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[PMID]:29292194
[Au] Autor:Singh H; Samani D; Nambiar N; Ghate MV; Gangakhedkar RR
[Ad] Endereço:Department of Molecular Biology, National AIDS Research Institute, Pune 411026, India. Electronic address: hsingh@nariindia.org.
[Ti] Título:Prevalence of MMP-8 gene polymorphisms in HIV-infected individuals and its association with HIV-associated neurocognitive disorder.
[So] Source:Gene;646:83-90, 2018 Mar 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Matrix metalloproteinases (MMPs) are well-known as mediators of neuroinflammation in HIV-associated neurocognitive disorder (HAND). Increased levels of MMP-8 have been observed in the HIV-infected patients. Thus, the aim of this study was to evaluate the association of MMP-8 gene polymorphisms with modulation of HAND severity and its prevalence in HIV-infected and healthy individuals. We enrolled a total of 150 HIV-infected individuals, 50 HAND patients, 100 HIV-infected and 150 healthy individuals. MMP-8 (-799C/T, +17C/G) polymorphisms were genotyped by PCR-RFLP. MMP-8 -799TT genotype and +17G allele showed the higher risk for modulation of HAND severity (OR=2.20, P=0.19; OR=1.97, P=0.23). MMP-8 -799TT genotype differed significantly in HIV-infected individuals compared to healthy controls (20.0% vs. 11.3%, OR=2.36, P=0.048). Haplotype TG increased the risk for modulation of HAND severity (OR=2.29, P=0.29). MMP-8 -799TT and +17CG genotypes were overrepresented in the intermediate HIV disease stage compared with healthy controls (25.9% vs. 11.3%, OR=4.34, P=0.021, 14.8% vs. 9.3%, OR=2.88, P=0.11). MMP-8 +17CG genotype enhanced the risk for modulation of HAND severity in tobacco using HAND patients (OR=5.01, P=0.17). MMP-8 -799TT genotype was more frequent in tobacco using HIV-infected individuals compared with nonusers (26.3% vs. 16.7%, OR=2.08, P=0.32). MMP-8 +17CG genotype increased the risk for modulation of HAND severity in alcohol using HAND patients (OR=4.99, P=0.18). In conclusion, MMP-8 polymorphisms independently and with alcohol and tobacco usage revealed a trend of higher risk for the modulation of HAND severity. MMP-8 -799TT genotype was associated with the advancement of HIV disease.
[Mh] Termos MeSH primário: Complexo AIDS Demência/genética
Infecções por HIV/genética
Metaloproteinase 8 da Matriz/genética
Polimorfismo de Nucleotídeo Único
Regulação para Cima
[Mh] Termos MeSH secundário: Adulto
Álcoois/efeitos adversos
Estudos de Casos e Controles
Feminino
Estudos de Associação Genética
Predisposição Genética para Doença
Genótipo
Infecções por HIV/complicações
Haplótipos
Seres Humanos
Masculino
Prevalência
Regiões Promotoras Genéticas
Fatores de Risco
Índice de Gravidade de Doença
Fumar/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); EC 3.4.24.34 (MMP8 protein, human); EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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[PMID]:28081646
[Au] Autor:Chaemsaithong P; Romero R; Docheva N; Chaiyasit N; Bhatti G; Pacora P; Hassan SS; Yeo L; Erez O
[Ad] Endereço:a Perinatology Research Branch , NICHD/NIH/DHHS, Bethesda, MD , and Detroit , MI , USA.
[Ti] Título:Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes .
[So] Source:J Matern Fetal Neonatal Med;31(2):228-244, 2018 Jan.
[Is] ISSN:1476-4954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Among patients presenting with preterm labor and intact membranes, those with intra-amniotic inflammation have adverse obstetrical and neonatal outcomes. The diagnosis of intra-amniotic inflammation can easily be made by detecting an elevated concentration of the cytokine interleukin (IL)-6 or the enzyme neutrophil collagenase, also known as matrix metalloproteinase (MMP)-8. The diagnostic performances of MMP-8 and IL-6 enzyme-linked immunosorbent assay tests are similar. Recently, a rapid test has become available for point-of-care determination of either MMP-8 or IL-6. The objectives of this study were to compare the diagnostic indices and predictive values between the rapid MMP-8 and IL-6 tests for the identification of intra-amniotic inflammation in patients with preterm labor and intact membranes. MATERIALS AND METHODS: We performed a retrospective cohort study including 124 women with singleton pregnancies who presented with symptoms of preterm labor and underwent transabdominal amniocentesis for the evaluation of microbial invasion of the amniotic cavity (MIAC). MIAC was defined according to amniotic fluid culture results (aerobic and anaerobic bacteria as well as genital Mycoplasmas). Amniotic fluid white blood cell (WBC) counts were determined using a hemocytometer chamber. An elevated amniotic fluid MMP-8 concentration was assessed using Yoon's MMP-8 Check (cutoff: 10 ng/mL). An elevated amniotic fluid IL-6 concentration was scored when there was a positive result for the lateral flow-based immunoassay (cutoff: ≥745 pg/mL and ≥1000 pg/mL). In order to objectively compare rapid MMP-8 and rapid IL-6 tests to identify intra-amniotic inflammation, an amniotic fluid WBC count of ≥50 cells/mm was used to define intra-amniotic inflammation. RESULTS: (1) The rapid tests had the same sensitivity for the detection of intra-amniotic inflammation [85.7% (18/21) for all]; (2) the specificity of the rapid MMP-8 test was higher than that of the rapid IL-6 test (cutoff: 745 pg/mL) for the identification of intra-amniotic inflammation [72.8% (75/103) vs. 64.1% (66/103); p < 0.05]; and (3) there were no differences in the sensitivity and specificity between the rapid MMP-8 test and the rapid IL-6 test (cutoff:1000 pg/mL) in the identification of intra-amniotic inflammation. Of 13 patients with discrepant results between the rapid MMP-8 and rapid IL-6 tests, two had a positive MMP-8 but a negative rapid IL-6 test, and both delivered preterm - one within 24 h, and the other within 10 days - and both had acute histologic chorioamnionitis. On the other hand, there were 11 patients with a positive rapid IL-6 but a negative rapid MMP-8 result: 10 delivered preterm, 3 had acute histologic chorioamnionitis and 1 had subacute chorionitis. CONCLUSION: We conclude that the rapid MMP-8 test has a better specificity than the rapid IL-6 (cutoff: 745 pg/mL) assay for the detection of intra-amniotic infection. Moreover, we observed that among patients who were not identified as having intra-amniotic infection or inflammation by the standard cultivation technique and amniotic fluid WBC count, those who had a positive MMP-8 rapid test delivered preterm and had acute histologic chorioamnionitis.
[Mh] Termos MeSH primário: Líquido Amniótico
Corioamnionite/diagnóstico
Interleucina-6/análise
Metaloproteinase 8 da Matriz/análise
Trabalho de Parto Prematuro
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: Adulto
Amniocentese
Líquido Amniótico/citologia
Líquido Amniótico/microbiologia
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Trabalho de Parto Prematuro/epidemiologia
Trabalho de Parto Prematuro/metabolismo
Gravidez
Estudos Retrospectivos
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL6 protein, human); 0 (Interleukin-6); EC 3.4.24.34 (MMP8 protein, human); EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1080/14767058.2017.1281904


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[PMID]:29215835
[Au] Autor:Shkorik EV; Markelova EV; Silaev AA; Geltser BI; Semenikhin AA; Fedjanina LN
[Ti] Título:[Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization].
[So] Source:Patol Fiziol Eksp Ter;61(2):37-45, 2017 Apr-Jun.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There is still a great need for detection of biomarkers for early prediction and diagnosis of cardiovascular complications (CVC) in patients with CHD. Objective: To determine the role of MMP-1, 8, 9 in the risk of CCO in patients with CHD before and after coronary artery bypass grafting (CABG). Methods. The study included 75 patients with coronary heart disease before and after myocardial revascularization by CABG, including 40 men and 35 women aged from 45 to 74 years. Patients were divided into two groups: I group - 25 patients with CVC registered after CABG (acute myocardial infarction, ischemic stroke, pulmonary thromboembolism Branch); II group - 50 patients with coronary heart disease without complications after myocardial revascularization. Blood sampling was performed the day before surgery, on the 1st, 3rd and 10th days after CABG. Determining the level of MMP-1, 8, 9 in the serum was performed by ELISA using reagents specific «RD Diagnostics Inc.¼, USA. Results are expressed in ng/ml. Data are presented as medians and quartiles of two (Me, Q25, Q75). Within and between-group differences were evaluated using the Mann - Whitney, Spearman correlation coefficient and c2 test within the application program SPSS â„–16. Statistically significant differences between the indicators considered when you reject the hypothesis and significance level of p<0,05. Results. A statistically increased concentration of MMP-1 and MMP-8 in patients in group I. Undetermined significant dynamics of MMP-9 in patients after myocardial revascularization. Conclusion. The results indicate that the level of MMP-1, 2.5 ng/ml or more in patients with CAD is a diagnostic criterion for the risk of TE complications. No association between high content of MMP-8 and the presence of complications in patients after surgery. There were no significant dynamics of MMP-9 in patients after myocardial revascularization.
[Mh] Termos MeSH primário: Ponte de Artéria Coronária
Doença das Coronárias
Metaloproteinase 1 da Matriz/sangue
Metaloproteinase 8 da Matriz/sangue
Metaloproteinase 9 da Matriz/sangue
Complicações Pós-Operatórias/sangue
[Mh] Termos MeSH secundário: Idoso
Doença das Coronárias/sangue
Doença das Coronárias/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.34 (MMP8 protein, human); EC 3.4.24.34 (Matrix Metalloproteinase 8); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:28958936
[Au] Autor:Kim J; Jeong YH; Lee EJ; Park JS; Seo H; Kim HS
[Ad] Endereço:Department of Molecular & Life Sciences, College of Science & Technology, Hanyang University, Ansan, South Korea.
[Ti] Título:Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
[So] Source:Biochem Biophys Res Commun;493(2):879-886, 2017 Nov 18.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microglial priming is caused by aging and neurodegenerative diseases, and is characterized by an exaggerated microglial inflammatory response to secondary and sub-threshold challenges. In the present study, we examined the effects of the matrix metalloproteinase-8 (MMP-8) inhibitor (M8I) on the brain of aged normal and leucine-rich repeat kinase 2 (LRRK2) G2019S Parkinson's disease (PD) model mice systemically stimulated with lipopolysaccharide (LPS). The results indicated that Iba-1 positive microglia and GFAP-positive astrocytes, which were increased by LPS, significantly decreased by M8I in aged normal and PD model mice. M8I also decreased the expression of pro-inflammatory markers in the hippocampus and midbrain of aged normal and PD model mice challenged with LPS, while it also improved the motor coordination of aged normal mice after LPS challenge in rotor rod test and the general crossing locomotor activities of LPS-treated LRRK2G2019S PD mice after LPS challenge in open field test. To assess the effects of M8I in an in vitro priming model, BV2 microglia were pretreated with macrophage colony-stimulating factor (CSF)-1 or interleukin (IL)-34, and subsequently stimulated with LPS or polyinosinic-polycytidylic acid (poly[I:C]). M8I inhibited the LPS- or poly(I:C)-induced production of the tumor necrosis factor-α and nitric oxide, alone or in combination with CSF-1 or IL-34. Collectively, the data suggested that M8I has a therapeutic potential in treating neurodegenerative diseases that are aggravated by systemic inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Inflamação/tratamento farmacológico
Lipopolissacarídeos/imunologia
Metaloproteinase 8 da Matriz/imunologia
Inibidores de Metaloproteinases de Matriz/uso terapêutico
Microglia/efeitos dos fármacos
Doença de Parkinson/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Inflamação/genética
Inflamação/imunologia
Inflamação/patologia
Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/genética
Locomoção/efeitos dos fármacos
Camundongos
Camundongos Transgênicos
Microglia/imunologia
Microglia/patologia
NF-kappa B/imunologia
Óxido Nítrico/imunologia
Doença de Parkinson/genética
Doença de Parkinson/imunologia
Doença de Parkinson/patologia
Mutação Puntual
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Matrix Metalloproteinase Inhibitors); 0 (NF-kappa B); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2); EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


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[PMID]:28826677
[Au] Autor:Caria CREP; Gotardo ÉMF; Santos PS; Acedo SC; de Morais TR; Ribeiro ML; Gambero A
[Ad] Endereço:Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP 12916-900, Brazil. Electronic address: cintiarabello@yahoo.com.br.
[Ti] Título:Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipose during weight cycling in mice.
[So] Source:Exp Cell Res;359(2):431-440, 2017 Oct 15.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Extracellular matrix (ECM) remodeling is necessary for a health adipose tissue (AT) expansion and also has a role during weight loss. We investigate the ECM alteration during weight cycling (WC) in mice and the role of matrix metalloproteinases (MMPs) was assessed using GM6001, an MMP inhibitor, during weight loss (WL). Obesity was induced in mice by a high-fat diet. Obese mice were subject to caloric restriction for WL followed by reintroduction to high-fat diet for weight regain (WR), resulting in a WC protocol. In addition, mice were treated with GM6001 during WL period and the effects were observed after WR. Activity and expression of MMPs was intense during WL. MMP inhibition during WL results in inflammation and collagen content reduction. MMP inhibition during WL period interferes with the period of subsequent expansion of AT resulting in improvements in local inflammation and systemic metabolic alterations induced by obesity. Our results suggest that MMPs inhibition could be an interesting target to improve adipose tissue inflammation during WL and to support weight cyclers.
[Mh] Termos MeSH primário: Dipeptídeos/farmacologia
Matriz Extracelular/metabolismo
Gordura Intra-Abdominal/metabolismo
Inibidores de Metaloproteinases de Matriz/farmacologia
Obesidade/enzimologia
[Mh] Termos MeSH secundário: Animais
Restrição Calórica
Colágeno/genética
Colágeno/metabolismo
Dieta Hiperlipídica/efeitos adversos
Metabolismo Energético
Matriz Extracelular/efeitos dos fármacos
Expressão Gênica
Inflamação/prevenção & controle
Gordura Intra-Abdominal/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
Masculino
Metaloproteinase 12 da Matriz/genética
Metaloproteinase 12 da Matriz/metabolismo
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 3 da Matriz/genética
Metaloproteinase 3 da Matriz/metabolismo
Metaloproteinase 8 da Matriz/genética
Metaloproteinase 8 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/genética
Metaloproteinase 9 da Matriz/metabolismo
Camundongos
Obesidade/etiologia
Obesidade/genética
Obesidade/patologia
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Ganho de Peso/efeitos dos fármacos
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dipeptides); 0 (Matrix Metalloproteinase Inhibitors); 0 (N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide); 0 (Protein Isoforms); 9007-34-5 (Collagen); EC 3.4.24.17 (Matrix Metalloproteinase 3); EC 3.4.24.17 (Mmp3 protein, mouse); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.24 (Mmp2 protein, mouse); EC 3.4.24.34 (MMP8 protein, mouse); EC 3.4.24.34 (Matrix Metalloproteinase 8); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse); EC 3.4.24.65 (Matrix Metalloproteinase 12); EC 3.4.24.65 (matrix metallopeptidase 12, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28772283
[Au] Autor:Åström P; Juurikka K; Hadler-Olsen ES; Svineng G; Cervigne NK; Coletta RD; Risteli J; Kauppila JH; Skarp S; Kuttner S; Oteiza A; Sutinen M; Salo T
[Ad] Endereço:Cancer and Translational Medicine Research Unit, University of Oulu, PO Box 5281, Oulu 90014, Finland.
[Ti] Título:The interplay of matrix metalloproteinase-8, transforming growth factor-ß1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
[So] Source:Br J Cancer;117(7):1007-1016, 2017 Sep 26.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Matrix metalloproteinase-8 (MMP-8) has oncosuppressive properties in various cancers. We attempted to assess MMP-8 function in oral tongue squamous cell carcinoma (OTSCC). METHODS: MMP-8 overexpressing OTSCC cells were used to study the effect of MMP-8 on proliferation, apoptosis, migration, invasion and gene and protein expression. Moreover, MMP-8 functions were assessed in the orthotopic mouse tongue cancer model and by immunohistochemistry in patient samples. RESULTS: MMP-8 reduced the invasion and migration of OTSCC cells and decreased the expression of MMP-1, cathepsin-K and vascular endothelial growth factor-C (VEGF-C). VEGF-C was induced by transforming growth factor-ß1 (TGF-ß1) in control cells, but not in MMP-8 overexpressing cells. In human OTSCC samples, low MMP-8 in combination with high VEGF-C was an independent predictor of poor cancer-specific survival. TGF-ß1 treatment also restored the migration of MMP-8 overexpressing cells to the level of control cells. In mouse tongue cancer, MMP-8 did not inhibit metastasis, possibly because it was eliminated in the peripheral carcinoma cells. CONCLUSIONS: The suppressive effects of MMP-8 in OTSCC may be mediated through interference of TGF-ß1 and VEGF-C function and altered proteinase expression. Together, low MMP-8 and high VEGF-C expression have strong independent prognostic value in OTSCC.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/metabolismo
Metaloproteinase 8 da Matriz/genética
Metaloproteinase 8 da Matriz/metabolismo
Neoplasias da Língua/metabolismo
Fator de Crescimento Transformador beta1/metabolismo
Fator C de Crescimento do Endotélio Vascular/metabolismo
[Mh] Termos MeSH secundário: Idoso
Animais
Apoptose
Carcinoma de Células Escamosas/química
Carcinoma de Células Escamosas/genética
Carcinoma de Células Escamosas/secundário
Catepsina K/metabolismo
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Movimento Celular/genética
Proliferação Celular
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Masculino
Metaloproteinase 1 da Matriz/metabolismo
Metaloproteinase 8 da Matriz/análise
Camundongos
Camundongos Endogâmicos BALB C
Meia-Idade
Transplante de Neoplasias
Prognóstico
Taxa de Sobrevida
Neoplasias da Língua/química
Neoplasias da Língua/genética
Neoplasias da Língua/patologia
Fator de Crescimento Transformador beta1/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1); 0 (Vascular Endothelial Growth Factor C); EC 3.4.22.38 (Cathepsin K); EC 3.4.24.34 (Matrix Metalloproteinase 8); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.249


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[PMID]:28683915
[Au] Autor:Karabencheva-Christova TG; Christov CZ; Fields GB
[Ad] Endereço:Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom.
[Ti] Título:Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies.
[So] Source:Adv Protein Chem Struct Biol;109:1-24, 2017.
[Is] ISSN:1876-1623
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Several members of the zinc-dependent matrix metalloproteinase (MMP) family catalyze collagen degradation. Experimental data reveal a collaboration between different MMP domains in order to achieve efficient collagenolysis. Molecular dynamics (MD) simulations have been utilized to provide atomistic details of the collagenolytic process. The triple-helical structure of collagen exhibits local regions of flexibility, with modulation of interchain salt bridges and water bridges contributing to accessibility of individual chains by the enzyme. In turn, the hemopexin-like (HPX) domain of the MMP initially binds the triple helix and facilitates the presentation of individual strands to active site in the catalytic (CAT) domain. Extensive positive and negative correlated motions are observed between the CAT and HPX domains when collagen is bound. Ultimately, the MD simulation studies have complemented structural (NMR spectroscopy, X-ray crystallography) and kinetic analyses to provide a more detailed mechanistic view of MMP-catalyzed collagenolysis.
[Mh] Termos MeSH primário: Colágeno/metabolismo
Metaloproteinases da Matriz/metabolismo
Simulação de Dinâmica Molecular
[Mh] Termos MeSH secundário: Animais
Domínio Catalítico
Colágeno/química
Cristalografia por Raios X
Seres Humanos
Metaloproteinase 1 da Matriz/química
Metaloproteinase 1 da Matriz/metabolismo
Metaloproteinase 2 da Matriz/química
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 8 da Matriz/química
Metaloproteinase 8 da Matriz/metabolismo
Metaloproteinases da Matriz/química
Ressonância Magnética Nuclear Biomolecular
Conformação Proteica
Proteólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-34-5 (Collagen); EC 3.4.24.- (Matrix Metalloproteinases); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.34 (Matrix Metalloproteinase 8); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28668847
[Au] Autor:Shen TC; Hsia TC; Chao CY; Chen WC; Chen CY; Chen WC; Lin YT; Hsiao CL; Chang WS; Tsai CW; Bau DT
[Ad] Endereço:Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
[Ti] Título:The Contribution of Promoter Polymorphisms in Lung Cancer.
[So] Source:Anticancer Res;37(7):3563-3567, 2017 07.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Accumulated evidence has supported the hypothesis that the functional polymorphisms of matrix metalloproteinases (MMP) were associated with the risk of various types of cancer. However, few reports have studied the contribution of MMP-8 genotypes to either diagnostic or prognostic potential in lung cancer. In this study, we focused on the contribution of a polymorphism in the promoter region of MMP-8 (C-799T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to lung cancer risk. PATIENTS AND METHODS: Genomic DNA was isolated from peripheral blood of 358 patients with lung cancer and 716 non-cancer healthy individuals. MMP-8 C-799T (rs11225395), Val436Ala (rs34009635) and Lys460Thr (rs35866072) polymorphic genotypes of each subject were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The results showed that the three polymorphisms were not significantly associated with increased risk of lung cancer in the overall investigated population. Furthermore, when the analyses were stratified according to age, sex, status of smoking and drinking, pack-years of smoking and family history of lung cancer, there was also no significant association between these genotypes and increased lung cancer risk. CONCLUSION: The polymorphisms MMP-8 C-799T, Val436Ala and Lys460Thr may not play a major role in mediating personal susceptibility to lung cancer in Taiwan.
[Mh] Termos MeSH primário: Predisposição Genética para Doença/genética
Neoplasias Pulmonares/genética
Metaloproteinase 8 da Matriz/genética
Polimorfismo de Fragmento de Restrição/genética
Regiões Promotoras Genéticas/genética
[Mh] Termos MeSH secundário: Alelos
Estudos de Casos e Controles
Feminino
Frequência do Gene/genética
Genótipo
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Fumar/efeitos adversos
Fumar/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  9 / 1063 MEDLINE  
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[PMID]:28423488
[Au] Autor:An F; Du J; Cao Y; Shi J; Guo Y; Jin T; Li J; Chen J; Li P; Dong M; Wang G; Wang J
[Ad] Endereço:Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
[Ti] Título:MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population.
[So] Source:Oncotarget;8(13):21561-21566, 2017 Mar 28.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteonecrosis of the femoral head (ONFH) is an orthopedic refractory disease that adversely affects quality of life. Matrix metalloproteinase-8 (MMP-8) produced by the bone marrow has been implicated in the degradation of collagen during bone development. We assessed whether MMP8 polymorphisms are associated with ONFH. In a case-control study, using χ2 tests and genetic model analyses, we genotyped 5 MMP8 single-nucleotide polymorphisms (SNPs) in 585 ONFH patients and 507 healthy control subjects in a Chinese Han population. The MMP8 rs11225394 SNP was associated with an increased risk of ONFH in an allele model (OR=1.34; 95% CI, 1.003-1.786, P=0.047). In addition, rs11225394 was associated with an increased risk of ONFH in a dominant model (OR =1.39, 95% CI, 1.02-1.89, P=0.036), over-dominant model (OR=1.39, 95% CI, 1.02-1.89, P=0.038), and log-additive model (OR =1.36, 95% CI, 1.01-1.84, P=0.039). After adjusting for age and gender, rs11225394 was associated with ONFH in a dominant (OR =1.44, 95% CI, 1.05-1.96, P=0.023), over-dominant (OR =1.44, 95% CI, 1.05-1.98, P=0.022), and log-additive model (OR =1.40, 95% CI, 1.04-1.90, P=0.027). These results provide the first evidence that MMP8 SNP at the rs11225394 locus is associated with the increased risk of ONFH in Chinese Han population.
[Mh] Termos MeSH primário: Necrose da Cabeça do Fêmur/genética
Predisposição Genética para Doença/genética
Metaloproteinase 8 da Matriz/genética
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático/genética
Estudos de Casos e Controles
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Análise de Sequência com Séries de Oligonucleotídeos
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.34 (MMP8 protein, human); EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15371


  10 / 1063 MEDLINE  
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[PMID]:28403357
[Au] Autor:Santos BF; Souza EQ; Brigagão MR; Lima DC; Fernandes LA
[Ad] Endereço:Universidade Federal de Alfenas, Faculdade de Odontologia, Alfenas, MG, Brasil.
[Ti] Título:Local application of statins in the treatment of experimental periodontal disease in rats.
[So] Source:J Appl Oral Sci;25(2):168-176, 2017 Mar-Apr.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods: Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results: The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions: Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/farmacologia
Periodontite/tratamento farmacológico
Aplainamento Radicular/métodos
Sinvastatina/farmacologia
[Mh] Termos MeSH secundário: Animais
Biópsia
Quimioterapia Adjuvante
Gengiva/efeitos dos fármacos
Gengiva/patologia
Masculino
Mandíbula/diagnóstico por imagem
Mandíbula/patologia
Metaloproteinase 8 da Matriz/análise
Periodontite/patologia
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); AGG2FN16EV (Simvastatin); EC 3.4.24.34 (MMP-8 protein, rat); EC 3.4.24.34 (Matrix Metalloproteinase 8)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE



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