Base de dados : MEDLINE
Pesquisa : D09.408.514 [Categoria DeCS]
Referências encontradas : 869 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 87 ir para página                         

  1 / 869 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26342821
[Au] Autor:Taleb-Mokhtari IN; Lazreg A; Sekkal-Rahal M; Bestaoui N
[Ad] Endereço:Laboratoire de Microscopie, Microanalyse de la matière et Spectroscopie Moléculaire (L2MSM), Département de Chimie, Faculté des Sciences, Djillali Liabes University, B.P. 89, 22000, Sidi Bel Abbes, Algeria. Electronic address: il_taleb@yahoo.fr.
[Ti] Título:Vibrational normal modes calculation in the crystalline state of methylated monosaccharides: Anomers of the methyl-D-glucopyranoside and methyl-D-xylopyranoside molecules.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;153:363-73, 2016 Jan 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A structural investigation of the organic molecules is being carried out using vibrational spectroscopy. In this study, normal co-ordinate calculations of anomers of the methyl-D-glucopyranoside and methyl-ß-D-xylopyranoside in the crystalline state have been performed using the modified Urey-Bradley-Shimanouchi force field (mUBSFF) combined with an intermolecular potential energy function. The latter includes Van der Waals interactions, electrostatic terms, and explicit hydrogen bond functions. The vibrational spectra of the compounds recorded in the crystalline state, in the 4000-500 cm(-1) spectral region for the IR spectra, and in the 4000-20 cm(-1) spectral range for the Raman spectra are presented. After their careful examination, several differences in the intensities and frequency shifts have been observed. The theoretical spectra have been obtained after a tedious refinement of the force constants. Thus, on the basis of the obtained potential distribution, each observed band in IR and in Raman has been assigned to a vibrational mode. The obtained results are indeed in agreement with those observed experimentally and thus confirm the previous assignments made for the methyl-α and ß-D-glucopyranoside, as well as for the methyl-ß-D-xylopyranoside.
[Mh] Termos MeSH primário: Metilglucosídeos/química
Metilglicosídeos/química
Monossacarídeos/química
Análise Espectral Raman
Vibração
Xilose/química
[Mh] Termos MeSH secundário: Configuração de Carboidratos
Cristalização
Cristalografia por Raios X
Ligações de Hidrogênio
Isomerismo
Metilação
Eletricidade Estática
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylglucosides); 0 (Methylglycosides); 0 (Monosaccharides); 54L5T38NI8 (methylglucoside); 612-05-5 (methyl xylopyranoside); A1TA934AKO (Xylose)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150907
[St] Status:MEDLINE


  2 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26297117
[Au] Autor:Lee K; Jun SH; Song SH; Park HD; Park KU; Song J
[Ad] Endereço:Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
[Ti] Título:Direct assay of iduronate-2-sulfatase for Hunter disease using UPLC-tandem mass spectrometry and fluorogenic substrate.
[So] Source:Clin Biochem;48(18):1350-3, 2015 Dec.
[Is] ISSN:1873-2933
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We devised iduronate-2-sulfatase (IDS) enzyme activity assays by combining fluorometric substrate and LC-MS/MS based detection. DESIGN AND METHODS: 4-Methylumbelliferyl α-L-idopyranosiduronic acid 2-sulfate (IDS-S) was used as a substrate for IDS. Its enzymatic product, 4-methylumbelliferyl α-L-idopyranosiduronic acid (IDS-P) and internal standard, 4-methylumbelliferyl α-L-idopyranoside (IDS-IS), were directly measured by UPLC-MS/MS. We determined the precision of our enzyme assay and the effects of sample amounts and incubation time based on the results. Dried blood spots (DBSs) of 110 normal newborns and three patients with Hunter disease were analyzed. RESULTS: IDS-IS, IDS-P and IDS-S were fully separated using UPLC without any ion suppressions. The intra- and inter-assay precisions were 8.5-10.5% and 11.9-15.3%, respectively. The amount of product obtained was proportional to the number of DBSs and increased linearly with the incubation period from 0 to 15 h. The enzyme activities in DBSs from three patients with MPS II were markedly lower than those in the DBSs of 110 normal newborns. CONCLUSION: To the best of our knowledge, this is the first report describing the use of LC-MS/MS for the diagnosis of Hunter disease with a commercially available substrate. Our method would be a rapid and effective screening tool for the diagnosis of Hunter disease with further study.
[Mh] Termos MeSH primário: Bioensaio
Glicoproteínas/sangue
Mucopolissacaridose II/sangue
Triagem Neonatal/métodos
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Cromatografia Líquida de Alta Pressão
Teste em Amostras de Sangue Seco/instrumentação
Expressão Gênica
Glicoproteínas/genética
Seres Humanos
Ácido Idurônico/análogos & derivados
Recém-Nascido
Metilglicosídeos/química
Mucopolissacaridose II/diagnóstico
Mucopolissacaridose II/genética
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glycoproteins); 0 (IDS protein, human); 0 (Methylglycosides); 3402-98-0 (Iduronic Acid)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150823
[St] Status:MEDLINE


  3 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26233841
[Au] Autor:Hao DC; Xiao PG; Ma HY; Peng Y; He CN
[Ad] Endereço:Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China. Electronic address: hao@djtu.edu.cn.
[Ti] Título:Mining chemodiversity from biodiversity: pharmacophylogeny of medicinal plants of Ranunculaceae.
[So] Source:Chin J Nat Med;13(7):507-20, 2015 Jul.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:This paper reports a pharmacophylogenetic study of a medicinal plant family, Ranunculaceae, investigating the correlations between their phylogeny, chemical constituents, and pharmaceutical properties. Phytochemical, ethnopharmacological, and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the Ranunculaceae. The chemical components of this family included several representative metabolic groups: benzylisoquinoline alkaloids, ranunculin, triterpenoid saponin, and diterpene alkaloids, among others. Ranunculin and magnoflorine were found to coexist in some genera. The pharmacophylogenetic analysis, integrated with therapeutic information, agreed with the taxonomy proposed previously, in which the family Ranunculaceae was divided into five sub-families: Ranunculoideae, Thalictroideae, Coptidoideae, Hydrastidoideae, and Glaucidioideae. It was plausible to organize the sub-family Ranunculoideae into ten tribes. The chemical constituents and therapeutic efficacy of each taxonomic group were reviewed, revealing the underlying connections between phylogeny, chemical diversity, and clinical use, which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae.
[Mh] Termos MeSH primário: Alcaloides/análise
Biodiversidade
Filogenia
Extratos Vegetais/química
Ranunculaceae/química
Saponinas/análise
Terpenos/análise
[Mh] Termos MeSH secundário: Alcaloides/uso terapêutico
Aporfinas/análise
Aporfinas/uso terapêutico
Furanos/análise
Seres Humanos
Metilglicosídeos/análise
Fitoterapia
Extratos Vegetais/uso terapêutico
Plantas Medicinais/química
Saponinas/uso terapêutico
Terpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Aporphines); 0 (Furans); 0 (Methylglycosides); 0 (Plant Extracts); 0 (Saponins); 0 (Terpenes); IBP7446K1O (ranunculin); NI8K6962K4 (magnoflorine)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150803
[St] Status:MEDLINE


  4 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24569595
[Au] Autor:Sakakibara K; Fujisawa T; Hill JP; Ariga K
[Ad] Endereço:World Premier International (WPI) Centre for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan. Ariga.Katsuhiko@nims.go.jp.
[Ti] Título:Conformational interchange of a carbohydrate by mechanical compression at the air-water interface.
[So] Source:Phys Chem Chem Phys;16(22):10286-94, 2014 Jun 14.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methyl xylopyranoside containing three 4-(pyrene-1-yl)benzoyl groups (PyXy) undergoes conformational interchange within a Langmuir monolayer upon mechanical compression. This xylose-type molecular machine PyXy was immobilized within two different matrix lipids, methyl stearate and methyl 2,3,4-tri-O-stearoyl-ß-D-xylopyranoside, which respectively form rigid and soft monolayers. Structural properties of the monolayer were characterized by assessing the compressibility, compression modulus, and ideal limiting molecular area of PyXy, all of which were estimated from the π-A isotherm measurements. Only the rigid monolayer exhibited a transition to the condensed phase with a limiting molecular area of PyXy smaller than that of the cross-sectional area of the xylopyranose ring in its C1 chair conformation. This suggests conformational interchange of PyXy from the most stable (4)C1 (C1) form to the metastable (1)C4 (1C) form. Surface-reflective fluorescence spectroscopy of the monolayer was applied to detect excimer emission resulting from the face-to-face dimerization of pyrenes attached at the O-2 and O-4 positions of xylose. Fluorescence intensity of the excimer increased abruptly in the condensed region only when the rigid monolayer was applied. These results indicate that the rigidity of the matrix monolayer is a critical aspect of the precise manipulation of molecular machines at interfaces. Consequently, this study demonstrates that including a molecular machine into a rigid lipid matrix is a promising means for the preparation of a novel nanoassembly with dynamic functionalities variable depending on a mechanical stimulus.
[Mh] Termos MeSH primário: Metilglicosídeos/química
Água/química
[Mh] Termos MeSH secundário: Ar
Metilglicosídeos/síntese química
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Methylglycosides); 059QF0KO0R (Water); 612-05-5 (methyl xylopyranoside)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140514
[Lr] Data última revisão:
140514
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140227
[St] Status:MEDLINE
[do] DOI:10.1039/c3cp55078h


  5 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:23803568
[Au] Autor:Adolphson SJ; Dunn ML; Jefferies LK; Steele FM
[Ad] Endereço:Department of Nutrition, Dietetics and Food Science, Brigham Young University, S-221 ESC, Provo, UT 84602, USA.
[Ti] Título:Isolation and characterization of the microflora of nixtamalized corn masa.
[So] Source:Int J Food Microbiol;165(3):209-13, 2013 Aug 01.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Corn tortillas are a staple in the diet among the Mexican population, and are traditionally produced through a process known as nixtamalization. This traditional process involves steeping whole-kernel corn in an alkaline solution overnight and then grinding the corn into dough (masa), which is then baked. While the masa is held before baking, significant microbial change can occur which leads to fermentation and spoilage. The objective of this research was to characterize and identify the microflora of nixtamalized corn masa from six different commercial tortilla mills throughout Guadalajara, Mexico. The identification of samples was conducted using the microbial identification system (MIS), which analyzes cellular fatty acids via gas chromatography to identify bacterial species. Lactic acid bacteria and aerobic mesophiles were the predominant organisms, with both groups having counts ranging from 10(4) to 10(7)cfu/g across all mills. Coliform populations were observed at counts of 10(2) to 10(3)cfu/g, while yeast and mold counts were typically less than 10(1)cfu/g. Some mills showed no presence of coliforms or yeast or mold. Streptococcus bovis and Lactobacillus oris were isolated from all mills, and were the most prevalent organisms representing 43% and 17% of all lactic acid bacteria isolated, respectively. S. bovis was also isolated on the aerobic tryptic soy plates and was the most prevalent species representing 19% of the total organisms from these aerobic plates.
[Mh] Termos MeSH primário: Biodiversidade
Manipulação de Alimentos
Microbiologia de Alimentos
Zea mays/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Contagem de Colônia Microbiana
Lactobacillus/isolamento & purificação
Metilglicosídeos/química
México
Leveduras/isolamento & purificação
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylglycosides); 49754-59-8 (methyl N-acetylsibirosaminide)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:130723
[Lr] Data última revisão:
130723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130628
[St] Status:MEDLINE


  6 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22893559
[Au] Autor:Liu L; Bai Y; Sun N; Xia L; Lowary TL; Klassen JS
[Ad] Endereço:Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
[Ti] Título:Carbohydrate-lipid interactions: affinities of methylmannose polysaccharides for lipids in aqueous solution.
[So] Source:Chemistry;18(38):12059-67, 2012 Sep 17.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The interactions between 3-O-methyl-mannose polysaccharides (MMPs), extracted from Mycobacterium smegmatis (consisting of a mixture of MMP-10, -11, -12 and -13) or obtained by chemical synthesis (MMP-5(s), -8(s), -11(s) and -14(s)), and linear saturated and unsaturated fatty acids (FAs), and a commercial mixture of naphthenic acids (NAs) in aqueous solution at 25 °C and pH 8.5 were quantified by electrospray ionization mass spectrometry (ESI-MS). Association constants (K(a)) for MMP binding to four FAs (myristic acid, palmitic acid, stearic acid and trans-parinaric acid) were measured by using an indirect ESI-MS assay, the "proxy protein" method. The K(a) values are in the 10(4)-10(5) M(-1) range and, based on results obtained for the binding of the synthetic MMPs with palmitic acid, increase with the size of the carbohydrate. Notably, the measured affinity of the extracted MMPs for trans-parinaric acid is two orders of magnitude smaller than the reported value, which was determined by using a fluorescence assay. Using a newly developed competitive binding assay, referred to as the "proxy protein/proxy ligand" ESI-MS method, it was shown that MMPs bind specifically to NAs in aqueous solution, with apparent affinities of approximately (5×10(4)) M(-1) for the mixture of NAs tested. This represents the first demonstration that MMPs can bind to hydrophobic species more complex than those containing linear alkyl/alkenyl chains. Moreover, the approach developed here represents a novel method for probing carbohydrate-lipid interactions.
[Mh] Termos MeSH primário: Carboidratos/química
Ácidos Carboxílicos/química
Lipídeos/química
Metilglicosídeos/química
Metilmanosídeos/química
Mycobacterium/química
Ácidos Palmíticos/química
Polissacarídeos/química
Soluções/química
[Mh] Termos MeSH secundário: Conformação Molecular
Estrutura Molecular
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Carboxylic Acids); 0 (Lipids); 0 (Methylglycosides); 0 (Methylmannosides); 0 (Palmitic Acids); 0 (Polysaccharides); 0 (Solutions); 51023-63-3 (methylmannoside); YNM5U6B7A4 (naphthenic acid)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120816
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201201222


  7 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22711029
[Au] Autor:Sedivy C; Piskorski R; Müller A; Dorn S
[Ad] Endereço:ETH Zurich, Institute of Agricultural Sciences, Applied Entomology, Schmelzbergstrasse 9/LFO, 8092 Zurich, Switzerland.
[Ti] Título:Too low to kill: concentration of the secondary metabolite ranunculin in buttercup pollen does not affect bee larval survival.
[So] Source:J Chem Ecol;38(8):996-1002, 2012 Aug.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growing evidence suggests that the freely accessible pollen of some plants is chemically protected against pollen-feeding flower visitors. For example, a diet of pollen from buttercup plants (Ranunculus) recently was shown to have a deleterious effect on developing larvae of several bee species not specialized on Ranunculus. Numerous Ranunculus species contain ranunculin, the glucosyl hydrate form of the highly reactive and toxic lactone protoanemonin, that causes the toxicity of these plants. We tested whether the presence of ranunculin is responsible for the lethal effects of R. acris pollen on the larvae of two bee species that are not Ranunculus specialists. To investigate the effect on bee larval development, we added ranunculin to the pollen provisions of the Campanula specialist bee Chelostoma rapunculi and the Asteraceae specialist bee Heriades truncorum, and allowed the larvae to feed on these provisions. We quantified ranunculin in pollen of R. acris and in brood cell provisions collected by the Ranunculus specialist bee Chelostoma florisomne. We demonstrated that although ranunculin was lethal to both tested bee species in high concentrations, the concentration in the pollen of R. acris was at least fourfold lower than that tolerated by the larvae of C. rapunculi and H. truncorum in the feeding experiments. Ranunculin concentration in the brood cells of C. florisomne was on average even twentyfold lower than that in Ranunculus pollen, suggesting that a mechanism different from ranunculin intoxication accounts for the larval mortality reported for bees not specialized on Ranunculus pollen.
[Mh] Termos MeSH primário: Abelhas/efeitos dos fármacos
Furanos/toxicidade
Metilglicosídeos/toxicidade
Pólen/química
[Mh] Termos MeSH secundário: Animais
Abelhas/crescimento & desenvolvimento
Furanos/química
Estimativa de Kaplan-Meier
Larva/efeitos dos fármacos
Metilglicosídeos/química
Ranunculus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 0 (Methylglycosides); 66FQZ1A5SO (protoanemonin); IBP7446K1O (ranunculin)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120620
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-012-0153-3


  8 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22533917
[Au] Autor:Johnsson R
[Ad] Endereço:Center for Analysis and Synthesis, Lund University, PO Box 124, SE-221 00 Lund, Sweden. richard.johnsson@organic.lu.se
[Ti] Título:Tetraisopropyldisiloxane-1,3-diyl as a versatile protecting group for pentopyranosides.
[So] Source:Carbohydr Res;353:92-5, 2012 May 15.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The protecting group tetraisopropyldisiloxane-1,3-yl has been investigated for simultaneous protection of two hydroxyls on pentopyranosides. Methyl α-D-xylopyranoside is protected in excellent regioselectivity and high yield to form the 2,3-protected xylopyranoside whereas methyl ß-D-xylopyranoside gives the 3,4-protected product also with excellent regioselectivity.
[Mh] Termos MeSH primário: Silanos/química
[Mh] Termos MeSH secundário: Metilglicosídeos/química
Estrutura Molecular
Estereoisomerismo
Especificidade por Substrato
Xilose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Methylglycosides); 0 (Silanes); 13597-73-4 (disiloxane); 612-05-5 (methyl xylopyranoside); A1TA934AKO (Xylose)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120427
[St] Status:MEDLINE
[do] DOI:10.1016/j.carres.2012.03.016


  9 / 869 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22296272
[Au] Autor:Park DK; Choi WS; Park HJ
[Ad] Endereço:Department of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of Korea.
[Ti] Título:Antiallergic activity of novel isoflavone methyl-glycosides from Cordyceps militaris grown on germinated soybeans in antigen-stimulated mast cells.
[So] Source:J Agric Food Chem;60(9):2309-15, 2012 Mar 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isoflavones are known to possess immunomodulating and antiallergic activities. Previously we identified novel isoflavone methyl-glycosides (daidzein 7-O-ß-d-glucoside 4″-O-methylate (CDGM), glycitein 7-O-ß-D-glucoside 4″-O-methylate (CGLM), genistein 7-O-ß-D-glucoside 4″-O-methylate (CGNMI) and genistein 4'-O-ß-D-glucoside 4″-O-methylate (CGNMII)) from Cordyceps militaris grown on germinated soybeans (GSC). The biological activity of novel isoflavone methyl-glycosides, however, remains unknown. In this study, CGNMII showed the strongest inhibition of degranulation. Additionally, the release of interleukin (IL)-4 and tumor necrosis factor (TNF)-α was decreased by CGNMII in antigen-stimulated RBL-2H3 cells. To elucidate the antiallergic mechanism of CGNMII, we examined whether it affected levels of signaling molecules responsible for degranulation. The levels of activated Lyn, Syk, PLCγ1 and LAT proteins were reduced in CGNMII treated RBL-2H3 cells. CGNMII also inhibited the activation of AKT and ERK1/2 proteins. These results suggest that CGNMII might be used as a therapeutic agent for allergic diseases.
[Mh] Termos MeSH primário: Antialérgicos/farmacologia
Cordyceps/crescimento & desenvolvimento
Isoflavonas/farmacologia
Mastócitos/imunologia
Metilglicosídeos/farmacologia
Feijão de Soja/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Células da Medula Óssea
Degranulação Celular/efeitos dos fármacos
Células Cultivadas
Cordyceps/química
Ativação Enzimática/efeitos dos fármacos
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Germinação
Imunoglobulina E/imunologia
Interleucina-4/secreção
Masculino
Mastócitos/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos BALB C
Células Neoplásicas Circulantes
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ratos
Fator de Necrose Tumoral alfa/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Isoflavones); 0 (Methylglycosides); 0 (Tumor Necrosis Factor-alpha); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:120307
[Lr] Data última revisão:
120307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120203
[St] Status:MEDLINE
[do] DOI:10.1021/jf205199j


  10 / 869 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20603556
[Au] Autor:Allscher T; Klüfers P
[Ad] Endereço:Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
[Ti] Título:Methyl beta-D-fructopyranoside.
[So] Source:Acta Crystallogr C;66(Pt 7):o321-3, 2010 Jul.
[Is] ISSN:1600-5759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In methyl beta-D-fructopyranoside, C(7)H(14)O(6), the thermodynamically most stable methyl glycoside of the ketose D-fructose, the pyranose ring is close to being an ideal (2)C(5) chair. The compound forms bilayers involving a complex hydrogen-bonding pattern of five independent hydrogen bonds. Graph-set analysis was applied to distinguish the hydrogen-bond patterns at unary and higher level graph sets.
[Mh] Termos MeSH primário: Cristalografia por Raios X
Metilglicosídeos/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Estrutura Molecular
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylglycosides); 0 (methyl beta-D-fructopyranoside)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:100706
[Lr] Data última revisão:
100706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100707
[St] Status:MEDLINE
[do] DOI:10.1107/S0108270110019888



página 1 de 87 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde