Base de dados : MEDLINE
Pesquisa : D08.811.913.477.700 [Categoria DeCS]
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[PMID]:29307827
[Au] Autor:Manning ME; Danson EJ; Calderone CT
[Ad] Endereço:Department of Chemistry, Carleton College, 1 North College Street, Northfield, MN 55057, United States.
[Ti] Título:Functional chararacterization of the enzymes TabB and TabD involved in tabtoxin biosynthesis by Pseudomonas syringae.
[So] Source:Biochem Biophys Res Commun;496(1):212-217, 2018 01 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pseudomonas syringae pv. tabaci ATCC 11528 produces tabtoxin, a ß-lactam-containing dipeptide phytotoxin. Tabtoxinine-ß-lactam (TßL), one of tabtoxin's constituent amino acids, structurally mimics lysine, and many of the proteins encoded by the tabtoxin biosynthetic gene cluster are homologs of lysine biosynthetic enzymes, suggesting that the tabtoxin and lysine biosynthetic routes parallel one another. We cloned and expressed TabB and TabD, predicted homologs of tetrahydrodipicolinate (THDPA)-N-acyltransferase and N-acyl-THDPA aminotransferase, respectively, to determine their activities in vitro. We confirmed that TabB succinylates THDPA and that TabD is a PLP-dependent aminotransferase that utilizes glutamate as an amine donor. Surprisingly, we also found that though TabD could utilize the TabB product N-succinyl-THDPA as a substrate, THDPA itself was also recognized. These observations reveal that TabB functionally duplicates DapD, the THDPA-N-succinyltransferase involved in lysine biosynthesis, and reinforce the close relationship between the metabolic logics underpinning the respective biosynthetic pathways.
[Mh] Termos MeSH primário: Acetiltransferases/química
Acetiltransferases/metabolismo
Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
Dipeptídeos/biossíntese
Pseudomonas syringae/metabolismo
Transaminases/química
Transaminases/metabolismo
[Mh] Termos MeSH secundário: Ativação Enzimática
Estabilidade Enzimática
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Dipeptides); EC 2.3.1.- (Acetyltransferases); EC 2.3.1.- (TabB protein, Pseudomonas syringae); EC 2.6.1.- (Transaminases); H3YX70R64N (tabtoxin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


  2 / 9807 MEDLINE  
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[PMID]:28464785
[Au] Autor:Jacobs KR; Castellano-Gonzalez G; Guillemin GJ; Lovejoy DB
[Ad] Endereço:Neuroinflammation Group, Department of Biomedical Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney. Australia.
[Ti] Título:Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
[So] Source:Curr Med Chem;24(23):2471-2495, 2017.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Disrupted kynurenine pathway (KP) metabolism has been implicated in the progression of neurodegenerative disease, psychiatric disorders and cancer. Modulation of enzyme activity along this pathway may therefore offer potential new therapeutic strategies for these conditions. Considering their prominent positions in the KP, the enzymes indoleamine 2,3-dioxygenase, kynurenine 3-monooxygenase and kynurenine aminotransferase, appear the most attractive targets. Already, increasing interest in this pathway has led to the identification of a number of potent and selective enzyme inhibitors with promising pre-clinical data and the elucidation of several enzyme crystal structures provides scope to rationalize the molecular mechanisms of inhibitor activity. The field seems poised to yield one or more inhibitors that should find clinical utility.
[Mh] Termos MeSH primário: Desenho de Drogas
Inibidores Enzimáticos/farmacologia
Indolamina-Pirrol 2,3,-Dioxigenase/antagonistas & inibidores
Quinurenina 3-Mono-Oxigenase/antagonistas & inibidores
Cinurenina/metabolismo
Transaminases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/química
Inibidores Enzimáticos/metabolismo
Seres Humanos
Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo
Quinurenina 3-Mono-Oxigenase/metabolismo
Transaminases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 343-65-7 (Kynurenine); EC 1.14.13.9 (Kynurenine 3-Monooxygenase); EC 2.6.1.- (Transaminases); EC 2.6.1.7 (kynurenine-oxoglutarate transaminase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170502123114


  3 / 9807 MEDLINE  
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[PMID]:28470825
[Au] Autor:Börner T; Rämisch S; Bartsch S; Vogel A; Adlercreutz P; Grey C
[Ad] Endereço:Department of Chemistry and Biotechnology, Institute of Materials Science, Nestlé Research Center, Route du Jorat 57, 1000, Lausanne 26, Switzerland.
[Ti] Título:Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor-Binding Element of Amine Transaminase.
[So] Source:Chembiochem;18(15):1482-1486, 2017 08 04.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Amine transaminase (ATA) catalyse enantioselectively the direct amination of ketones, but insufficient stability during catalysis limits their industrial applicability. Recently, we revealed that ATAs suffer from substrate-induced inactivation mechanism involving dissociation of the enzyme-cofactor intermediate. Here, we report on engineering the cofactor-ring-binding element, which also shapes the active-site entrance. Only two point mutations in this motif improved temperature and catalytic stability in both biphasic media and organic solvent. Thermodynamic analysis revealed a higher melting point for the enzyme-cofactor intermediate. The high cofactor affinity eliminates the need for pyridoxal 5'-phosphate supply, thus making large-scale reactions more cost effective. This is the first report on stabilising a tetrameric ATA by mutating a single structural element. As this structural "hotspot" is a common feature of other transaminases it could serve as a general engineering target.
[Mh] Termos MeSH primário: Transaminases/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Dimetil Sulfóxido/química
Estabilidade Enzimática
Propilaminas/química
Engenharia de Proteínas
Estrutura Quaternária de Proteína
Fosfato de Piridoxal/química
Piridoxamina/análogos & derivados
Piridoxamina/química
Solventes/química
Temperatura Ambiente
Temperatura de Transição
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Propylamines); 0 (Solvents); 059QF0KO0R (Water); 5V5IOJ8338 (Pyridoxal Phosphate); 6466NM3W93 (Pyridoxamine); EC 2.6.1.- (Transaminases); P8W26T4MTD (2-propylamine); QWW7V29814 (pyridoxamine phosphate); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700236


  4 / 9807 MEDLINE  
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[PMID]:28469048
[Au] Autor:Kootte RS; Faber LM
[Ad] Endereço:Department of Internal Medicine, Rode Kruis Hospital, Beverwijk, the Netherlands.
[Ti] Título:Hepatitis E during lenalidomide treatment for multiple myeloma in complete remission.
[So] Source:Neth J Med;75(3):117-121, 2017 Apr.
[Is] ISSN:1872-9061
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lenalidomide has a central role in the treatment of multiple myeloma and results in improved survival. As with other chemotherapeutics, it can cause several serious side effects. This is the first reported case of hepatitis E during lenalidomide treatment for multiple myeloma in complete remission. In case of liver chemistry abnormalities during lenalidomide treatment, the differential diagnosis should include hepatitis E infection.
[Mh] Termos MeSH primário: Hepatite E/induzido quimicamente
Fatores Imunológicos/efeitos adversos
Mieloma Múltiplo/tratamento farmacológico
Talidomida/análogos & derivados
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Testes de Função Hepática
Quimioterapia de Manutenção
Talidomida/efeitos adversos
Transaminases/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 4Z8R6ORS6L (Thalidomide); EC 2.6.1.- (Transaminases); F0P408N6V4 (lenalidomide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  5 / 9807 MEDLINE  
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[PMID]:27770224
[Au] Autor:Wang Z; Bai X; Guo X; He X
[Ad] Endereço:CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
[Ti] Título:Regulation of crucial enzymes and transcription factors on 2-phenylethanol biosynthesis via Ehrlich pathway in Saccharomyces cerevisiae.
[So] Source:J Ind Microbiol Biotechnol;44(1):129-139, 2017 Jan.
[Is] ISSN:1476-5535
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:2-Phenylethanol (2-PE) is widely used in food, perfume and pharmaceutical industry, but lower production in microbes and less known regulatory mechanisms of 2-PE make further study necessary. In this study, crucial genes like ARO8 and ARO10 of Ehrlich pathway for 2-PE synthesis and key transcription factor ARO80 in Saccharomyces cerevisiae were re-regulated using constitutive promoter; in the meantime, the effect of nitrogen source in synthetic complete (SC) medium with L-phenylalanine (L-Phe) on Aro8/Aro9 and Aro10 was investigated. The results showed that aromatic aminotransferase activities of ARO8 over-expressing strains were seriously inhibited by ammonia sulfate in SC + Phe medium. Flask fermentation test demonstrated that over-expressing ARO8 or ARO10 led to about 42 % increase in 2-PE production when compared with the control strain. Furthermore, influence of transcription factors Cat8 and Mig1 on 2-PE biosynthesis was explored. CAT8 over-expression or MIG1 deletion increased in the transcription of ARO9 and ARO10. 2-PE production of CAT8 over-expressing strain was 62 % higher than that of control strain. Deletion of MIG1 also led to 2-PE biosynthesis enhancement. The strain of CAT8 over-expression and MIG1 deletion was most effective in regulating expression of ARO9 and ARO10. Analysis of mRNA levels and enzyme activities indicates that transaminase in Ehrlich pathway is the crucial target of Nitrogen Catabolize Repression (NCR). Among the engineering strains, the higher 3.73 g/L 2-PE production in CAT8 over-expressing strain without in situ product recovery suggests that the robust strain has potentiality for commercial exploitation.
[Mh] Termos MeSH primário: Álcool Feniletílico/metabolismo
Proteínas de Saccharomyces cerevisiae/metabolismo
Saccharomyces cerevisiae/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Carboxiliases/metabolismo
Fermentação
Metabolismo
Fenilalanina/metabolismo
Engenharia de Proteínas/métodos
RNA Mensageiro/metabolismo
Transaminases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Saccharomyces cerevisiae Proteins); 0 (Transcription Factors); 47E5O17Y3R (Phenylalanine); EC 2.6.1.- (Transaminases); EC 4.1.1.- (Carboxy-Lyases); ML9LGA7468 (Phenylethyl Alcohol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s10295-016-1852-5


  6 / 9807 MEDLINE  
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[PMID]:28872150
[Au] Autor:Ungprasert P; Crowson CS; Simonetto DA; Matteson EL
[Ad] Endereço:Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:Clinical Characteristics and Outcome of Hepatic Sarcoidosis: A Population-Based Study 1976-2013.
[So] Source:Am J Gastroenterol;112(10):1556-1563, 2017 Oct.
[Is] ISSN:1572-0241
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Data on clinical manifestations and outcome of hepatic sarcoidosis are scarce. This study aimed to use a population-based cohort of patients with incident sarcoidosis to better describe the characteristics of hepatic sarcoidosis. METHODS: A cohort of incident cases of sarcoidosis in Olmsted County, MN, USA, from 1976 to 2013 was identified from the database. Diagnosis was verified by individual medical record review. Confirmed cases of sarcoidosis were then reviewed for liver involvement. Data on clinical manifestations, imaging study, liver biochemical tests, treatment, and outcome were collected. Cumulative incidence of cirrhosis adjusted for the competing risk of death was estimated. RESULTS: A total of 345 cases of incident sarcoidosis were identified. Of these, 19 cases (6%) had liver involvement (mean age 46.1 years, 53% female and 79% Caucasian). Most patients had asymptomatic liver disease and were discovered in pursuit of abnormal biochemical tests and imaging studies. Alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were elevated in the majority of patients (88 and 90%, respectively). Elevated transaminases were less common and less severe. About half of patients had abnormal imaging study with hypodense nodular lesions being the most common abnormality (six patients) followed by hepatomegaly (three patients). Liver biopsy revealed non-caseating granuloma in 88% (14 of 16 patients). A total of four patients developed cirrhosis. CONCLUSIONS: Involvement of the liver by sarcoidosis was seen in 6% of patients with sarcoidosis. The majority of patients were asymptomatic. Elevated ALP and GGT were the most common abnormal biochemical tests. Liver biopsy revealed non-caseating granuloma in almost all cases. Cirrhosis was seen in a significant number of patients. Generalizability of the observations to other populations may be limited, as the studied population was predominantly Caucasian. The prevalence of liver disease may be higher in more diverse populations.
[Mh] Termos MeSH primário: Hepatopatias
Fígado
Sarcoidose
[Mh] Termos MeSH secundário: Idoso
Doenças Assintomáticas/epidemiologia
Biópsia/métodos
Estudos de Coortes
Feminino
Seres Humanos
Incidência
Fígado/diagnóstico por imagem
Fígado/patologia
Cirrose Hepática/epidemiologia
Hepatopatias/diagnóstico
Hepatopatias/epidemiologia
Hepatopatias/fisiopatologia
Hepatopatias/terapia
Testes de Função Hepática/métodos
Masculino
Registros Médicos Orientados a Problemas/estatística & dados numéricos
Meia-Idade
Estudos Retrospectivos
Sarcoidose/diagnóstico
Sarcoidose/epidemiologia
Sarcoidose/fisiopatologia
Sarcoidose/terapia
Transaminases/análise
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2017.231


  7 / 9807 MEDLINE  
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[PMID]:28864554
[Au] Autor:DeKlotz CMC; Roby KD; Friedlander SF
[Ad] Endereço:MedStar Washington Hospital Center/Georgetown University Hospital, Washington, District of Columbia; and Cynthia.M.DeKlotz@medstar.net.
[Ti] Título:Dietary Supplements, Isotretinoin, and Liver Toxicity in Adolescents: A Retrospective Case Series.
[So] Source:Pediatrics;140(4), 2017 Oct.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretinoin therapy who were concurrently ingesting protein or herbal supplementation and who developed transaminitis. In 100% (8/8) of cases, dietary supplementation was determined to be at least a possible cause of elevated liver transaminases. In 75% (6/8) of cases, dietary supplement appears to be the most likely cause at some point in their evaluation. Most of our patients' elevations in aspartate aminotransferase and/or alanine aminotransferase were likely caused by supplementation with protein, creatine, or herbal extracts, rather than prescribed isotretinoin or tetracycline antibiotics for acne. Hence, dietary supplementation may cause liver function abnormalities. As supplement usage appears common in teenagers, clinicians should consider counseling their patients to avoid these products, particularly when prescribing known hepatotoxic drugs.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Fármacos Dermatológicos/efeitos adversos
Suplementos Nutricionais/efeitos adversos
Isotretinoína/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores/metabolismo
Camellia sinensis/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/enzimologia
Creatina/efeitos adversos
Fármacos Dermatológicos/uso terapêutico
Proteínas na Dieta/efeitos adversos
Feminino
Seguimentos
Seres Humanos
Isotretinoína/uso terapêutico
Masculino
Preparações de Plantas/efeitos adversos
Estudos Retrospectivos
Transaminases/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dermatologic Agents); 0 (Dietary Proteins); 0 (Plant Preparations); EC 2.6.1.- (Transaminases); EH28UP18IF (Isotretinoin); MU72812GK0 (Creatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


  8 / 9807 MEDLINE  
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[PMID]:28781260
[Au] Autor:Pogorelova TN; Gunko VO; Avrutskaya VV; Kaushanskaya LV; Durnitsyna OA
[Ad] Endereço:Rostov Scientific-Research Institute of Obstetrics and Pediatrics.
[Ti] Título:[Impairments of placental amino acid metabolism in fetal growth restriction].
[Ti] Título:Narushenie platsentarnogo obmena aminokislot pri zaderzhke rosta ploda..
[So] Source:Biomed Khim;63(3):266-271, 2017 May.
[Is] ISSN:2310-6972
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The content of the amino acids in the placenta during physiological pregnancy and fetal growth restriction (FGR) has been investigated my means of the method of ion-exchange chromatography. It has been found that in FGR the placental amino acid pool is characterized by a decreased content of arginine, proline, alanine, serine, cysteine, methionine, tryptophan, leucine, threonine, tyrosine, phenylalanine, glutamine and an increased content of dicarboxylic amino acids, lysine, histidine and glycine. These changes are accompanied by altered activity of some enzymes of amino acid metabolism, and the degree of these changes correlates with the level of corresponding amino acids.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Retardo do Crescimento Fetal/metabolismo
Recém-Nascido de Baixo Peso
Placenta/metabolismo
[Mh] Termos MeSH secundário: Adulto
Alanina Transaminase/metabolismo
Arginase/metabolismo
Aspartato Aminotransferases/metabolismo
Estudos de Casos e Controles
Feminino
Desenvolvimento Fetal/fisiologia
Retardo do Crescimento Fetal/patologia
Glutamato Sintase/metabolismo
Homeostase
Seres Humanos
Recém-Nascido
Troca Materno-Fetal/fisiologia
Placenta/química
Placenta/patologia
Gravidez
Transaminases/metabolismo
Tirosina Transaminase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); EC 1.4.1.13 (Glutamate Synthase); EC 2.6.1.- (Transaminases); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 2.6.1.3 (cysteine aminotransferase); EC 2.6.1.5 (Tyrosine Transaminase); EC 3.5.3.1 (Arginase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.18097/PBMC20176303266


  9 / 9807 MEDLINE  
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[PMID]:28777048
[Au] Autor:Terziroli Beretta-Piccoli B; Vergani D; Mieli-Vergani G
[Ad] Endereço:1 Epatocentro Ticino, Lugano.
[Ti] Título:Autoimmunhepatitis: das Wichtigste für die Praxis..
[So] Source:Ther Umsch;74(3):115-121, 2017 Jul.
[Is] ISSN:0040-5930
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Hepatite Autoimune/diagnóstico
Hepatite Autoimune/terapia
Imunoglobulina G/sangue
Transaminases/sangue
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Diagnóstico Diferencial
Medicina Baseada em Evidências
Hepatite Autoimune/sangue
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Immunoglobulin G); EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1024/0040-5930/a000894


  10 / 9807 MEDLINE  
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[PMID]:28777046
[Au] Autor:von Köckritz L; De Gottardi A
[Ad] Endereço:1 Universitätsklinik für Viszerale Chirurgie und Medizin, Hepatologie, Inselspital, Bern.
[Ti] Título:Rationale Abklärung von Lebererkrankungen..
[So] Source:Ther Umsch;74(3):79-86, 2017 07.
[Is] ISSN:0040-5930
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Ensaios Enzimáticos Clínicos/métodos
Hepatopatias/diagnóstico
Hepatopatias/patologia
Transaminases/metabolismo
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Diagnóstico Diferencial
Medicina Baseada em Evidências
Seres Humanos
Hepatopatias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1024/0040-5930/a000889



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde