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[PMID]:28077446
[Au] Autor:Alleva B; Balukoff N; Peiper A; Smolikove S
[Ad] Endereço:Department of Biology, University of Iowa, Iowa City, IA 52242.
[Ti] Título:Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.
[So] Source:J Cell Biol;216(2):393-408, 2017 Feb.
[Is] ISSN:1540-8140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement leads to pairing defects and SC polycomplex formation. We show that FKB-6 plays a role in SC assembly and is required for timely pairing and proper double-strand break repair kinetics. FKB-6 localizes outside the nucleus, and in its absence, the microtubule network is altered. FKB-6 is required for proper movement of dynein, increasing resting time between movements. Attenuating chromosomal movement in fkb-6 mutants partially restores the defects in synapsis, in agreement with FKB-6 acting by decreasing chromosomal movement. Therefore, we suggest that FKB-6 plays a role in regulating dynein movement by preventing excess chromosome movement, which is essential for proper SC assembly and homologous chromosome pairing.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/enzimologia
Pareamento Cromossômico
Posicionamento Cromossômico
Imunofilinas/metabolismo
Chaperonas Moleculares/metabolismo
Complexo Sinaptonêmico/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Caenorhabditis elegans/genética
Caenorhabditis elegans/crescimento & desenvolvimento
Proteínas de Caenorhabditis elegans/genética
Dineínas do Citoplasma/genética
Dineínas do Citoplasma/metabolismo
Dineínas/genética
Dineínas/metabolismo
Genótipo
Imunofilinas/genética
Hibridização in Situ Fluorescente
Microscopia de Fluorescência
Chaperonas Moleculares/genética
Mutação
Fenótipo
Interferência de RNA
Transdução de Sinais
Complexo Sinaptonêmico/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Molecular Chaperones); EC 3.6.4.2 (Cytoplasmic Dyneins); EC 3.6.4.2 (DHC-1 protein, C elegans); EC 3.6.4.2 (Dyneins); EC 5.2.1.8 (FKB-6 protein, C elegans); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1083/jcb.201606126


  2 / 591 MEDLINE  
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[PMID]:27479355
[Au] Autor:Zhou W; Jiang Y; Zhu M; Hang D; Chen J; Zhou J; Dai J; Ma H; Hu Z; Jin G; Sha J; Shen H
[Ad] Endereço:State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
[Ti] Título:Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women.
[So] Source:Mol Carcinog;56(2):774-780, 2017 Feb.
[Is] ISSN:1098-2744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genome-wide association studies have reported more than 100 independent common loci associated with breast cancer risk. The contribution of low-frequency or rare variants to breast cancer susceptibility has not been well explored. Thus, we applied exome chip to genotype >200 000 low-frequency and rare variants in 1064 breast cancer cases and 1125 cancer-free controls and subsequently validated promising associations in another 1040 breast cancer cases and 1240 controls. We identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 × 10 ) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 × 10 ) associated with breast cancer risk. In stratification analyses, we found that the protective effect of rs200847762 was stronger in ER-positive breast cancer (OR = 0.18, 95% CI = 0.06-0.42) than that in ER-negative one (OR = 0.59, 95% CI = 0.31-1.05). Our findings indicate that low-frequency variants may also contribute to breast cancer susceptibility and genetic variants in 6p21.33 and 7q22.1 are important in breast carcinogenesis. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Complexo 2-3 de Proteínas Relacionadas à Actina/genética
Neoplasias da Mama/genética
Imunofilinas/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático/genética
Mama/patologia
Neoplasias da Mama/diagnóstico
Neoplasias da Mama/epidemiologia
Estudos de Casos e Controles
China/epidemiologia
Feminino
Frequência do Gene
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ARPC1B protein, human); 0 (Actin-Related Protein 2-3 Complex); 0 (FKBPL protein, human); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE
[do] DOI:10.1002/mc.22534


  3 / 591 MEDLINE  
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[PMID]:27787514
[Au] Autor:Li L; Yang SH; Yao Y; Xie YQ; Yang YQ; Wang YH; Yin XY; Ma HD; Gershwin M; Lian ZX
[Ad] Endereço:Liver Immunology Laboratory, Institute of Immunology and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
[Ti] Título:Block of both TGF-ß and IL-2 signaling impedes Neurophilin-1 regulatory T cell and follicular regulatory T cell development.
[So] Source:Cell Death Dis;7(10):e2439, 2016 Oct 27.
[Is] ISSN:2041-4889
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-ß and IL-2 on the function regulatory T cells. We have taken advantage of dnTGF-ßRII Il2ra (abbreviated as Il2ra Tg) mouse model, which allows a direct mechanistic approach to define the relative roles of TGF-ß and IL-2 on Treg development. Il2ra Tg mice spontaneously developed multi-organ autoimmune diseases with expansion of pathogenic T cells and enhanced germinal center response at 3-4 weeks of age. Importantly, peripheral Treg cells from Il2ra Tg mice demonstrated an activated Th1-like stable phenotype and normal in vitro suppressive function, while thymus Treg increased but manifested decreased suppressive function. Interestingly, neither thymus nor peripheral Treg cells of Il2ra Tg mice contained Neuropilin-1 or PD-1 phenotype, resulting in defective follicular regulatory T (Tfr) cell development. Such defective Tfr development led to elevated follicular T helper cells, enhanced germinal center responses and increased plasma cell infiltration. These data demonstrate an important synergetic role of TGF-ß and IL-2 in the generation, activation and stability of Treg cells, as well as their subsequent development into Tfr cells.
[Mh] Termos MeSH primário: Imunofilinas/metabolismo
Interleucina-2/metabolismo
Transdução de Sinais
Linfócitos T Reguladores/metabolismo
Fator de Crescimento Transformador beta/metabolismo
[Mh] Termos MeSH secundário: Animais
Centro Germinativo/metabolismo
Inflamação/patologia
Subunidade alfa de Receptor de Interleucina-2/metabolismo
Linfadenopatia/patologia
Ativação Linfocitária/imunologia
Camundongos Transgênicos
Fenótipo
Linfócitos T Auxiliares-Indutores/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-2); 0 (Interleukin-2 Receptor alpha Subunit); 0 (Transforming Growth Factor beta); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1038/cddis.2016.348


  4 / 591 MEDLINE  
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[PMID]:26861912
[Au] Autor:Ye Z; Shuai P; Zhai Y; Li F; Jiang L; Lu F; Wen F; Huang L; Zhang D; Liu X; Lin Y; Luo H; Zhang H; Zhu X; Wu Z; Yang Z; Gong B; Shi Y
[Ad] Endereço:Sichuan Provincial Key Laboratory for Human Disease Gene Study, School of Medicine, Sichuan Academy of Medical Sciences &Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
[Ti] Título:Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
[So] Source:Sci Rep;6:20914, 2016 Feb 10.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of blindness in aging populations. This study was conducted to investigate the associations of chromosome 6p21.3 region, including CFB-SKIV2L-TNXB-FKBPL-NOTCH4 genes, with both neovascular AMD and PCV. Six single nucleotide polymorphisms (SNPs) in this region and two known AMD-associated SNPs in CFH (rs800292) and HTRA1 (rs11200638) were genotyped in a Han Chinese cohort composed of 490 neovascular AMD patients, 419 PCV patients and 1316 controls. Among the SNPs, TNXB rs12153855 and FKBPL rs9391734 conferred an increased susceptibility to neovascular AMD (P = 2.8 × 10(-4) and 0.001, OR = 1.80 and 1.76, respectively), while SKIV2L exerted a protective effect on neovascular AMD (P = 2.2 × 10(-4), OR = 0.49). Rs12153855C and rs9391734A alleles could further increase the susceptibility to AMD in subjects with rs800292, rs11200638 and rs429608 risk alleles. However, only the association of SKIV2L rs429608 remained significant after adjusting for rs800292, rs11200638 and the other 5 SNPs. The protective haplotype AATGAG exhibited significant association with neovascular AMD (permutation P = 0.015, OR = 0.34). None of the SNPs in this region was associated with PCV. Association profiles of 6p21.3 region showed discrepancy between neovascular AMD and PCV, indicating possible molecular and pathological differences between these two retinal disorders.
[Mh] Termos MeSH primário: Neovascularização de Coroide/genética
Cromossomos Humanos Par 6
Estudos de Associação Genética
Variação Genética
Degeneração Macular/genética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Alelos
Estudos de Casos e Controles
Neovascularização de Coroide/patologia
DNA Helicases/genética
Feminino
Frequência do Gene
Loci Gênicos
Genótipo
Seres Humanos
Imunofilinas/genética
Desequilíbrio de Ligação
Degeneração Macular/patologia
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Proteínas Proto-Oncogênicas/genética
Receptor Notch4
Receptores Notch/genética
Tenascina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (FKBPL protein, human); 0 (NOTCH4 protein, human); 0 (Proto-Oncogene Proteins); 0 (Receptor, Notch4); 0 (Receptors, Notch); 0 (Tenascin); 0 (tenascin X); EC 3.6.4.- (DNA Helicases); EC 5.2.1.8 (Immunophilins); EC 5.99.- (SKIV2L protein, human)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE
[do] DOI:10.1038/srep20914


  5 / 591 MEDLINE  
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[PMID]:26792730
[Au] Autor:Nath PR; Dong G; Braiman A; Isakov N
[Ad] Endereço:The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel.
[Ti] Título:In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein.
[So] Source:Biochem Biophys Res Commun;470(2):411-416, 2016 Feb 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Members of the Crk family of adaptor proteins are key players in signal transduction from a variety of cell surface receptors. CrkI and CrkII are two alternative-spliced forms of a single gene which possess an N-terminal SH2 domain and an SH3 domain that mediate interaction with other proteins. CrkII possesses an additional C-terminal linker region plus an extra SH3 domain, which does not interact with other proteins, but operates as regulatory moiety. Utilizing human Jurkat T cells, we demonstrate that CrkII-SH3N binding of C3G is inhibited by cyclosporin A (CsA) plus FK506 that inhibit the cyclophilin A (CypA) and FK506 binding protein (FKBP) peptidyl-prolyl cis-trans isomerases (PPIases; also termed immunophilins), respectively. Jurkat T cells were found to express ∼ 5-fold lower levels of CrkI protein compared to CrkII, but the efficiency of C3G binding by CrkI was ∼ 5-fold higher than that of CrkII, suggesting that the majority of cellular CrkII proteins adopt a conformation that is inaccessible for C3G. Treatment of Jurkat T cells with CsA plus FK506 led to a time-dependent conformational change in overexpressed human CrkII1-236 protein-containing FRET-based biosensor, supporting the accumulation of cis conformers of human CrkII1-236 in the presence of PPIase inhibitors. Our data suggest that the Gly(219)-Pro-Tyr motif in the human CrkII linker region serves as the recognition and isomerization site of PPIases, and raise the possibility that CsA and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.
[Mh] Termos MeSH primário: Ciclofilina A/metabolismo
Regulação da Expressão Gênica/fisiologia
Imunofilinas/metabolismo
Proteínas Proto-Oncogênicas c-crk/metabolismo
Proteínas de Ligação a Tacrolimo/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Células Jurkat
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-crk); EC 5.2.1.- (Cyclophilin A); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE


  6 / 591 MEDLINE  
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[PMID]:26762975
[Au] Autor:Prakash A; Shin J; Rajan S; Yoon HS
[Ad] Endereço:School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore.
[Ti] Título:Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin.
[So] Source:Nucleic Acids Res;44(6):2909-25, 2016 Apr 07.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The nuclear immunophilin FKBP25 interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids. Currently the structural basis of nucleic acid binding by FKBP25 is unknown. Here we determined the nuclear magnetic resonance (NMR) solution structure of full-length human FKBP25 and studied its interaction with DNA. The FKBP25 structure revealed that the N-terminal helix-loop-helix (HLH) domain and C-terminal FK506-binding domain (FKBD) interact with each other and that both of the domains are involved in DNA binding. The HLH domain forms major-groove interactions and the basic FKBD loop cooperates to form interactions with an adjacent minor-groove of DNA. The FKBP25-DNA complex model, supported by NMR and mutational studies, provides structural and mechanistic insights into the nuclear immunophilin-mediated nucleic acid recognition.
[Mh] Termos MeSH primário: DNA/química
Imunofilinas/química
Proteínas de Ligação a Tacrolimo/química
[Mh] Termos MeSH secundário: Sequência de Bases
Sítios de Ligação
Clonagem Molecular
DNA/genética
DNA/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Seres Humanos
Imunofilinas/genética
Imunofilinas/metabolismo
Simulação de Acoplamento Molecular
Dados de Sequência Molecular
Ressonância Magnética Nuclear Biomolecular
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Proteínas de Ligação a Tacrolimo/genética
Proteínas de Ligação a Tacrolimo/metabolismo
Fator de Transcrição YY1/química
Fator de Transcrição YY1/genética
Fator de Transcrição YY1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Recombinant Proteins); 0 (YY1 Transcription Factor); 0 (YY1 protein, human); 147478-69-1 (FKBP3 protein, human); 9007-49-2 (DNA); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkw001


  7 / 591 MEDLINE  
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[PMID]:26654092
[Au] Autor:Galigniana MD
[Ad] Endereço:Instituto de Biología y Medicina Experimental-CONICET, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (1428), Argentina.
[Ti] Título:Editorial: Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets - Part II.
[So] Source:Curr Mol Pharmacol;9(2):97-8, 2016.
[Is] ISSN:1874-4702
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Mh] Termos MeSH primário: Descoberta de Drogas
Imunofilinas/química
Imunofilinas/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Imunofilinas/antagonistas & inibidores
Ligantes
Terapia de Alvo Molecular
Ligação Proteica
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE


  8 / 591 MEDLINE  
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[PMID]:25963286
[Au] Autor:Tomasic Paic A; Fulgosi H
[Ad] Endereço:Division of Molecular Biology, Rudjer Boskovic Institute, Bijenicka cesta 54, HR-10002, Zagreb, Croatia.
[Ti] Título:Chloroplast immunophilins.
[So] Source:Protoplasma;253(2):249-58, 2016 Mar.
[Is] ISSN:1615-6102
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Immunophilins occur in almost all living organisms. They are ubiquitously expressed proteins including cyclophilins, FK506/rapamycin-binding proteins, and parvulins. Their functional significance in vascular plants is mostly related to plant developmental processes, signalling, and regulation of photosynthesis. Enzymatically active immunophilins catalyse isomerization of proline imidic peptide bonds and assist in rapid folding of nascent proline-containing polypeptides. They also participate in protein trafficking and assembly of supramolecular protein complexes. Complex immunophilins possess various additional functional domains associated with a multitude of molecular interactions. A considerable number of immunophilins act as auxiliary and/or regulatory proteins in highly specialized cellular compartments, such as lumen of thylakoids. In this review, we present a comprehensive overview of so far identified chloroplast immunophilins that assist in specific assembly/repair processes necessary for the maintenance of efficient photosynthetic energy conversion.
[Mh] Termos MeSH primário: Cloroplastos/enzimologia
Imunofilinas/fisiologia
Proteínas de Plantas/fisiologia
[Mh] Termos MeSH secundário: Cloroplastos/metabolismo
Fotossíntese
Plantas/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Proteins); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150513
[St] Status:MEDLINE
[do] DOI:10.1007/s00709-015-0828-z


  9 / 591 MEDLINE  
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[PMID]:25754838
[Au] Autor:Mazaira GI; Camisay MF; De Leo S; Erlejman AG; Galigniana MD
[Ad] Endereço:Departamento De Química Biológica, Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires and IQUIBICEN-CONICET, Buenos Aires, Argentina.
[Ti] Título:Biological relevance of Hsp90-binding immunophilins in cancer development and treatment.
[So] Source:Int J Cancer;138(4):797-808, 2016 Feb 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Immunophilins are a family of intracellular receptors for immunosuppressive drugs. Those immunophilins that are related to immunosuppression are the smallest proteins of the family, i.e., FKBP12 and CyPA, whereas the other members of the family have higher molecular weight because the show additional domains to the drug-binding site. Among these extra domains, the TPR-domain is perhaps the most relevant because it permits the interaction of high molecular weight immunophilins with the 90-kDa heat-shock protein, Hsp90. This essential molecular chaperone regulates the biological function of several protein-kinases, oncogenes, protein phosphatases, transcription factors and cofactors . Hsp90-binding immunophilins where first characterized due to their association with steroid receptors. They regulate the cytoplasmic transport and the subcellular localization of these and other Hsp90 client proteins, as well as transcriptional activity, cell proliferation, cell differentiation and apoptosis. Hsp90-binding immunophilins are frequently overexpressed in several types of cancers and play a key role in cell survival. In this article we analyze the most important biological actions of the best characterized Hsp90-binding immunophilins in both steroid receptor function and cancer development and discuss the potential use of these immunophilins for therapeutic purposes as potential targets of specific small molecules.
[Mh] Termos MeSH primário: Proteínas de Choque Térmico HSP90/metabolismo
Imunofilinas/metabolismo
Neoplasias/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (HSP90 Heat-Shock Proteins); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160115
[Lr] Data última revisão:
160115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150311
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.29509


  10 / 591 MEDLINE  
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[PMID]:26653049
[Au] Autor:Galigniana MD
[Ad] Endereço:Instituto de Biologia y Medicina Experimental-CONICET, and Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (1428), Argentina.
[Ti] Título:Editorial: Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets - Part I.
[So] Source:Curr Mol Pharmacol;9(1):3-4, 2015.
[Is] ISSN:1874-4702
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Mh] Termos MeSH primário: Descoberta de Drogas
Imunofilinas/química
Imunofilinas/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Imunofilinas/antagonistas & inibidores
Ligantes
Terapia de Alvo Molecular
Conformação Proteica
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); EC 5.2.1.8 (Immunophilins)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE



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