; Azrmaiparashili E; Ghirdaladze D
[Ad] Endereço:Tbilisi State Medical University, Institute of Hematology and Transfusiology. Tbilisi, Georgia.
[Ti] Título:THE PROGNOSTIC SIGNIFICANCE OF COMBAIND EXPRESSION OF ZAP-70 AND CD38 IN CHRONIC LYMPHOCYTIC LEUKEMIA.
[So] Source:Georgian Med News;(267):12-16, 2017 Jun.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:Our aim was to assess the inter links of the markers CD38 and ZAP-70 based on our materials, the attitude according to the disease stage, and to document which of them had leading meaning for prognosis and treatmend of the disease. In our study we have used flow cytometry for detection CD38 and ZAP-70+ markers expression. (58 patients to assessments their prognostic value in сhronic lymphocytic leukemia (CLL), Correlation to Rai stages and relationships between this markers and outcome of therapy). We divided all patients in two groups based on level of ZAP-70+ cell and CD38+cells,(I group-patients) ZAP-70+ cells <20% CD38+<30% and ZAP-70+ cells >20% and CD38>30%,(II group) becaus our in investigation shows, that ZAP -70+ is very importance independent prognoctic marker as why in ZAP-70+ cases when its number was <20%, patients had favorable prognosis - the big part of them (13(40.6%) didn't need treatment during a long period, but which need the treatment was effective and this patients life expectancy was long (62 mounts). When ZAP-70 cells were>20% (II group n=26) prognosis was unfavorable, patients treatment was not effective and accordingly life expectancy was shorter (39 mounts). Despite CD38 positive or negative cells number. During research where compared were ZAP-70+ and ZAP-70- cases events treatment results and the research was held on the minimal residual disease existence, in ZAP-70+ positive cases treatment the remission obtained was always incomplete, and on the contrary, where the ZAP-70+ was negative - complete. In our study we didn,t reveal the importance of CD38 as a prognostic independent marker and there were not correlation between CD38+ and CD38- cells numbers in CLL prognosis. Because our study data confirm that ZAP-70 marker is more importance marker then CD38 and it has seriously prognostic significance, we think that information about ZAP-70 marker expression. Because our study data confirm that ZAP-70 marker has the advantageous prognostic meaning, we reckon the information on CLL disease debut on ZAP-70 market expression can be used not only for defining the aggressive process of the disease, but also in greater part, to define the refracterity towards the modern chemotherapy regimens.
[Mh] Termos MeSH primário: ADP-Ribosil Ciclase 1/metabolismo
Biomarcadores Tumorais/metabolismo
Leucemia Linfocítica Crônica de Células B/diagnóstico
Glicoproteínas de Membrana/metabolismo
Proteína-Tirosina Quinase ZAP-70/metabolismo
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Leucemia Linfocítica Crônica de Células B/metabolismo
Leucemia Linfocítica Crônica de Células B/patologia
Masculino
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Membrane Glycoproteins); EC 2.7.10.2 (ZAP-70 Protein-Tyrosine Kinase); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


  10 / 2609 MEDLINE  
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Texto completo
[PMID]:28718379
[Au] Autor:Picot T; Aanei CM; Fayard A; Flandrin-Gresta P; Tondeur S; Gouttenoire M; Tavernier-Tardy E; Wattel E; Guyotat D; Campos L
[Ad] Endereço:1 Laboratoire d'Hématologie, CHU de Saint-Etienne, Saint-Etienne, France.
[Ti] Título:Expression of embryonic stem cell markers in acute myeloid leukemia.
[So] Source:Tumour Biol;39(7):1010428317716629, 2017 Jul.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute myeloid leukemia is driven by leukemic stem cells which can be identified by cross lineage expression or arrest of differentiation compared to normal hematopoietic stem cells. Self-renewal and lack of differentiation are also features of stem cells and have been associated with the expression of embryonic genes. The aim of our study was to evaluate the expression of embryonic antigens (OCT4, NANOG, SOX2, SSEA1, SSEA3) in hematopoietic stem cell subsets (CD34 CD38 and CD34 CD38 ) from normal bone marrows and in samples from acute myeloid leukemia patients. We observed an upregulation of the transcription factors OCT4 and SOX2 in leukemic cells as compared to normal cells. Conversely, SSEA1 protein was downregulated in leukemic cells. The expression of OCT4, SOX2, and SSEA3 was higher in CD34 CD38 than in CD34 CD38 subsets in leukemic cells. There was no correlation with biological characteristics of the leukemia. We evaluated the prognostic value of marker expression in 69 patients who received an intensive treatment. The rate of complete remission was not influenced by the level of expression of markers. Overall survival was significantly better for patients with high SOX2 levels, which was unexpected because of the inverse correlation with favorable genetic subtypes. These results prompt us to evaluate the potential role of these markers in leukemogenesis and to test their relevance for better leukemic stem cell identification.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/biossíntese
Fucosiltransferases/biossíntese
Leucemia Mieloide Aguda/tratamento farmacológico
Antígeno Lewis X/biossíntese
Fator 3 de Transcrição de Octâmero/biossíntese
Fatores de Transcrição SOXB1/biossíntese
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/genética
Adulto
Idoso
Antígenos CD34/genética
Células da Medula Óssea/metabolismo
Diferenciação Celular/genética
Células-Tronco Embrionárias/metabolismo
Células-Tronco Embrionárias/patologia
Feminino
Citometria de Fluxo
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células-Tronco Hematopoéticas/efeitos dos fármacos
Células-Tronco Hematopoéticas/patologia
Seres Humanos
Imunofenotipagem
Leucemia Mieloide Aguda/genética
Leucemia Mieloide Aguda/patologia
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (Biomarkers, Tumor); 0 (Lewis X Antigen); 0 (Octamer Transcription Factor-3); 0 (POU5F1 protein, human); 0 (SOX2 protein, human); 0 (SOXB1 Transcription Factors); EC 2.4.1.- (FUT4 protein, human); EC 2.4.1.- (Fucosyltransferases); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317716629



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