[PMID]: | 28933688 |
[Au] Autor: | Luna AP; Rodríguez-Negrete EA; Morilla G; Wang L; Lozano-Durán R; Castillo AG; Bejarano ER |
[Ad] Endereço: | 1​Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Area de Genética, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, E-29071 Málaga, Spain. |
[Ti] Título: | V2 from a curtovirus is a suppressor of post-transcriptional gene silencing. |
[So] Source: | J Gen Virol;98(10):2607-2614, 2017 Oct. |
[Is] ISSN: | 1465-2099 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway. |
[Mh] Termos MeSH primário: |
Proteínas de Arabidopsis/genética Begomovirus/genética Interferência de RNA/fisiologia RNA Replicase/metabolismo Proteínas Virais/genética
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[Mh] Termos MeSH secundário: |
Arabidopsis/virologia Proteínas de Arabidopsis/metabolismo Doenças das Plantas/virologia Plantas Geneticamente Modificadas/genética Plantas Geneticamente Modificadas/virologia RNA Replicase/genética
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Arabidopsis Proteins); 0 (SGS3 protein, Arabidopsis); 0 (Viral Proteins); EC 2.7.7.48 (RDR6 protein, Arabidopsis); EC 2.7.7.48 (RNA Replicase) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 171102 |
[Lr] Data última revisão:
| 171102 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170922 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1099/jgv.0.000933 |
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