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  1 / 11751 MEDLINE  
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[PMID]:28744580
[Au] Autor:Wester A; Devocelle M; Tallant EA; Chappell MC; Gallagher PE; Paradisi F
[Ad] Endereço:School of Chemistry, University College Dublin, Dublin, Ireland.
[Ti] Título:Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid.
[So] Source:Amino Acids;49(10):1733-1742, 2017 10.
[Is] ISSN:1438-2199
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailability resulting from rapid enzymatic metabolism by peptidases including angiotensin-converting enzyme (ACE) and dipeptidyl peptidase 3 (DPP 3). We report the facile assembly of three novel Ang-(1-7) analogues by solid-phase peptide synthesis which incorporates the cyclic non-natural δ-amino acid ACCA. The analogues containing the ACCA substitution at the site of ACE cleavage exhibit complete resistance to human ACE, while substitution at the DDP 3 cleavage site provided stability against DPP 3 hydrolysis. Furthermore, the analogues retain the anti-proliferative properties of Ang-(1-7) against the 4T1 and HT-1080 cancer cell lines. These results suggest that ACCA-substituted Ang-(1-7) analogues which show resistance against proteolytic degradation by peptidases known to hydrolyze the native heptapeptide may be novel therapeutics in the treatment of cancer.
[Mh] Termos MeSH primário: Substituição de Aminoácidos
Angiotensina I
Dipeptidil Peptidases e Tripeptidil Peptidases/química
Fragmentos de Peptídeos
Peptidil Dipeptidase A/química
Proteólise
[Mh] Termos MeSH secundário: Angiotensina I/síntese química
Angiotensina I/química
Seres Humanos
Fragmentos de Peptídeos/síntese química
Fragmentos de Peptídeos/química
Estabilidade Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Peptide Fragments); 9041-90-1 (Angiotensin I); EC 3.4.14.- (Dipeptidyl-Peptidases and Tripeptidyl-Peptidases); EC 3.4.14.4 (DPP3 protein, human); EC 3.4.15.1 (Peptidyl-Dipeptidase A); IJ3FUK8MOF (angiotensin I (1-7))
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s00726-017-2471-9


  2 / 11751 MEDLINE  
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[PMID]:29390444
[Au] Autor:Pan YH; Huang YM; Qiao YC; Ling W; Geng LJ; Xiao JL; Zhang XX; Zhao HL
[Ad] Endereço:Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence.
[Ti] Título:Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus.
[So] Source:Medicine (Baltimore);96(51):e9148, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it.Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR) was performed for angiotensin-converting enzyme (ACE) genotyping and PCR-restricted fragment length polymorphism was used for angiotensinogen (AGT) genotyping.Patients with a negative family history had higher level of triglyceride and blood pressure, whereas those with a positive family history showed younger onset age and lower body mass index value (All P < .05), these findings were age-dependent. The percentage of hypertension was lower with a higher percentage of overweight among the patients with a positive family history (All P < .05). Patients with a positive family history and those with a negative family history had comparable genotype and allele distribution of ACE gene insertion/deletion polymorphisms and AGT gene M/T polymorphisms.A positive family history of diabetes was not associated with the RAS gene polymorphisms.
[Mh] Termos MeSH primário: Angiotensinogênio/genética
Diabetes Mellitus Tipo 2/epidemiologia
Peptidil Dipeptidase A/genética
Polimorfismo de Fragmento de Restrição
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Grupo com Ancestrais do Continente Asiático
Pressão Sanguínea
Índice de Massa Corporal
China/epidemiologia
Estudos Transversais
Feminino
Frequência do Gene
Genótipo
Seres Humanos
Masculino
Meia-Idade
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triglycerides); 11002-13-4 (Angiotensinogen); EC 3.4.15.1 (ACE protein, human); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009148


  3 / 11751 MEDLINE  
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[PMID]:29211853
[Au] Autor:Zhao S; Ghosh A; Lo CS; Chenier I; Scholey JW; Filep JG; Ingelfinger JR; Zhang SL; Chan JSD
[Ad] Endereço:Centre de Recherche, Centre Hospitalier de l'Université de Montréal and Département de Médecine, Université de Montréal, Montréal, Quebec, Canada.
[Ti] Título:Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice.
[So] Source:Endocrinology;159(2):836-852, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal tubule cells (RPTCs) and in the development of systemic hypertension and kidney injury in diabetic Akita mice. We used adult male Akita Nrf2 knockout mice and Akita mice treated with trigonelline (an Nrf2 inhibitor) or oltipraz (an Nrf2 activator). We also examined rat immortalized RPTCs (IRPTCs) stably transfected with control plasmids or plasmids containing rat angiotensinogen (Agt), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (Ace2), or angiotensin 1-7 (Ang 1-7) receptor (MasR) gene promoters. Genetic deletion of Nrf2 or pharmacological inhibition of Nrf2 in Akita mice attenuated hypertension, renal injury, tubulointerstitial fibrosis, and the urinary albumin/creatinine ratio. Furthermore, loss of Nrf2 upregulated RPTC Ace2 and MasR expression, increased urinary Ang 1-7 levels, and downregulated expression of Agt, ACE, and profibrotic genes in Akita mice. In cultured IRPTCs, Nrf2 small interfering RNA transfection or trigonelline treatment prevented high glucose stimulation of Nrf2 nuclear translocation, Agt, and ACE transcription with augmentation of Ace2 and MasR transcription, which was reversed by oltipraz. These data identify a mechanism, Nrf2-mediated stimulation of intrarenal RAS gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
[Mh] Termos MeSH primário: Nefropatias Diabéticas/genética
Hipertensão/genética
Rim/metabolismo
Fator 2 Relacionado a NF-E2/genética
Peptidil Dipeptidase A/genética
Receptor Tipo 2 de Angiotensina/genética
[Mh] Termos MeSH secundário: Angiotensina I/metabolismo
Animais
Células Cultivadas
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/genética
Diabetes Mellitus Experimental/metabolismo
Nefropatias Diabéticas/metabolismo
Nefropatias Diabéticas/patologia
Regulação Enzimológica da Expressão Gênica
Hipertensão/complicações
Hipertensão/metabolismo
Hipertensão/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Fragmentos de Peptídeos/metabolismo
Peptidil Dipeptidase A/metabolismo
Ratos
Receptor Tipo 2 de Angiotensina/metabolismo
Sistema Renina-Angiotensina/genética
Sistema Renina-Angiotensina/fisiologia
Regulação para Cima/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (Peptide Fragments); 0 (Receptor, Angiotensin, Type 2); 9041-90-1 (Angiotensin I); EC 3.4.15.1 (Peptidyl-Dipeptidase A); EC 3.4.17.- (angiotensin converting enzyme 2); IJ3FUK8MOF (angiotensin I (1-7))
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00752


  4 / 11751 MEDLINE  
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[PMID]:29310338
[Au] Autor:Yuan Y; Meng L; Zhou Y; Lu N
[Ad] Endereço:Department of Anesthesiology.
[Ti] Título:Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk: A systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);96(48):e8639, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Genetic factors in the pathogenesis of cardiomyopathies have received a lot of attention during the past 2 decades. Some studies have reported that angiotensin-converting enzyme (ACE) gene has been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. To clarify the influence of ACE on HCM, a systemic review and meta-analysis of case-control studies were performed. METHODS: The following databases were searched to indentify related studies: PubMed database, the Embase database, the Cochrane Central Register of Controlled Trials database, China National Knowledge Information database, and Chinese Scientific and Technological Journal database. Search terms included "hypertrophic cardiomyopathy," "angiotensin converting enzyme" or "ACE," and "polymorphism or mutation." RESULTS: Fifteen separate studies were suitable for the inclusion criterion. The selected studies contained 2972 participants, including 1047 in HCM group and 1925 controls. Pooled odds ratios (ORs) were calculated to assess the association between ACE insertion/deletion (I/D) polymorphism and HCM. Our case-control data indicated that D allele carrier is a risk allele in all genetic models: allele contrast (D vs I: OR = 1.35, 95% confidence interval [CI]: 1.10-1.65, P = .004), homozygous comparison (DD vs II: OR = 1.69; 95% CI: 1.12-2.54; P = .01), dominant model (DD + ID vs II: OR = 1.52, 95% CI: 1.15-2.02, P = .003), and recessive model (DD vs ID + II: OR = 1.34, 95% CI: 0.99-1.81, P = .03). CONCLUSION: In summary, the current meta-analysis provided solid evidence suggesting that ACE gene I/D polymorphism was probably a genetic risk factor for HCM.
[Mh] Termos MeSH primário: Cardiomiopatia Hipertrófica/genética
Peptidil Dipeptidase A/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Alelos
Predisposição Genética para Doença
Seres Humanos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008639


  5 / 11751 MEDLINE  
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[PMID]:29215878
[Au] Autor:Liu L; Wei Y; Chang Q; Sun H; Chai K; Huang Z; Zhao Z; Zhao Z
[Ad] Endereço:Guangxi Colleges and Universities Key Laboratory of New Technology and Application in Resource Chemical Engineering, School of Chemistry and Chemical Engineering, Guangxi University , Nanning 530004, China.
[Ti] Título:Ultrafast Screening of a Novel, Moderately Hydrophilic Angiotensin-Converting-Enzyme-Inhibitory Peptide, RYL, from Silkworm Pupa Using an Fe-Doped-Silkworm-Excrement-Derived Biocarbon: Waste Conversion by Waste.
[So] Source:J Agric Food Chem;65(51):11202-11211, 2017 Dec 27.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel, moderately hydrophilic peptide (RYL) with high ACE-inhibitory activity was screened ultrafast via a concept of waste conversion using waste. This novel peptide was screened from silkworm pupa using an Fe-doped porous biocarbon (FL/Z-SE) derived from silkworm excrement. FL/Z-SE possessed magnetic properties and specific selection for peptides due to Fe's dual functions. The selected RYL, which has moderate hydrophilicity (LogP = -0.22), exhibited a comparatively high ACE-inhibitory activity (IC = 3.31 ± 0.11 µM). The inhibitory kinetics and docking-simulation results show that, as a competitive ACE inhibitor, RYL formed five hydrogen bonds with the ACE residues in the S1 and S2 pockets. In this work, both the screening carbon material and the selected ACE-inhibitory peptide were derived from agricultural waste (silkworm excrement and pupa), which offers a new way of thinking about the development of advanced uses of the silkworm byproducts and wastes.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/isolamento & purificação
Bombyx/química
Carbono/química
Proteínas de Insetos/química
Peptídeos/isolamento & purificação
Pupa/química
Resíduos/análise
[Mh] Termos MeSH secundário: Inibidores da Enzima Conversora de Angiotensina/química
Animais
Ligações de Hidrogênio
Hidrólise
Interações Hidrofóbicas e Hidrofílicas
Cinética
Simulação de Acoplamento Molecular
Peptídeos/química
Peptidil Dipeptidase A/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Insect Proteins); 0 (Peptides); 0 (Waste Products); 7440-44-0 (Carbon); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04442


  6 / 11751 MEDLINE  
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[PMID]:29017962
[Au] Autor:Pandith AA; Qasim I; Zahoor W; Shah P; Bhat AR
[Ad] Endereço:Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J&K, India. Electronic address: arshad.pandith@skims.ac.in.
[Ti] Título:ACE I/D sequence variants but not MTHFR C677T, is strongly linked to malignant glioma risk and its variant DD genotype may act as a promising predictive biomarker for overall survival of glioma patients.
[So] Source:Gene;639:62-68, 2018 Jan 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: ACE I/D and MTHFR C677T gene polymorphisms can be seen as candidate genes for glioma on the basis of their biological functions and their involvement in different cancers. The aim of this study was to analyze potential association and overall survival between MTHFR C677T and ACE I/D polymorphism in glioma patients in our population. MATERIALS AND METHODS: We tested genotype distribution of 112 glioma patients against 141 cancer-free controls from the same region. Kaplan-Meier survival analysis was performed to evaluate overall survival of patients for both genes. RESULTS: No significant differences were found among MTHFR C677T wild type C and variant genotypes CT/TT with glioma patients. In ACE, the distribution of variant ID and DD was found to be significantly higher in glioma cases as compared to controls (p<0.0001). ACE DD genotypes were highly presented in glioma cases 26.8% versus 10.6% in controls (p<0.0001) and conferred 5-fold risk for predisposition in glioma cases. Per copy D allele frequency was found higher in cases than in controls (0.54 versus 0.25: p<0.0001). Interestingly we found a significant overall survival (with log rank p<0.01) in patients who presented with ACE DD genotypes had the least estimated overall survival of 13.4months in comparison to 21. 7 and 17.6months for ACE II and I/D genotypes respectively. CONCLUSION: We conclude ACE I/D polymorphism plays a vital role in predisposition of higher risk for glioma. We also suggest that ACE DD genotypes may act as an important predictive biomarker for overall survival of glioma patients.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Neoplasias Encefálicas/genética
Glioma/genética
Metilenotetra-Hidrofolato Redutase (NADPH2)/genética
Peptidil Dipeptidase A/genética
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE


  7 / 11751 MEDLINE  
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[PMID]:28873590
[Au] Autor:Abdelhedi O; Nasri R; Mora L; Jridi M; Toldrá F; Nasri M
[Ad] Endereço:Laboratoire de Génie Enzymatique et de Microbiologie, Université de Sfax, Ecole Nationale d'Ingénieurs de Sfax, B.P. 1173-3038 Sfax, Tunisia. Electronic address: abd.ola1502@gmail.com.
[Ti] Título:In silico analysis and molecular docking study of angiotensin I-converting enzyme inhibitory peptides from smooth-hound viscera protein hydrolysates fractionated by ultrafiltration.
[So] Source:Food Chem;239:453-463, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Smooth-hound viscera hydrolysates (SHVHs) were prepared by treatment with Neutrase (SHVH-N) and Purafect (SHVH-P). Hydrolysates were then separated according to their molecular weight, using the ultra-filtration membrane system, into 5 fractions (≥50, 50-5, 5-3, 3-1 and ≤1kDa). Fractions showed different amino acid compositions and angiotensin I-converting enzyme (ACE) inhibitory potentials. The SHVH-P-FV (≤1kDa) and SHVH-N-FIV (3-1kDa) fractions showed the best ACE-inhibitory activities with IC values of 53.31 and 75.05µg/ml, respectively. According to their high ACE-inhibitory potential, FIV and FV were fractionated by RP-HPLC and then analyzed by LC-MS/MS to identify peptide sequences. A systematic peptidomic study resulted in the identification of numerous novel sequences. Furthermore, in silico data, based on the molecular docking simulation, showed that GPAGPRGPAG, AVVPPSDKM, TTMYPGIA, and VKPLPQSG could bind ACE active site with low interaction scores. Indeed, they share hydrogen bonds and Van der Waals and electrostatic interactions with ACE catalytic pockets.
[Mh] Termos MeSH primário: Vísceras
[Mh] Termos MeSH secundário: Inibidores da Enzima Conversora de Angiotensina
Simulação de Acoplamento Molecular
Peptídeos
Peptidil Dipeptidase A
Hidrolisados de Proteína
Espectrometria de Massas em Tandem
Ultrafiltração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Peptides); 0 (Protein Hydrolysates); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  8 / 11751 MEDLINE  
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Vassallo, Dalton Valentim
Texto completo
[PMID]:28987480
[Au] Autor:Rizzetti DA; Martín Á; Corrales P; Fernandez F; Simões MR; Peçanha FM; Vassallo DV; Miguel M; Wiggers GA
[Ad] Endereço:Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana, Rio Grande do Sul, Brazil. Electronic address: danize.rizzetti@gmail.com.
[Ti] Título:Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase.
[So] Source:Toxicol Lett;281:158-174, 2017 Nov 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The study aimed to investigate the effects of egg white hydrolysate (EWH) on vascular disorders induced by mercury (Hg). For this, male Wistar rats were treated for 60days: Untreated (saline, i.m.); Mercury (HgCl , i.m., 1st dose 4.6µg/kg, subsequent doses 0.07µg/kg/day); Hydrolysate (EWH, gavage, 1g/kg/day); Hydrolysate-Mercury. Systolic (SBP) and diastolic (DBP) blood pressure measurement and vascular reactivity experiments in aorta were performed. We analyzed endothelial dependent and independent vasodilator responses and vasoconstrictor response to phenylephrine (Phe) in absence and presence of endothelium, a NOS inhibitor, a NADPH oxidase inhibitor, the superoxide dismutase, a non-selective COX inhibitor, a selective COX-2 inhibitor, an AT-1 receptors blocker. In situ superoxide anion production, SOD-1, NOX-4, p22phox, COX-2 and AT-1 mRNA levels and NOX-1 protein expression were performed in aorta while the determination of angiotensin converting enzyme (ACE) activity was measured in plasma. As results, EWH prevented the increase in SBP and Phe responses and the endothelial dysfunction elicited by Hg, which was related to decreased ACE activity and NOX activation by EWH and, subsequently, alleviated ROS production and improved NO bioavailability in aorta. In conclusion, EWH could be considered as alternative or complementary treatment tools for Hg-induced cardiovascular damage.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/tratamento farmacológico
Clara de Ovo/química
Mercúrio/toxicidade
NADPH Oxidases/sangue
Peptídeos/farmacologia
Peptidil Dipeptidase A/sangue
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Pressão Sanguínea/efeitos dos fármacos
Doenças Cardiovasculares/induzido quimicamente
Relação Dose-Resposta a Droga
Endotélio Vascular/efeitos dos fármacos
Masculino
NADPH Oxidases/antagonistas & inibidores
Estresse Oxidativo/efeitos dos fármacos
Fenilefrina/farmacologia
Ratos
Ratos Wistar
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides); 0 (Vasoconstrictor Agents); 1WS297W6MV (Phenylephrine); EC 1.6.3.- (NADPH Oxidases); EC 3.4.15.1 (Peptidyl-Dipeptidase A); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  9 / 11751 MEDLINE  
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[PMID]:28935757
[Au] Autor:Moran CS; Biros E; Krishna SM; Wang Y; Tikellis C; Morton SK; Moxon JV; Cooper ME; Norman PE; Burrell LM; Thomas MC; Golledge J
[Ad] Endereço:From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia (C.S.M., E.B., S.M.K., S.K.M., J.V.M., J.G.); School of Applied and Biomedical Sciences, Faculty of Science and Technology, Fede
[Ti] Título:Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2.
[So] Source:Arterioscler Thromb Vasc Biol;37(11):2195-2203, 2017 Nov.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Recent evidence suggests an important role for angiotensin-converting enzyme 2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of ACE2 deficiency on AAA development and the efficacy of resveratrol to upregulate ACE2 in experimental AAA. APPROACH AND RESULTS: deletion in apolipoprotein-deficient mice ( ) resulted in increased aortic diameter and spontaneous aneurysm of the suprarenal aorta associated with increased expression of inflammation and proteolytic enzyme markers. In humans, serum ACE2 activity was negatively associated with AAA diagnosis. expression was lower in infrarenal biopsies of patients with AAA than organ donors. AAA was more severe in mice compared with controls in 2 experimental models. Resveratrol (0.05/100-g chow) inhibited growth of pre-established AAAs in mice fed high-fat chow and infused with angiotensin II continuously for 56 days. Reduced suprarenal aorta dilatation in mice receiving resveratrol was associated with elevated serum ACE2 and increased suprarenal aorta tissue levels of ACE2 and sirtuin 1 activity. In addition, the relative phosphorylation of Akt and ERK (extracellular signal-regulated kinase) 1/2 within suprarenal aorta tissue and gene expression for nuclear factor of kappa light polypeptide gene enhancer in B cells 1, angiotensin type-1 receptor, and metallopeptidase 2 and 9 were significantly reduced. Upregulation of ACE2 in human aortic smooth muscle cells by resveratrol in vitro was sirtuin 1-dependent. CONCLUSIONS: This study provides experimental evidence of an important role for ACE2 in limiting AAA development and growth. Resveratrol upregulated ACE2 and inhibited AAA growth in a mouse model.
[Mh] Termos MeSH primário: Aorta Abdominal/efeitos dos fármacos
Aneurisma da Aorta Abdominal/prevenção & controle
Ruptura Aórtica/prevenção & controle
Peptidil Dipeptidase A/deficiência
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Angiotensina II
Animais
Aorta Abdominal/enzimologia
Aorta Abdominal/patologia
Aneurisma da Aorta Abdominal/enzimologia
Aneurisma da Aorta Abdominal/genética
Aneurisma da Aorta Abdominal/patologia
Ruptura Aórtica/enzimologia
Ruptura Aórtica/genética
Ruptura Aórtica/patologia
Apolipoproteínas E/deficiência
Apolipoproteínas E/genética
Células Cultivadas
Dieta Hiperlipídica
Dilatação Patológica
Modelos Animais de Doenças
Indução Enzimática
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Predisposição Genética para Doença
Seres Humanos
Mediadores da Inflamação/metabolismo
Camundongos Knockout
Músculo Liso Vascular/efeitos dos fármacos
Músculo Liso Vascular/enzimologia
Músculo Liso Vascular/patologia
Miócitos de Músculo Liso/efeitos dos fármacos
Miócitos de Músculo Liso/metabolismo
Miócitos de Músculo Liso/patologia
Subunidade p50 de NF-kappa B/metabolismo
Peptidil Dipeptidase A/biossíntese
Peptidil Dipeptidase A/genética
Fenótipo
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Sirtuína 1/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Inflammation Mediators); 0 (NF-kappa B p50 Subunit); 0 (Stilbenes); 11128-99-7 (Angiotensin II); 147257-52-1 (Nfkb1 protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.4.15.1 (Peptidyl-Dipeptidase A); EC 3.4.17.- (angiotensin converting enzyme 2); EC 3.5.1.- (Sirt1 protein, mouse); EC 3.5.1.- (Sirtuin 1); Q369O8926L (resveratrol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.310129


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[PMID]:28915252
[Au] Autor:Jando J; Camargo SMR; Herzog B; Verrey F
[Ad] Endereço:Institute of Physiology, Zurich Center of Integrative Human Physiology and NCCR Kidney.CH, University of Zurich, Zurich, Switzerland.
[Ti] Título:Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine.
[So] Source:PLoS One;12(9):e0184845, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Absorption of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B0AT1 (SLC6A19). Its intestinal expression depends on co-expression of the membrane-anchored peptidase angiotensin converting enzyme 2 (ACE2) and is additionally enhanced by aminopeptidase N (CD13). We investigated in this study the expression of B0AT1 and its auxiliary peptidases as well as its transport function along the rat small intestine. Additionally, we tested its possible short- and long-term regulation by dietary proteins and amino acids. We showed by immunofluorescence that B0AT1, ACE2 and CD13 co-localize on the luminal membrane of small intestinal villi and by Western blotting that their protein expression increases in distal direction. Furthermore, we observed an elevated transport activity of the neutral amino acid L-isoleucine during the nocturnal active phase compared to the inactive one. Gastric emptying was delayed by intragastric application of an amino acid cocktail but we observed no acute dietary regulation of B0AT1 protein expression and L-isoleucine transport. Investigation of the chronic dietary regulation of B0AT1, ACE2 and CD13 by different diets revealed an increased B0AT1 protein expression under amino acid-supplemented diet in the proximal section but not in the distal one and for ACE2 protein expression a reverse localization of the effect. Dietary regulation for CD13 protein expression was not as distinct as for the two other proteins. Ring uptake experiments showed a tendency for increased L-isoleucine uptake under amino acid-supplemented diet and in vivo L-isoleucine absorption was more efficient under high protein and amino acid-supplemented diet. Additionally, plasma levels of branched-chain amino acids were elevated under high protein and amino acid diet. Taken together, our experiments did not reveal an acute amino acid-induced regulation of B0AT1 but revealed a chronic dietary adaptation mainly restricted to the proximal segment of the small intestine.
[Mh] Termos MeSH primário: Sistemas de Transporte de Aminoácidos Neutros/biossíntese
Antígenos CD13/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Intestino Delgado/metabolismo
Isoleucina/farmacologia
Peptidil Dipeptidase A/metabolismo
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acid Transport Systems, Neutral); 0 (SLC6A19 protein, rat); 04Y7590D77 (Isoleucine); EC 3.4.11.2 (CD13 Antigens); EC 3.4.15.1 (Peptidyl-Dipeptidase A); EC 3.4.17.- (angiotensin converting enzyme 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184845



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