Base de dados : MEDLINE
Pesquisa : D08.811.682.670.550 [Categoria DeCS]
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  1 / 179 MEDLINE  
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[PMID]:8069058
[Au] Autor:Oshima Y; Kobayashi K; Hidaka C; Izu S; Imada N
[Ad] Endereço:Kyushu University, Faculty of Agriculture, Department of Fisheries, Japan.
[Ti] Título:Differences in the drug-metabolizing enzyme activities among fish and bivalves living in waters near industrial and non-industrial areas.
[So] Source:Bull Environ Contam Toxicol;53(1):106-12, 1994 Jul.
[Is] ISSN:0007-4861
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Arilsulfotransferase/metabolismo
Resíduos Industriais
Microssomos Hepáticos/enzimologia
[Mh] Termos MeSH secundário: Animais
Benzopireno Hidroxilase/metabolismo
Bivalves
Sistema Enzimático do Citocromo P-450/metabolismo
Ativação Enzimática/efeitos dos fármacos
Peixes
Glucuronosiltransferase/metabolismo
Japão
Microssomos Hepáticos/efeitos dos fármacos
NADPH-Ferri-Hemoproteína Redutase/metabolismo
Nitroanisol O-Desmetilase/metabolismo
Água do Mar
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Industrial Waste); 0 (Water Pollutants, Chemical); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.14.- (Benzopyrene Hydroxylase); EC 1.6.2.4 (NADPH-Ferrihemoprotein Reductase); EC 2.4.1.17 (Glucuronosyltransferase); EC 2.8.2.1 (Arylsulfotransferase)
[Em] Mês de entrada:9409
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940701
[St] Status:MEDLINE


  2 / 179 MEDLINE  
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[PMID]:8066792
[Au] Autor:Izuishi K; Hamamoto I; Ichikawa Y; Okano K; Akram HM; Maeba T; Tanaka S
[Ad] Endereço:First Department of Surgery, Kagawa Medical School, Japan.
[Ti] Título:Effect of liver warm ischemia on the hepatic microsomal cytochrome P-450 monooxygenase system.
[So] Source:Transplant Proc;26(4):2417-9, 1994 Aug.
[Is] ISSN:0041-1345
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/metabolismo
Isquemia/metabolismo
Fígado/irrigação sanguínea
Microssomos Hepáticos/enzimologia
Reperfusão
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Aminopirina N-Desmetilase/metabolismo
Análise de Variância
Animais
Citocromos b5/metabolismo
Masculino
Nitroanisol O-Desmetilase/metabolismo
Ratos
Ratos Sprague-Dawley
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
9035-39-6 (Cytochromes b5); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.5.3.- (Aminopyrine N-Demethylase); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:9409
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940801
[St] Status:MEDLINE


  3 / 179 MEDLINE  
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[PMID]:8059533
[Au] Autor:Tanaka E; Daling Z; Abe K; Nakamura T; Horie T
[Ad] Endereço:Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan.
[Ti] Título:Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog.
[So] Source:Xenobiotica;24(4):293-300, 1994 Apr.
[Is] ISSN:0049-8254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. We have examined the effects of (S)-(+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8, 11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido[4',3':4,5]thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine (E-6123), a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing capacity in beagle dog, using antipyrine (AP) and trimethadione (TMO) as two model substrates. 2. The plasma half-life (t1/2) and area under the curve (AUC) of AP (0.5 mg/kg, i.v. injection) increased in a dose-dependent manner after a single oral dose of E-6123 (0.2, 1 or 10 mg/kg), whereas the total body clearance (Cl) of AP was decreased, and the apparent volume of distribution (Vd) was unchanged. 3. The pharmacokinetic parameters (t1/2, Cl and AUC) of the metabolism of TMO (4 mg/kg, i.v.) after repeated oral administration of E-6123 (10 mg/kg for 7 days) were not significantly changed in comparison with findings in control dog. The ratio of dimethadione (DMO), being the only TMO metabolite, to TMO in plasma after i.v. administration of TMO in E-6123-treated dog was increased only 5 and 15 min after the final dose, but was not changed at other sampling times (0.5, 1, 2 4, 6, 8 and 12 h). 4. The content of b5, the activity of p-nitroanisole O-demethylase and benzphetamine N-demethylase were significantly increased, compared with controls, by repeated E-6123 treatment. However, aniline hydroxylase activity was not significantly changed. 5. Content of P450 2B was significantly increased in E-6123 treated dog, while that of 3A was not.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Antipirina/metabolismo
Azepinas/farmacologia
Sistema Enzimático do Citocromo P-450/metabolismo
Microssomos Hepáticos/enzimologia
Fator de Ativação de Plaquetas/antagonistas & inibidores
Triazóis/farmacologia
Trimetadiona/farmacocinética
[Mh] Termos MeSH secundário: Animais
Antipirina/farmacocinética
Cães
Meia-Vida
Masculino
Taxa de Depuração Metabólica
Nitroanisol O-Desmetilase/metabolismo
Oxirredutases N-Desmetilantes/metabolismo
Análise de Regressão
Trimetadiona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azepines); 0 (Platelet Activating Factor); 0 (Triazoles); 131614-02-3 (E 6123); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.14.1 (benzphetamine N-demethylase); EC 1.5.- (Oxidoreductases, N-Demethylating); R7GV3H6FQ4 (Trimethadione); T3CHA1B51H (Antipyrine)
[Em] Mês de entrada:9409
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940401
[St] Status:MEDLINE


  4 / 179 MEDLINE  
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[PMID]:8053926
[Au] Autor:Qu W; Kauffman FC; Thurman RG
[Ad] Endereço:Department of Pharmacology, University of North Carolina at Chapel Hill, 27599-7365.
[Ti] Título:Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver.
[So] Source:Biochem Pharmacol;48(2):311-7, 1994 Jul 19.
[Is] ISSN:0006-2952
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study assessed the effect of food restriction on the metabolism of model monooxygenase substrates in the perfused rat liver. Female Sprague-Dawley rats has access ad lib. to a Purina 5001 nonpurified diet (control) or were given 65% of the intake of controls for 3 weeks. Livers were perfused with oxygenated Krebs-Henseleit buffer using a non-recirculating system, and the rates of monooxygenation of p-nitroanisole and 7-ethoxycoumarin were measured. The results indicate that food restriction stimulated p-nitroanisole O-demethylation from 2.9 +/- 0.2 to 4.6 +/- 0.5 mumol/(g.hr) when saturating concentrations of p-nitroanisole were infused. Concomitantly, the ratio of beta-hydroxybutyrate to acetoacetate (B/A) and the rates of ketogenesis (B + A) were increased significantly by food restriction. Further, p-nitroanisole (200 mumol/L) increased hepatic malate concentration nearly 3-fold in liver extracts from food-restricted rats. However, infusion of either a low concentration of p-nitroanisole (50 mumol/L) or 7-ethoxycoumarin (200 mumol/L) did not alter these parameters. On the other hand, food restriction did not alter rates of monooxygenation in isolated microsomes supplemented with excess NADPH. Taken together, these data support the hypothesis that high concentrations of p-nitroanisole increased monooxygenation in food-restricted rats by stimulating fatty acid oxidation, which elevates the mitochondrial NADH/NAD+ ratio. This, in turn, increases the availability of reducing equivalents in the form of NADPH by a malate-pyruvate exchange system, leading to increased drug metabolism.
[Mh] Termos MeSH primário: Ingestão de Alimentos
Fígado/enzimologia
Nitroanisol O-Desmetilase/metabolismo
[Mh] Termos MeSH secundário: O-Dealquilase 7-Alcoxicumarina/metabolismo
Animais
Anisóis/farmacologia
Ativação Enzimática/efeitos dos fármacos
Ácidos Graxos/metabolismo
Feminino
Corpos Cetônicos/análise
NADP
Perfusão
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Anisoles); 0 (Fatty Acids); 0 (Ketone Bodies); 53-59-8 (NADP); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.13.- (7-Alkoxycoumarin O-Dealkylase); G989Z7WOLH (4-nitroanisole)
[Em] Mês de entrada:9409
[Cu] Atualização por classe:121115
[Lr] Data última revisão:
121115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940719
[St] Status:MEDLINE


  5 / 179 MEDLINE  
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[PMID]:8009884
[Au] Autor:Daling Z; Tanaka E; Nakamura T; Horie T
[Ad] Endereço:Eisai Research Laboratories, Eisai, Co., Ltd, Ibaraki-ken, Japan.
[Ti] Título:Effect of E-5110, a novel non-steroidal anti-inflammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog.
[So] Source:Xenobiotica;24(3):215-20, 1994 Mar.
[Is] ISSN:0049-8254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. We examined the effects of N-methoxy-3-(3,5-di-tert-butyl-4- hydroxybenzylidene pyrrolidin-2-one (E-5110), a novel non-steroidal anti-inflammatory drug, on the pharmacokinetics of trimethadione (TMO) and characterized the P450 isozymes involved in the metabolism of TMO in beagle dog. 2. In the E-5110-treated dog (50 mg/kg/day for 7 days: oral) the plasma half-life (t1/2) and the area under the curve (AUC) of TMO (4 mg/kg, i.v.) in vivo were decreased, and total body clearance (CL) was increased; the apparent volume of distribution (Vd) was relatively unchanged. 3. Contents of P450 and b5, and the activity of p-nitroanisole O-demethylase and benzphetamine N-demethylase in vitro were significantly increased compared with controls by repeated E-5110 treatment in dog. 4. Contents of CYP2B and 3A were increased by E-5110 pretreatment in dog. 5. TMO N-demethylation was inhibited by the anti-CYP2B and 3A IgG fractions in liver microsomes obtained from the E-5110-treated dog. 6. Results of both the in vivo and in vitro studies of the effects of E-5110 treatment in dog on TMO indicate that these effects may be attributed to the induction of CYP2B and 3A.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Fígado/efeitos dos fármacos
Pirrolidinonas/farmacologia
Trimetadiona/farmacocinética
[Mh] Termos MeSH secundário: Animais
Sistema Enzimático do Citocromo P-450/metabolismo
Citocromos b5/metabolismo
Cães
Meia-Vida
Isoenzimas/metabolismo
Fígado/enzimologia
Masculino
Microssomos Hepáticos/enzimologia
Nitroanisol O-Desmetilase/metabolismo
Oxirredução
Oxirredutases N-Desmetilantes/metabolismo
Trimetadiona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Isoenzymes); 0 (Pyrrolidinones); 107746-52-1 (E 5110); 9035-39-6 (Cytochromes b5); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.14.1 (benzphetamine N-demethylase); EC 1.5.- (Oxidoreductases, N-Demethylating); R7GV3H6FQ4 (Trimethadione)
[Em] Mês de entrada:9407
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940301
[St] Status:MEDLINE


  6 / 179 MEDLINE  
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[PMID]:7822682
[Au] Autor:Kostka G; Palut D; Kopec-Szlezak J
[Ad] Endereço:Department of Environmental Toxicology, National Institute of Hygiene, Warsaw, Poland.
[Ti] Título:Early hepatic changes induced by nuarimol in rats.
[So] Source:J Appl Toxicol;14(5):337-42, 1994 Sep-Oct.
[Is] ISSN:0260-437X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It is commonly believed that in short-term tests hepatic cytochrome P-450b inducers stimulate liver enlargement and mitogenesis in the absence of overt hepatotoxic effects. In this investigation male Wistar rats received naurimol (an organochlorine pesticide) in one, three and five oral doses of 31.5, 62.5 and 125 mg kg-body wt. day-, whereupon the effects on liver were determined. The early effects were dose-dependent increases in p-nitroanisole metabolism, hepatocyte proliferation (DNA synthesis and mitotic activity) and liver weight. Five administrations of the lowest does (31.5 mg kg-1 body wt. day-1) did not change liver weight, despite increased p-nitroanisole metabolism and hepatocyte proliferation. In contrast to p-nitroanisole metabolism and hepatomegaly, proliferation was only transient and disappeared even when treatment continued. The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect of nuarimol reflected a regenerative response, which may simulate the proliferation caused by partial hepatectomy.
[Mh] Termos MeSH primário: Fungicidas Industriais/toxicidade
Fígado/efeitos dos fármacos
Pirimidinas/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Replicação do DNA/efeitos dos fármacos
Fígado/enzimologia
Fígado/patologia
Masculino
Mitose/efeitos dos fármacos
Testes de Mutagenicidade
Nitroanisol O-Desmetilase/efeitos dos fármacos
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 0 (Pyrimidines); EC 1.- (Nitroanisole O-Demethylase); ZU7K80U0CY (nuarimol)
[Em] Mês de entrada:9502
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940901
[St] Status:MEDLINE


  7 / 179 MEDLINE  
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[PMID]:7517235
[Au] Autor:Krechniak J; Englot B; Wrzesniowska K; Hac E
[Ad] Endereço:Medical Academy, Department of Toxicology, Gdansk, Poland.
[Ti] Título:Interaction of lindane and carbaryl on hepatic microsomal enzymes in rats.
[So] Source:Bull Environ Contam Toxicol;52(6):927-34, 1994 Jun.
[Is] ISSN:0007-4861
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carbaril/farmacologia
Lindano/farmacologia
Microssomos Hepáticos/enzimologia
[Mh] Termos MeSH secundário: Anilina Hidroxilase/biossíntese
Animais
Sistema Enzimático do Citocromo P-450/biossíntese
Citocromos b5/biossíntese
Interações Medicamentosas
Indução Enzimática/efeitos dos fármacos
Masculino
Microssomos Hepáticos/efeitos dos fármacos
Nitroanisol O-Desmetilase/biossíntese
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
59NEE7PCAB (Lindane); 9035-39-6 (Cytochromes b5); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.14.- (Aniline Hydroxylase); R890C8J3N1 (Carbaryl)
[Em] Mês de entrada:9408
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940601
[St] Status:MEDLINE


  8 / 179 MEDLINE  
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[PMID]:7508249
[Au] Autor:Iscan M; Coban T; Eke BC; Iscan M
[Ad] Endereço:Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Turkey.
[Ti] Título:The responses of hepatic monooxygenases of guinea pig to cadmium and nickel.
[So] Source:Biol Trace Elem Res;38(2):129-37, 1993 Aug.
[Is] ISSN:0163-4984
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:When Cd (3.58 mg CdCl2.H2O/kg, ip) was administered to male guinea pigs 72 h prior to sacrifice, the metal significantly inhibited the aniline 4-hydroxylase (AH) (16%), ethylmorphone N-demethylase (EMND) (26%), and aminopyrine N-demethylase (AMND) (18%) activities and cytochrome P-450 (12%) and cytochrome b5 (10%) levels. Cd did not alter the hepatic microsomal heme level. Cd, however, significantly increased the hepatic microsomal p-nitroanisole O-demethylase (p-NAOD) (53%) activity. When Ni (59.5 mg NiCl2 x 6H2O/kg, sc) was administered to the guinea pigs 16 h prior to sacrifice, the metal significantly depressed AH (49%), p-NAOD (66%), EMND (47%), and AMND (37%) activities, and cytochrome P-450 (15%), cytochrome b5 (24%), and microsomal heme (28%) levels. For the combined treatment, animals received the single dose of Ni 56 h after the single dose of Cd and then were killed 16 h later. In these animals, significant inhibitions were noted in AH (51%), EMND (47%), and AMND (30%) activities, and cytochrome P-450 (15%), cytochrome b5 (26%), and microsomal heme (30%) compared to those of controls. In the case of p-NAOD activity, the influence was in favor of Ni, i.e., the inhibition was about 61% by the combined treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Cádmio/toxicidade
Fígado/enzimologia
Níquel/toxicidade
Oxirredutases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Aminopirina N-Desmetilase/antagonistas & inibidores
Anilina Hidroxilase/antagonistas & inibidores
Animais
Inibidores das Enzimas do Citocromo P-450
Cobaias
Fígado/efeitos dos fármacos
Masculino
Nitroanisol O-Desmetilase/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytochrome P-450 Enzyme Inhibitors); 00BH33GNGH (Cadmium); 7OV03QG267 (Nickel); EC 1.- (Nitroanisole O-Demethylase); EC 1.- (Oxidoreductases); EC 1.14.14.- (Aniline Hydroxylase); EC 1.5.3.- (Aminopyrine N-Demethylase)
[Em] Mês de entrada:9403
[Cu] Atualização por classe:170905
[Lr] Data última revisão:
170905
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930801
[St] Status:MEDLINE


  9 / 179 MEDLINE  
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[PMID]:1373902
[Au] Autor:Mori T; Kitamura R; Imaoka S; Funae Y; Kitada M; Kamataki T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
[Ti] Título:Examination for lipid peroxidation in liver microsomes of guinea pigs as a causal factor in the decrease in the content of cytochrome P-450 due to ascorbic acid deficiency.
[So] Source:Res Commun Chem Pathol Pharmacol;75(2):209-19, 1992 Feb.
[Is] ISSN:0034-5164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The content of cytochrome P-450 in liver microsomes from guinea pigs was decreased by ascorbic acid-deficiency. Since ascorbic acid is an antioxidant in vivo, the possible involvement of lipid peroxidation in this phenomenon was investigated. In fact, the level of lipid peroxides in liver homogenates of guinea pigs was increased by ascorbic acid deficiency. The level was significantly decreased when the animals were given tocopherol acetate (25 mg/kg/day, s.c.) with an ascorbic acid-free diet. The activities of aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole O-demethylase and 7-ethoxycoumarin O-deethylase, and the content of cytochrome P-450 spectrally determined did not restore the control level by the administration of tocopherol acetate to the ascorbic acid-deficient animals. Western blot analysis of liver microsomes with antibodies to rat P-450IA2 (P-448-H), P-450IIB1 (P-450b) and human P-450IIIA4 (P-450NF) showed that ascorbic acid-deficiency resulted in a decrease in the amount of cytochrome P-450 immunochemically related to P-450IA2, but not the amounts of the forms of cytochrome P-450 cross-reactive with antibodies to P-450IIB1 and P-450IIIA4. The reduced amounts of cytochrome P-450 cross-reactive with antibodies to rat P-450IA2 in liver microsomes of ascorbic acid-deficient animals remained unchanged even when lipid peroxidation was inhibited by tocopherol acetate, suggesting that there is a mechanism(s) other than lipid peroxidation involved in the reduction of amounts of cytochrome P-450 by ascorbic acid deficiency.
[Mh] Termos MeSH primário: Deficiência de Ácido Ascórbico/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Peroxidação de Lipídeos
Microssomos Hepáticos/metabolismo
Vitamina E/farmacologia
[Mh] Termos MeSH secundário: O-Dealquilase 7-Alcoxicumarina/metabolismo
Aminopirina N-Desmetilase/metabolismo
Anilina Hidroxilase/metabolismo
Animais
Western Blotting
Eletroforese em Gel de Poliacrilamida
Cobaias
Masculino
Nitroanisol O-Desmetilase/metabolismo
RNA/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-18-4 (Vitamin E); 63231-63-0 (RNA); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.13.- (7-Alkoxycoumarin O-Dealkylase); EC 1.14.14.- (Aniline Hydroxylase); EC 1.5.3.- (Aminopyrine N-Demethylase)
[Em] Mês de entrada:9205
[Cu] Atualização por classe:031114
[Lr] Data última revisão:
031114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920201
[St] Status:MEDLINE


  10 / 179 MEDLINE  
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[PMID]:1907908
[Au] Autor:Krechniak J; Wrzesniowska K
[Ad] Endereço:Medical Academy, Department of Toxicology, Gdansk-Wrzeszcz, Poland.
[Ti] Título:Effects of pyrethroid insecticides on hepatic microsomal enzymes in rats.
[So] Source:Environ Res;55(2):129-34, 1991 Aug.
[Is] ISSN:0013-9351
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The effects of pyrethroid insecticides on hepatic microsomal enzymes were studied in rats. Animals were treated orally with cypermethrin (80 mg/kg), deltamethrin (15 mg/kg), and permethrin (100 mg/kg), as a solution in soyabean oil, for 1 to 20 days. The content of cytochromes P-450 and b5, activity of NADPH cytochrome P-450 reductase, glutathione S-transferase, aniline 4-hydroxylase, p-nitroanisole O-demethylase in microsomes, the activity of glutathione S-transferase, and the level of sulfhydryl groups in cytosol were determined. Also the relative liver weight was measured. Only few changes in the investigated parameters were ascertained. These changes have an irregular and transient character. On the whole, the action of pyrethroids on microsomal enzymes results in a slight induction.
[Mh] Termos MeSH primário: Inseticidas/farmacologia
Microssomos Hepáticos/enzimologia
Piretrinas/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Anilina Hidroxilase/metabolismo
Animais
Sistema Enzimático do Citocromo P-450/metabolismo
Citosol/metabolismo
Glutationa Transferase/metabolismo
Inseticidas/administração & dosagem
Fígado/anatomia & histologia
Fígado/enzimologia
Fígado/ultraestrutura
Masculino
Microssomos Hepáticos/efeitos dos fármacos
Microssomos Hepáticos/ultraestrutura
NADPH-Ferri-Hemoproteína Redutase/metabolismo
Nitrilos
Nitroanisol O-Desmetilase/metabolismo
Tamanho do Órgão
Permetrina
Piretrinas/administração & dosagem
Ratos
Compostos de Sulfidrila/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 0 (Sulfhydryl Compounds); 1TR49121NP (cypermethrin); 2JTS8R821G (decamethrin); 509F88P9SZ (Permethrin); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Nitroanisole O-Demethylase); EC 1.14.14.- (Aniline Hydroxylase); EC 1.6.2.4 (NADPH-Ferrihemoprotein Reductase); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:9109
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910801
[St] Status:MEDLINE



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