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  1 / 10914 MEDLINE  
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[PMID]:29268134
[Au] Autor:Plebanek E; Lescrinier E; Andrei G; Snoeck R; Herdewijn P; De Jonghe S
[Ad] Endereço:Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49 - bus 1041, 3000 Leuven, Belgium.
[Ti] Título:Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
[So] Source:Eur J Med Chem;144:93-103, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2'-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of antiviral activity against RNA viruses. In contrast, some of the 2'-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.
[Mh] Termos MeSH primário: Antivirais/química
Antivirais/farmacologia
Nucleosídeos/química
Nucleosídeos/farmacologia
Pirazinas/química
Pirazinas/farmacologia
[Mh] Termos MeSH secundário: Antivirais/síntese química
Linhagem Celular
Herpes Simples/tratamento farmacológico
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 1/fisiologia
Herpesvirus Humano 3/efeitos dos fármacos
Herpesvirus Humano 3/fisiologia
Seres Humanos
Nucleosídeos/síntese química
Pirazinas/síntese química
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Nucleosides); 0 (Pyrazines); R14TE35LHD (emimycin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 10914 MEDLINE  
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[PMID]:28453010
[Au] Autor:Sethi S; Ooe M; Sakamoto T; Fujimoto K
[Ad] Endereço:School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan. kenzo@jaist.ac.jp.
[Ti] Título:Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.
[So] Source:Mol Biosyst;13(6):1152-1156, 2017 Jun 01.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Photo-chemical deamination of cytosine using 3-cyanovinylcarbazole nucleoside ( K) mediated photo-cross-linking is a technique for site-directed mutagenesis. Using this technique in vivo requires the elimination of a high-temperature incubation step; instead, incubation should be carried out under physiological conditions. To improve the reactivity of K mediated photo-cross-link induced deamination of cytosine under physiological conditions, an evaluation of base pairing in cytosine was carried out with respect to its deamination. Guanine was replaced with 4 different counter bases (inosine, 2-aminopurine, 5-nitroindole, and nebularine), showing distinct hydrogen bonding patterns with target cytosine, which was incorporated at the -1 position with respect to K in the K-modified photo-responsive oligodeoxyribonucleotides to ascertain the role of hydrogen bonding in deamination under physiological conditions. Among the counter bases, inosine showed the highest acceleration towards the photo-induced deamination reaction.
[Mh] Termos MeSH primário: Citosina/química
DNA/química
Guanina/química
Nucleosídeos/química
[Mh] Termos MeSH secundário: 2-Aminopurina/química
Pareamento de Bases
Desaminação
Ligações de Hidrogênio
Indóis/química
Estrutura Molecular
Mutagênese Sítio-Dirigida
Oligodesoxirribonucleotídeos/química
Nucleosídeos de Purina/química
Ribonucleosídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Nucleosides); 0 (Oligodeoxyribonucleotides); 0 (Purine Nucleosides); 0 (Ribonucleosides); 452-06-2 (2-Aminopurine); 5Z93L87A1R (Guanine); 8J337D1HZY (Cytosine); 9007-49-2 (DNA); B8B604PS4P (nebularine); O2BHX6EDBN (5-nitroindole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1039/c7mb00082k


  3 / 10914 MEDLINE  
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[PMID]:29215337
[Au] Autor:Tütüncü EE; Güner R; Gürbüz Y; Kaya Kalem A; Öztürk B; Hasanoglu I; Sencan I; Tasyaran MA
[Ad] Endereço:Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
[Ti] Título:Adherence to Nucleoside/Nucleotide Analogue Treatment in Patients with Chronic Hepatitis B.
[So] Source:Balkan Med J;34(6):540-545, 2017 12 01.
[Is] ISSN:2146-3131
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adherence to medication is an important aspect of preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B. AIMS: To assess adherence to nucleoside/nucleotide analogues in chronic hepatitis B treatment and to determine factors associated with non-adherence. STUDY DESIGN: Cross-sectional study. METHODS: The study enrolled 85 chronic hepatitis B patients who had been receiving nucleoside/nucleotide analogues for ≥3 months. A questionnaire was completed by patients themselves, and adherence was evaluated based on patients' self-reporting. The use of at least 95% of the drugs in the previous month was considered as adequate adherence. RESULTS: Adherence was adequate in 82.4% of patients. Female gender (p=0.003), unemployment (p=0.041) and lower monthly family income (p=0.001) were related to lower adherence. Better adherence was significantly linked to adequate basic knowledge regarding chronic hepatitis B (p=0.049), longer treatment duration than 12 months (p<0.001), previous use of other medications for chronic hepatitis B (p=0.014) and regular follow-up by the same physician (p<0.001). CONCLUSION: Counselling patients about their disease state and the consequences of non-adherence is an important intervention for enhancing adherence. Naïve patients should be followed up more frequently to reinforce adherence.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Aconselhamento Diretivo/métodos
Alfabetização em Saúde/estatística & dados numéricos
Hepatite B Crônica/tratamento farmacológico
Adesão à Medicação/estatística & dados numéricos
Nucleosídeos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Masculino
Meia-Idade
Fatores Socioeconômicos
Inquéritos e Questionários
Turquia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Nucleosides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.4274/balkanmedj.2016.1461


  4 / 10914 MEDLINE  
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[PMID]:29386460
[Au] Autor:Shuto S
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Hokkaido University.
[Ti] Título:Foreword.
[So] Source:Chem Pharm Bull (Tokyo);66(2):116, 2018.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antivirais/farmacologia
Nucleosídeos/farmacologia
Nucleotídeos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Antivirais/síntese química
Antivirais/química
Pesquisa Biomédica
Química Farmacêutica
Sistemas de Liberação de Medicamentos
Seres Humanos
Nucleosídeos/síntese química
Nucleosídeos/química
Nucleotídeos/síntese química
Nucleotídeos/química
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Nucleosides); 0 (Nucleotides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c18-ctf6602


  5 / 10914 MEDLINE  
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[PMID]:29323115
[Au] Autor:Becker S; Schneider C; Okamura H; Crisp A; Amatov T; Dejmek M; Carell T
[Ad] Endereço:Center for Integrated Protein Science Munich CiPSM at the Department of Chemistry, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
[Ti] Título:Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.
[So] Source:Nat Commun;9(1):163, 2018 01 11.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet-dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental biopolymer during chemical evolution. The question of how a complex multistep chemical synthesis of RNA building blocks was possible in such an environment remains unanswered. Here we report that geothermal fields could provide the right setup for establishing wet-dry cycles that allow for the synthesis of RNA nucleosides by continuous synthesis. Our model provides both the canonical and many ubiquitous non-canonical purine nucleosides in parallel by simple changes of physical parameters such as temperature, pH and concentration. The data show that modified nucleosides were potentially formed as competitor molecules. They could in this sense be considered as molecular fossils.
[Mh] Termos MeSH primário: Biopolímeros/química
Nucleosídeos/química
RNA/química
Água/química
[Mh] Termos MeSH secundário: Terra (Planeta)
Evolução Química
Modelos Químicos
Estrutura Molecular
Origem da Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biopolymers); 0 (Nucleosides); 059QF0KO0R (Water); 63231-63-0 (RNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02639-1


  6 / 10914 MEDLINE  
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[PMID]:29174506
[Au] Autor:Qiu X; Huang Y; Wu D; Mao F; Zhu J; Yan W; Luo HB; Li J
[Ad] Endereço:Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.
[Ti] Título:Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.
[So] Source:Bioorg Med Chem;26(1):119-133, 2018 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phosphodiesterase 2 (PDE2) has received much attention for the potential treatment of the central nervous system (CNS) disorders and pulmonary hypertension. Herein, we identified that clofarabine (4), an FDA-approved drug, displayed potential PDE2 inhibitory activity (IC = 3.12 ±â€¯0.67 µM) by structure-based virtual screening and bioassay. Considering the potential therapeutic benefit of PDE2, a series of purine nucleoside derivatives based on the structure and binding mode of 4 were designed, synthesized and evaluated, which led to the discovery of the best compound 14e with a significant improvement of inhibitory potency (IC = 0.32 ±â€¯0.04 µM). Further molecular docking and molecular dynamic (MD) simulations studies revealed that 5'-benzyl group of 14e could interact with the unique hydrophobic pocket of PDE2 by forming extra van der Waals interactions with hydrophobic residues such as Leu770, Thr768, Thr805 and Leu809, which might contribute to its enhancement of PDE2 inhibition. These potential compounds reported in this article and the valuable structure-activity relationships (SARs) might bring significant instruction for further development of potent PDE2 inhibitors.
[Mh] Termos MeSH primário: Nucleotídeo Cíclico Fosfodiesterase do Tipo 2/antagonistas & inibidores
Descoberta de Drogas
Nucleosídeos/farmacologia
Inibidores de Fosfodiesterase/farmacologia
Purinas/farmacologia
[Mh] Termos MeSH secundário: Nucleotídeo Cíclico Fosfodiesterase do Tipo 2/metabolismo
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Modelos Moleculares
Estrutura Molecular
Nucleosídeos/síntese química
Nucleosídeos/química
Inibidores de Fosfodiesterase/síntese química
Inibidores de Fosfodiesterase/química
Purinas/síntese química
Purinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nucleosides); 0 (Phosphodiesterase Inhibitors); 0 (Purines); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 2); EC 3.1.4.17 (PDE2A protein, human); W60KTZ3IZY (purine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  7 / 10914 MEDLINE  
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[PMID]:29174810
[Au] Autor:Liu Y; Peng Y; Lu J; Wang J; Ma H; Song C; Liu B; Qiao Y; Yu W; Wu J; Chang J
[Ad] Endereço:College of Chemistry and Molecular Engineering, Zhengzhou University, Henan 450001, PR China.
[Ti] Título:Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2'-deoxy-2'-fluoro- 4'-azido nucleoside derivatives as potent anti-HBV agents.
[So] Source:Eur J Med Chem;143:137-149, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Novel drugs are urgently needed to combat hepatitis B virus (HBV) infection due to drug-resistant virus. In this paper, a series of novel 4-monosubstituted 2'-deoxy-2'-ß-fluoro-4'-azido-ß-d-arabinofuranosyl 1,2,3-triazole nucleoside analogues (1a-g) were designed, synthesized and screened for in vitro anti-HBV activity. At 5.0 µM in the cellular model, all the synthetic compounds display activities comparable to that of the positive control, lamivudine at 20 µM. Of the compounds tested, the amide-substituted analogue (1a) shows the most promising anti-HBV activity and low cytotoxicity in the cell model. In particular, it retains excellent activity against lamivudine-resistant HBV mutants. In duck HBV (DHBV)-infected duck models, both the serum and liver DHBV DNA levels (67.4% and 53.3%, respectively) were reduced markedly by the treatment with 1a. Analysis of the structure of HBV polymer/1a-triphosphate (1a-TP) complex shows that 1a-TP is stabilized by specific van der Waals interactions with the enzyme residues arising from 4-amino-1,2,3-triazole and the 4'-azido group.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Desenho de Drogas
Vírus da Hepatite B do Pato/efeitos dos fármacos
Vírus da Hepatite B/efeitos dos fármacos
Hepatite B/tratamento farmacológico
Monossacarídeos/farmacologia
Nucleosídeos/farmacologia
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/síntese química
Antivirais/química
Sobrevivência Celular/efeitos dos fármacos
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Patos
Células Hep G2
Vírus da Hepatite B/genética
Seres Humanos
Modelos Moleculares
Estrutura Molecular
Monossacarídeos/síntese química
Monossacarídeos/química
Nucleosídeos/síntese química
Nucleosídeos/química
Relação Estrutura-Atividade
Triazóis/síntese química
Triazóis/química
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2'-deoxy-2'-beta-fluoro-4'-azido-b-D-arabinofuranosyl 1,2,3-triazole); 0 (Antiviral Agents); 0 (Monosaccharides); 0 (Nucleosides); 0 (Triazoles)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  8 / 10914 MEDLINE  
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[PMID]:29239699
[Au] Autor:Mohamed MANM; Abu-Alola LMB; Aljaied NMG
[Ad] Endereço:a Department of Chemistry, Faculty of Science , Taif University , Saudi Arabia , Taif , KSA.
[Ti] Título:Nucleosides 9: Design and synthesis of new 8-nitro and 8-amino xanthine nucleosides of expected biological activity.
[So] Source:Nucleosides Nucleotides Nucleic Acids;36(12):745-756, 2017 Dec 02.
[Is] ISSN:1532-2335
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The coupling reaction of 1,3-dimethylxanthine (theophylline), 3-benzylxanthine and 3-benzyl-1-methylxanthine with 1-O-acetyl-2,3,5-tri-O-benzoyl-ß-D-ribofuranose afforded the corresponding protected nucleosides, respectively. Nitration of each of the theophylline and 3-benzy-1-methyllxanthine protected nucleosides yielded the corresponding 8-nitronucleosides derivatives, which were reduced to give the corresponding 8-aminonucleoside derivatives. Debenzoylation of protected nucleosides formed by using methanolic sodium methoxide afforded the corresponding free N-nucleosides, respectively. The structures of products have been elucidated and reported and also some of the products were screened for their antimicrobial activity. Some of tested products showed moderate activity.
[Mh] Termos MeSH primário: Anti-Infecciosos/síntese química
Anti-Infecciosos/farmacologia
Desenho de Drogas
Nucleosídeos/síntese química
Nucleosídeos/farmacologia
Xantina/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Técnicas de Química Sintética
Nucleosídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Nucleosides); 1AVZ07U9S7 (Xanthine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1080/15257770.2017.1395036


  9 / 10914 MEDLINE  
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[PMID]:29232373
[Au] Autor:Kesnerová L; Mars RAT; Ellegaard KM; Troilo M; Sauer U; Engel P
[Ad] Endereço:Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
[Ti] Título:Disentangling metabolic functions of bacteria in the honey bee gut.
[So] Source:PLoS Biol;15(12):e2003467, 2017 Dec.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is presently unclear how much individual community members contribute to the overall metabolic output of a gut microbiota. To address this question, we used the honey bee, which harbors a relatively simple and remarkably conserved gut microbiota with striking parallels to the mammalian system and importance for bee health. Using untargeted metabolomics, we profiled metabolic changes in gnotobiotic bees that were colonized with the complete microbiota reconstituted from cultured strains. We then determined the contribution of individual community members in mono-colonized bees and recapitulated our findings using in vitro cultures. Our results show that the honey bee gut microbiota utilizes a wide range of pollen-derived substrates, including flavonoids and outer pollen wall components, suggesting a key role for degradation of recalcitrant secondary plant metabolites and pollen digestion. In turn, multiple species were responsible for the accumulation of organic acids and aromatic compound degradation intermediates. Moreover, a specific gut symbiont, Bifidobacterium asteroides, stimulated the production of host hormones known to impact bee development. While we found evidence for cross-feeding interactions, approximately 80% of the identified metabolic changes were also observed in mono-colonized bees, with Lactobacilli being responsible for the largest share of the metabolic output. These results show that, despite prolonged evolutionary associations, honey bee gut bacteria can independently establish and metabolize a wide range of compounds in the gut. Our study reveals diverse bacterial functions that are likely to contribute to bee health and provide fundamental insights into how metabolic activities are partitioned within gut communities.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Abelhas/metabolismo
Abelhas/microbiologia
Microbioma Gastrointestinal
[Mh] Termos MeSH secundário: Animais
Bactérias/isolamento & purificação
Fermentação
Flavonoides/metabolismo
Cadeia Alimentar
Microbioma Gastrointestinal/fisiologia
Metabolômica
Nucleosídeos/metabolismo
Pólen/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Nucleosides)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2003467


  10 / 10914 MEDLINE  
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[PMID]:28450641
[Au] Autor:DiRocco DA; Ji Y; Sherer EC; Klapars A; Reibarkh M; Dropinski J; Mathew R; Maligres P; Hyde AM; Limanto J; Brunskill A; Ruck RT; Campeau LC; Davies IW
[Ad] Endereço:Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA. daniel.dirocco@merck.com.
[Ti] Título:A multifunctional catalyst that stereoselectively assembles prodrugs.
[So] Source:Science;356(6336):426-430, 2017 Apr 28.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The catalytic stereoselective synthesis of compounds with chiral phosphorus centers remains an unsolved problem. State-of-the-art methods rely on resolution or stoichiometric chiral auxiliaries. Phosphoramidate prodrugs are a critical component of pronucleotide (ProTide) therapies used in the treatment of viral disease and cancer. Here we describe the development of a catalytic stereoselective method for the installation of phosphorus-stereogenic phosphoramidates to nucleosides through a dynamic stereoselective process. Detailed mechanistic studies and computational modeling led to the rational design of a multifunctional catalyst that enables stereoselectivity as high as 99:1.
[Mh] Termos MeSH primário: Amidas/síntese química
Antineoplásicos/síntese química
Antivirais/síntese química
Nucleosídeos/síntese química
Ácidos Fosfóricos/síntese química
Pró-Fármacos/síntese química
[Mh] Termos MeSH secundário: Catálise
Simulação por Computador
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Nucleosides); 0 (Phosphoric Acids); 0 (Prodrugs); 9Q189608GB (phosphoramidic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1126/science.aam7936



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