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[PMID]:28859149
[Au] Autor:Seng R; Kitti T; Thummeepak R; Kongthai P; Leungtongkam U; Wannalerdsakun S; Sitthisak S
[Ad] Endereço:Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
[Ti] Título:Biofilm formation of methicillin-resistant coagulase negative staphylococci (MR-CoNS) isolated from community and hospital environments.
[So] Source:PLoS One;12(8):e0184172, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methicillin-resistant coagulase negative staphylococci (MR-CoNS) are the major cause of infectious diseases because of their potential ability to form biofilm and colonize the community or hospital environments. This study was designed to investigate the biofilm producing ability, and the presence of mecA, icaAD, bap and fnbA genes in MR-CoNS isolates. The MR-CoNS used in this study were isolated from various samples of community environment and five wards of hospital environments, using mannitol salt agar (MSA) supplemented with 4 µg/ml of oxacillin. The specie level of Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus hominis and Staphylococcus warneri was identified by specific primers of groESL (S. haemolyticus), rdr (S. epidermidis) and nuc (S. hominis and S. warneri). The remainder isolates were identified by tuf gene sequencing. Biofilm production was determined using Congo red agar (CRA) and Microtiter plate (MTP) assay. The mecA and biofilm associated genes (icaAD, fnbA and bap) were detected using PCR method. From the 558 samples from community and hospital environments, 292 MR-CoNS were isolated (41 from community environments, and 251 from hospital environments). S. haemolyticus (41.1%) and S. epidermidis (30.1%) were the predominant species in this study. Biofilm production was detected in 265 (90.7%) isolates by CRA, and 260 (88.6%) isolates were detected by MTP assay. The staphylococci isolates derived from hospital environments were more associated with biofilm production than the community-derived isolates. Overall, the icaAD and bap genes were detected in 74 (29.5%) and 14 (5.6%) of all isolates from hospital environments. When tested by MTP, the icaAD gene from hospital environment isolates was associated with biofilm biomass. No association was found between bap gene and biofilm formation. The MR-CoNS isolates obtained from community environments did not harbor the icaAD and bap genes. Conversely, fnbA gene presented in MR-CoNS isolated from both community and hospital environments. The high prevalence of biofilm producing MR-CoNS strains demonstrated in this study indicates the persisting ability in environments, and is useful in developing prevention strategies countering the spread of MR-CoNS.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Infecção Hospitalar/genética
Resistência a Meticilina/genética
Infecções Estafilocócicas/genética
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Coagulase/genética
Infecção Hospitalar/microbiologia
Seres Humanos
Oxacilina/administração & dosagem
Proteínas de Ligação às Penicilinas/genética
Infecções Estafilocócicas/microbiologia
Staphylococcus epidermidis/genética
Staphylococcus epidermidis/crescimento & desenvolvimento
Staphylococcus haemolyticus/genética
Staphylococcus haemolyticus/crescimento & desenvolvimento
Staphylococcus hominis/genética
Staphylococcus hominis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Bap protein, Staphylococcus aureus); 0 (Coagulase); 0 (Penicillin-Binding Proteins); 0 (mecA protein, Staphylococcus aureus); UH95VD7V76 (Oxacillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184172


  2 / 3127 MEDLINE  
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[PMID]:28787002
[Au] Autor:Obiero CW; Seale AC; Jones K; Ngari M; Bendon CL; Morpeth S; Mohammed S; Mturi N; Fegan G; Berkley JA
[Ad] Endereço:Clinical Research Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
[Ti] Título:Should first-line empiric treatment strategies cover coagulase-negative staphylococcal infections in severely malnourished or HIV-infected children in Kenya?
[So] Source:PLoS One;12(8):e0182354, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bloodstream infection is a common cause of morbidity in children aged <5 years in developing countries. In studies reporting bacteremia in Africa, coagulase-negative Staphylococci (CoNS) are commonly isolated. However, it is currently unclear whether children who are highly susceptible to infection because of severe acute malnutrition (SAM) or HIV should be treated with antimicrobials specifically to cover CoNS. We aimed to determine the clinical significance of CoNS amongst children admitted to a rural hospital in Kenya in relation to nutritional and HIV status. METHODS: Systematically collected clinical and microbiological surveillance data from children aged 6-59 months admitted to Kilifi County Hospital (2007-2013) were analysed. Multivariable regression was used to test associations between CoNS isolation from blood cultures and SAM (MUAC <11.5cm or nutritional oedema (kwashiorkor)), and HIV serostatus; and among children with SAM or HIV, associations between CoNS isolation and mortality, duration of hospitalization and clinical features. RESULTS: CoNS were isolated from blood culture in 906/13,315 (6.8%) children, of whom 135/906 (14.9%) had SAM and 54/906 (6.0%) were HIV antibody positive. CoNS isolation was not associated with SAM (MUAC<11.5cm (aOR 1.11, 95% CI 0.88-1.40) or kwashiorkor (aOR 0.84, 95% CI 0.48-1.49)), or a positive HIV antibody test (aOR 1.25, 95% CI 0.92-1.71). Among children with SAM or a positive HIV antibody test, CoNS isolation was not associated with mortality or prolonged hospitalization. CONCLUSION: In a large, systematic study, there was no evidence that antimicrobial therapy should specifically target CoNS amongst children with SAM or HIV-infection or exposure.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções por HIV/complicações
Kwashiorkor/complicações
Infecções Estafilocócicas/complicações
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus/enzimologia
Staphylococcus/fisiologia
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Bacteriemia/complicações
Pré-Escolar
Coagulase/metabolismo
Feminino
Seres Humanos
Lactente
Quênia
Masculino
Staphylococcus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182354


  3 / 3127 MEDLINE  
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[PMID]:28731901
[Au] Autor:Seale AC; Obiero CW; Jones KD; Barsosio HC; Thitiri J; Ngari M; Morpeth S; Mohammed S; Fegan G; Mturi N; Berkley JA
[Ad] Endereço:From the *Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Institution, Kilifi, Kenya; †University of Oxford, Oxford, United Kingdom; and ‡London School of Hygiene and Tropical Medicine, and §Imperial College London, London, United Kingdom.
[Ti] Título:Should First-line Empiric Treatment Strategies for Neonates Cover Coagulase-negative Staphylococcal Infections in Kenya?
[So] Source:Pediatr Infect Dis J;36(11):1073-1078, 2017 Nov.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neonatal mortality remains high in sub-Saharan Africa, and a third of deaths are estimated to result from infection. While coagulase-negative staphylococci (CoNS) are leading neonatal pathogens in resource-rich settings, their role, and the need for early anti-Staphylococcal treatment in empiric antibiotic guidelines, is unknown in sub-Saharan Africa. METHODS: We examined systematic clinical and microbiologic surveillance data from all neonatal admissions to Kilifi County Hospital (1998-2013) to determine associated case fatality and/or prolonged duration of admission associated with CoNS in neonates treated according to standard World Health Organization guidelines. RESULTS: CoNS was isolated from blood culture in 995 of 9552 (10%) neonates. Case fatality among neonates with CoNS isolated from blood did not differ from other neonatal admissions (P = 0.2), and duration of admission was not prolonged [odds ratio (OR) = 0.9 (0.7-1.0), P = 0.040]. Neonates with CoNS were more likely to have convulsions [OR = 1.4 (1.0-1.8), P = 0.031] but less likely to have impaired consciousness or severe indrawing [OR = 0.8 (0.7-0.9), P = 0.025; OR = 0.9 (0.7-1.0), P = 0.065]. CONCLUSIONS: CoNS isolation in blood cultures at admission was not associated with adverse clinical outcomes in neonates treated according to standard World Health Organization guidelines for hospital care in this setting. There is no evidence that first-line antimicrobial treatment guidelines should be altered to increase cover for CoNS infections in neonates in this setting.
[Mh] Termos MeSH primário: Bacteriemia/tratamento farmacológico
Bacteriemia/microbiologia
Doenças do Recém-Nascido/tratamento farmacológico
Doenças do Recém-Nascido/microbiologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Bacteriemia/epidemiologia
Bacteriemia/mortalidade
Hemocultura/estatística & dados numéricos
Criança
Pré-Escolar
Coagulase
Pesquisa Empírica
Feminino
Seres Humanos
Lactente
Recém-Nascido
Doenças do Recém-Nascido/epidemiologia
Doenças do Recém-Nascido/mortalidade
Quênia
Masculino
Estudos Retrospectivos
Infecções Estafilocócicas/epidemiologia
Staphylococcus/efeitos dos fármacos
Staphylococcus/enzimologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001699


  4 / 3127 MEDLINE  
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[PMID]:28724830
[Au] Autor:Mahalingam P; Topiwalla TT; Ganesan G
[Ad] Endereço:Sankara Eye Centre, Coimbatore, Tamil Nadu, India.
[Ti] Título:Drug-resistant coagulase-negative staphylococcal endophthalmitis following dexamethasone intravitreal implant.
[So] Source:Indian J Ophthalmol;65(7):634-636, 2017 Jul.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:A 60-year-old female came to our hospital with defective vision due to persistent diabetic macular edema and was treated with intravitreal ozurdex implant in the right eye. Three days later, the patient presented with diminution of vision, ocular pain, congestion, and hypopyon with no fundus view. B-scan ultrasonography showed vitritis, and diagnosis of endophthalmitis was made. Subsequently, 25-gauge pars plana vitrectomy was performed along with intravitreal vancomycin and amikacin and removal of implant. On culture, there was growth of coagulase-negative staphylococcus which was resistant to ofloxacin antibiotic. A week following treatment, there was significant improvement in the patient's sign and symptoms with improvement in vision. Our case demonstrated that acute endophthalmitis can occur following dexamethasone intravitreal implant.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Coagulase/metabolismo
Dexametasona/administração & dosagem
Endoftalmite/tratamento farmacológico
Infecções Oculares Bacterianas/tratamento farmacológico
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus/enzimologia
[Mh] Termos MeSH secundário: Retinopatia Diabética/complicações
Retinopatia Diabética/tratamento farmacológico
Retinopatia Diabética/cirurgia
Implantes de Medicamento
Resistência a Medicamentos
Endoftalmite/diagnóstico
Endoftalmite/microbiologia
Infecções Oculares Bacterianas/diagnóstico
Infecções Oculares Bacterianas/microbiologia
Feminino
Glucocorticoides/administração & dosagem
Seres Humanos
Injeções Intravítreas
Edema Macular/tratamento farmacológico
Edema Macular/etiologia
Edema Macular/cirurgia
Meia-Idade
Infecções Estafilocócicas/diagnóstico
Infecções Estafilocócicas/microbiologia
Staphylococcus/isolamento & purificação
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase); 0 (Drug Implants); 0 (Glucocorticoids); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_810_16


  5 / 3127 MEDLINE  
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[PMID]:28587645
[Au] Autor:Kosciuczuk EM; Lisowski P; Jarczak J; Majewska A; Rzewuska M; Zwierzchowski L; Bagnicka E
[Ad] Endereço:Department of Animal Improvement, Institute of Genetics and Animal Breeding Polish Academy of Sciences, 36a Postepu str., Jastrzebiec, 05-552, Poland.
[Ti] Título:Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma.
[So] Source:BMC Vet Res;13(1):161, 2017 Jun 06.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Genome-wide gene expression profiling allows for identification of genes involved in the defense response of the host against pathogens. As presented here, transcriptomic analysis and bioinformatics tools were applied in order to identify genes expressed in the mammary gland parenchyma of cows naturally infected with coagulase-positive and coagulase-negative Staphylococci. RESULTS: In cows infected with coagulase-positive Staphylococci, being in 1st or 2nd lactation, 1700 differentially expressed genes (DEGs) were identified. However, examination of the 3rd or 4th lactations revealed 2200 DEGs. Gene ontology functional classification showed the molecular functions of the DEGs overrepresented the activity of cytokines, chemokines, and their receptors. In cows infected with coagulase-negative Staphylococci, in the 1st or 2nd lactations 418 DEGs, while in the 3rd or 4th lactations, 1200 DEGs were identified that involved in molecular functions such as protein, calcium ion and lipid binding, chemokine activity, and protein homodimerization. Gene network analysis showed DEGs associated with inflammation, cell migration, and immune response to infection, development of cells and tissues, and humoral responses to infections caused by both types of Staphylococci. CONCLUSION: A coagulase-positive Staphylococci infection caused a markedly stronger host response than that of coagulase-negative, resulting in vastly increased DEGs. A significant increase in the expression of the FOS, TNF, and genes encoding the major histocompatibility complex proteins (MHC) was observed. It suggests these genes play a key role in the synchronization of the immune response of the cow's parenchyma against mastitis-causing bacteria. Moreover, the following genes that belong to several physiological pathways (KEGG pathways) were selected for further studies as candidate genes of mammary gland immune response for use in Marker Assisted Selection (MAS): chemokine signaling pathway (CCL2, CXCL5, HCK, CCR1), cell adhesion molecules (CAMs) pathway (BOLA-DQA2, BOLA-DQA1, F11R, ITGAL, CD86), antigen processing and presentation pathway (CD8A, PDIA3, LGMN, IFI30, HSPA1A), and NOD-like receptor signaling pathway (TNF, IL8, IL18, NFKBIA).
[Mh] Termos MeSH primário: Glândulas Mamárias Animais/metabolismo
Mastite Bovina/microbiologia
Tecido Parenquimatoso/microbiologia
Infecções Estafilocócicas/genética
[Mh] Termos MeSH secundário: Animais
Bovinos
Coagulase/metabolismo
Bases de Dados Genéticas
Feminino
Perfilação da Expressão Gênica/veterinária
Mastite Bovina/genética
Família Multigênica
Tecido Parenquimatoso/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Staphylococcus/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coagulase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1088-2


  6 / 3127 MEDLINE  
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[PMID]:28430811
[Au] Autor:Saputra S; Jordan D; Worthing KA; Norris JM; Wong HS; Abraham R; Trott DJ; Abraham S
[Ad] Endereço:Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia.
[Ti] Título:Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study.
[So] Source:PLoS One;12(4):e0176379, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from clinical infections in companion animals (dogs, cats and horses) as part of the first nation-wide survey on antimicrobial resistance in animal pathogens in Australia for a one-year period (January 2013 to January 2014). Clinical Staphylococcus spp. isolates (n = 888) obtained from 22 veterinary diagnostic laboratories were identified by MALDI-TOF mass spectrometry and subjected to antimicrobial susceptibility testing for 16 antimicrobials, representing 12 antimicrobial classes. Potential risk factors associated with methicillin resistance in Staphylococcus pseudintermedius isolates from dogs were analysed based on demographic factors and clinical history, including gender, age, previous antimicrobial treatment, chronic and/or recurrent diseases and site of infections. The most commonly identified CoPS were S. pseudintermedius (70.8%; dogs n = 616, cats n = 13) and S. aureus (13.2%, horses n = 53, dogs n = 47 and cats n = 17). Overall, the frequency of methicillin resistance among S. pseudintermedius (MRSP) and S. aureus (MRSA) was 11.8% and 12.8%, respectively. MRSP isolates were strongly associated with resistance to fluoroquinolones (OR 287; 95%CI 91.2-1144.8) and clindamycin (OR 105.2, 95%CI 48.5-231.9). MRSA isolates from dogs and cats were also more likely to be resistant to fluoroquinolones (OR 5.4, 95%CI 0.6-252.1), whereas MRSA from horses were more likely to be resistant to rifampicin. In multivariate analysis, MRSP-positive status was significantly associated with particular infection sites, including surgical (OR 8.8; 95%CI 3.74-20.7), and skin and soft tissue (OR 3.9; 95%CI 1.97-7.51). S. pseudintermedius isolated from dogs with surgical site infections were three times more likely to be methicillin-resistant if cases had received prior antimicrobial treatment. Whilst the survey results indicate the proportion of CoPS obtained from Australian companion animals that are methicillin-resistant is currently moderate, the identified risk factors suggest that it could rapidly increase without adequate biosecurity and infection control procedures in veterinary practice.
[Mh] Termos MeSH primário: Gatos/microbiologia
Coagulase/metabolismo
Cães/microbiologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Austrália
Testes de Sensibilidade Microbiana
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Staphylococcus aureus/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coagulase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176379


  7 / 3127 MEDLINE  
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[PMID]:28418807
[Au] Autor:Soeorg H; Metsvaht T; Eelmäe I; Metsvaht HK; Treumuth S; Merila M; Ilmoja ML; Lutsar I
[Ad] Endereço:1 Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
[Ti] Título:Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates.
[So] Source:J Hum Lact;33(2):329-340, 2017 May.
[Is] ISSN:1552-5732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human milk is the preferred nutrition for neonates and a source of bacteria. Research aim: The authors aimed to characterize the molecular epidemiology and genetic content of staphylococci in the human milk of mothers of preterm and term neonates. METHODS: Staphylococci were isolated once per week in the 1st month postpartum from the human milk of mothers of 20 healthy term and 49 preterm neonates hospitalized in the neonatal intensive care unit. Multilocus variable-number tandem-repeats analysis and multilocus sequence typing were used. The presence of the mecA gene, icaA gene of the ica-operon, IS 256, and ACME genetic elements was determined by PCR. RESULTS: The human milk of mothers of preterm compared with term neonates had higher counts of staphylococci but lower species diversity. The human milk of mothers of preterm compared with term neonates more often contained Staphylococcus epidermidis mecA (32.7% vs. 2.6%), icaA (18.8% vs. 6%), IS 256 (7.9% vs. 0.9%), and ACME (15.4% vs. 5.1%), as well as Staphylococcus haemolyticus mecA (90.5% vs. 10%) and IS 256 (61.9% vs. 10%). The overall distribution of multilocus variable-number tandem-repeats analysis (MLVA) types and sequence types was similar between the human milk of mothers of preterm and term neonates, but a few mecA-IS 256-positive MLVA types colonized only mothers of preterm neonates. Maternal hospitalization within 1 month postpartum and the use of an arterial catheter or antibacterial treatment in the neonate increased the odds of harboring mecA-positive staphylococci in human milk. CONCLUSION: Limiting exposure of mothers of preterm neonates to the hospital could prevent human milk colonization with more pathogenic staphylococci.
[Mh] Termos MeSH primário: Recém-Nascido Prematuro/fisiologia
Leite Humano/química
Staphylococcus/isolamento & purificação
Nascimento a Termo/fisiologia
[Mh] Termos MeSH secundário: Adulto
Amoxicilina/farmacologia
Amoxicilina/uso terapêutico
Ampicilina/farmacologia
Ampicilina/uso terapêutico
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Aleitamento Materno
Cefuroxima/farmacologia
Cefuroxima/uso terapêutico
Coagulase/análise
Estônia
Feminino
Seres Humanos
Unidades de Terapia Intensiva Neonatal/organização & administração
Unidades de Terapia Intensiva Neonatal/estatística & dados numéricos
Estudos Longitudinais
Leite Humano/microbiologia
Mães/estatística & dados numéricos
Penicilinas/farmacologia
Penicilinas/uso terapêutico
Estudos Prospectivos
Staphylococcus/metabolismo
Staphylococcus epidermidis/isolamento & purificação
Staphylococcus epidermidis/metabolismo
Staphylococcus haemolyticus/isolamento & purificação
Staphylococcus haemolyticus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase); 0 (Penicillins); 7C782967RD (Ampicillin); 804826J2HU (Amoxicillin); O1R9FJ93ED (Cefuroxime)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1177/0890334417691505


  8 / 3127 MEDLINE  
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[PMID]:28399999
[Au] Autor:Sánchez Mainar M; Matheuse F; De Vuyst L; Leroy F
[Ad] Endereço:Research Group of Industrial Microbiology and Food Biotechnology (IMDO), Faculty of Sciences and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
[Ti] Título:Effects of glucose and oxygen on arginine metabolism by coagulase-negative staphylococci.
[So] Source:Food Microbiol;65:170-178, 2017 Aug.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coagulase-negative staphylococci (CNS) are not only part of the desirable microbiota of fermented meat products but also commonly inhabit skin and flesh wounds. Their proliferation depends on the versatility to use energy sources and the adaptation to fluctuating environmental parameters. In this study, the conversion of the amino acid arginine by two strains with arginine deiminase (ADI) activity (Staphylococcus carnosus 833 and S. pasteuri αs3-13) and a strain with nitric oxide synthase (NOS) activity (S. haemolyticus G110) was modelled as a function of glucose and oxygen availability. Both factors moderately inhibited the ADI-based conversion kinetics, never leading to full repression. However, for NOS-driven conversion of arginine by S. haemolyticus G110, oxygen was an absolute requirement. When changing from microaerobic conditions to aerobiosis, a switch from homolactic fermentation to a combined formation of lactic acid, acetic acid, and acetoin was found in all cases, after which lactic acid and acetic acid were used as substrates. The kinetic model proposed provided a suitable description of the data of glucose and arginine co-metabolism as a function of oxygen levels and may serve as a tool to further analyse the behaviour of staphylococci in different ecosystems or when applying specific food processing conditions.
[Mh] Termos MeSH primário: Arginina/metabolismo
Glucose/farmacologia
Produtos da Carne/microbiologia
Oxigênio/farmacologia
Staphylococcus haemolyticus/metabolismo
Staphylococcus/metabolismo
[Mh] Termos MeSH secundário: Ácido Acético/metabolismo
Coagulase/metabolismo
Fermentação
Manipulação de Alimentos
Microbiologia de Alimentos
Glucose/metabolismo
Concentração de Íons de Hidrogênio
Hidrolases/metabolismo
Cinética
Ácido Láctico/metabolismo
Óxido Nítrico Sintase/metabolismo
Oxirredução
Staphylococcus/enzimologia
Staphylococcus haemolyticus/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coagulase); 33X04XA5AT (Lactic Acid); 94ZLA3W45F (Arginine); EC 1.14.13.39 (Nitric Oxide Synthase); EC 3.- (Hydrolases); EC 3.5.3.6 (arginine deiminase); IY9XDZ35W2 (Glucose); Q40Q9N063P (Acetic Acid); S88TT14065 (Oxygen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


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[PMID]:28381743
[Au] Autor:Yamada K; Namikawa H; Fujimoto H; Nakaie K; Takizawa E; Okada Y; Fujita A; Kawaguchi H; Nakamura Y; Abe J; Kaneko Y; Kakeya H
[Ad] Endereço:Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
[Ti] Título:Clinical Characteristics of Methicillin-resistant Coagulase-negative Staphylococcal Bacteremia in a Tertiary Hospital.
[So] Source:Intern Med;56(7):781-785, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Objective Coagulase-negative staphylococci are among the most frequently isolated microorganisms in blood cultures. The aim of this study was to assess [1] the clinical characteristics of methicillin-resistant, coagulase-negative staphylococci bacteremia and [2] the susceptibility of the isolated bacteria to glycopeptides. Methods We retrospectively reviewed the medical records of 70 patients from whom methicillin-resistant coagulase-negative staphylococci had been isolated at Osaka City University Hospital between January 2010 and December 2013. We evaluated the patients' background, severity and prognosis of the disease, and the susceptibility of the isolated methicillin-resistant coagulase-negative staphylococci to glycopeptides. Results Out of the 70 patients tested, 28 (40.0%) had leukemia, and 36 (51.4%) had been treated for febrile neutropenia. Infection with Staphylococcus epidermidis accounted for 78.6% of patients. Thirty-nine cases (55.7%) were related to intravascular catheters, and 39 (55.7%) were treated using teicoplanin as a first-line therapy. The 30-day mortality rate was 4.3%. Regarding susceptibility, 20% of all isolates were non-susceptible to teicoplanin. According to multivariate analyses, it was observed that premedication using glycopeptides was independently associated with teicoplanin non-susceptibility (p=0.03; hazard ratio = 5.64; 95% confidence interval, 1.16-26.76). Conclusion Our results suggest that clinicians must use glycopeptides appropriately to prevent the development of further antibiotic resistance in methicillin-resistant coagulase-negative staphylococci.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Bacteriemia/tratamento farmacológico
Bacteriemia/fisiopatologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bacteriemia/microbiologia
Coagulase
Farmacorresistência Bacteriana
Feminino
Seres Humanos
Masculino
Resistência a Meticilina
Testes de Sensibilidade Microbiana
Meia-Idade
Prognóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
Infecções Estafilocócicas/microbiologia
Staphylococcus epidermidis/isolamento & purificação
Teicoplanina/uso terapêutico
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase); 61036-62-2 (Teicoplanin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7715


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[PMID]:28341052
[Au] Autor:Taponen S; Liski E; Heikkilä AM; Pyörälä S
[Ad] Endereço:Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkula 20, FI-04920 Saarentaus, Finland. Electronic address: suvi.taponen@helsinki.fi.
[Ti] Título:Factors associated with intramammary infection in dairy cows caused by coagulase-negative staphylococci, Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, Corynebacterium bovis, or Escherichia coli.
[So] Source:J Dairy Sci;100(1):493-503, 2017 Jan.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine risk factors for bovine intramammary infection (IMI) associated with the most common bacterial species in Finland. Large databases of the Finnish milk-recording system and results of microbiological analyses of mastitic milk samples from Valio Ltd. (Helsinki, Finland) were analyzed. The study group comprised 29,969 cows with IMI from 4,173 dairy herds. A cow with a quarter milk sample in which DNA of target species was detected in the PathoProof Mastitis PCR Assay (Thermo Fisher Scientific, Waltham, MA) was determined to have IMI. Only cows with IMI caused by the 6 most common pathogens or groups of pathogens, coagulase-negative staphylococci (CNS), Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, Corynebacterium bovis, and Escherichia coli, were included. The control group comprised 160,176 IMI-free cows from the same herds as the study group. A multilevel logistic regression model was used to study herd- and cow-specific risk factors for incidence of IMI. Pathogen-specific results confirmed those of earlier studies, specifically that increasing parity increases prevalence of IMI regardless of causative pathogen. Holsteins were more susceptible to IMI than Nordic Reds except when the causative pathogen was CNS. Occurrence of IMI caused by C. bovis was not related to milk yield, in contrast to IMI caused by all other pathogens investigated. Organic milk production was associated with IMI only when the causative pathogen of IMI was Staph. aureus; Staph. aureus IMI was more likely to occur in conventional than in organic production. Cows in older freestall barns with parlor milking had an increased probability of contracting an IMI compared with cows in tiestall barns or in new freestall barns with automatic milking. This was the case for all IMI, except those caused by CNS, the prevalence of which was not associated with the milking system, and IMI caused by Staph. aureus, which was most common in cows housed in tiestall barns. A better breeding index for milk somatic cell count was associated with decreased occurrence of IMI, indicating that breeding for improved udder health has been successful in reducing the incidence of IMI caused by the most common pathogens in Finland. In the Finnish dairy sector, the importance of other measures to control IMI will increase as the Holstein breed progressively takes the place of the Nordic Red breed. Attention should be paid to hygiene and cleanliness, especially in old freestall barns. Based on our results, the increasing prevalence of automatic milking is not a reason for special concern.
[Mh] Termos MeSH primário: Mastite Bovina/microbiologia
Staphylococcus aureus
[Mh] Termos MeSH secundário: Animais
Bovinos
Coagulase
Corynebacterium
Escherichia coli
Feminino
Leite/microbiologia
Infecções Estafilocócicas/veterinária
Streptococcus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coagulase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE



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