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[PMID]:28219009
[Au] Autor:Hirota S; Takahama U
[Ad] Endereço:Department of Health and Nutrition Care, Faculty of Allied Health Sciences, University of East Asia , Shimonoseki 751-8503, Japan.
[Ti] Título:Inhibition of Pancreatin-Induced Digestion of Cooked Rice Starch by Adzuki (Vigana angularis) Bean Flavonoids and the Possibility of a Decrease in the Inhibitory Effects in the Stomach.
[So] Source:J Agric Food Chem;65(10):2172-2179, 2017 Mar 15.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Flavonoids of adzuki bean bind to starch when the beans are cooked with rice. The purpose of this study is to show that adzuki flavonoids can suppress pancreatin-induced digestion of cooked rice starch. The diethyl ether extract of water boiled with adzuki bean inhibited starch digestion, and quercetin and a cyanidin-catechin conjugate (vignacyanidin) but not taxifolin in the extract contributed to the inhibition. The order of their inhibitory effects (taxifolin < quercetin < vignacyanidin) suggested that the effects increased with an increase in their hydrophobicity. The diethyl ether extract also inhibited the starch digestion of cooked rice preincubated in artificial gastric juice, and the level of inhibition was decreased by nitrite. The decrease was due to nitrite-induced consumption of quercetin and vignacyanidin. Taking these results into account, we discuss mechanisms of quercetin- and vignacyanidin-dependent inhibition of starch digestion and the possibility of the decrease in their inhibitory effects by nitrite in the stomach.
[Mh] Termos MeSH primário: Digestão
Flavonoides/metabolismo
Oryza/metabolismo
Pancreatina/metabolismo
Extratos Vegetais/metabolismo
Amido/metabolismo
Estômago/metabolismo
[Mh] Termos MeSH secundário: Culinária
Fabaceae/química
Fabaceae/metabolismo
Flavonoides/química
Seres Humanos
Modelos Biológicos
Oryza/química
Extratos Vegetais/química
Sementes/química
Sementes/metabolismo
Amido/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 8049-47-6 (Pancreatin); 9005-25-8 (Starch)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05442


  2 / 1228 MEDLINE  
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[PMID]:28118567
[Au] Autor:Hegazy MA; Hassanain WA; Abdel Fattah LE; El-Fatatry HM
[Ad] Endereço:Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr El-Aini St, 11562 Cairo, Egypt.
[Ti] Título:Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form.
[So] Source:J AOAC Int;100(2):422-428, 2017 Mar 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two specific, sensitive, and precise stability-indicating chromatographic methods were developed, optimized, and validated for the determination of Azintamide (AZ) in the presence of its degradation product. The first method was TLC combined with the densitometric determination of the separated bands. Separation was achieved using silica gel 60 F254 TLC plates and chloroform-acetone-glacial acetic acid (7.5 + 2.1 + 0.4, v/v/v) as the developing system. Good correlations were obtained between the integrated peak area of the studied drug and its corresponding concentrations in the linearity range. The second method used HPLC with UV diode-array detection, in which the proposed method was applied for the quantitative determination of AZ in the presence of its acidic degradation product and the quantitative determination of the acid-induced degradation product of AZ (AZ Deg) using pentoxifylline as the internal standard. The proposed components were separated on a reversed-phase C18 analytical column using acetonitrile-water (50 + 50, v/v). The flow rate was maintained at 0.55 mL/min and the detection wavelength was 260 nm. Linear regressions were obtained in the range of 1-30 and 0.3-16 µg/mL for AZ and AZ Deg, respectively. Different parameters affecting the suggested methods were optimized for maximum separation of the cited components. The suggested methods were validated in compliance with the International Conference on Harmonization guidelines and successfully applied for the determination of AZ in its pure powder form and in its pharmaceutical formulation. Both methods were also statistically compared with the reported method with no significant difference in performance observed.
[Mh] Termos MeSH primário: Piridazinas/análise
[Mh] Termos MeSH secundário: Celulase/análise
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Acurácia dos Dados
Densitometria
Combinação de Medicamentos
Hidrólise
Modelos Lineares
Pancreatina/análise
Piridazinas/administração & dosagem
Piridazinas/química
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Pyridazines); 0 (Tablets); 0 (zymagallin); 1830-32-6 (azintamid); 8049-47-6 (Pancreatin); EC 3.2.1.4 (Cellulase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0049


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[PMID]:27933988
[Au] Autor:Liang R; Chen L; Yokoyama W; Williams PA; Zhong F
[Ad] Endereço:Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi 214122, P. R. China.
[Ti] Título:Niosomes Consisting of Tween-60 and Cholesterol Improve the Chemical Stability and Antioxidant Activity of (-)-Epigallocatechin Gallate under Intestinal Tract Conditions.
[So] Source:J Agric Food Chem;64(48):9180-9188, 2016 Dec 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF). Pancreatin was found to impact the stability of niosomes in SIF mainly. Furthermore, the results from ferric reducing antioxidant power and cellular antioxidant activity tests indicated that EGCG loaded niosomes exhibited stronger antioxidant ability than free EGCG during intestinal digestion. Thus, we can infer that niosomal encapsulation might be a promising approach to improve the oral bioavailability of EGCG in the body.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Catequina/análogos & derivados
Portadores de Fármacos/química
Intestinos/metabolismo
Lipossomos/química
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Catequina/farmacologia
Colesterol/química
Digestão
Estabilidade de Medicamentos
Células Hep G2
Seres Humanos
Concentração de Íons de Hidrogênio
Nanopartículas/química
Pancreatina/química
Tamanho da Partícula
Polissorbatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Drug Carriers); 0 (Liposomes); 0 (Polysorbates); 8049-47-6 (Pancreatin); 8R1V1STN48 (Catechin); 97C5T2UQ7J (Cholesterol); BQM438CTEL (epigallocatechin gallate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


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[PMID]:27789354
[Au] Autor:Heider M; Hause G; Mäder K
[Ad] Endereço:Institute of Pharmacy, Faculty of Biosciences, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Strasse 4, D-06120 Halle (Saale), Germany. Electronic address: martha.heider@pharmazie.uni-halle.de.
[Ti] Título:Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN).
[So] Source:Eur J Pharm Biopharm;109:194-205, 2016 Dec.
[Is] ISSN:1873-3441
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Enzymatic digestion of lipid drug carriers is very important. Commonly, pancreatin induced formation of fatty acids is monitored by the pH-stat method, which provides a fast, but unspecific readout. However, according to the literature, the pKa values of long chain fatty acids are strongly dependent on the local environment and might vary between 4.2 and 10.15. The high pKa values would lead to an incomplete detection of the lipid digestion and false results. In order to investigate these issues in more detail, we produced cetyl palmitate solid lipid nanoparticles (CP-SLN) stabilized with poloxamer 188 or polysorbate 80. The digestion of CP-SLN was investigated by two different and independent readouts. A HPTLC assay was used in addition to the pH-stat method (with or without back titration). An incomplete digestion of CP-SLN was observed with all methods. Partial digestion of polysorbate 80 contributed to the formation of fatty acids. Depending on the investigated system and the experimental conditions (FaSSIF or FeSSIF) the results of both readout methods were comparable or not. For example, in FeSSIF conditions, the values detected by HPTLC were roughly twice as high as the pH-stat results. Our findings on solid lipids agree with data from Helbig et al. on lipid emulsions, where a gas chromatography method detected much higher values than the pH-stat assay (Food Hydrocoll. 28 (2012) 10-19). The results of our pH-stat experiments with back titration at different pH values showed increased values for fatty acids from pH 7.5 to pH 10. The values obtained by back titration at high pH values (pH 9 or higher) did exceed the digestion values measured by HPTLC. Therefore, we conclude that the pH-stat method might give the same results as more specific reference methods, but it might also both under- (without back titration) or overestimate (with back titration) the enzymatic digestion of lipid drug delivery systems. A further outcome of our study was the proof that lipase is the main enzyme involved in the digestion of the solid wax cetyl palmitate, because CP-SLN loaded with the inhibitor orlistat were not digestible and gave similar values as the corresponding control samples. In summary, our experimental results confirm the theoretical considerations (based on published pKa values) that the pH-stat method will not detect all fatty acids quantitatively. The very strong impact of the local environment on the pKa value of long chain fatty acids is a serious limitation and might lead to misleading interpretations.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
Lipídeos/química
Nanomedicina/métodos
Nanopartículas/química
[Mh] Termos MeSH secundário: Ácidos e Sais Biliares/química
Varredura Diferencial de Calorimetria
Cromatografia Gasosa
Cromatografia Líquida de Alta Pressão
Portadores de Fármacos/química
Ácidos Graxos/química
Seres Humanos
Concentração de Íons de Hidrogênio
Hidrólise
Lactonas/química
Lipase/química
Lipólise
Micelas
Microscopia Eletrônica
Microscopia Eletrônica de Transmissão
Palmitatos/química
Pâncreas/enzimologia
Pancreatina/química
Tamanho da Partícula
Poloxâmero/química
Polissorbatos/química
Tensoativos/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Drug Carriers); 0 (Fatty Acids); 0 (Lactones); 0 (Lipids); 0 (Micelles); 0 (Palmitates); 0 (Polysorbates); 0 (Surface-Active Agents); 106392-12-5 (Poloxamer); 5ZA2S6B08X (cetyl palmitate); 8049-47-6 (Pancreatin); 95M8R751W8 (orlistat); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  5 / 1228 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:27618657
[Au] Autor:Woo SM; Joo J; Kim SY; Park SJ; Han SS; Kim TH; Koh YH; Chung SH; Kim YH; Moon H; Hong EK; Lee WJ
[Ad] Endereço:Center for Liver Cancer, National Cancer Center, Republic of Korea. Electronic address: wsm@ncc.re.kr.
[Ti] Título:Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial.
[So] Source:Pancreatology;16(6):1099-1105, 2016 Nov - Dec.
[Is] ISSN:1424-3911
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Weight loss in pancreatic cancer is associated with maldigestion due to pancreatic duct obstruction. Pancreatic exocrine replacement therapy (PERT) may significantly improve fat and protein absorption. OBJECTIVES: This prospective, double-blind, randomized, placebo-controlled phase II trial assessed whether PERT could reduce or prevent weight loss in patients with unresectable pancreatic cancer. METHODS: Sixty seven patients with unresectable pancreatic cancer were randomized to receive enteric coated PERT, consisting of 6-9 capsules of pancreatin (457.7 mg/capsule), or placebo. Patients took two capsules each three times daily during main meals and one capsule each up to three times daily when having between-meal snacks. The primary endpoint was the percentage change in body weight at eight weeks. RESULTS: The mean percentage change in body weight (1.49% [1.12 kg] vs. 2.99% [1.63 kg], P = 0.381) and the mean percent change in Patient-Generated Subjective Global Assessment (PG-SGA) score (8.85% vs. 15.69%, p = 0.18) did not differ significantly between the PERT and placebo groups. There was no improvement in quality of life and overall survival did not differ significantly between the PERT and placebo groups (5.84 months vs 8.13 months, p = 0.744). CONCLUSIONS: PERT did not reduce weight loss in patients with unresectable pancreatic cancer. Larger randomized trials are needed to identify those patients who may benefit from PERT. TRIAL REGISTRATION: ClinicalTrials.gov Number NCT01587534.
[Mh] Termos MeSH primário: Terapia de Reposição Hormonal/métodos
Pâncreas Exócrino
Neoplasias Pancreáticas/terapia
Pancreatina/uso terapêutico
Pancrelipase/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Peso Corporal/efeitos dos fármacos
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Pancreatina/administração & dosagem
Pancrelipase/administração & dosagem
Estudos Prospectivos
Qualidade de Vida
Análise de Sobrevida
Resultado do Tratamento
Perda de Peso
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
53608-75-6 (Pancrelipase); 8049-47-6 (Pancreatin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:27575686
[Au] Autor:Wang C; Glenn KC; Kessenich C; Bell E; Burzio LA; Koch MS; Li B; Silvanovich A
[Ad] Endereço:Monsanto Company, 800 North Lindbergh Blvd, St. Louis, MO 63167, USA. Electronic address: cunxi.wang@monsanto.com.
[Ti] Título:Safety assessment of dicamba mono-oxygenases that confer dicamba tolerance to various crops.
[So] Source:Regul Toxicol Pharmacol;81:171-182, 2016 Nov.
[Is] ISSN:1096-0295
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dicamba tolerant (DT) soybean, cotton and maize were developed through constitutive expression of dicamba mono-oxygenase (DMO) in chloroplasts. DMO expressed in three DT crops exhibit 91.6-97.1% amino acid sequence identity to wild type DMO. All DMO forms maintain the characteristics of Rieske oxygenases that have a history of safe use. Additionally, they are all functionally similar in vivo since the three DT crops are all tolerant to dicamba treatment. None of these DMO sequences were found to have similarity to any known allergens or toxins. Herein, to further understand the safety of these DMO variants, a weight of evidence approach was employed. Each purified DMO protein was found to be completely deactivated in vitro by heating at temperatures 55 °C and above, and all were completely digested within 30 s or 5 min by pepsin and pancreatin, respectively. Mice orally dosed with each of these DMO proteins showed no adverse effects as evidenced by analysis of body weight gain, food consumption and clinical observations. Therefore, the weight of evidence from all these protein safety studies support the conclusion that the various forms of DMO proteins introduced into DT soybean, cotton and maize are safe for food and feed consumption, and the small amino acid sequence differences outside the active site of DMO do not raise any additional safety concerns.
[Mh] Termos MeSH primário: Produtos Agrícolas/toxicidade
Dicamba/farmacologia
Resistência a Medicamentos
Alimentos Geneticamente Modificados/toxicidade
Gossypium/toxicidade
Herbicidas/farmacologia
Oxigenases de Função Mista/toxicidade
Oxirredutases O-Desmetilantes/toxicidade
Plantas Geneticamente Modificadas/toxicidade
Feijão de Soja/toxicidade
Zea mays/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Sequência de Aminoácidos
Animais
Biologia Computacional
Segurança de Produtos ao Consumidor
Produtos Agrícolas/enzimologia
Produtos Agrícolas/genética
Bases de Dados de Proteínas
Resistência a Medicamentos/genética
Estabilidade Enzimática
Feminino
Inocuidade dos Alimentos
Alimentos Geneticamente Modificados/parasitologia
Regulação da Expressão Gênica de Plantas
Gossypium/enzimologia
Gossypium/genética
Seres Humanos
Masculino
Camundongos
Oxigenases de Função Mista/administração & dosagem
Oxigenases de Função Mista/genética
Oxigenases de Função Mista/metabolismo
Pancreatina/metabolismo
Pepsina A/metabolismo
Plantas Geneticamente Modificadas/enzimologia
Plantas Geneticamente Modificadas/genética
Desnaturação Proteica
Proteólise
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Proteínas Recombinantes/toxicidade
Medição de Risco
Feijão de Soja/enzimologia
Feijão de Soja/genética
Stenotrophomonas maltophilia/enzimologia
Stenotrophomonas maltophilia/genética
Temperatura Ambiente
Testes de Toxicidade Aguda
Zea mays/enzimologia
Zea mays/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Recombinant Proteins); 8049-47-6 (Pancreatin); EC 1.- (Mixed Function Oxygenases); EC 1.- (Oxidoreductases, O-Demethylating); EC 1.- (dicamba O-demethylase); EC 3.4.23.1 (Pepsin A); SJG3M6RY6H (Dicamba)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE


  7 / 1228 MEDLINE  
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[PMID]:27553262
[Au] Autor:Mante A; Heider M; Zlomke C; Mäder K
[Ad] Endereço:Institute of Pharmacy, Faculty of Biosciences, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, D-06120 Halle (Saale), Germany. Electronic address: anika.mante@medizin.uni-leipzig.de.
[Ti] Título:PLGA nanoparticles for peroral delivery: How important is pancreatic digestion and can we control it?
[So] Source:Eur J Pharm Biopharm;108:32-40, 2016 Nov.
[Is] ISSN:1873-3441
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biodegradable nanoparticles made of Poly(lactide-co-glycolide) are increasingly proposed for the improvement of oral drug absorption, but also as carriers for the treatment of colonic diseases. Unfortunately, our knowledge of the digestibility of PLGA-NPs is rather limited. Therefore, we investigated the impact of pancreatin on the digestibility of PLGA-NPs stabilized with different emulsifiers. The pancreatin induced degradation was monitored by the pH-stat method and an enzymatic l-lactic acid assay. A high digestibility was found for poloxamer 188 and polysorbate 80 stabilized PLGA-NPs. The digestion could be blocked by Orlistat, indicating a major role of pancreatic lipase. PLGA-NPs stabilized with Poly(vinyl alcohol) (=PVA) were not digested at comparable surfactant concentrations (0.6%). However, PLGA-NPs stabilized with very low amounts of PVA (0.1%) were digestible. In conclusion, PLGA-NPs are substrates for the pancreatic lipase. The digestibility can be enhanced or blocked by the proper selection of the surfactant composition and concentration.
[Mh] Termos MeSH primário: Administração Oral
Sistemas de Liberação de Medicamentos
Ácido Láctico/química
Nanopartículas/química
Pâncreas/efeitos dos fármacos
Ácido Poliglicólico/química
[Mh] Termos MeSH secundário: Animais
Portadores de Fármacos/química
Seres Humanos
Concentração de Íons de Hidrogênio
Lipase/química
Pâncreas/enzimologia
Pancreatina/química
Tamanho da Partícula
Poloxâmero/química
Polímeros/química
Polissorbatos/química
Álcool de Polivinil/química
Tensoativos/química
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Polymers); 0 (Polysorbates); 0 (Surface-Active Agents); 0 (polylactic acid-polyglycolic acid copolymer); 106392-12-5 (Poloxamer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 8049-47-6 (Pancreatin); 9002-89-5 (Polyvinyl Alcohol); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170924
[Lr] Data última revisão:
170924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


  8 / 1228 MEDLINE  
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[PMID]:27446871
[Au] Autor:Yaghoobi M; McNabb-Baltar J; Bijarchi R; Cotton PB
[Ad] Endereço:Division of Gastroenterology, McMaster University, Hamilton, ON, Canada.
[Ti] Título:Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
[So] Source:Can J Gastroenterol Hepatol;2016:8541839, 2016.
[Is] ISSN:2291-2797
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Background. Pancreatic enzyme supplementation is widely used to treat pain in patients with chronic pancreatitis, despite little evidence for efficacy. We performed a systematic review of the literature and a meta-analysis to investigate its effectiveness. Methods. All randomized controlled parallel or crossover trials in patients with chronic pancreatitis comparing pancreatic enzyme supplementation to placebo were included. The main outcome was improvement in pain score or reduced analgesic consumption. Two independent reviewers extracted data. Mantel-Haenszel random effect model meta-analysis was used whenever methodologically appropriate. Results. Five out of 434 retrieved studies were included in the systematic review. All studies used relatively similar methodology. Four studies using enteric-coated pancreatic enzyme supplementation failed to show any improvement in pain as compared to placebo. The only study using non-enteric-coated enzymes did show reduction in the pain score. There was significant heterogeneity among studies in both analyses. Random model meta-analysis of three studies showed no significant difference in the mean of daily pain score (mean difference: 0.09 (1.57-1.39), p = 0.91) or average weekly analgesic consumption (mean difference: -0.30 (-2.37-1.77), p = 0.77) between the periods of administering pancreatic enzyme supplementation versus placebo. Conclusion. Pancreatic enzyme supplements do not seem to relieve abdominal pain in patients with chronic pancreatitis and should not be prescribed solely for this purpose, given their significant cost and potential side effects.
[Mh] Termos MeSH primário: Dor Abdominal/tratamento farmacológico
Fármacos Gastrointestinais/administração & dosagem
Pancreatina/administração & dosagem
Pancreatite Crônica/complicações
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Pancreatite Crônica/tratamento farmacológico
Ensaios Clínicos Controlados Aleatórios como Assunto
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 8049-47-6 (Pancreatin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8541839


  9 / 1228 MEDLINE  
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[PMID]:27383890
[Au] Autor:Terra Gde P; Vinícius De Farias M; Trevisan MG; Garcia JS
[Ti] Título:Evaluation of pancreatin stability through enzyme activity determination.
[So] Source:Acta Pharm;66(3):423-31, 2016 Sep 01.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Pancreatin is a biotechnological product containing an enzyme complex, obtained from porcine pancreas, that is employed in treating pancreatic diseases. Experiments regarding the stability of the pharmaceutical formulation containing pancreatin were performed using standard binary mixtures with 6 excipients in a 1:1 ratio (m/m) and a commercial formulation. To accomplish these goals, samples were stored for 1, 3 and 6 months at 40 ± 1 °C and 75 ± 5 % relative humidity (RH) and 40 ± 1 °C and 0 % RH. Stress testing was also performed. All samples were analyzed to evaluate the α-amylase, lipase and protease activities through UV/Vis spectrophotometry. The results revealed that the excipient proprieties and the storage conditions affected enzyme stability. Humidity was a strong influencing factor in the reduction of α-amylase and protease activities. Stress testing indicated that pH 9.0 and UV light did not induce substantial alterations in enzyme activity.
[Mh] Termos MeSH primário: Excipientes/química
Fármacos Gastrointestinais/metabolismo
Pancreatina/metabolismo
[Mh] Termos MeSH secundário: Animais
Brasil
Química Farmacêutica
Estabilidade de Medicamentos
Armazenamento de Medicamentos
Estabilidade Enzimática
Fármacos Gastrointestinais/química
Guias como Assunto
Temperatura Alta/efeitos adversos
Umidade/efeitos adversos
Concentração de Íons de Hidrogênio
Lipase/química
Lipase/metabolismo
Oxirredução
alfa-Amilases Pancreáticas/química
alfa-Amilases Pancreáticas/metabolismo
Pancreatina/química
Peptídeo Hidrolases/química
Peptídeo Hidrolases/metabolismo
Pós
Sus scrofa
Raios Ultravioleta/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Gastrointestinal Agents); 0 (Powders); 8049-47-6 (Pancreatin); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (Pancreatic alpha-Amylases); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE


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[PMID]:27376465
[Au] Autor:Liu Y; Wang Z; Li H; Liang M; Yang L
[Ad] Endereço:Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, 150090, China.
[Ti] Título:In vitro antioxidant activity of rice protein affected by alkaline degree and gastrointestinal protease digestion.
[So] Source:J Sci Food Agric;96(15):4940-4950, 2016 Dec.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To elucidate whether and how alkali treatment, which is a common process for rice protein (RP) extraction, affects antioxidant activity of RP, the different degree of alkali (from 0.1% to 0.4% of NaOH) was used to extract RP (RP-1, RP-2, RP-3, RP-4). RESULTS: The antioxidant capacities of scavenging free radicals [2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid] diammonium salt, ABTS; 1,1-diphenyl-2-picrylhydrazyl, DPPH), chelating metals (iron, copper) and reducing power investigated in the hydrolysates of RPs (RP-1, RP-2, RP-3, RP-4) during in vitro pepsin-pancreatin digestion were effectively affected by alkali treatment. The present study demonstrated that the weakest antioxidant responses to ABTS radical-scavenging activity, DPPH radical-scavenging activity, iron chelating activity, copper chelating activity and reducing power were produced by RP-4 extracted by the highest alkali proportion (0.4% NaOH). CONCULSION: The present study indicates that antioxidant capacity of RP could be more readily depressed by strict alkali degree and affected by gastrointestinal proteases. Results suggest that alkali extraction is a vital process to regulate the antioxidant activity of RP through modifying the compositions of amino acids, which are dependent on alkali magnitude. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Antioxidantes
Trato Gastrointestinal/enzimologia
Oryza/química
Peptídeo Hidrolases/metabolismo
Proteínas de Plantas/metabolismo
Proteínas de Plantas/farmacologia
[Mh] Termos MeSH secundário: Aminoácidos/análise
Quelantes
Cobre/química
Depuradores de Radicais Livres
Concentração de Íons de Hidrogênio
Quelantes de Ferro
Pancreatina/metabolismo
Pepsina A/metabolismo
Proteínas de Plantas/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Antioxidants); 0 (Chelating Agents); 0 (Free Radical Scavengers); 0 (Iron Chelating Agents); 0 (Plant Proteins); 789U1901C5 (Copper); 8049-47-6 (Pancreatin); EC 3.4.- (Peptide Hydrolases); EC 3.4.23.1 (Pepsin A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.7877



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