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[PMID]:28781237
[Au] Autor:Fan Y; Evans CR; Barber KW; Banerjee K; Weiss KJ; Margolin W; Igoshin OA; Rinehart J; Ling J
[Ad] Endereço:Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.
[Ti] Título:Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness.
[So] Source:Mol Cell;67(5):826-836.e5, 2017 Sep 07.
[Is] ISSN:1097-4164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gene expression noise (heterogeneity) leads to phenotypic diversity among isogenic individual cells. Our current understanding of gene expression noise is mostly limited to transcription, as separating translational noise from transcriptional noise has been challenging. It also remains unclear how translational heterogeneity originates. Using a transcription-normalized reporter system, we discovered that stop codon readthrough is heterogeneous among single cells, and individual cells with higher UGA readthrough grow faster from stationary phase. Our work also revealed that individual cells with lower protein synthesis levels exhibited higher UGA readthrough, which was confirmed with ribosome-targeting antibiotics (e.g., chloramphenicol). Further experiments and mathematical modeling suggest that varied competition between ternary complexes and release factors perturbs the UGA readthrough level. Our results indicate that fluctuations in the concentrations of translational components lead to UGA readthrough heterogeneity among single cells, which enhances phenotypic diversity of the genetically identical population and facilitates its adaptation to changing environments.
[Mh] Termos MeSH primário: Códon de Terminação
Proteínas de Escherichia coli/biossíntese
Proteínas de Escherichia coli/genética
Escherichia coli/genética
Escherichia coli/metabolismo
Genes Reporter
Microscopia de Fluorescência
Transferases de Grupo de Um Carbono
[Mh] Termos MeSH secundário: Proteínas de Bactérias/biossíntese
Proteínas de Bactérias/genética
Escherichia coli/crescimento & desenvolvimento
Regulação Bacteriana da Expressão Gênica
Aptidão Genética
Genótipo
Cinética
Proteínas Luminescentes/biossíntese
Proteínas Luminescentes/genética
Modelos Genéticos
Fenótipo
RNA Bacteriano/biossíntese
RNA Bacteriano/genética
RNA Mensageiro/biossíntese
RNA Mensageiro/genética
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Codon, Terminator); 0 (Escherichia coli Proteins); 0 (Luminescent Proteins); 0 (RNA, Bacterial); 0 (RNA, Messenger); 0 (red fluorescent protein); 0 (yellow fluorescent protein, Bacteria); EC 2.1.- (One-Carbon Group Transferases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE


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[PMID]:27764113
[Au] Autor:Kobayashi K; Kanesaki Y; Yoshikawa H
[Ad] Endereço:Graduate School of Biological Sciences, Nara Institute of Science & Technology, Ikoma, Japan.
[Ti] Título:Genetic Analysis of Collective Motility of Paenibacillus sp. NAIST15-1.
[So] Source:PLoS Genet;12(10):e1006387, 2016 Oct.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacteria have developed various motility mechanisms to adapt to a variety of solid surfaces. A rhizosphere isolate, Paenibacillus sp. NAIST15-1, exhibited unusual motility behavior. When spotted onto 1.5% agar media, Paenibacillus sp. formed many colonies, each of which moved around actively at a speed of 3.6 µm/sec. As their density increased, each moving colony began to spiral, finally forming a static round colony. Despite its unusual motility behavior, draft genome sequencing revealed that both the composition and organization of flagellar genes in Paenibacillus sp. were very similar to those in Bacillus subtilis. Disruption of flagellar genes and flagellar stator operons resulted in loss of motility. Paenibacillus sp. showed increased transcription of flagellar genes and hyperflagellation on hard agar media. Thus, increased flagella and their rotation drive Paenibacillus sp. motility. We also identified a large extracellular protein, CmoA, which is conserved only in several Paenibacillus and related species. A cmoA mutant could neither form moving colonies nor move on hard agar media; however, motility was restored by exogenous CmoA. CmoA was located around cells and enveloped cell clusters. Comparison of cellular behavior between the wild type and cmoA mutant indicated that extracellular CmoA is involved in drawing water out of agar media and/or smoothing the cell surface interface. This function of CmoA probably enables Paenibacillus sp. to move on hard agar media.
[Mh] Termos MeSH primário: Bacillus subtilis/genética
Movimento Celular/genética
Transferases de Grupo de Um Carbono/genética
Paenibacillus/genética
[Mh] Termos MeSH secundário: Bacillus subtilis/crescimento & desenvolvimento
Flagelos/genética
Paenibacillus/crescimento & desenvolvimento
Filogenia
Rizosfera
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.1.- (One-Carbon Group Transferases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006387


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[PMID]:27086212
[Au] Autor:Misiak B; Laczmanski L; Sloka NK; Szmida E; Piotrowski P; Loska O; Slezak R; Kiejna A; Frydecka D
[Ad] Endereço:Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland. Electronic address: mblazej@interia.eu.
[Ti] Título:Metabolic dysregulation in first-episode schizophrenia patients with respect to genetic variation in one-carbon metabolism.
[So] Source:Psychiatry Res;238:60-67, 2016 Apr 30.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the prevalence of metabolic disturbances in patients with first-episode schizophrenia (FES) and test the hypothesis that genetic variation in one-carbon metabolism may account for metabolic dysregulation in early psychosis. We measured fasting glucose, lipid profile parameters, homocysteine, folate and vitamin B12 in 135 patients with FES and 146 healthy controls (HCs). Polymorphisms in the following genes were determined: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G) and BHMT (G742A). Serum levels of folate and high-density lipoproteins (HDL) were significantly lower in patients with FES compared to HCs. In turn, serum levels of homocysteine and triglycerides were significantly higher in patients with FES than in HCs. Prevalence of hyperhomocysteinemia, low folate and HDL levels together with dyslipidemia was significantly higher in patients with FES compared to HCs. Higher homocysteine levels, lower vitamin B12 levels and the presence of metabolic syndrome were associated with higher severity of negative symptoms. None of studied polymorphisms was associated with schizophrenia risk. Several associations between studied polymorphisms and cardio-metabolic parameters were found. None of them remained significant after Bonferroni correction. Our results indicate that metabolic dysregulation in patients with FES is not associated with genetic variation in one-carbon metabolism.
[Mh] Termos MeSH primário: Dislipidemias/psicologia
Hiper-Homocisteinemia/psicologia
Síndrome Metabólica/psicologia
Transtornos Psicóticos/complicações
Esquizofrenia/sangue
[Mh] Termos MeSH secundário: Adulto
Betaína-Homocisteína S-Metiltransferase/genética
Glicemia/análise
Carbono/metabolismo
Estudos de Casos e Controles
Dislipidemias/sangue
Dislipidemias/epidemiologia
Jejum/sangue
Feminino
Ferredoxina-NADP Redutase/genética
Ácido Fólico/sangue
Homocisteína/sangue
Seres Humanos
Hiper-Homocisteinemia/sangue
Hiper-Homocisteinemia/epidemiologia
Lipoproteínas HDL/sangue
Masculino
Síndrome Metabólica/sangue
Síndrome Metabólica/epidemiologia
Metilenotetra-Hidrofolato Desidrogenase (NADP)/genética
Metilenotetra-Hidrofolato Redutase (NADPH2)/genética
Antígenos de Histocompatibilidade Menor/genética
Transferases de Grupo de Um Carbono
Polimorfismo Genético
Prevalência
Transtornos Psicóticos/sangue
Transtornos Psicóticos/genética
Esquizofrenia/complicações
Esquizofrenia/genética
Triglicerídeos/sangue
Vitamina B 12
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Lipoproteins, HDL); 0 (Minor Histocompatibility Antigens); 0 (Triglycerides); 0LVT1QZ0BA (Homocysteine); 7440-44-0 (Carbon); 935E97BOY8 (Folic Acid); EC 1.18.1.- (methionine synthase reductase); EC 1.18.1.2 (Ferredoxin-NADP Reductase); EC 1.5.1.20 (MTHFR protein, human); EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)); EC 1.5.1.5 (MTHFD1 protein, human); EC 1.5.1.5 (Methylenetetrahydrofolate Dehydrogenase (NADP)); EC 2.1.- (One-Carbon Group Transferases); EC 2.1.1.5 (BHMT protein, human); EC 2.1.1.5 (Betaine-Homocysteine S-Methyltransferase); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE


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[PMID]:26742069
[Au] Autor:Lysne V; Strand E; Svingen GF; Bjørndal B; Pedersen ER; Midttun Ø; Olsen T; Ueland PM; Berge RK; Nygård O
[Ad] Endereço:Department of Clinical Science, University of Bergen, 5020 Bergen, Norway. vegard.lysne@uib.no.
[Ti] Título:Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats.
[So] Source:Nutrients;8(1), 2016 Jan 05.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of key enzymes along this pathway. In this study, we investigated the effect of PPAR activation on circulating and urinary one-carbon metabolites as well as markers of B-vitamin status. Male Wistar rats (n = 20) received for 50 weeks either a high-fat control diet or a high-fat diet with tetradecylthioacetic acid (TTA), a modified fatty acid and pan-PPAR agonist with high affinity towards PPARα. Hepatic gene expression of PPARα, PPARß/δ and the enzymes involved in the choline oxidation pathway were analyzed and concentrations of metabolites were analyzed in plasma and urine. TTA treatment altered most biomarkers, and the largest effect sizes were observed for plasma concentrations of dimethylglycine, nicotinamide, methylnicotinamide, methylmalonic acid and pyridoxal, which were all higher in the TTA group (all p < 0.01). Hepatic Pparα mRNA was increased after TTA treatment, but genes of the choline oxidation pathway were not affected. Long-term TTA treatment was associated with pronounced alterations on the plasma and urinary concentrations of metabolites related to one-carbon metabolism and B-vitamin status in rats.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Dieta Hiperlipídica/efeitos adversos
Transferases de Grupo de Um Carbono/sangue
Receptores Ativados por Proliferador de Peroxissomo/metabolismo
Sulfetos/farmacologia
Complexo Vitamínico B/análise
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Colina/metabolismo
Expressão Gênica
Fígado/metabolismo
Masculino
Redes e Vias Metabólicas/genética
Ácido Metilmalônico/sangue
Niacinamida/sangue
Ácidos Nicotínicos/sangue
PPAR alfa/genética
PPAR beta/metabolismo
Receptores Ativados por Proliferador de Peroxissomo/genética
Piridoxal/sangue
RNA Mensageiro/metabolismo
Distribuição Aleatória
Ratos
Ratos Wistar
Sarcosina/análogos & derivados
Sarcosina/sangue
Sulfetos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Nicotinic Acids); 0 (PPAR alpha); 0 (PPAR-beta); 0 (Peroxisome Proliferator-Activated Receptors); 0 (RNA, Messenger); 0 (Sulfides); 12001-76-2 (Vitamin B Complex); 25X51I8RD4 (Niacinamide); 3THM379K8A (Pyridoxal); 7797M4CPPA (dimethylglycine); 7B1AVU9DJN (methyl nicotinate); 7ZU5I25S2O (1-(carboxymethylthio)tetradecane); 8LL8S712J7 (Methylmalonic Acid); EC 2.1.- (One-Carbon Group Transferases); N91BDP6H0X (Choline); Z711V88R5F (Sarcosine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


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[PMID]:26427881
[Au] Autor:Shippy DC; Fadl AA
[Ad] Endereço:Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
[Ti] Título:RNA modification enzymes encoded by the gid operon: Implications in biology and virulence of bacteria.
[So] Source:Microb Pathog;89:100-7, 2015 Dec.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ribonucleic acid (RNA) molecules consist of numerous chemically modified nucleosides that are highly conserved in eukarya, archeae, and bacteria, while others are unique to each domain of life. In bacteria, hundreds of RNA modification enzymes have been identified and implicated in biological pathways associated with many cell processes. The glucose-inhibited division (gid) operon encodes genes for two RNA modification enzymes named GidA and GidB. Studies have shown GidA is essential for the proper biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) of bacterial transfer RNA (tRNA) with GidB responsible for the methylation of the 16S ribosomal RNA (rRNA). Furthermore, deletion of gidA and gidB has shown to alter numerous bacterial properties like virulence, stress response, morphology, growth, antibiotic susceptibility, and others. In this review, we discuss the present knowledge of the RNA modification enzymes GidA and GidB, and their potential role in the biology and virulence of bacteria.
[Mh] Termos MeSH primário: Bactérias/enzimologia
Transferases de Grupo de Um Carbono/genética
Transferases de Grupo de Um Carbono/metabolismo
Óperon
Processamento Pós-Transcricional do RNA
RNA Bacteriano/metabolismo
[Mh] Termos MeSH secundário: Bactérias/genética
Deleção de Genes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (RNA, Bacterial); EC 2.1.- (One-Carbon Group Transferases)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151003
[St] Status:MEDLINE


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[PMID]:26411344
[Au] Autor:Mentch SJ; Mehrmohamadi M; Huang L; Liu X; Gupta D; Mattocks D; Gómez Padilla P; Ables G; Bamman MM; Thalacker-Mercer AE; Nichenametla SN; Locasale JW
[Ad] Endereço:Department of Molecular Biology and Genetics, Field of Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, NY 14853, USA; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durh
[Ti] Título:Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.
[So] Source:Cell Metab;22(5):861-73, 2015 Nov 03.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status. However, it is unknown whether regulation of SAM and SAH by nutrient availability can be directly sensed to alter the kinetics of key histone methylation marks. We provide evidence that the status of methionine metabolism is sufficient to determine levels of histone methylation by modulating SAM and SAH. This dynamic interaction led to rapid changes in H3K4me3, altered gene transcription, provided feedback regulation to one-carbon metabolism, and could be fully recovered upon restoration of methionine. Modulation of methionine in diet led to changes in metabolism and histone methylation in the liver. In humans, methionine variability in fasting serum was commensurate with concentrations needed for these dynamics and could be partly explained by diet. Together these findings demonstrate that flux through methionine metabolism and the sensing of methionine availability may allow direct communication to the chromatin state in cells.
[Mh] Termos MeSH primário: Carbono/metabolismo
Epigênese Genética/genética
Histonas/metabolismo
Metionina/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatina/genética
Regulação da Expressão Gênica
Histona-Lisina N-Metiltransferase/genética
Histona-Lisina N-Metiltransferase/metabolismo
Histonas/genética
Seres Humanos
Fígado/metabolismo
Metilação
Camundongos
Transferases de Grupo de Um Carbono/genética
Transferases de Grupo de Um Carbono/metabolismo
S-Adenosil-Homocisteína/metabolismo
S-Adenosilmetionina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chromatin); 0 (Histones); 7440-44-0 (Carbon); 7LP2MPO46S (S-Adenosylmethionine); 979-92-0 (S-Adenosylhomocysteine); AE28F7PNPL (Methionine); EC 2.1.- (One-Carbon Group Transferases); EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150929
[St] Status:MEDLINE


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[PMID]:25840420
[Au] Autor:Zhao T; Gu D; Xu Z; Huo X; Shen L; Wang C; Tang Y; Wu P; He J; Gong W; He ML; Chen J
[Ad] Endereço:Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
[Ti] Título:Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study.
[So] Source:Oncotarget;6(11):9564-76, 2015 Apr 20.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although it has been shown that polymorphisms in one-carbon metabolism (OCM) pathway are associated with gastric cancer (GC), their interactions and contributions for patients' survival are elusive. In this study, we investigated the effects of polymorphisms and their interactions on the survival of GC patients, including genes of Methylenetetrahydrofolate reductase (MTHFR 677C > T, 1298A > C), Methionine synthase reductase (MTRR 66A > G), Methionine synthase (MTR 2756A > G), and Thymidylate synthase (TS 3'-UTR ins6 > del6, 5'-UTR 2R > 3R). We recruited 919 GC patients from 1998 to 2006. The Kaplan-Meier plots, Cox regression analyses and the log-rank tests were carried out in this study. MTHFR 1298CC genotype showed protective effect (HR = 0.444, 95% CI = 0.210-0.940). MTRR 66 GA + GG genotypes decreased the risk of death (HR = 0.793, 95% CI = 0.651-0.967) in general, and in subgroups with more pronounced diffuse type, greater depth of invasion (T2/T3/T4), higher level lymph node metastasis (N1/N2/N3), advanced TNM stages (II/III level) and 5-Fu treatment. However, the improved survival disappeared when GC patients simultaneously had MTR 2756 GA + GG genotypes (HR = 1.063, 95% CI = 0.750-1.507). Although MTRR 66GA genotype was not associated with the survival of GC patients, patients with simultaneous MTRR 66GA and MTR 2756AA genotypes exhibited significant risk reduction of death (HR = 0.773, 95% CI = 0.609-0.981). MTHFR 1298 CA + CC combined with TS 5-UTR 2R3R + 3R3R genotypes (HR = 0.536, 95% CI = 0.315-0.913) also increased patient survival rates. Our results suggest that the MTRR 66A > G and MTHFR 1298A > C polymorphisms may be useful prognostic biomarkers for GC patients.
[Mh] Termos MeSH primário: Carcinoma/genética
Ferredoxina-NADP Redutase/genética
Metilenotetra-Hidrofolato Redutase (NADPH2)/genética
Proteínas de Neoplasias/genética
Transferases de Grupo de Um Carbono/genética
Polimorfismo Genético
Neoplasias Gástricas/genética
[Mh] Termos MeSH secundário: Regiões 5' não Traduzidas/genética
5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase/genética
Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma/enzimologia
Carcinoma/mortalidade
Carcinoma/patologia
Feminino
Predisposição Genética para Doença
Genótipo
Seres Humanos
Estimativa de Kaplan-Meier
Metástase Linfática
Masculino
Meia-Idade
Mutagênese Insercional
Invasividade Neoplásica/genética
Mutação Puntual
Polimorfismo de Nucleotídeo Único
Modelos de Riscos Proporcionais
Neoplasias Gástricas/enzimologia
Neoplasias Gástricas/mortalidade
Neoplasias Gástricas/patologia
Timidilato Sintase/genética
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (Neoplasm Proteins); EC 1.18.1.- (methionine synthase reductase); EC 1.18.1.2 (Ferredoxin-NADP Reductase); EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)); EC 2.1.- (One-Carbon Group Transferases); EC 2.1.1.13 (5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase); EC 2.1.1.45 (Thymidylate Synthase)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150404
[St] Status:MEDLINE


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[PMID]:25630355
[Au] Autor:Drake AJ; O'Shaughnessy PJ; Bhattacharya S; Monteiro A; Kerrigan D; Goetz S; Raab A; Rhind SM; Sinclair KD; Meharg AA; Feldmann J; Fowler PA
[Ad] Endereço:Endocrinology Unit, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. mandy.drake@ed.ac.uk.
[Ti] Título:In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver.
[So] Source:BMC Med;13:18, 2015 Jan 29.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vitamin B12 and is associated with altered DNA methylation at birth. Altered DNA methylation may be an important mechanism underlying increased disease susceptibility; however, the extent to which this can be induced in the developing fetus is unknown. METHODS: In this retrospective study, we measured concentrations of cobalt, vitamin B12, and mRNA transcripts encoding key enzymes in the 1-carbon cycle in 55 fetal human livers obtained from 11 to 21 weeks of gestation elective terminations and matched for gestation and maternal smoking. DNA methylation was measured at critical regions known to be susceptible to the in utero environment. Homocysteine concentrations were analyzed in plasma from 60 fetuses. RESULTS: In addition to identifying baseline sex differences, we found that maternal smoking was associated with sex-specific alterations of fetal liver vitamin B12, plasma homocysteine and expression of enzymes in the 1-carbon cycle in fetal liver. In the majority of the measured parameters which showed a sex difference, maternal smoking reduced the magnitude of that difference. Maternal smoking also altered DNA methylation at the imprinted gene IGF2 and the glucocorticoid receptor (GR/NR3C1). CONCLUSIONS: Our unique data strengthen studies linking in utero exposures to altered DNA methylation by showing, for the first time, that such changes are present in fetal life and in a key metabolic target tissue, human fetal liver. Furthermore, these data propose a novel mechanism by which such changes are induced, namely through alterations in methyl donor availability and changes in 1-carbon metabolism.
[Mh] Termos MeSH primário: Carbono/metabolismo
Metilação de DNA/efeitos dos fármacos
Feto/metabolismo
Fígado/metabolismo
Transferases de Grupo de Um Carbono/metabolismo
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Peso Corporal
Cobalto/análise
Feminino
Seres Humanos
Fator de Crescimento Insulin-Like II/genética
Fator de Crescimento Insulin-Like II/metabolismo
Fígado/química
Masculino
Transferases de Grupo de Um Carbono/genética
Gravidez
RNA Mensageiro/análise
Receptores de Glucocorticoides/metabolismo
Estudos Retrospectivos
Fatores Sexuais
Vitamina B 12/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (IGF2 protein, human); 0 (NR3C1 protein, human); 0 (RNA, Messenger); 0 (Receptors, Glucocorticoid); 3G0H8C9362 (Cobalt); 67763-97-7 (Insulin-Like Growth Factor II); 7440-44-0 (Carbon); EC 2.1.- (One-Carbon Group Transferases); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150130
[St] Status:MEDLINE
[do] DOI:10.1186/s12916-014-0251-x


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[PMID]:25318605
[Au] Autor:Zhang H; Liu C; Han YC; Ma Z; Zhang H; Ma Y; Liu X
[Ad] Endereço:China Medical University, Shenyang, China.
[Ti] Título:Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.
[So] Source:Tumour Biol;36(2):997-1002, 2015 Feb.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatocellular carcinoma (HCC) is the sixth common cancer and the third common cause of cancer mortality worldwide. However, the exact molecular mechanism of HCC remains uncertain. Many enzymes are involved in one-carbon metabolism (OCM), and single nucleotide polymorphisms (SNPs) in the corresponding genes may play a role in liver carcinogenesis. In this study, we enrolled 1500 HCC patients and 1500 cancer-free controls, which were frequency-matched by age, gender, and HBV infection status. Then eight SNPs from seven OCM genes (MTHFR, MTR, MTRR, FTHFD, GART, SHMT, and CBS) were evaluated. Results showed that six SNPs (MTHFR rs1801133, MTRR rs2287780, MTRR rs10380, FTHFD rs1127717, GART rs8971, and SHMT rs1979277) were significantly associated with HCC risk in Chinese population, with P values range from 2.26 × 10(-4) to 0.035). The most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype and 1.30 (95% CI: 1.10-1.53) for those with CT genotype. Under the log-additive model, each additional copy of minor allele C was associated with a 1.28-fold increased risk of HCC (OR = 1.28, 95% CI: 1.12-1.45). These findings indicated that genetic variants in OCM genes might contribute to HCC susceptibility.
[Mh] Termos MeSH primário: Carbono-Nitrogênio Ligases/genética
Carcinoma Hepatocelular/genética
Neoplasias Hepáticas/genética
Transferases de Grupo de Um Carbono/genética
Fosforribosilglicinamido Formiltransferase/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Alelos
Grupo com Ancestrais do Continente Asiático
Carcinoma Hepatocelular/patologia
Feminino
Estudos de Associação Genética
Predisposição Genética para Doença
Genótipo
Seres Humanos
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.1.- (One-Carbon Group Transferases); EC 2.1.2.2 (Phosphoribosylglycinamide Formyltransferase); EC 6.3.- (Carbon-Nitrogen Ligases); EC 6.3.4.13 (GART protein, human)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141017
[St] Status:MEDLINE
[do] DOI:10.1007/s13277-014-2725-z


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[PMID]:25607529
[Au] Autor:Armengod ME; Meseguer S; Villarroya M; Prado S; Moukadiri I; Ruiz-Partida R; Garzón MJ; Navarro-González C; Martínez-Zamora A
[Ad] Endereço:a Laboratory of RNA Modification and Mitochondrial Diseases ; Centro de Investigación Príncipe Felipe ; Valencia , Spain.
[Ti] Título:Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes.
[So] Source:RNA Biol;11(12):1495-507, 2014.
[Is] ISSN:1555-8584
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Posttranscriptional modification of the uridine located at the wobble position (U34) of tRNAs is crucial for optimization of translation. Defects in the U34 modification of mitochondrial-tRNAs are associated with a group of rare diseases collectively characterized by the impairment of the oxidative phosphorylation system. Retrograde signaling pathways from mitochondria to nucleus are involved in the pathophysiology of these diseases. These pathways may be triggered by not only the disturbance of the mitochondrial (mt) translation caused by hypomodification of tRNAs, but also as a result of nonconventional roles of mt-tRNAs and mt-tRNA-modifying enzymes. The evolutionary conservation of these enzymes supports their importance for cell and organismal functions. Interestingly, bacterial and eukaryotic cells respond to stress by altering the expression or activity of these tRNA-modifying enzymes, which leads to changes in the modification status of tRNAs. This review summarizes recent findings about these enzymes and sets them within the previous data context.
[Mh] Termos MeSH primário: Escherichia coli/metabolismo
Processamento Pós-Transcricional do RNA
RNA/metabolismo
Uridina/análogos & derivados
Uridina/metabolismo
[Mh] Termos MeSH secundário: Anticódon/metabolismo
Núcleo Celular/genética
Núcleo Celular/metabolismo
Códon/metabolismo
Escherichia coli/genética
Proteínas de Escherichia coli/genética
Proteínas de Escherichia coli/metabolismo
GTP Fosfo-Hidrolases/genética
GTP Fosfo-Hidrolases/metabolismo
Mitocôndrias/genética
Mitocôndrias/metabolismo
Complexos Multienzimáticos/genética
Complexos Multienzimáticos/metabolismo
Transferases de Grupo de Um Carbono/genética
Transferases de Grupo de Um Carbono/metabolismo
Fosforilação Oxidativa
RNA/genética
RNA de Transferência Aminoácido-Específico/genética
RNA de Transferência Aminoácido-Específico/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (5-carboxy-methylaminomethyl-2'-O-methyluridine); 0 (Anticodon); 0 (Codon); 0 (Escherichia coli Proteins); 0 (MnmC protein, E coli); 0 (Multienzyme Complexes); 0 (RNA, Transfer, Amino Acid-Specific); 0 (RNA, mitochondrial); 63231-63-0 (RNA); EC 2.1.- (MnmG protein, E coli); EC 2.1.- (One-Carbon Group Transferases); EC 3.6.1.- (GTP Phosphohydrolases); EC 3.6.1.- (MnmE protein, E coli); WHI7HQ7H85 (Uridine)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150122
[St] Status:MEDLINE
[do] DOI:10.4161/15476286.2014.992269



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