Base de dados : MEDLINE
Pesquisa : D08.811.682.226 [Categoria DeCS]
Referências encontradas : 5699 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 570 ir para página                         

  1 / 5699 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324775
[Au] Autor:Xu R; Jiang YF; Zhang YH; Yang X
[Ad] Endereço:Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
[Ti] Título:The optimal threshold of serum ceruloplasmin in the diagnosis of Wilson's disease: A large hospital-based study.
[So] Source:PLoS One;13(1):e0190887, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: A ceruloplasmin (CP) concentration <200 mg/L is conventionally considered as one of the major diagnostic criteria for Wilson's disease (WD). However, the diagnostic accuracy of this threshold has never been investigated in a sufficiently large group of patients. This study aims to present the results of serum CP measurements in various patients and to identify the optimal cutoff value of CP for the diagnosis of WD. MATERIALS AND METHODS: We identified patients whose CP levels were evaluated from January 1, 2016 to December 31, 2016 using a laboratory information database. Data related to CP measurement were retrieved. We carefully reviewed patients' electronic medical records to correct errors and to obtain other necessary data. Data related to WD were retrieved from a special document containing medical records of patients with WD, which were created, modified, and maintained by authors. RESULTS: CP level was determined in 4048 patients (WD, 297; non-WD, 3751). The mean serum CP level in patients with WD was 50.6±44.2 mg/L, which was significantly lower than that in non-WD patients (293.2±117.3 mg/L, p<0.001). Only 1.0% of patients with WD had CP ≥200 mg/L. The sensitivity and specificity of CP for the diagnosis of WD were 99.0 and 80.9%, respectively, for the conventional cutoff value <200 mg/L and 95.6 and 95.5%, respectively, for the cutoff value <150 mg/L; the latter provided a higher diagnostic accuracy for WD. 53.0% of patients with liver failure, 37.7% of patients with nephrotic syndrome, and 23.0% of patients age 1 to 6 months had serum CP <200 mg/L. Patients who were pregnant and those with malignant tumors, and infectious and inflammatory diseases had significantly higher mean serum CP levels. CONCLUSION: The optimal cutoff value of CP for the diagnosis of WD in China is 150 mg/L, with a sensitivity of 95.6% and specificity of 95.5%, thereby providing the highest diagnostic accuracy for WD.
[Mh] Termos MeSH primário: Ceruloplasmina/metabolismo
Degeneração Hepatolenticular/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Criança
Pré-Escolar
China
Registros Eletrônicos de Saúde
Feminino
Seguimentos
Degeneração Hepatolenticular/complicações
Degeneração Hepatolenticular/terapia
Hospitalização
Seres Humanos
Lactente
Masculino
Meia-Idade
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190887


  2 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27777002
[Au] Autor:Kim S; Lee JH; Seok JH; Park YH; Jung SW; Cho AE; Lee C; Chung MS; Kim KH
[Ad] Endereço:Department of Biotechnology & Bioinformatics, Korea University, Sejong 339-700, Korea.
[Ti] Título:Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
[So] Source:J Mol Biol;428(24 Pt B):5007-5018, 2016 12 04.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Iron and oxygen chemistry is mediated by iron proteins for many biological functions. Carboxylate-bridged diiron enzymes including ferritin have the common mechanism of oxygen activation via peroxodiferric intermediates. However, the route for iron uptake and the structural identification of intermediates still remain incomplete. The 4-fold symmetry channel of Helicobacter pylori ferritin was previously proposed as the iron-uptake route in eubacteria, but the amino acid residues at the 4-fold channel are not highly conserved. Here, we show evidence for a short path for iron uptake from His93 on the surface to the ferroxidase center in H. pylori ferritin and Escherichia coli ferritin. The amino acid residues along this path are highly conserved in Gram-negative bacteria and some archaea, and the mutants containing S20A and H93L showed significantly decreased iron oxidation. Surprisingly, the E. coli ferritin S20A crystal structure showed oxygen binding and side-on, symmetric µ-η :η peroxodiferric and oxodiferric intermediates. The results provide the structural basis for understanding the chemical nature of intermediates in iron oxidation in bacteria and some of archaea.
[Mh] Termos MeSH primário: Ceruloplasmina/química
Ceruloplasmina/metabolismo
Escherichia coli/metabolismo
Ferritinas/química
Ferritinas/metabolismo
Helicobacter pylori/metabolismo
Ferro/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Ceruloplasmina/genética
Cristalografia por Raios X
Análise Mutacional de DNA
Escherichia coli/enzimologia
Escherichia coli/genética
Ferritinas/genética
Helicobacter pylori/enzimologia
Helicobacter pylori/genética
Modelos Moleculares
Proteínas Mutantes/química
Proteínas Mutantes/genética
Proteínas Mutantes/metabolismo
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Mutant Proteins); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE


  3 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28450461
[Au] Autor:Chen TD; Rotival M; Chiu LY; Bagnati M; Ko JH; Srivastava PK; Petretto E; Pusey CD; Lai PC; Aitman TJ; Cook HT; Behmoaras J
[Ad] Endereço:Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom.
[Ti] Título:Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.
[So] Source:Genetics;206(2):1139-1151, 2017 06.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely susceptible Wistar Kyoto (WKY) rat strain, we have identified multiple crescentic glomerulonephritis QTL ( ) and positionally cloned genes underlying and , which accounted for 40% of total variance in glomerular inflammation. Here, we have generated a backcross (BC) population ( = 166) where and were genetically fixed and found significant linkage to glomerular crescents on chromosome 2 ( , LOD = 3.8). Fine mapping analysis by integration with genome-wide expression QTLs (eQTLs) from the same BC population identified ceruloplasmin ( ) as a positional eQTL in macrophages but not in serum. Liquid chromatography-tandem mass spectrometry confirmed Cp as a protein QTL in rat macrophages. WKY macrophages overexpress Cp and its downregulation by RNA interference decreases markers of glomerular proinflammatory macrophage activation. Similarly, short incubation with Cp results in a strain-dependent macrophage polarization in the rat. These results suggest that genetically determined Cp levels can alter susceptibility to Crgn through macrophage function and propose a new role for Cp in early macrophage activation.
[Mh] Termos MeSH primário: Ceruloplasmina/genética
Predisposição Genética para Doença
Glomerulonefrite/genética
[Mh] Termos MeSH secundário: Animais
Ceruloplasmina/biossíntese
Mapeamento Cromossômico
Regulação da Expressão Gênica
Ligação Genética
Glomerulonefrite/patologia
Seres Humanos
Macrófagos/metabolismo
Macrófagos/patologia
Ratos
Ratos Endogâmicos WKY
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.116.197376


  4 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28988537
[Au] Autor:Sokolov AV; Voynova IV; Kostevich VA; Vlasenko AY; Zakharova ET; Vasilyev VB
[Ad] Endereço:Institute of Experimental Medicine, St. Petersburg, 197376, Russia. biochemsokolov@gmail.com.
[Ti] Título:Comparison of Interaction between Ceruloplasmin and Lactoferrin/Transferrin: to Bind or Not to Bind.
[So] Source:Biochemistry (Mosc);82(9):1073-1078, 2017 Sep.
[Is] ISSN:1608-3040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The year 2016 marked the 50th anniversary of the discovery by S. Osaki who first showed that ceruloplasmin (CP, ferro:O -oxidoreductase or ferroxidase) is capable of oxidizing Fe(II) to Fe(III) and favors the incorporation of the latter into transferrin (TF). However, much debate remains in the literature concerning the existence of a complex between the enzyme oxidizing iron and the protein facilitating its transport in plasma. We studied CP in exocrine fluids and demonstrated its high-affinity interaction with transferrin found in breast milk and in lacrimal fluid, i.e. with lactoferrin (LF). Here we present data obtained by comparing the interaction of CP with LF and TF using surface plasmon resonance and Hummel-Dreyer chromatography. Binding of apo-LF within the range of concentrations 1.6-51.3 µM with CP immobilized on a CM5-chip is characterized by K = 1.07 µM. Under similar conditions, the K for apo-TF was measured and appeared to be higher than 51.3 µM. Hummel-Dreyer chromatography of CP with 51 µM apo-LF/apo-TF in the effluent demonstrated the absence of interaction between apo-TF and CP in solution, contrary to efficient interaction between apo-LF and CP. In contrast to LF, the interaction of apo-TF with CP is probably not stable within the physiological range of concentrations of TF.
[Mh] Termos MeSH primário: Ceruloplasmina/metabolismo
Lactoferrina/metabolismo
Leite Humano/química
Lágrimas/química
Transferrina/metabolismo
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Leite Humano/metabolismo
Ligação Proteica
Lágrimas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transferrin); EC 1.16.3.1 (Ceruloplasmin); EC 3.4.21.- (Lactoferrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.1134/S0006297917090115


  5 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28880952
[Au] Autor:Deshpande CN; Xin V; Lu Y; Savage T; Anderson GJ; Jormakka M
[Ad] Endereço:Structural Biology Program, Centenary Institute, Sydney, New South Wales, Australia.
[Ti] Título:Large scale expression and purification of secreted mouse hephaestin.
[So] Source:PLoS One;12(9):e0184366, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the transported iron to its ferric form and promoting its release from ferroportin. Deletion or mutation of the hephaestin gene leads to systemic anemia with iron accumulation in the intestinal epithelium. The crystal structure of human ceruloplasmin, another multicopper ferroxidase with 50% sequence identity to hephaestin, has provided a framework for comparative analysis and modelling. However, detailed structural information for hephaestin is still absent, leaving questions relating to metal coordination and binding sites unanswered. To obtain structural information for hephaestin, a reliable protocol for large-scale purification is required. Here, we present an expression and purification protocol of soluble mouse hephaestin, yielding milligram amounts of enzymatically active, purified protein using the baculovirus/insect cell system.
[Mh] Termos MeSH primário: Proteínas de Membrana/metabolismo
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Western Blotting
Proteínas de Transporte de Cátions/química
Proteínas de Transporte de Cátions/genética
Proteínas de Transporte de Cátions/metabolismo
Linhagem Celular
Ceruloplasmina/metabolismo
Seres Humanos
Cinética
Proteínas de Membrana/química
Proteínas de Membrana/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Mutação
Estrutura Secundária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cation Transport Proteins); 0 (Heph protein, mouse); 0 (Membrane Proteins); 0 (metal transporting protein 1); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184366


  6 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28855492
[Au] Autor:Tsuchiya M; Takaki R; Kobayashi F; Nagasaka T; Shindo K; Takiyama Y
[Ad] Endereço:Department of Neurology, Faculty of Medicine, University of Yamanashi.
[Ti] Título:Multiple pseudofractures due to Fanconi's syndrome associated with Wilson's disease.
[So] Source:Rinsho Shinkeigaku;57(9):527-530, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a 40-year-old man who presented with multiple bone pseudofractures after about 20 years from the onset of Wilson's disease (WD). At age 36, he first noticed pain in his left shoulder. At age 39, he had multiple chest pain. On neurologic examinations, dysarthria and dysphagia due to pseudobulbar palsy, rigidity and tremor on right upper lim were observed. WD was confirmed because of low levels of plasma cupper and ceruloplasmin in addition to ATP7B gene mutation. The chest X-ray revealed multiple fractures of the several ribs. We diagnosed osteomalacia due to Fanconi's syndrome because of hypophosphatemia and the impairment of renal tubules for WD. After administration of vitamin D, there happened no new bone pseudofractures. Although bone pseudofractures accompanied by Wilson's disease generally happen in childhood, we should be aware of this symptom even in adulthood.
[Mh] Termos MeSH primário: Síndrome de Fanconi/etiologia
Fraturas Múltiplas/etiologia
Degeneração Hepatolenticular/complicações
Fraturas das Costelas/etiologia
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/genética
Adulto
Biomarcadores/sangue
Proteínas de Transporte de Cátions/genética
Ceruloplasmina
Cobre/sangue
ATPases Transportadoras de Cobre
Síndrome de Fanconi/diagnóstico
Fraturas Múltiplas/diagnóstico por imagem
Fraturas Múltiplas/tratamento farmacológico
Degeneração Hepatolenticular/diagnóstico
Seres Humanos
Masculino
Mutação
Osteomalacia/etiologia
Fraturas das Costelas/tratamento farmacológico
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Vitamina D/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cation Transport Proteins); 1406-16-2 (Vitamin D); 789U1901C5 (Copper); EC 1.16.3.1 (Ceruloplasmin); EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.3.54 (ATP7B protein, human); EC 3.6.3.54 (Copper-transporting ATPases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-000953


  7 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28791960
[Au] Autor:Ogórek M; Gasior L; Pierzchala O; Daszkiewicz R; Lenartowicz M
[Ad] Endereço:Uniwersytet Jagiellonski w Krakowie, Wydzial Biologii i Nauk o Ziemi, Instytut Zoologii, Zaklad Genetyki i Ewolucjonizmu.
[Ti] Título:Role of copper in the process of spermatogenesis.
[So] Source:Postepy Hig Med Dosw (Online);71(0):663-683, 2017 Aug 09.
[Is] ISSN:1732-2693
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Copper (Cu) is an essential trace element required for the normal development of living organisms. Due to its redox potential, copper is a cofactor in many enzymes responsible for important processes in cells. Copper deficiency has a significant influence on the reduction or the total eradication of copper-dependent enzymes in the body, thereby inhibiting cell life processes. On the other hand, copper is a very reactive element and in its free state, it can trigger the production of large amounts of free radicals, which will consequently lead to the damage of proteins and DNA. Because of those reasons, living organisms have developed precise mechanisms regulating the concentration of copper in cells. Copper also plays a very important role in male fertility. It is an essential element for the production of male gametes. The significant role of copper is also described in the processes of cell division - mitotic and meiotic. Copper-dependent enzymes such as ceruloplasmin, superoxide dismutase SOD1 and SOD3, group of metallothionein and cytochrome c oxidase are present at all stages of gametogenesis as well as in the somatic cells of the testis and in the somatic cells of epididymis. Substantial amounts of copper can also be found in liquids associated with sperm in the epididymis and prostate. Copper also affects the integral androgen distribution in terms of fertility on the line hypothalamic-pituitary-testis. Both copper increase and deficiency leads to a significant reduction in male fertility, which spans the entire spectrum of abnormalities at the sperm level, male gonad, production of hormones and distribution of micronutrients such as zinc and iron. Nowadays, the effects of copper on gametes production have become more important and are connected with the increasing levels of pollution with heavy metals in environment.
[Mh] Termos MeSH primário: Cobre/metabolismo
Estresse Oxidativo
Espermatogênese
[Mh] Termos MeSH secundário: Ceruloplasmina
Cobre/fisiologia
Seres Humanos
Masculino
Superóxido Dismutase
Oligoelementos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Trace Elements); 789U1901C5 (Copper); EC 1.15.1.1 (Superoxide Dismutase); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE


  8 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28759637
[Au] Autor:Eneman B; Elmonem MA; van den Heuvel LP; Khodaparast L; Khodaparast L; van Geet C; Freson K; Levtchenko E
[Ad] Endereço:Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium.
[Ti] Título:Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome.
[So] Source:PLoS One;12(7):e0182100, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in children with nephrotic syndrome (NS), associated with increased platelet count and aggregability and increased risk of thrombosis. To further study PACAP deficiency in NS, we used transgenic Tg(cd41:EGFP) zebrafish with GFP-labeled thrombocytes. We generated two models for congenital NS, a morpholino injected model targeting nphs1 (nephrin), which is mutated in the Finnish-type congenital NS. The second model was induced by exposure to the nephrotoxic compound adriamycin. Nephrin RNA expression was quantified and zebrafish embryos were live-screened for proteinuria and pericardial edema as evidence of renal impairment. Protein levels of PACAP and its binding-protein ceruloplasmin were measured and GFP-labeled thrombocytes were quantified. We also evaluated the effects of PACAP morpholino injection and the rescue effects of PACAP-38 peptide in both congenital NS models. Nephrin downregulation and pericardial edema were observed in both nephrin morpholino injected and adriamycin exposed congenital NS models. However, PACAP deficiency was demonstrated only in the adriamycin exposed condition. Ceruloplasmin levels and the number of GFP-labeled thrombocytes remained unchanged in both models. PACAP morpholino injections worsened survival rates and the edema phenotype in both congenital NS models while injection with human PACAP-38 could only rescue the adriamycin exposed model. We hereby report, for the first time, PACAP deficiency in a NS zebrafish model as a consequence of adriamycin exposure. However, distinct from the human congenital NS, both zebrafish models retained normal levels of ceruloplasmin and thrombocytes. We further extend the renoprotective effects of the PACAP-38 peptide against adriamycin toxicity in zebrafish.
[Mh] Termos MeSH primário: Proteínas de Membrana/metabolismo
Síndrome Nefrótica/metabolismo
Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/metabolismo
Proteínas de Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Plaquetas/metabolismo
Ceruloplasmina/metabolismo
Doxorrubicina/toxicidade
Proteínas de Membrana/genética
Síndrome Nefrótica/etiologia
Síndrome Nefrótica/genética
Fragmentos de Peptídeos/farmacologia
Pericárdio/efeitos dos fármacos
Pericárdio/metabolismo
Pericárdio/patologia
Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/química
Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/genética
Peixe-Zebra
Proteínas de Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (Peptide Fragments); 0 (Pituitary Adenylate Cyclase-Activating Polypeptide); 0 (Zebrafish Proteins); 0 (nephrin); 80168379AG (Doxorubicin); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182100


  9 / 5699 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28759613
[Au] Autor:Muhammad IF; Borné Y; Östling G; Kennbäck C; Gottsäter M; Persson M; Nilsson PM; Engström G
[Ad] Endereço:Department of Clinical Sciences, Lund University, Malmö, Sweden.
[Ti] Título:Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort.
[So] Source:PLoS One;12(7):e0181718, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. METHOD: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991-1994) and follow-up examinations (2007-2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. RESULTS: After adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (p<0.05), C3 (10.35 m/s vs 10.06 m/s) (p<0.05) and CRP (10.37 m/s vs 9.96 m/s) (p<0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation. CONCLUSION: Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/análise
Artérias/fisiopatologia
Doenças Cardiovasculares/sangue
Rigidez Vascular
[Mh] Termos MeSH secundário: Idoso
Proteína C-Reativa/análise
Doenças Cardiovasculares/epidemiologia
Ceruloplasmina/análise
Estudos de Coortes
Complemento C3/análise
Feminino
Seguimentos
Haptoglobinas/análise
Seres Humanos
Inflamação
Modelos Lineares
Masculino
Meia-Idade
Orosomucoide/análise
Estudos Prospectivos
Análise de Onda de Pulso
Fatores de Risco
alfa 1-Antitripsina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Complement C3); 0 (HP protein, human); 0 (Haptoglobins); 0 (Orosomucoid); 0 (alpha 1-Antitrypsin); 9007-41-4 (C-Reactive Protein); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181718


  10 / 5699 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28678687
[Au] Autor:Zhao K; Wu C; Yao Y; Cao L; Zhang Z; Yuan Y; Wang Y; Pei R; Chen J; Hu X; Zhou Y; Lu M; Chen X
[Ad] Endereço:2​University of Chinese Academy of Sciences, Beijing, PR China 1​State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, PR China.
[Ti] Título:Ceruloplasmin inhibits the production of extracellular hepatitis B virions by targeting its middle surface protein.
[So] Source:J Gen Virol;98(6):1410-1421, 2017 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ceruloplasmin (CP) is mainly synthesized by hepatocytes and plays an essential role in iron metabolism. Previous reports have shown that CP levels correlate negatively with disease progression in patients with chronic hepatitis B. However, the function of CP in the hepatitis B virus (HBV) life cycle and the mechanism underlying the above correlation remain unclear. Here, we report that CP can selectively inhibit the production of extracellular HBV virions without altering intracellular viral replication. HBV expression can also downregulate the expression of CP. Knockdown of CP using small interfering RNA significantly increased the level of extracellular HBV virions in both Huh7 and HepG2.2.15 cells, while overexpression of CP decreased this level. Mechanistically, CP could specifically interact with the HBV middle surface protein (MHB). Using an HBV replication-competent clone unable to express MHBs, we demonstrated that the overexpression of CP did not affect the production of extracellular HBV virions in the absence of MHBs. Furthermore, introduction of an MHB expression construct could rescue the impairment in virion production caused by CP. Taken together, our results suggest that CP may be an important host factor that targets MHBs during the envelopment and/or release of virions.
[Mh] Termos MeSH primário: Ceruloplasmina/metabolismo
Antígenos de Superfície da Hepatite B/metabolismo
Vírus da Hepatite B/crescimento & desenvolvimento
Vírus da Hepatite B/imunologia
[Mh] Termos MeSH secundário: Adulto
Linhagem Celular
Ceruloplasmina/análise
Feminino
Hepatite B Crônica/virologia
Hepatócitos/virologia
Seres Humanos
Masculino
Meia-Idade
Mapeamento de Interação de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis B Surface Antigens); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000794



página 1 de 570 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde