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[PMID]:28654285
[Au] Autor:Hao GF; Zuo Y; Yang SG; Chen Q; Zhang Y; Yin CY; Niu CW; Xi Z; Yang GF
[Ad] Endereço:Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, People's Republic of China.
[Ti] Título:Computational Discovery of Potent and Bioselective Protoporphyrinogen IX Oxidase Inhibitor via Fragment Deconstruction Analysis.
[So] Source:J Agric Food Chem;65(28):5581-5588, 2017 Jul 19.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tuning the binding selectivity through appropriate ways is a primary goal in the design and optimization of a lead toward agrochemical discovery. However, how to achieve rational design of selectivity is still a big challenge. Herein, we developed a novel computational fragment generation and coupling (CFGC) strategy that led to a series of highly potent and bioselective inhibitors targeting protoporphyrinogen IX oxidase. This enzyme plays a vital role in heme and chlorophyll biosynthesis, which has been proven to be associated with many drugs and agrochemicals. However, existing agrochemicals are nonbioselective, resulting in a great threat to nontargeted organisms. To the best of our knowledge, this is the first bioselective inhibitor targeting the tetrapyrrole biosynthesis pathway. In addition, the candidate showed excellent in vivo bioactivity and much better safety toward humans.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Protoporfirinogênio Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Clorofila/metabolismo
Biologia Computacional
Heme/metabolismo
Seres Humanos
Protoporfirinogênio Oxidase/química
Protoporfirinogênio Oxidase/metabolismo
Tabaco/química
Tabaco/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 1406-65-1 (Chlorophyll); 42VZT0U6YR (Heme); EC 1.3.3.4 (Protoporphyrinogen Oxidase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01557


  2 / 300 MEDLINE  
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[PMID]:28653968
[Au] Autor:Makki AY; Leddy J; Takano K; Jain R
[Ad] Endereço:UBMD Orthopaedics & Sports Medicine Department, University at Buffalo.
[Ti] Título:An Unusual Cause of Headache and Fatigue in a Division 1 Collegiate Athlete.
[So] Source:Clin J Sport Med;27(4):e58-e59, 2017 Jul.
[Is] ISSN:1536-3724
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Variegate porphyria (VP) is an autosomal dominant disorder of porphyrin metabolism. We report a case of a 21-year-old male collegiate athlete who complained of recurrent headache and fatigue. Extensive testing after initial presentation failed to identify a cause. Months later, his grandmother was diagnosed with VP after being hospitalized; hence, he was tested. He was positive for a heterozygous missense mutation, R168H, in one protoporphyrinogen oxidase allele. This case highlights a rare disorder of heme synthesis that should be considered in the differential diagnosis of exertional fatigue and headaches in athletes. When other more common causes of fatigue and/or headache are unable to be identified, a more focused history and examination may lead to a more unusual but crucial diagnosis. To our knowledge, there are no reported cases of this condition in Division I collegiate athletes.
[Mh] Termos MeSH primário: Fadiga/etiologia
Cefaleia/etiologia
Porfiria Variegada/complicações
[Mh] Termos MeSH secundário: Atletas
Seres Humanos
Masculino
Mutação de Sentido Incorreto
Porfiria Variegada/diagnóstico
Protoporfirinogênio Oxidase/genética
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.3.3.4 (Protoporphyrinogen Oxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1097/JSM.0000000000000350


  3 / 300 MEDLINE  
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[PMID]:28616976
[Au] Autor:Wang DW; Li Q; Wen K; Ismail I; Liu DD; Niu CW; Wen X; Yang GF; Xi Z
[Ad] Endereço:State Key Laboratory of Elemento-Organic Chemistry, and Department of Chemical Biology, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, P. R. China.
[Ti] Título:Synthesis and Herbicidal Activity of Pyrido[2,3-d]pyrimidine-2,4-dione-Benzoxazinone Hybrids as Protoporphyrinogen Oxidase Inhibitors.
[So] Source:J Agric Food Chem;65(26):5278-5286, 2017 Jul 05.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To search for new protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors with improved bioactivity, a series of novel pyrido[2,3-d]pyrimidine-2,4-dione-benzoxazinone hybrids, 9-13, were designed and synthesized. Several compounds with improved tobacco PPO (mtPPO)-inhibiting and promising herbicidal activities were found. Among them, the most potent compound, 3-(7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-benzo[b][1,4] oxazin-6-yl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 11q, with a K value of 0.0074 µM, showed six times more activity than flumioxazin (K = 0.046 µM) against mtPPO. Compound 11q displayed a strong and broad spectrum of weed control at 37.5-150 g of active ingredient (ai)/ha by both post- and pre-emergence application, which was comparable to that of flumioxazin. 11q was safe to maize, soybean, peanut, and cotton at 150 g ai/ha, and selective to rice and wheat at 75 g ai/ha by pre-emergence application, indicating potential applicability in these fields.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/farmacologia
Herbicidas/síntese química
Herbicidas/farmacologia
Proteínas de Plantas/antagonistas & inibidores
Protoporfirinogênio Oxidase/antagonistas & inibidores
Pirimidinas/química
[Mh] Termos MeSH secundário: Benzoxazinas/química
Inibidores Enzimáticos/química
Herbicidas/química
Cinética
Proteínas de Plantas/química
Plantas Daninhas/efeitos dos fármacos
Plantas Daninhas/enzimologia
Protoporfirinogênio Oxidase/química
Relação Estrutura-Atividade
Tabaco/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazines); 0 (Enzyme Inhibitors); 0 (Herbicides); 0 (Plant Proteins); 0 (Pyrimidines); EC 1.3.3.4 (Protoporphyrinogen Oxidase); K8CXK5Q32L (pyrimidine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01990


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[PMID]:27848944
[Au] Autor:Trujillano D; Bertoli-Avella AM; Kumar Kandaswamy K; Weiss ME; Köster J; Marais A; Paknia O; Schröder R; Garcia-Aznar JM; Werber M; Brandau O; Calvo Del Castillo M; Baldi C; Wessel K; Kishore S; Nahavandi N; Eyaid W; Al Rifai MT; Al-Rumayyan A; Al-Twaijri W; Alothaim A; Alhashem A; Al-Sannaa N; Al-Balwi M; Alfadhel M; Rolfs A; Abou Jamra R
[Ad] Endereço:Centogene AG, Rostock, Germany.
[Ti] Título:Clinical exome sequencing: results from 2819 samples reflecting 1000 families.
[So] Source:Eur J Hum Genet;25(2):176-182, 2017 Feb.
[Is] ISSN:1476-5438
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report our results of 1000 diagnostic WES cases based on 2819 sequenced samples from 54 countries with a wide phenotypic spectrum. Clinical information given by the requesting physicians was translated to HPO terms. WES processes were performed according to standardized settings. We identified the underlying pathogenic or likely pathogenic variants in 307 families (30.7%). In further 253 families (25.3%) a variant of unknown significance, possibly explaining the clinical symptoms of the index patient was identified. WES enabled timely diagnosing of genetic diseases, validation of causality of specific genetic disorders of PTPN23, KCTD3, SCN3A, PPOX, FRMPD4, and SCN1B, and setting dual diagnoses by detecting two causative variants in distinct genes in the same patient. We observed a better diagnostic yield in consanguineous families, in severe and in syndromic phenotypes. Our results suggest that WES has a better yield in patients that present with several symptoms, rather than an isolated abnormality. We also validate the clinical benefit of WES as an effective diagnostic tool, particularly in nonspecific or heterogeneous phenotypes. We recommend WES as a first-line diagnostic in all cases without a clear differential diagnosis, to facilitate personal medical care.
[Mh] Termos MeSH primário: Exoma
Testes Genéticos/métodos
Técnicas de Genotipagem/métodos
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Flavoproteínas/genética
Testes Genéticos/normas
Técnicas de Genotipagem/normas
Seres Humanos
Lactente
Recém-Nascido
Peptídeos e Proteínas de Sinalização Intracelular/genética
Masculino
Meia-Idade
Proteínas Mitocondriais/genética
Canal de Sódio Disparado por Voltagem NAV1.3/genética
Núcleo Familiar
Fenótipo
Canais de Potássio/genética
Proteínas Tirosina Fosfatases não Receptoras/genética
Protoporfirinogênio Oxidase/genética
Análise de Sequência de DNA/normas
Canais de Sódio/genética
Subunidade beta-1 do Canal de Sódio Disparado por Voltagem/genética
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavoproteins); 0 (Intracellular Signaling Peptides and Proteins); 0 (KCTD3 protein, human); 0 (Mitochondrial Proteins); 0 (NAV1.3 Voltage-Gated Sodium Channel); 0 (Potassium Channels); 0 (Preso protein, human); 0 (SCN1B protein, human); 0 (SCN3A protein, human); 0 (Sodium Channels); 0 (Voltage-Gated Sodium Channel beta-1 Subunit); EC 1.3.3.4 (PPOX protein, human); EC 1.3.3.4 (Protoporphyrinogen Oxidase); EC 3.1.3.48 (PTPN23 protein, human); EC 3.1.3.48 (Protein Tyrosine Phosphatases, Non-Receptor)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1038/ejhg.2016.146


  5 / 300 MEDLINE  
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[PMID]:27788171
[Au] Autor:Ferrer MD; Mestre-Alfaro A; Martínez-Tomé M; Carrera-Quintanar L; Capó X; Jiménez-Monreal AM; García-Diz L; Roche E; Murcia MA; Tur JA; Pons A
[Ad] Endereço:Laboratory for Physical Activity Sciences. Research Group in Community Nutrition and Oxidative Stress. Department of Basic Biology and Health Sciences. IUNICS, University of Balearic Islands, Palma, Spain.
[Ti] Título:Haem Biosynthesis and Antioxidant Enzymes in Circulating Cells of Acute Intermittent Porphyria Patients.
[So] Source:PLoS One;11(10):e0164857, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aims of the present study were to explore the expression pattern of haem biosynthesis enzymes in circulating cells of patients affected by two types of porphyria (acute intermittent, AIP, and variegate porphyria, VP), together with the antioxidant enzyme pattern in AIP in order to identify a possible situation of oxidative stress. Sixteen and twelve patients affected by AIP and VP, respectively, were analysed with the same numbers of healthy matched controls. Erythrocytes, neutrophils and peripheral blood mononuclear cells (PBMCs) were purified from blood, and RNA and proteins were extracted for quantitative real time PCR (qRT-PCR) and Western-blot analysis, respectively. Porhobilinogen deaminase (PBGD) and protoporphyrinogen oxidase (PPOX) gene and protein expression was analysed. Antioxidant enzyme activity and gene expression were additionally determined in blood cells, together with protein carbonyl content in plasma. PBMCs isolated from AIP patients presented low mRNA levels of PBGD when compared to controls, while PBMCs isolated from VP patients presented a decrease in PPOX mRNA. PPOX protein content was higher in AIP patients and lower in VP patients, compared to healthy controls. Regarding antioxidant enzymes, PBMCs and erythrocyte superoxide dismutase (SOD) presented statistically significant higher activity in AIP patients compared to controls, while catalase activity tended to be lower in these patients. No differences were observed regarding antioxidant gene expression in white blood cells. Circulating cells in AIP and VP patients present altered expression of haem biosynthetic enzymes, which could be useful for the differential diagnosis of these two types of porphyria in certain difficult cases. AIP patients present a condition of potential oxidative stress similar to VP patients, evidenced by the post-transcriptional activation of SOD and possible catalase impairment.
[Mh] Termos MeSH primário: Heme/biossíntese
Hidroximetilbilano Sintase/sangue
Protoporfirinogênio Oxidase/sangue
[Mh] Termos MeSH secundário: Western Blotting
Estudos de Casos e Controles
Eritrócitos/enzimologia
Feminino
Expressão Gênica
Heme/análise
Seres Humanos
Leucócitos/enzimologia
Masculino
Estresse Oxidativo
Porfiria Aguda Intermitente/sangue
Porfiria Aguda Intermitente/enzimologia
Porfiria Variegada/sangue
Porfiria Variegada/enzimologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
42VZT0U6YR (Heme); EC 1.3.3.4 (Protoporphyrinogen Oxidase); EC 2.5.1.61 (Hydroxymethylbilane Synthase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164857


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[PMID]:27746433
[Au] Autor:Susa S; Sato-Monma F; Ishii K; Hada Y; Takase K; Tada K; Wada K; Kameda W; Watanabe K; Oizumi T; Suzuki T; Daimon M; Kato T
[Ad] Endereço:Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan.
[Ti] Título:Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient.
[So] Source:Intern Med;55(20):2965-2969, 2016.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Variegate porphyria (VP) is an autosomal dominant disease caused by mutations of the protoporphyrinogen oxidase (PPOX) gene. This porphyria has unique characteristics which can induce acute neurovisceral attacks and cutaneous lesions that may occur separately or together. We herin report a 58-years-old VP patient complicated with cholelithiasis. A sequencing analysis indicated a novel c.40G>C mutation (p.G14R) in the PPOX gene. His cutaneous photosensitivity had been worsening for 3 years before the emergence of cholecystitis and it then gradually improved after cholecystectomy and ursodeoxycholic acid treatment with a slight decline in the porphyrin levels in his blood, urine and stool. In VP patients, a worsening of photosensitivity can thus be induced due to complications associated with some other disease, thereby affecting their porphyrin-heme biosynthesis.
[Mh] Termos MeSH primário: Colelitíase/complicações
Transtornos de Fotossensibilidade/etiologia
Porfiria Variegada/complicações
Porfiria Variegada/fisiopatologia
[Mh] Termos MeSH secundário: Colecistectomia
Colelitíase/terapia
Feminino
Seres Humanos
Masculino
Transtornos de Fotossensibilidade/terapia
Protoporfirinogênio Oxidase
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.3.3.4 (Protoporphyrinogen Oxidase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  7 / 300 MEDLINE  
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[PMID]:27597779
[Au] Autor:Hobbs C; Dailey HA; Shepherd M
[Ad] Endereço:School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, U.K.
[Ti] Título:The HemQ coprohaem decarboxylase generates reactive oxygen species: implications for the evolution of classical haem biosynthesis.
[So] Source:Biochem J;473(21):3997-4009, 2016 Nov 01.
[Is] ISSN:1470-8728
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bacteria require a haem biosynthetic pathway for the assembly of a variety of protein complexes, including cytochromes, peroxidases, globins, and catalase. Haem is synthesised via a series of tetrapyrrole intermediates, including non-metallated porphyrins, such as protoporphyrin IX, which is well known to generate reactive oxygen species in the presence of light and oxygen. Staphylococcus aureus has an ancient haem biosynthetic pathway that proceeds via the formation of coproporphyrin III, a less reactive porphyrin. Here, we demonstrate, for the first time, that HemY of S. aureus is able to generate both protoporphyrin IX and coproporphyrin III, and that the terminal enzyme of this pathway, HemQ, can stimulate the generation of protoporphyrin IX (but not coproporphyrin III). Assays with hydrogen peroxide, horseradish peroxidase, superoxide dismutase, and catalase confirm that this stimulatory effect is mediated by superoxide. Structural modelling reveals that HemQ enzymes do not possess the structural attributes that are common to peroxidases that form compound I [Fe ==O] , which taken together with the superoxide data leaves Fenton chemistry as a likely route for the superoxide-mediated stimulation of protoporphyrinogen IX oxidase activity of HemY. This generation of toxic free radicals could explain why HemQ enzymes have not been identified in organisms that synthesise haem via the classical protoporphyrin IX pathway. This work has implications for the divergent evolution of haem biosynthesis in ancestral microorganisms, and provides new structural and mechanistic insights into a recently discovered oxidative decarboxylase reaction.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Heme/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Staphylococcus aureus/enzimologia
Staphylococcus aureus/metabolismo
[Mh] Termos MeSH secundário: Catalase/metabolismo
Coproporfirinogênio Oxidase/metabolismo
Coproporfirinas/metabolismo
Radicais Livres/metabolismo
Peroxidase do Rábano Silvestre/metabolismo
Peróxido de Hidrogênio/metabolismo
Modelos Químicos
Protoporfirinogênio Oxidase/metabolismo
Protoporfirinas/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Coproporphyrins); 0 (Free Radicals); 0 (Protoporphyrins); 0 (Reactive Oxygen Species); 14643-66-4 (coproporphyrin III); 42VZT0U6YR (Heme); BBX060AN9V (Hydrogen Peroxide); C2K325S808 (protoporphyrin IX); EC 1.11.1.- (Horseradish Peroxidase); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); EC 1.3.3.3 (Coproporphyrinogen Oxidase); EC 1.3.3.4 (Protoporphyrinogen Oxidase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


  8 / 300 MEDLINE  
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[PMID]:26865470
[Au] Autor:Kawamura S; Yoshioka T; Mito N; Kishimoto N; Nakaoka M; Fantel AG
[Ad] Endereço:Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd, Konohana-ku, Osaka, Japan.
[Ti] Título:Mechanism of Developmental Effects in Rats Caused by an N-Phenylimide Herbicide: Transient Fetal Anemia and Sequelae during Mid-to-Late Gestation.
[So] Source:Birth Defects Res B Dev Reprod Toxicol;107(1):45-59, 2016 Feb.
[Is] ISSN:1542-9741
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rat developmental toxicity including embryolethality and teratogenicity (mainly ventricular septal defects [VSDs] and wavy ribs) was produced by an N-phenylimide herbicide that inhibits protoporphyrinogen oxidase (PPO) common to chlorophyll and heme biosynthesis. Major characteristics of the developmental toxicity included species difference between rats and rabbits, compound-specific difference among structurally similar herbicides, and sensitive period. Protoporphyrin accumulation in treated fetuses closely correlated with the major characteristics. Iron deposits in erythroblastic mitochondria and degeneration of erythroblasts were observed in treated rat fetuses. In this study we investigated fetal anemia and subsequent developmental effects in rats, and inhibition of PPO in rats, rabbits, and humans by the herbicides in vitro. METHODS: Fetuses were treated on gestational day (GD) 12 and removed on GDs 13 through 20. All litters were examined externally. One half of litters were examined for blood and skeletal development, and the other half for interventricular foramen closure. Effects on PPO were determined in mitochondria from embryos and adult livers. RESULTS: Fetal anemia in rats was evident on GDs 13 through 16. Subsequently, enlarged heart, delayed closure of the foramen, reduced serum protein, and retarded rib ossification were observed. In vitro PPO inhibition exhibited species- and compound-specific differences corresponding to the developmental toxicity. CONCLUSION: We propose that developmental toxicity results from PPO inhibition in primitive erythroblasts, causing transient fetal anemia followed by death. Compensatory enlargement of the fetal heart results in failure of interventricular foramen closure and VSD. Reduced serum protein leads to delayed ossification and wavy ribs.
[Mh] Termos MeSH primário: Anemia/embriologia
Anemia/patologia
Feto/anormalidades
Feto/embriologia
Herbicidas/toxicidade
Imidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Benzoxazinas/farmacologia
Proteínas Sanguíneas/metabolismo
Contagem de Eritrócitos
Feminino
Mortalidade Fetal
Feto/efeitos dos fármacos
Feto/patologia
Coração/efeitos dos fármacos
Coração/embriologia
Heme/biossíntese
Hemoglobinas/metabolismo
Herbicidas/química
Seres Humanos
Imidas/química
Concentração Inibidora 50
Ftalimidas/farmacologia
Gravidez
Protoporfirinogênio Oxidase/antagonistas & inibidores
Protoporfirinogênio Oxidase/metabolismo
Coelhos
Ratos Sprague-Dawley
Costelas/anormalidades
Costelas/embriologia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazines); 0 (Blood Proteins); 0 (Hemoglobins); 0 (Herbicides); 0 (Imides); 0 (Phthalimides); 42VZT0U6YR (Heme); EC 1.3.3.4 (Protoporphyrinogen Oxidase); L0PX7OGI22 (flumioxazin)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1002/bdrb.21172


  9 / 300 MEDLINE  
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[PMID]:26817647
[Au] Autor:Salas RA; Burgos NR; Tranel PJ; Singh S; Glasgow L; Scott RC; Nichols RL
[Ad] Endereço:Department of Crop, Soil and Environmental Sciences, University of Arkansas, Fayetteville, AR, USA.
[Ti] Título:Resistance to PPO-inhibiting herbicide in Palmer amaranth from Arkansas.
[So] Source:Pest Manag Sci;72(5):864-9, 2016 May.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The widespread occurrence of ALS inhibitor- and glyphosate-resistant Amaranthus palmeri has led to increasing use of protoporphyrinogen oxidase (PPO)-inhibiting herbicides in cotton and soybean. Studies were conducted to confirm resistance to fomesafen (a PPO inhibitor), determine the resistance frequency, examine the resistance profile to other foliar-applied herbicides and investigate the resistance mechanism of resistant plants in a population collected in 2011 (AR11-LAW B) and its progenies from two cycles of fomesafen selection (C1 and C2). RESULTS: The frequency of fomesafen-resistant plants increased from 5% in the original AR11-LAW-B to 17% in the C2 population. The amounts of fomesafen that caused 50% growth reduction were 6-, 13- and 21-fold greater in AR11-LAW-B, C1 and C2 populations, respectively, than in the sensitive ecotype. The AR11-LAW-B population was sensitive to atrazine, dicamba, glufosinate, glyphosate and mesotrione but resistant to ALS-inhibiting herbicides pyrithiobac and trifloxysulfuron. Fomesafen survivors from C1 and C2 populations tested positive for the PPO glycine 210 deletion previously reported in waterhemp (Amaranthus tuberculatus). CONCLUSION: These studies confirmed that Palmer amaranth in Arkansas has evolved resistance to foliar-applied PPO-inhibiting herbicide.
[Mh] Termos MeSH primário: Amaranthus/efeitos dos fármacos
Benzamidas/farmacologia
Resistência a Herbicidas
Herbicidas/farmacologia
Protoporfirinogênio Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Arkansas
Plantas Daninhas/efeitos dos fármacos
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzamides); 0 (Herbicides); EC 1.3.3.4 (Protoporphyrinogen Oxidase); M0A3U4CDTF (fomesafen)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4241


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[PMID]:26728549
[Au] Autor:Zuo Y; Wu Q; Su SW; Niu CW; Xi Z; Yang GF
[Ad] Endereço:Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
[Ti] Título:Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors.
[So] Source:J Agric Food Chem;64(3):552-62, 2016 Jan 27.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Protoporphyrinogen oxidase (PPO, E.C. 1.3.3.4) is known as a key action target for several structurally diverse herbicides. As a continuation of our research work on the development of new PPO-inhibiting herbicides, a series of novel 3-(2'-halo-5'-substituted-benzothiazol-1'-yl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4-diones 9 were designed and synthesized. The bioassay results indicated that a number of the newly synthesized compounds exhibited higher inhibition activity against tobacco PPO (mtPPO) than the controls, saflufenacil and sulfentrazone. Compound 9F-5 was identified as the most potent inhibitor with a Ki value of 0.0072 µM against mtPPO, showing about 4.2-fold and 1.4-fold higher potency than sulfentrazone (Ki = 0.03 µM) and saflufenacil (Ki = 0.01 µM), respectively. An additional green house assay demonstrated that compound 9F-6 (Ki = 0.012 µM) displayed the most promising postemergence herbicidal activity with a broad spectrum even at a concentration as low as 37.5 g of active ingredient (ai)/ha. Maize exhibits relative tolerance against compound 9F-6 at the dosage of 150 g ai/ha, but it is susceptible to saflufenacil even at 75 g ai/ha. Thus, compound 9F-6 exhibits the potential to be a new herbicide for weed control in maize fields.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Herbicidas/farmacologia
Proteínas de Plantas/química
Protoporfirinogênio Oxidase/química
Tabaco/enzimologia
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/química
Herbicidas/síntese química
Herbicidas/química
Cinética
Proteínas de Plantas/metabolismo
Protoporfirinogênio Oxidase/metabolismo
Pirimidinonas/química
Pirimidinonas/farmacologia
Relação Quantitativa Estrutura-Atividade
Sulfonamidas/química
Sulfonamidas/farmacologia
Tabaco/efeitos dos fármacos
Triazóis/química
Triazóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Herbicides); 0 (N'-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4(trifluoromethyl)-3,6-dihydro-1(2H)-pyrimidinyl)benzoyl)-N-isopropyl-N-methylsulfamide); 0 (Plant Proteins); 0 (Pyrimidinones); 0 (Sulfonamides); 0 (Triazoles); 7TY7WT1599 (N-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenyl)methanesulfonamide); EC 1.3.3.4 (Protoporphyrinogen Oxidase)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160127
[Lr] Data última revisão:
160127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b05378



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